Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study

Human Molecular Genetics

Volumn 18, Issue 6, 2009, Pages 1140-1147

  Calton, Melissa A ^a   Ersoy, Baran A ^a   Zhang, Sumei ^a   Kane, John P ^a,b   Malloy, Mary J ^a,b   Pullinger, Clive R ^a   Bromberg, Yana ^c   Pennacchio, Len A ^d,e   Dent, Robert ^f   McPherson, Ruth ^f   Ahituv, Nadav ^a,d,e   Vaisse, Christian ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d U S DEPARTMENT OF ENERGY   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; GLUTAMINE; ISOLEUCINE; LEUCINE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; METHIONINE; PHENYLALANINE; SERINE; TYROSINE;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FRAMESHIFT MUTATION; GENE FUNCTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NORTH AMERICA; OBESITY; PREVALENCE; PRIORITY JOURNAL;

ADULT; CASE-CONTROL STUDIES; CELL LINE; COHORT STUDIES; COMPUTATIONAL BIOLOGY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MUTANT PROTEINS; MUTATION; NORTH AMERICA; OBESITY, MORBID; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; THINNESS;

EID: 61849161252     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn431     Document Type: Article

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