Human SH2B1 mutations are associated with maladaptive behaviors and obesity

Journal of Clinical Investigation

Volumn 122, Issue 12, 2012, Pages 4732-4736

  Doche, Michael E ^a   Bochukova, Elena G ^b   Su, Hsiao Wen ^a   Pearce, Laura R ^b   Keogh, Julia M ^b   Henning, Elana ^b   Cline, Joel M ^a   Dale, Anne ^c   Cheetham, Tim ^d   Barroso, Inês ^b,e   Argetsinger, Lawrence S ^a   O'Rahilly, Stephen ^b   Rui, Liangyou ^a   Carter Su, Christin ^a   Farooqi, I Sadaf ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE; SRC HOMOLOGY 2 B ADAPTER PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BEHAVIOR DISORDER; BEHAVIOR GENETICS; BODY WEIGHT; CASE REPORT; CHILD; COHORT ANALYSIS; FEMALE; FOOD INTAKE; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; MALADAPTIVE BEHAVIOR; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SCHOOL CHILD; SOCIAL ISOLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; AGGRESSION; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL MOVEMENT; CHILD; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; ENERGY INTAKE; FEMALE; FRAMESHIFT MUTATION; GENETIC ASSOCIATION STUDIES; HEK293 CELLS; HUMANS; MALE; MIDDLE AGED; MUTATION, MISSENSE; OBESITY; PHENOTYPE; PROTEIN TRANSPORT; SOCIAL ISOLATION; YOUNG ADULT;

EID: 84870541022     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI62696     Document Type: Article

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