메뉴 건너뛰기




Volumn 16, Issue 8, 2008, Pages 1861-1868

Genetic architecture of adiposity and organ weight using combined generation QTL analysis

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ANIMAL; ARTICLE; DISEASE MODEL; FEMALE; GENETIC EPISTASIS; GENETICS; HEART MUSCLE; KIDNEY; LIVER; MALE; MOUSE; MOUSE STRAIN; OBESITY; ORGAN SIZE; PATHOLOGY; QUANTITATIVE TRAIT LOCUS; SEXUAL DEVELOPMENT; SPLEEN;

EID: 48749098611     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.300     Document Type: Article
Times cited : (32)

References (38)
  • 1
    • 0000469907 scopus 로고
    • Familial diabetes mellitus in mice, associated with insulin resistance, obesity, and hyperplasia of the islands of langerhans
    • Bleisch VR, Mayer J, Dickie MM. Familial diabetes mellitus in mice, associated with insulin resistance, obesity, and hyperplasia of the islands of langerhans. Am J Pathol 1952;28:369-385.
    • (1952) Am J Pathol , vol.28 , pp. 369-385
    • Bleisch, V.R.1    Mayer, J.2    Dickie, M.M.3
  • 2
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 1966;153:1127-1128.
    • (1966) Science , vol.153 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 3
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D, Lynch CA, Fairchild-Huntress V et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997;88:131-141.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 4
    • 0035145192 scopus 로고    scopus 로고
    • Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice
    • Cheverud JM, Vaughn TT, Pletscher LS et al. Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice. Mamm Genome 2001;12:3-12.
    • (2001) Mamm Genome , vol.12 , pp. 3-12
    • Cheverud, J.M.1    Vaughn, T.T.2    Pletscher, L.S.3
  • 5
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-247.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 7
    • 0037067395 scopus 로고    scopus 로고
    • Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    • Leamy LJ, Pomp D, Eisen EJ, Cheverud JM. Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice. Physiol Genomics 2002;10:21-29.
    • (2002) Physiol Genomics , vol.10 , pp. 21-29
    • Leamy, L.J.1    Pomp, D.2    Eisen, E.J.3    Cheverud, J.M.4
  • 8
    • 33745186461 scopus 로고    scopus 로고
    • Quantitative trait loci for body size components in mice
    • Kenney-Hunt JP, Vaughn TT, Pletscher LS et al. Quantitative trait loci for body size components in mice. Mamm Genome 2006;17:526-537.
    • (2006) Mamm Genome , vol.17 , pp. 526-537
    • Kenney-Hunt, J.P.1    Vaughn, T.T.2    Pletscher, L.S.3
  • 9
    • 9444270960 scopus 로고    scopus 로고
    • Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains
    • Cheverud JM, Ehrich TH, Hrbek T et al. Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes 2004;53:3328-3336.
    • (2004) Diabetes , vol.53 , pp. 3328-3336
    • Cheverud, J.M.1    Ehrich, T.H.2    Hrbek, T.3
  • 10
    • 33747619846 scopus 로고    scopus 로고
    • The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    • Wolf JB, Pomp D, Eisen EJ, Cheverud JM, Leamy LJ. The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice. Evol Dev 2006;8:468-476.
    • (2006) Evol Dev , vol.8 , pp. 468-476
    • Wolf, J.B.1    Pomp, D.2    Eisen, E.J.3    Cheverud, J.M.4    Leamy, L.J.5
  • 11
    • 34548831642 scopus 로고    scopus 로고
    • Identification of positional candidate genes for body weight and adiposity in subcongenic mice
    • Chiu S, Kim K, Haus KA et al. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Physiol Genomics 2007;31:75-85.
    • (2007) Physiol Genomics , vol.31 , pp. 75-85
    • Chiu, S.1    Kim, K.2    Haus, K.A.3
  • 12
    • 33846519286 scopus 로고    scopus 로고
    • Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11
    • Farber CR, Medrano JF. Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11. Genetics 2007;175:349-360.
    • (2007) Genetics , vol.175 , pp. 349-360
    • Farber, C.R.1    Medrano, J.F.2
  • 13
    • 21244473273 scopus 로고    scopus 로고
    • Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2
    • Jerez-Timaure NC, Eisen EJ, Pomp D. Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2. Physiol Genomics 2005;21:411-422.
    • (2005) Physiol Genomics , vol.21 , pp. 411-422
    • Jerez-Timaure, N.C.1    Eisen, E.J.2    Pomp, D.3
  • 14
    • 33745206959 scopus 로고    scopus 로고
    • Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the intercross of SM/J and LG/J inbred mouse strains
    • Hrbek T, Alves de Brito R, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the intercross of SM/J and LG/J inbred mouse strains. Mamm Genome 2006;17:417-429.
    • (2006) Mamm Genome , vol.17 , pp. 417-429
    • Hrbek, T.1    Alves de Brito, R.2    Wang, B.3    Pletscher, L.S.4    Cheverud, J.M.5
  • 15
    • 0344196924 scopus 로고    scopus 로고
    • QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks
    • Valdar WS, Flint J, Mott R. QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks. Mamm Genome 2003;14:830-838.
    • (2003) Mamm Genome , vol.14 , pp. 830-838
    • Valdar, W.S.1    Flint, J.2    Mott, R.3
  • 16
    • 0036641368 scopus 로고    scopus 로고
    • Using mouse models to dissect the genetics of obesity
    • Brockmann GA, Bevova MR. Using mouse models to dissect the genetics of obesity. Trends Genet 2002;18:367-376.
    • (2002) Trends Genet , vol.18 , pp. 367-376
    • Brockmann, G.A.1    Bevova, M.R.2
  • 17
    • 0028803358 scopus 로고
    • Advanced intercross lines, an experimental population for fine genetic mapping
    • Darvasi A, Soller M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 1995;141:1199-1207.
    • (1995) Genetics , vol.141 , pp. 1199-1207
    • Darvasi, A.1    Soller, M.2
  • 18
    • 0031715122 scopus 로고    scopus 로고
    • Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice
    • Kramer MG, Vaughn TT, Pletscher LS et al. Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice. Genet Mol Biol 1998;21:211-218.
    • (1998) Genet Mol Biol , vol.21 , pp. 211-218
    • Kramer, M.G.1    Vaughn, T.T.2    Pletscher, L.S.3
  • 19
    • 0029918703 scopus 로고    scopus 로고
    • Quantitative trait loci for murine growth
    • Cheverud JM, Routman EJ, Duarte FA et al. Quantitative trait loci for murine growth. Genetics 1996;142:1305-1319.
    • (1996) Genetics , vol.142 , pp. 1305-1319
    • Cheverud, J.M.1    Routman, E.J.2    Duarte, F.A.3
  • 21
    • 33646942472 scopus 로고
    • A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
    • Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992;69:315-324.
    • (1992) Heredity , vol.69 , pp. 315-324
    • Haley, C.S.1    Knott, S.A.2
  • 22
    • 0033394504 scopus 로고    scopus 로고
    • Mapping quantitative trait loci for murine growth: A closer look at genetic architecture
    • Vaughn TT, Pletscher LS, Peripato A et al. Mapping quantitative trait loci for murine growth: a closer look at genetic architecture. Genet Res 1999;74:313-322.
    • (1999) Genet Res , vol.74 , pp. 313-322
    • Vaughn, T.T.1    Pletscher, L.S.2    Peripato, A.3
  • 24
    • 0033790231 scopus 로고    scopus 로고
    • Multitrait least squares for quantitative trait loci detection
    • Knott SA, Haley CS. Multitrait least squares for quantitative trait loci detection. Genetics 2000;156:899-911.
    • (2000) Genetics , vol.156 , pp. 899-911
    • Knott, S.A.1    Haley, C.S.2
  • 25
    • 0034781050 scopus 로고    scopus 로고
    • A simple correction for multiple comparisons in interval mapping genome scans
    • Cheverud JM. A simple correction for multiple comparisons in interval mapping genome scans. Heredity 2001;87:52-58.
    • (2001) Heredity , vol.87 , pp. 52-58
    • Cheverud, J.M.1
  • 26
    • 20044390391 scopus 로고    scopus 로고
    • Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J X SM/J murine model of obesity
    • Ehrich TH, Hrbek T, Kenney-Hunt JP et al. Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J X SM/J murine model of obesity. Diabetes 2005;54:1863-1872.
