메뉴 건너뛰기




Volumn 6, Issue 7, 2003, Pages 736-742

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MELANOCORTIN 4 RECEPTOR;

EID: 0038392755     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1073     Document Type: Article
Times cited : (736)

References (45)
  • 1
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • Huang, E.J. & Reichardt, L.F. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 24, 677-736 (2001).
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 2
    • 0033592920 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    • Lyons, W.E. et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc. Natl. Acad. Sci. USA 96, 15239-15244 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 15239-15244
    • Lyons, W.E.1
  • 3
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie, S.G., Liebl, D.J. & Parada, L.F. BDNF regulates eating behavior and locomotor activity in mice. EMBO J. 19, 1290-1300 (2000).
    • (2000) EMBO J. , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 4
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios, M. et al. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol. Endocrinol. 15, 1748-1757 (2001).
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1748-1757
    • Rios, M.1
  • 5
    • 0031577526 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice
    • Ono, M. et al. Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem. Biophys. Res. Commun. 238, 633-637 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , pp. 633-637
    • Ono, M.1
  • 6
    • 18144435678 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice
    • Nakagawa, T. et al. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49, 436-444 (2000).
    • (2000) Diabetes , vol.49 , pp. 436-444
    • Nakagawa, T.1
  • 7
    • 0035200051 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice
    • Nonomura, T. et al. Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice. Int. J. Exp. Diabetes Res. 2, 201-209 (2001).
    • (2001) Int. J. Exp. Diabetes Res. , vol.2 , pp. 201-209
    • Nonomura, T.1
  • 8
    • 0034840204 scopus 로고    scopus 로고
    • Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice
    • Tsuchida, A. et al. Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice. Int. J. Obes. Relat. Metab. Disord. 25, 1286-1293 (2001).
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , pp. 1286-1293
    • Tsuchida, A.1
  • 9
    • 0038071082 scopus 로고
    • A study of the effect of hypothalamic lesions on the eating habits of the albino rat
    • Brooks, C.M., Lockwood, R.A. & Wiggins, M.L. A study of the effect of hypothalamic lesions on the eating habits of the albino rat. Am. J. Physiol. 147, 735-741 (1946).
    • (1946) Am. J. Physiol. , vol.147 , pp. 735-741
    • Brooks, C.M.1    Lockwood, R.A.2    Wiggins, M.L.3
  • 10
    • 84981834057 scopus 로고
    • The relation of various hypothalamic lesions to adiposity in the rat
    • Hetherington, A.W. & Ranson, S.W. The relation of various hypothalamic lesions to adiposity in the rat. J. Comp. Neurol. 76, 475-499 (1942).
    • (1942) J. Comp. Neurol. , vol.76 , pp. 475-499
    • Hetherington, A.W.1    Ranson, S.W.2
  • 11
    • 0023186581 scopus 로고
    • Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus
    • Shimizu, N., Oomura, Y., Plata-Salaman, C.R. & Morimoto, M. Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus. Brain Res. 416, 153-156 (1987).
    • (1987) Brain Res. , vol.416 , pp. 153-156
    • Shimizu, N.1    Oomura, Y.2    Plata-Salaman, C.R.3    Morimoto, M.4
  • 12
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J.M. & Halaas, J.L. Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 13
    • 0032548825 scopus 로고    scopus 로고
    • Obesity and the hypothalamus: Novel peptides for new pathways
    • Flier, J.S. & Maratos-Flier, E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 92, 437-440 (1998).
    • (1998) Cell , vol.92 , pp. 437-440
    • Flier, J.S.1    Maratos-Flier, E.2
  • 15
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist, J.K., Elias, C.F. & Saper, C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22, 221-232 (1999).
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 16
    • 0023959725 scopus 로고
    • Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
    • Smith, A.I. & Funder, J.W. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr. Rev. 9, 159-179 (1988).
    • (1988) Endocr. Rev. , vol.9 , pp. 159-179
    • Smith, A.I.1    Funder, J.W.2
  • 17
    • 0033436355 scopus 로고    scopus 로고
    • Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight
    • Baskin, D.G. et al. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res. 848, 114-123 (1999).
    • (1999) Brain Res. , vol.848 , pp. 114-123
    • Baskin, D.G.1
  • 18
    • 0037043704 scopus 로고    scopus 로고
    • Gut hormone PYY(3-36) physiologically inhibits food intake
    • Batterham, R.L. et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418, 650-654 (2002).
