Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1

Endocrinology (United States)

Volumn 155, Issue 9, 2014, Pages 3219-3226

  Pearce, Laura R ^a   Joe, Ray ^b   Doche, Michael E ^b   Su, Hsiao Wen ^b   Keogh, Julia M ^a   Henning, Elana ^a   Argetsinger, Lawrence S ^b   Bochukova, Elena G ^a   Cline, Joel M ^b   Garg, Sumedha ^a   Saeed, Sadia ^a   Shoelson, Steven ^c   O'Rahilly, Stephen ^a   Barroso, Inês ^a,d   Rui, Liangyou ^b   Farooqi, I Sadaf ^a   Carter Su, Christin ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GROWTH HORMONE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; ISOPROTEIN; LEPTIN; NERVE GROWTH FACTOR; SARCOMA HOMOLOGY 2 B ADAPTOR PROTEIN 1 ALPHA; SARCOMA HOMOLOGY 2 B ADAPTOR PROTEIN 1 BETA; UNCLASSIFIED DRUG; SH2B1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ARTICLE; ASSAY; CELL MOTILITY; DISEASE SEVERITY; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYPERINSULINEMIA; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; NERVE FIBER GROWTH; NUCLEOTIDE SEQUENCE; OBESITY; PHENOTYPE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ADOLESCENT; ALTERNATIVE RNA SPLICING; CHILD; GENETICS; METABOLISM; MISSENSE MUTATION; YOUNG ADULT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; ALTERNATIVE SPLICING; CHILD; FEMALE; HUMANS; INSULIN; LEPTIN; MALE; MUTATION, MISSENSE; OBESITY; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84907042725     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1264     Document Type: Article

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