-
1
-
-
35848935201
-
Cause-specific excess deaths associated with underweight, overweight, and obesity
-
Flegal, K.M., Graubard, B.I., Williamson, D.F. & Gail, M.H. Cause-specific excess deaths associated with underweight, overweight, and obesity. J. Am. Med. Assoc. 298, 2028-2037 (2007).
-
(2007)
J. Am. Med. Assoc
, vol.298
, pp. 2028-2037
-
-
Flegal, K.M.1
Graubard, B.I.2
Williamson, D.F.3
Gail, M.H.4
-
2
-
-
48749110626
-
The lifetime medical cost burden of overweight and obesity: Implications for obesity prevention
-
2008
-
Finkelstein, E.A. et al. The lifetime medical cost burden of overweight and obesity: implications for obesity prevention. Obesity (Silver Spring) 16, 1843-1848 (2008).
-
(1843)
Obesity (Silver Spring)
, vol.16
-
-
Finkelstein, E.A.1
-
3
-
-
0030843960
-
Genetic and environmental factors in relative body weight and human adiposity
-
Maes, H.H., Neale, M.C. & Eaves, L.J. Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 27, 325-351 (1997).
-
(1997)
Behav. Genet
, vol.27
, pp. 325-351
-
-
Maes, H.H.1
Neale, M.C.2
Eaves, L.J.3
-
4
-
-
0036844002
-
Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study
-
Atwood, L.D. et al. Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am. J. Hum. Genet. 71, 1044-1050 (2002).
-
(2002)
Am. J. Hum. Genet
, vol.71
, pp. 1044-1050
-
-
Atwood, L.D.1
-
5
-
-
33846515775
-
Genetic aspects of severe childhood obesity
-
Farooqi, I.S. Genetic aspects of severe childhood obesity. Pediatr. Endocrinol. Rev. 3(Suppl. 4), 528-536 (2006).
-
(2006)
Pediatr. Endocrinol. Rev
, vol.3
, Issue.SUPPL. 4
, pp. 528-536
-
-
Farooqi, I.S.1
-
6
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri, A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007).
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
-
7
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling, T.M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007).
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
-
8
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
Dina, C. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39, 724-726 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 724-726
-
-
Dina, C.1
-
9
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos, R.J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768-775 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
-
10
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
Chambers, J.C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716-718 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 716-718
-
-
Chambers, J.C.1
-
11
-
-
48349113289
-
Common nonsynonymous variants in PCSK1 confer risk of obesity
-
Benzinou, M. et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat. Genet. 40, 943-945 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 943-945
-
-
Benzinou, M.1
-
12
-
-
58149163141
-
-
Thorleifsson, G. et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. advance online publication, doi:10.1038/ng.274 (14 December 2008).
-
Thorleifsson, G. et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. advance online publication, doi:10.1038/ng.274 (14 December 2008).
-
-
-
-
13
-
-
33645825830
-
A common genetic variant is associated with adult and childhood obesity
-
Herbert, A. et al. A common genetic variant is associated with adult and childhood obesity. Science 312, 279-283 (2006).
-
(2006)
Science
, vol.312
, pp. 279-283
-
-
Herbert, A.1
-
14
-
-
44849086097
-
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
-
Liu, Y.J. et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum. Mol. Genet. 17, 1803-1813 (2008).
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 1803-1813
-
-
Liu, Y.J.1
-
15
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Zeggini, E. et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 40, 638-645 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
-
16
-
-
38649125868
-
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
-
Willer, C.J. et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat. Genet. 40, 161-169 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 161-169
-
-
Willer, C.J.1
-
17
-
-
34547623750
-
Genomewide association analysis of coronary artery disease
-
Samani, N.J. et al. Genomewide association analysis of coronary artery disease. N. Engl. J. Med. 357, 443-453 (2007).
