Genetic Epidemiology 2: Genetic linkage studies

Lancet

Volumn 366, Issue 9490, 2005, Pages 1036-1044

  Teare, M Dawn ^a   Barrett, Jennifer H ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; EHLERS DANLOS SYNDROME; GENE LOCUS; GENETIC DISORDER; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC MODEL; HUMAN; LINKAGE ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; SCORING SYSTEM; SIBLING; STATISTICAL SIGNIFICANCE; CHROMOSOME MAP; GENETICS; NONPARAMETRIC TEST; REVIEW;

CHROMOSOME MAPPING; EHLERS-DANLOS SYNDROME; GENETIC HETEROGENEITY; LINKAGE (GENETICS); LOD SCORE; PHENOTYPE; STATISTICS, NONPARAMETRIC;

EID: 24944561852     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)67382-5     Document Type: Review

References (49)

1. PR Burton, MD Tobin, JL Hopper Key concepts in genetic epidemiology Lancet 366 2005 941 951
2. Cordell HJ, Clayton DG. Genetic association studies. Lancet (in press).
3. N Rahman, M Dunstan, MD Teare Ehlers-Danlos syndrome with severe early-onset periodontal disease (EDS-VIII) is a distinct, heterogeneous disorder with one predisposition gene at chromosome 12p13 Am J Hum Genet 73 2003 198 204
4. JBS Haldane, CAB Smith A new estimate of the linkage between the genes for colour-blindness and haemophilia in man Ann Eugen 14 1947 10 31
5. NE Morton Sequential tests for the detection of linkage Am J Hum Genet 7 1955 277 318
6. J Chotai On the LOD score method in linkage analysis Ann Hum Genet 48 1984 359 378
7. ES Lander, L Kruglyak Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results Nat Genet 11 1995 241 247
8. P Berger, P Young, U Suter Molecular cell biology of Charcot-Marie-Tooth disease Neurogenetics 4 2002 1 15
9. JM Hall, MK Lee, B Newman Linkage of early-onset familial breast cancer to chromosome 17q21 Science 250 1990 1684 1689
10. R Wooster, G Bignell, J Lancaster Identification of the breast cancer susceptibility gene BRCA2 Nature 378 1995 789 792
11. WC Blackwelder, RC Elston A comparison of sib-pair linkage tests for disease susceptibility loci Genet Epidemiol 2 1985 85 97
12. JK Hasemen, RC Elston The investigation of linkage between a quantitative trait and a marker locus Behav Genet 2 1972 3 19
13. N Risch Genetics of IDDM: evidence for complex inheritance with HLA Genet Epidemiol 6 1989 143 148
14. N Risch Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs Am J Hum Genet 46 1990 242 253
15. N Risch Linkage strategies for genetically complex traits. II. The power of affected relative pairs Am J Hum Genet 46 1990 229 241
16. P Holmans Asymptotic properties of affected-sib-pair linkage analysis Am J Hum Genet 52 1993 362 374
17. L Kruglyak, ES Lander Complete multipoint sib-pair analysis of qualitative and quantitative traits Am J Hum Genet 57 1995 439 454
18. BK Suarez, P Van Eerdewegh A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes Am J Med Genet 18 1984 135 146
19. P Holmans Likelihood-ratio affected sib-pair tests applied to multiply affected sibships: issues of power and type I error rate Genet Epidemiol 20 2001 44 56
20. S Sawcer, HB Jones, D Judge Empirical genomewide significance levels established by whole genome simulations Genet Epidemiol 14 1997 223 229
21. AS Whittemore, J Halpern A class of tests for linkage using affected pedigree members Biometrics 50 1994 118 127
22. L Kruglyak, MJ Daly, MP Reeve-Daly, ES Lander Parametric and nonparametric linkage analysis: a unified approach Am J Hum Genet 58 1996 1347 1363
23. A Kong, NJ Cox Allele-sharing models: LOD scores and accurate linkage tests Am J Hum Genet 61 1997 1179 1188
