Analysing complex genetic traits with chromosome substitution strains

Nature Genetics

Volumn 24, Issue 3, 2000, Pages 221-225

  Nadeau, Joseph H ^a,b   Singer, Jonathan B ^c   Matin, Angabin ^a   Lander, Eric S ^c,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME MAP; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; CROSSING OVER; GENE CONSTRUCT; GENE LOCUS; GENETIC ANALYSIS; GENETIC PROCEDURES; GENOME; INBRED STRAIN; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES; CROSSES, GENETIC; GENETIC MARKERS; GENOME; GENOTYPE; HUMANS; INBREEDING; MICE; MICE, INBRED STRAINS; MURIDAE; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE;

ANIMALIA;

EID: 0034054962     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/73427     Document Type: Review

References (18)

1. Bedell, M.A., Jenkins, N.A. & Copeland, N.G. Mouse models of human disease. Part I. Techniques and resources for genetic analysis in mice. Genes Dev. 11, 1-10 (1997).
2. Bedell, M.A., Jenkins, N.A. & Copeland, N.G. Mouse models of human disease. Part II. Recent progress and future directions. Genes Dev. 11, 11-43 (1997).
3. Lander, E.S. & Botstein, D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199 (1989).
4. Snell, G.D. Methods for the study of histocompatibility genes. J. Genet. 49, 87-108 (1948).
5. Dietrich, W.F. et al. A comprehensive genetic map of the mouse genome. Nature 380, 149-152 (1996).
6. Steen, R.G. et al. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 9, 1-8 (1999).
7. Gould, K.A., Dietrich, W.F., Borenstein, N., Lander, E.S. & Dove, W.F. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144, 1769-1776 (1996).
8. Markel, P. et al. Theoretical and empirical issues for marker-assisted breeding of congenic strains. Nature Genet 17, 280-284 (1997).
9. Wakeland, E.K., Morel, L., Achey, K., Yui, M. & Longmate, J. Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol. Today 18, 472-477 (1997).
10. Darvasi, A. Experimental strategies for the genetic dissection of complex traits in animal models. Nature Genet. 18, 19-24 (1998).
11. Matin, A., Collin, G.B., Asada, Y., Varnum, D. & Nadeau, J.H. Susceptibility to testicular germ cell tumors in 129.MOLF-Chr19 mice. Nature Genet 23, 237-240 (1999)
12. Darvasi, A. & Soller, M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141, 1199-1207 (1995).
13. Talbot, C.J. et al. High-resolution mapping of quantitative trait loci in outbred mice. Nature Genet. 21, 305-308 (1999).
14. Collin, G.B., Asada, Y., Varnum, D.S. & Nadeau, J.H. DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors. Mamm. Genome 7, 68-70 (1996).
15. Wang, D.G. et al. Large-scale identification, mapping and genotyping of single-nucleotide polymorphisms in the human genome. Science 280, 1077-1082 (1998).
16. Hudgins, C.C., Steinberg, R.T., Klinman, D.M., Reeves, M.J. & Steinberg, A.D. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J. Immunol. 134, 3849-3854 (1985).
17. Scribner, C.L. & Steinberg, A.D. The role of splenic colony-forming units in autoimmune disease. Clin. Immunol. Immunopathol. 49, 133-142 (1988).
18. Waters, N.S. & Deneberg, V.H. Analysis of two measures of paw preference in a large population of inbred mice. Behav. Brain Res. 63, 195-204 (1994).