-
(2007)
N. Engl. J. Med
, vol.357
, pp. 443-453
-
-
Samani, N.J.1
-
18
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
19
-
-
44749083224
-
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
-
Freathy, R.M. et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 57, 1419-1426 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 1419-1426
-
-
Freathy, R.M.1
-
20
-
-
52949141845
-
Integrated detection and population-genetic analysis of SNPs and copy number variation
-
McCarroll, S.A. et al. Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat. Genet. 40, 1166-1174 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 1166-1174
-
-
McCarroll, S.A.1
-
21
-
-
33846822094
-
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
-
Ren, D. et al. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J. Clin. Invest. 117, 397-406 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 397-406
-
-
Ren, D.1
-
22
-
-
46349103594
-
A mitochondrial protein compendium elucidates complex I disease biology
-
Pagliarini, D.J. et al. A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112-123 (2008).
-
(2008)
Cell
, vol.134
, pp. 112-123
-
-
Pagliarini, D.J.1
-
23
-
-
18944408104
-
Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha
-
Grinberg, M. et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 25, 4579-4590 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 4579-4590
-
-
Grinberg, M.1
-
24
-
-
0033577872
-
Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP
-
Marg, A. et al. Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J. Cell Biol. 145, 865-876 (1999).
-
(1999)
J. Cell Biol
, vol.145
, pp. 865-876
-
-
Marg, A.1
-
25
-
-
22144458983
-
Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion
-
Schafer, M., Brauer, A.U., Savaskan, N.E., Rathjen, F.G. & Brummendorf, T. Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol. Cell. Neurosci. 29, 580-590 (2005).
-
(2005)
Mol. Cell. Neurosci
, vol.29
, pp. 580-590
-
-
Schafer, M.1
Brauer, A.U.2
Savaskan, N.E.3
Rathjen, F.G.4
Brummendorf, T.5
-
26
-
-
33749017409
-
The human obesity gene map: The 2005 update
-
Rankinen, T. et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14, 529-644 (2006).
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 529-644
-
-
Rankinen, T.1
-
27
-
-
36549053104
-
A survey of genetic human cortical gene expression
-
Myers, A.J. et al. A survey of genetic human cortical gene expression. Nat. Genet. 39, 1494-1499 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 1494-1499
-
-
Myers, A.J.1
-
28
-
-
24144483438
-
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
-
Bramham, C.R. & Messaoudi, E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol. 76, 99-125 (2005).
-
(2005)
Prog. Neurobiol
, vol.76
, pp. 99-125
-
-
Bramham, C.R.1
Messaoudi, E.2
-
29
-
-
37549055474
-
Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
-
Unger, T.J., Calderon, G.A., Bradley, L.C., Sena-Esteves, M. & Rios, M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J. Neurosci. 27, 14265-14274 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 14265-14274
-
-
Unger, T.J.1
Calderon, G.A.2
Bradley, L.C.3
Sena-Esteves, M.4
Rios, M.5
-
30
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141 (1997).
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
-
31
-
-
0032900284
-
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
-
Marsh, D.J. et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. 21, 119-122 (1999).
-
(1999)
Nat. Genet
, vol.21
, pp. 119-122
-
-
Marsh, D.J.1
-
33
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
Gerken, T. et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-1472 (2007).
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
-
34
-
-
34548370733
-
-
Li, Z., Zhou, Y., Carter-Su, C., Myers, M.G. Jr & Rui, L. SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation- dependent and -independent mechanisms. Mol. Endocrinol. 21, 2270-2281 (2007).
-
Li, Z., Zhou, Y., Carter-Su, C., Myers, M.G. Jr & Rui, L. SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation- dependent and -independent mechanisms. Mol. Endocrinol. 21, 2270-2281 (2007).
-
-
-
-
35
-
-
0028977843
-
GABAA-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
-
Fritschy, J.M. & Mohler, H. GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. Comp. Neurol. 359, 154-194 (1995).
-
(1995)
J. Comp. Neurol
, vol.359
, pp. 154-194
-
-
Fritschy, J.M.1
Mohler, H.2
-
36
-
-
33646708528
-
Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis
-
Fehr, C. et al. Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr. Genet. 16, 9-17 (2006).