    • (2002) Nature , vol.418 , pp. 650-654
    • Batterham, R.L.1
  • 19
    • 0037178730 scopus 로고    scopus 로고
    • Activation of central melanocortin pathways by fenfluramine
    • Heisler, L.K. et al. Activation of central melanocortin pathways by fenfluramine. Science 297, 609-611 (2002).
    • (2002) Science , vol.297 , pp. 609-611
    • Heisler, L.K.1
  • 20
    • 0037109670 scopus 로고    scopus 로고
    • The catabolic action of insulin in the brain is mediated by melanocortins
    • Benoit, S.C. et al. The catabolic action of insulin in the brain is mediated by melanocortins. J. Neurosci. 22, 9048-9052 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 9048-9052
    • Benoit, S.C.1
  • 21
    • 0035709038 scopus 로고    scopus 로고
    • The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
    • Cone, R.D. et al. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int. J. Obes. Relat. Metab. Disord. 25, S63-67 (2001).
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25
    • Cone, R.D.1
  • 22
    • 0027049534 scopus 로고
    • Molecular characterization of the mouse agouti locus
    • Bultman, S.J., Michaud, E.J. & Woychik, R.P. Molecular characterization of the mouse agouti locus. Cell 71, 1195-1204 (1992).
    • (1992) Cell , vol.71 , pp. 1195-1204
    • Bultman, S.J.1    Michaud, E.J.2    Woychik, R.P.3
  • 23
    • 0027256438 scopus 로고
    • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
    • Miller, M.W. et al. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7, 454-467 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 454-467
    • Miller, M.W.1
  • 24
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141 (1997).
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1
  • 25
    • 0000304384 scopus 로고    scopus 로고
    • Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    • Chen, A.S. et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res. 9, 145-154 (2000).
    • (2000) Transgenic Res. , vol.9 , pp. 145-154
    • Chen, A.S.1
  • 26
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor
    • Lu, D. et al. Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 371, 799-802 (1994).
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1
  • 27
    • 0034981271 scopus 로고    scopus 로고
    • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
    • Butler, A.A. et al. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat. Neurosci. 4, 605-611 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 605-611
    • Butler, A.A.1
  • 28
    • 0032730576 scopus 로고    scopus 로고
    • Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye
    • Bennett, J.L., Zeiler, S.R. & Jones, K.R. Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye. Invest. Ophthalmol. Vis. Sci. 40, 2996-3005 (1999).
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 2996-3005
    • Bennett, J.L.1    Zeiler, S.R.2    Jones, K.R.3
  • 29
    • 0036325531 scopus 로고    scopus 로고
    • Genetic approaches to studying energy balance: Perception and integration
    • Barsh, G.S. & Schwartz, M.W. Genetic approaches to studying energy balance: perception and integration. Nat. Rev. Genet. 3, 589-600 (2002).
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 589-600
    • Barsh, G.S.1    Schwartz, M.W.2
  • 30
    • 0033710349 scopus 로고    scopus 로고
    • Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB
    • Xu, B. et al. Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 26, 233-245 (2000).
    • (2000) Neuron , vol.26 , pp. 233-245
    • Xu, B.1
  • 31
    • 0034666105 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor receptors in the mature hippocampus: Modulation of long-term potentiation through a presynaptic mechanism involving TrkB
    • Xu, B. et al. The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J. Neurosci. 20, 6888-6897 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 6888-6897
    • Xu, B.1
  • 32
    • 0003279556 scopus 로고    scopus 로고
    • Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain
    • Bagnol, D. et al. Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. J. Neurosci. 19, 1-7 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 1-7
    • Bagnol, D.1
  • 33
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168 (1997).
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 34
    • 0037430140 scopus 로고    scopus 로고
    • Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
    • Kishi, T. et al. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. 457, 213-235 (2003).
    • (2003) J. Comp. Neurol. , vol.457 , pp. 213-235
    • Kishi, T.1
  • 35
    • 0023109895 scopus 로고
    • Phaseolus vulgaris leuco-agglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat
    • Ter Horst, G.J. & Luiten, P.G. Phaseolus vulgaris leuco-agglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat. Brain Res. Bull. 18, 191-203 (1987).
    • (1987) Brain Res. Bull. , vol.18 , pp. 191-203
    • Ter Horst, G.J.1    Luiten, P.G.2
  • 36
    • 0035937575 scopus 로고    scopus 로고
    • Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons
    • Kohara, K., Kitamura, A., Morishima, M. & Tsumoto, T. Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons. Science 291, 2419-2423 (2001).