    • (2005) Diabetes , vol.54 , pp. 1863-1872
    • Ehrich, T.H.1    Hrbek, T.2    Kenney-Hunt, J.P.3
  • 28
    • 34249826350 scopus 로고    scopus 로고
    • Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice
    • Neuschl C, Brockmann GA, Knott SA. Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice. Genet Res 2007;89:47-59.
    • (2007) Genet Res , vol.89 , pp. 47-59
    • Neuschl, C.1    Brockmann, G.A.2    Knott, S.A.3
  • 29
    • 33749990615 scopus 로고    scopus 로고
    • Identifying genes for diabetic nephropathy - current difficulties and future directions
    • Conway BR, Savage DA, Maxwell AP. Identifying genes for diabetic nephropathy - current difficulties and future directions. Nephrol Dial Transplant 2006;21:3012-3017.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 3012-3017
    • Conway, B.R.1    Savage, D.A.2    Maxwell, A.P.3
  • 30
    • 34248222588 scopus 로고    scopus 로고
    • Gene polymorphisms and susceptibility to coronary artery disease
    • Shah SH. Gene polymorphisms and susceptibility to coronary artery disease. Pediatr Blood Cancer 2007;48:738-741.
    • (2007) Pediatr Blood Cancer , vol.48 , pp. 738-741
    • Shah, S.H.1
  • 31
    • 33749597707 scopus 로고    scopus 로고
    • Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease
    • Day CP. Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int 2006;26:1021-1028.
    • (2006) Liver Int , vol.26 , pp. 1021-1028
    • Day, C.P.1
  • 32
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP kinase-mediated phophorylation of PPARgamma
    • Hu E, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through MAP kinase-mediated phophorylation of PPARgamma. Science 1996;274:2100-2103.
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.1    Kim, J.B.2    Sarraf, P.3    Spiegelman, B.M.4
  • 33
    • 33845227224 scopus 로고    scopus 로고
    • Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program
    • Louet JF, Coste A, Amazit L et al. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci USA 2006;103:17868-17873.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17868-17873
    • Louet, J.F.1    Coste, A.2    Amazit, L.3
  • 34
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
    • Lu D, Willard D, Patel IR et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 1994;371:799-802.
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1    Willard, D.2    Patel, I.R.3
  • 35
    • 33846905695 scopus 로고    scopus 로고
    • Circadian rhythms in the development of obesity: Potential role for the circadian clock within the adipocyte
    • Bray MS, Young ME. Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte. Obes Rev 2007;8:169-181.
    • (2007) Obes Rev , vol.8 , pp. 169-181
    • Bray, M.S.1    Young, M.E.2
  • 36
    • 0018964918 scopus 로고
    • Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis
    • Brooks SL, Rothwell NJ, Stock MJ, Goodbody AE, Trayhurn P. Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 1980;286:274-276.
    • (1980) Nature , vol.286 , pp. 274-276
    • Brooks, S.L.1    Rothwell, N.J.2    Stock, M.J.3    Goodbody, A.E.4    Trayhurn, P.5
  • 37
    • 33644846630 scopus 로고
    • Altered brown adipose tissue and Na,K pump activities during diet-induced obesity and weight loss in rats
    • Harper ME, Patrick J, Himms-Hagen J. Altered brown adipose tissue and Na,K pump activities during diet-induced obesity and weight loss in rats. Obes Res 1993;1:106-117.
    • (1993) Obes Res , vol.1 , pp. 106-117
    • Harper, M.E.1    Patrick, J.2    Himms-Hagen, J.3
  • 38
    • 37249074063 scopus 로고    scopus 로고
    • The role of interleukin-6 in insulin resistance, body fat distribution and energy balance
    • Hoene M, Weigert C. The role of interleukin-6 in insulin resistance, body fat distribution and energy balance. Obes Res 2007;9:20-29.
    • (2007) Obes Res , vol.9 , pp. 20-29
    • Hoene, M.1    Weigert, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.