-
(2006)
Psychiatr. Genet
, vol.16
, pp. 9-17
-
-
Fehr, C.1
-
37
-
-
3343022586
-
Allelic and haplotypic association of GABRA2 with alcohol dependence
-
Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M. & Kranzler, H.R. Allelic and haplotypic association of GABRA2 with alcohol dependence. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 129B, 104-109 (2004).
-
(2004)
Am. J. Med. Genet. B. Neuropsychiatr. Genet
, vol.129 B
, pp. 104-109
-
-
Covault, J.1
Gelernter, J.2
Hesselbrock, V.3
Nellissery, M.4
Kranzler, H.R.5
-
38
-
-
12144288685
-
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
-
Edenberg, H.J. et al. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am. J. Hum. Genet. 74, 705-714 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.74
, pp. 705-714
-
-
Edenberg, H.J.1
-
39
-
-
41549136121
-
The brain, appetite, and obesity
-
Berthoud, H.R. & Morrison, C. The brain, appetite, and obesity. Annu. Rev. Psychol. 59, 55-92 (2008).
-
(2008)
Annu. Rev. Psychol
, vol.59
, pp. 55-92
-
-
Berthoud, H.R.1
Morrison, C.2
-
40
-
-
0042242582
-
ESEfinder: A web resource to identify exonic splicing enhancers
-
Cartegni, L., Wang, J., Zhu, Z., Zhang, M.Q. & Krainer, A.R. ESEfinder: a web resource to identify exonic splicing enhancers. Nucleic Acids Res. 31, 3568-3571 (2003).
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3568-3571
-
-
Cartegni, L.1
Wang, J.2
Zhu, Z.3
Zhang, M.Q.4
Krainer, A.R.5
-
41
-
-
0035794679
-
-
Sureau, A., Gattoni, R., Dooghe, Y., Stevenin, J. & Soret, J. SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J. 20, 1785-1796 (2001).
-
Sureau, A., Gattoni, R., Dooghe, Y., Stevenin, J. & Soret, J. SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J. 20, 1785-1796 (2001).
-
-
-
-
42
-
-
34548805282
-
A genome-wide association study of global gene expression
-
Dixon, A.L. et al. A genome-wide association study of global gene expression. Nat. Genet. 39, 1202-1207 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 1202-1207
-
-
Dixon, A.L.1
-
43
-
-
42649139571
-
Genome-wide association analysis identifies 20 loci that influence adult height
-
Weedon, M.N. et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nat. Genet. 40, 575-583 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 575-583
-
-
Weedon, M.N.1
-
44
-
-
42649092874
-
Identification of ten loci associated with height highlights new biological pathways in human growth
-
Lettre, G. et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat. Genet. 40, 584-591 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 584-591
-
-
Lettre, G.1
-
45
-
-
33847361938
-
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
-
Winckler, W. et al. Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 56, 685-693 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 685-693
-
-
Winckler, W.1
-
46
-
-
33750596924
-
Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns
-
Bonnycastle, L.L. et al. Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns. Diabetes 55, 2534-2540 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 2534-2540
-
-
Bonnycastle, L.L.1
-
47
-
-
34347344976
-
A new multipoint method for genome-wide association studies by imputation of genotypes
-
Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906-913 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 906-913
-
-
Marchini, J.1
Howie, B.2
Myers, S.3
McVean, G.4
Donnelly, P.5
-
48
-
-
0036338150
-
Merlin-rapid analysis of dense genetic maps using sparse gene flow trees
-
Abecasis, G.R., Cherny, S.S., Cookson, W.O. & Cardon, L.R. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 30, 97-101 (2002).
-
(2002)
Nat. Genet
, vol.30
, pp. 97-101
-
-
Abecasis, G.R.1
Cherny, S.S.2
Cookson, W.O.3
Cardon, L.R.4
-
49
-
-
34547628858
-
Family-based association tests for genomewide association scans
-
Chen, W.M. & Abecasis, G.R. Family-based association tests for genomewide association scans. Am. J. Hum. Genet. 81, 913-926 (2007).
-
(2007)
Am. J. Hum. Genet
, vol.81
, pp. 913-926
-
-
Chen, W.M.1
Abecasis, G.R.2
|