Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

PLoS Genetics

Volumn 9, Issue 7, 2013, Pages

  Ahmad, Shafqat ^a   Rukh, Gull ^b   Varga, Tibor V ^a   Ali, Ashfaq ^a   Kurbasic, Azra ^a,c   Shungin, Dmitry ^a,d   Ericson, Ulrika ^b   Koivula, Robert W ^a   Chu, Audrey Y ^e   Rose, Lynda M ^e   Ganna, Andrea ^f   Qi, Qibin ^g   Stančáková, Alena ^h   Sandholt, Camilla H ⁱ   Elks, Cathy E ^j   Curhan, Gary ^e,g   Jensen, Majken K ^g   Tamimi, Rulla M ^e,g   Allin, Kristine H ⁱ   Jørgensen, Torben ^k   Brage, Soren ^j   Langenberg, Claudia ^j   Aadahl, Mette ^k   Grarup, Niels ⁱ   Linneberg, Allan ^k   Paré, Guillaume ^l,m   Magnusson, Patrik K E ^f   Pedersen, Nancy L ^f   Boehnke, Michael ^q   Hamsten, Anders ^f   Mohlke, Karen L ^r   Pasquale, Louis T ^s   Pedersen, Oluf ^i,n,t   Scott, Robert A ^j   Ridker, Paul M ^e   Ingelsson, Erik ^u   Laakso, Markku ^h,p   Hansen, Torben ^i,n,o   Qi, Lu ^e,g   Wareham, Nicholas J ^j   Chasman, Daniel I ^e   Hallmans, Göran ^d   Hu, Frank B ^e,g   Renström, Frida ^a   Orho Melander, Marju ^b   Franks, Paul W ^a,d,g   more..

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c STENO DIABETES CENTER   (Denmark)

^d UMEÅ UNIVERSITY   (Sweden)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f KAROLINSKA INSTITUTE   (Sweden)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^h UNIVERSITY OF EASTERN FINLAND   (Finland)

ⁱ Capital Region   (Denmark)

^j ADDENBROOKE S HOSPITAL   (United Kingdom)

^k GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^l MCMASTER UNIVERSITY   (Canada)

^m MCMASTER UNIVERSITY   (Canada)

ⁿ UNIVERSITY OF COPENHAGEN   (Denmark)

^o UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^p KUOPIO UNIVERSITY HOSPITAL   (Finland)

^q UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^r UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^s HARVARD MEDICAL SCHOOL   (United States)

^t AARHUS UNIVERSITY   (Denmark)

^u UPPSALA UNIVERSITY   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MELANOCORTIN 4 RECEPTOR;

ARTICLE; BDNF GENE; BODY MASS; CAUCASIAN; CONTROLLED STUDY; ETV5 GENE; EUROPE; FAIM2 GENE; FTO GENE; GENE; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; KCTD15 GENE; MAJOR CLINICAL STUDY; MC4R GENE; NEGR1 GENE; OBESITY; PHYSICAL ACTIVITY; SCORING SYSTEM; SEC16B GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TMEM18 GENE;

ADULT; ALLELES; BODY MASS INDEX; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; MALE; MOTOR ACTIVITY; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; RISK FACTORS;

EID: 84880838336     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003607     Document Type: Article

References (33)

1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, et al. (2006) Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295: 1549-1555.
2. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
3. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
4. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115.
5. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
6. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
7. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, et al. (2008) Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57: 95-101.
8. Franks PW, Jablonski KA, Delahanty LM, McAteer JB, Kahn SE, et al. (2008) Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia 51: 2214-2223.
9. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfalt E, et al. (2009) Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 90: 1418-1425.
10. Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, et al. (2008) Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 168: 1791-1797.
11. Kilpelainen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, et al. (2011) Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 8: e1001116.
12. Li S, Zhao JH, Luan J, Ekelund U, Luben RN, et al. (2010) Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med 7: e1000332.
13. InterAct C, (2012) Validity of a short questionnaire to assess physical activity in 10 European countries. Eur J Epidemiol 27: 15-25.
14. Xiao R, Boehnke M, (2009) Quantifying and correcting for the winner's curse in genetic association studies. Genet Epidemiol 33: 453-462.
15. Ragland DR, (1992) Dichotomizing continuous outcome variables: dependence of the magnitude of association and statistical power on the cutpoint. Epidemiology 3: 434-440.
16. Wong MY, Day NE, Luan JA, Chan KP, Wareham NJ, (2003) The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol 32: 51-57.
17. Delahanty LM, Pan Q, Jablonski KA, Watson KE, McCaffery JM, et al. (2012) Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care 35: 363-366.
18. Goring HH, Terwilliger JD, Blangero J, (2001) Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 69: 1357-1369.
19. Franks PW, (2011) Gene × environment interactions in type 2 diabetes. Curr Diab Rep 11: 552-561.
20. Franks PW, Nettleton JA, (2010) Invited commentary: Gene × lifestyle interactions and complex disease traits-inferring cause and effect from observational data, sine qua non. Am J Epidemiol 172: 992-997 discussion 998-999.
21. Loos RJ, (2012) Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 26: 211-226.
22. Ekelund U, Brage S, Besson H, Sharp S, Wareham NJ, (2008) Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality? Am J Clin Nutr 88: 612-617.
23. Loos RJ, Rankinen T, Tremblay A, Perusse L, Chagnon Y, et al. (2005) Melanocortin-4 receptor gene and physical activity in the Quebec Family Study. Int J Obes (Lond) 29: 420-428.
24. Metcalf BS, Hosking J, Jeffery AN, Voss LD, Henley W, et al. (2011) Fatness leads to inactivity, but inactivity does not lead to fatness: a longitudinal study in children (EarlyBird 45). Arch Dis Child 96: 942-947.
25. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN, (2008) An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359: 2558-2566.
26. Jonsson A, Franks PW, (2009) Obesity, FTO gene variant, and energy intake in children. N Engl J Med 360: 1571-1572 author reply 1572.
27. Qi Q, Chu AY, Kang JH, Jensen MK, Curhan GC, et al. (2012) Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 367: 1387-1396.
28. Ridker PM, Chasman DI, Zee RY, Parker A, Rose L, et al. (2008) Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women. Clin Chem 54: 249-255.
29. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894: i-xii, 1-253.
30. Renstrom F, Shungin D, Johansson I, Investigators M, Florez JC, et al. (2011) Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. Diabetes 60: 345-354.
31. Renstrom F, Payne F, Nordstrom A, Brito EC, Rolandsson O, et al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 18: 1489-1496.
32. Langenberg C, Sharp S, Forouhi NG, Franks PW, et al. (2011) Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia 54: 2272-2282.
33. Browne WJ, Mousa G, Parker RMA (2009) A Guide to Sample Size Calculations for Random Effect Models via Simulation and the MLPowSim Software Package. Bristol, United Kingdom: University of Bristol.