    • (2001) Science , vol.291 , pp. 2419-2423
    • Kohara, K.1    Kitamura, A.2    Morishima, M.3    Tsumoto, T.4
  • 37
    • 0017138271 scopus 로고
    • The efferent connections of the ventromedial nucleus of the hypothalamus of the rat
    • Saper, C. B., Swanson, L.W. & Cowan, W.M. The efferent connections of the ventromedial nucleus of the hypothalamus of the rat. J. Comp. Neurol. 169, 409-442 (1976).
    • (1976) J. Comp. Neurol. , vol.169 , pp. 409-442
    • Saper, C.B.1    Swanson, L.W.2    Cowan, W.M.3
  • 38
    • 0018790698 scopus 로고
    • An autoradiographic study of the efferent connections of the ventromedial nucleus of the hypothalamus
    • Krieger, M.S., Conrad, L.C. & Pfaff, D.W. An autoradiographic study of the efferent connections of the ventromedial nucleus of the hypothalamus. J. Comp. Neurol. 183, 785-815 (1979).
    • (1979) J. Comp. Neurol. , vol.183 , pp. 785-815
    • Krieger, M.S.1    Conrad, L.C.2    Pfaff, D.W.3
  • 39
    • 0028133318 scopus 로고
    • Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris-leucoagglutinin study in the rat
    • Canteras, N.S., Simerly, R.B. & Swanson, L.W. Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 348, 41-79 (1994).
    • (1994) J. Comp. Neurol. , vol.348 , pp. 41-79
    • Canteras, N.S.1    Simerly, R.B.2    Swanson, L.W.3
  • 40
    • 0035851851 scopus 로고    scopus 로고
    • The hypothalamus and the control of energy homeostasis: Different circuits, different purposes
    • Williams, G. et al. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol. Behav. 74, 683-701 (2001).
    • (2001) Physiol. Behav. , vol.74 , pp. 683-701
    • Williams, G.1
  • 41
    • 0013919796 scopus 로고
    • Changes in caloric intake following brain stem lesions in cats. 3. Effects of lesions of the periaqueductal gray matter and rostral hypothalamus
    • Skultety, F.M. Changes in caloric intake following brain stem lesions in cats. 3. Effects of lesions of the periaqueductal gray matter and rostral hypothalamus. Arch. Neurol. 14, 670-680 (1966).
    • (1966) Arch. Neurol. , vol.14 , pp. 670-680
    • Skultety, F.M.1
  • 42
    • 0031856907 scopus 로고    scopus 로고
    • The dorsomedial hypothalamic nucleus revisited: 1998 Update
    • Bernardis, L.L. & Bellinger, L.L. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc. Soc. Exp. Biol. Med. 218, 284-306 (1998).
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.218 , pp. 284-306
    • Bernardis, L.L.1    Bellinger, L.L.2
  • 43
    • 0030901457 scopus 로고    scopus 로고
    • BDNF is required for the normal development of taste neurons in vivo
    • Zhang, C., Brandemihl, A., Lau, D., Lawton, A. & Oakley, B. BDNF is required for the normal development of taste neurons in vivo. Neuroreport. 8, 1013-1017 (1997).
    • (1997) Neuroreport. , vol.8 , pp. 1013-1017
    • Zhang, C.1    Brandemihl, A.2    Lau, D.3    Lawton, A.4    Oakley, B.5
  • 44
    • 0030859146 scopus 로고    scopus 로고
    • Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds
    • Fritzsch, B., Sarai, P.A., Barbacid, M. & Silos-Santiago, I. Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds. Int. J. Dev. Neurosci. 15, 563-576 (1997).
    • (1997) Int. J. Dev. Neurosci. , vol.15 , pp. 563-576
    • Fritzsch, B.1    Sarai, P.A.2    Barbacid, M.3    Silos-Santiago, I.4
  • 45
    • 0027716685 scopus 로고
    • Localization of neurotrophin receptors in olfactory epithelium and bulb
    • Deckner, M.L., Frisen, J., Verge, V.M., Hokfelt, T. & Risling, M. Localization of neurotrophin receptors in olfactory epithelium and bulb. Neuroreport. 5, 301-304 (1993).
    • (1993) Neuroreport. , vol.5 , pp. 301-304
    • Deckner, M.L.1    Frisen, J.2    Verge, V.M.3    Hokfelt, T.4    Risling, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.