24. DF Gudbjartsson, K Jonasson, ML Frigge, A Kong Allegro, a new computer program for multipoint linkage analysis Nat Genet 25 2000 12 13
25. E Sobel, K Lange Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics Am J Hum Genet 58 1996 1323 1337
26. G Kennedy, N Shephard, M Cao Whole genome scan in a complex disease using 11,245 SNPs Am J Hum Genet 73 suppl 2003 186
27. GR Abecasis, SS Cherny, WO Cookson, LR Cardon Merlin: rapid analysis of dense genetic maps using sparse gene flow trees Nat Genet 30 2002 97 101
28. RC Elston, S Buxbaum, KB Jacobs, JM Olson Haseman and Elston revisited Genet Epidemiol 19 2000 1 17
29. L Almasy, J Blangero Multipoint quantitative-trait linkage analysis in general pedigrees Am J Hum Genet 62 1998 1198 1211
30. JL Davies, Y Kawaguchi, ST Bennett A genome-wide search for human type 1 diabetes susceptibility genes Nature 371 1994 130 136
31. R Arya, R Duggirala, L Almasy Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans Nat Genet 30 2002 102 105
32. J Altmüller, LJ Palmer, G Fischer Genomewide scans of complex human diseases: true linkage is hard to find Am J Hum Genet 69 2001 936 950
33. U Broeckel, C Hengstenberg, B Mayer A comprehensive linkage analysis for myocardial infarction and its related risk factors Nat Genet 30 2002 210 214
34. M Caulfield, P Munroe, J Pembroke Genome-wide mapping of human loci for essential hypertension Lancet 361 2003 2118 2123
35. NM Williams, N Norton, H Williams A systematic genomewide linkage study in 353 sib pairs with schizophrenia Am J Hum Genet 73 2003 1355 1367
36. J Xu, DA Meyers, C Ober Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three US populations: collaborative study on the genetics of asthma Am J Hum Genet 68 2001 1437 1446
37. S Wiltshire, LR Cardon, MI McCarthy Evaluating the results of genomewide linkage scans of complex traits by locus counting Am J Hum Genet 71 2002 1175 1182
38. MM Kaback, DL Rimoin, JS O'Brien Tay-Sachs Disease: Screening and Prevention 1977 Alan R Liss New York
39. F Bray, R Sankila, J Ferlay, DM Parkin Estimates of cancer incidence and mortality in Europe in 1995 Eur J Can 38 2002 99 166
40. LL Cavalli-Sforza, P Menozzi, A Piazza The history and geography of human genes 1996 Princeton University Press Princeton, New Jersey
41. Risch N. Searching for genetic determinants in the new millennium. Nature 200; 405: 847-56.
42. JA Douglas, M Boehnke, K Lange A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data Am J Hum Genet 66 2000 1287 1297
43. JL Kennedy, LA Farrer, NC Andreasen, R Mayeux, P St George Hyslop The genetics of adult-onset neuropsychiatric disease: complexities and conundra? Science 302 2003 822 826
44. R Duggirala, JT Williams, S Williams-Blangero, J Blangero A variance component approach to dichotomous trait linkage analysis using a threshold model Genet Epidemiol 14 1997 987 992
45. YC Chagnon, T Rankinen, EE Snyder, SJ Weisnagal, L Perusse, C Bouchard The human obesity gene map: the 2002 update Obesity Res 11 2003 313 367
46. LH Wise, JS Lanchbury, CM Lewis Meta-analysis of genome searches Ann Hum Genet 63 1999 263 272
47. DF Levinson, MD Levinson, R Segurado, CM Lewis Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: methods and power analysis Am J Hum Genet 73 2003 17 33
48. SB Roberts, CJ MacLean, MC Neale, LJ Eaves, KS Kendler Replication of linkage studies of complex traits: an examination of variation in location estimates Am J Hum Genet 65 1999 876 884
49. P Parrella, VM Fazio, AP Gallo Fine mapping of chromosome 3 in uveal melanoma: identification of a minimal region of deletion on chromosomal arm 3p25.1-p25.2 Cancer Res 63 2003 8507 8510