Common nonsynonymous variants in PCSK1 confer risk of obesity

Nature Genetics

Volumn 40, Issue 8, 2008, Pages 943-945

  Benzinou, Michael ^a,b   Creemers, John W M ^c   Choquet, Helene ^b   Lobbens, Stephane ^b   Dina, Christian ^b   Durand, Emmanuelle ^b   Guerardel, Audrey ^b   Boutin, Philippe ^b   Jouret, Beatrice ^d   Heude, Barbara ^d,e   Balkau, Beverley ^d,e   Tichet, Jean ^f   Marre, Michel ^d,g,h   Potoczna, Natascha ^f   Horber, Fritz ⁱ   Le Stunff, Catherine ^j   Czernichow, Sebastien ^k   Sandbaek, Annelli ^l   Lauritzen, Torsten ^l   Borch Johnsen, Knut ^l,m   Andersen, Gitte ^m   Kiess, Wieland ⁿ   Körner, Antje ⁿ   Kovacs, Peter ⁿ   Jacobson, Peter ^o   Carlsson, Lena M S ^o   Walley, Andrew J ^a   Jørgensen, Torben ^p   Hansen, Torben ^m   Pedersen, Oluf ^l,m   Meyre, David ^b   Froguel, Philippe ^a,b   more..

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b CNRS   (France)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d INSERM   (France)

^e UNIVERSITÉ PARIS SACLAY   (France)

^f Regional Institute for Health   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h BICHAT HOSPITAL   (France)

ⁱ Klinik Lindberg AG   (Switzerland)

^j HÔPITAL SAINT VINCENT DE PAUL   (France)

^k AVICENNE HOSPITAL   (France)

^l AARHUS UNIVERSITY   (Denmark)

^m STENO DIABETES CENTER   (Denmark)

ⁿ UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^o UNIVERSITY OF GOTHENBURG   (Sweden)

^p GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PCSK1 ENZYME; PROPROTEIN CONVERTASE 1;

ARTICLE; DISEASE ASSOCIATION; ENZYME ACTIVITY; GENE FREQUENCY; GENOTYPE; HUMAN; MUTATIONAL ANALYSIS; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CHILD; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPROTEIN CONVERTASE 1;

EID: 48349113289     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.177     Document Type: Article

References (10)

1. Hager, J. et al. Nat. Genet. 20, 304-308 (1998).
2. Chagnon, Y.C. et al. J. Appl. Physiol. 90, 1777-1787 (2001).
3. Bell, C.G. et al. Diabetes 53, 1857-1865 (2004).
4. Chen, G. et al. Int. J. Obes. (Lond.) 29, 255-259 (2005).
5. Jackson, R.S. et al. Nat. Genet. 16, 303-306 (1997).
6. Jackson, R.S. et al. J. Clin. Invest. 112, 1550-1560 (2003).
7. Farooqi, I.S. et al. J. Clin. Endocrinol. Metab. 92, 3369-3373 (2007).
8. Balkau, B. Rev. Epidemiol. Sante Publique 44, 373-375 (1996).
9. Zhou, Y. & Lindberg, I. J. Biol. Chem. 269, 18408-18413 (1994).
10. Lloyd, D.J., Bohan, S. & Gekakis, N. Hum. Mol. Genet. 15, 1884-1893 (2006).