Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity

Science

Volumn 341, Issue 6143, 2013, Pages 275-278

  Asai, Masato ^a,b   Ramachandrappa, Shwetha ^c   Joachim, Maria ^a   Shen, Yuan ^a   Zhang, Rong ^a   Nuthalapati, Nikhil ^a   Ramanathan, Visali ^a   Strochlic, David E ^a   Ferket, Peter ^d   Linhart, Kirsten ^a,j   Ho, Caroline ^a   Novoselova, Tatiana V ^e   Garg, Sumedha ^c   Ridderstråle, Martin ^f,g   Marcus, Claude ^h   Hirschhorn, Joel N ^a,i   Keogh, Julia M ^c   O'Rahilly, Stephen ^c   Chan, Li F ^e   Clark, Adrian J ^e   Farooqi, I Sadaf ^c   Majzoub, Joseph A ^a   more..

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f LUND UNIVERSITY   (Sweden)

^g STENO DIABETES CENTER   (Denmark)

^h KAROLINSKA INSTITUTE   (Sweden)

ⁱ BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^j UNIVERSITY OF HEIDELBERG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; MELANOCORTIN 2 RECEPTOR; MESSENGER RNA;

BRAIN; GENE EXPRESSION; OBESITY; PHYSIOLOGY; PROTEIN; RODENT;

ANIMAL MODEL; ARTICLE; BODY MASS; BODY TEMPERATURE; BRAIN STEM; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENETIC VARIABILITY; HETEROZYGOTE; HOMEOSTASIS; HYPERPHAGIA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; LIGAND BINDING; LOCOMOTION; LOSS OF FUNCTION MUTATION; LUNG GAS EXCHANGE; MALE; MAMMALIAN DISEASE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; THALAMUS;

EID: 84880438580     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1233000     Document Type: Article

References (13)

1. R. D. Cone, Endocr. Rev. 27, 736-749 (2006).
2. D. L. Hay, D. R. Poyner, P. M. Sexton, Pharmacol. Ther. 109, 173 -197 (2006).
3. P. M. Hinkle, J. A. Sebag, Mol. Cell. Endocrinol. 300, 25-31 (2009).
4. S. N. Cooray, A. J. Clark, Mol. Cell. Endocrinol. 331, 215-221 (2011).
5. L. A. Metherell et al., Nat. Genet. 37, 166-170 (2005).
6. L. F. Chan, L. A. Metherell, A. J. Clark, Eur. J. Pharmacol. 660, 171 -180 (2011).
7. L. F. Chan et al., Proc. Natl. Acad. Sci. U.S.A. 106, 6146-6151 (2009).
8. J. A. Sebag, P. M. Hinkle, Sci. Signal. 3, ra28 (2010).
9. M. H. Tschöp et al., Nat. Methods 9, 57-63 (2012).
10. N. Balthasar et al., Cell 123, 493-505 (2005).
11. S. Farooqi, S. O'Rahilly, Endocr. Rev. 27, 710-718 (2006).
12. L. E. Johansson et al., PLoS ONE 4, e5327 (2009).
13. J. A. Sebag et al., Science 341, 278 (2013).