A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene

Diabetes

Volumn 53, Issue 6, 2004, Pages 1577-1583

  Toye, Ayo A ^a   Moir, Lee ^a   Hugill, Alison ^a   Bentley, Liz ^a   Quarterman, Julie ^a   Mijat, Vesna ^a   Hough, Tertius ^a   Goldsworthy, Michelle ^a   Haynes, Alison ^a   Hunter, A Jacqueline ^b   Browne, Mick ^b   Spurr, Nigel ^c   Cox, Roger D ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA; GLUCOKINASE; NITROSOUREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 11; ENZYME ACTIVITY; EXON; FEMALE; GENA348 GENE; GENE; GENE IDENTIFICATION; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; KNOCKOUT MOUSE; MALE; MATURITY ONSET DIABETES MELLITUS; MISSENSE MUTATION; MOLECULAR CLONING; MOUSE; MUTAGENESIS; MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; WILD TYPE;

ADENINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; ETHYLNITROSOUREA; GLUCOKINASE; GLUCOSE; GLUCOSE INTOLERANCE; HETEROZYGOTE; HOMOZYGOTE; ISOLEUCINE; MALE; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTAGENS; MUTATION, MISSENSE; PHENYLALANINE; PHOSPHORYLATION; THYMINE;

EID: 2542524743     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.6.1577     Document Type: Article

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