-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
-
2
-
-
0028322089
-
Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991
-
Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL (1994) Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. Jama 272: 205-211.
-
(1994)
Jama
, vol.272
, pp. 205-211
-
-
Kuczmarski, R.J.1
Flegal, K.M.2
Campbell, S.M.3
Johnson, C.L.4
-
3
-
-
33645523067
-
Prevalence of overweight and obesity in the United States, 1999-2004
-
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, et al. (2006) Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295: 1549-1555.
-
(2006)
JAMA
, vol.295
, pp. 1549-1555
-
-
Ogden, C.L.1
Carroll, M.D.2
Curtin, L.R.3
McDowell, M.A.4
Tabak, C.J.5
-
4
-
-
0032742418
-
The disease burden associated with overweight and obesity
-
Must A, Spadano J, Coakley EH, Field AE, Colditz G, et al. (1999) The disease burden associated with overweight and obesity. Jama 282: 1523-1529.
-
(1999)
Jama
, vol.282
, pp. 1523-1529
-
-
Must, A.1
Spadano, J.2
Coakley, E.H.3
Field, A.E.4
Colditz, G.5
-
5
-
-
0033533859
-
Bodymass index and mortality in a prospective cohort of U.S. adults
-
Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. (1999) Bodymass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 341: 1097-1105.
-
(1999)
N Engl J Med
, vol.341
, pp. 1097-1105
-
-
Calle, E.E.1
Thun, M.J.2
Petrelli, J.M.3
Rodriguez, C.4
Heath Jr., C.W.5
-
6
-
-
0344394255
-
Physical inactivity, excess adiposity and premature mortality
-
Katzmarzyk PT, Janssen I, Ardern CI (2003) Physical inactivity, excess adiposity and premature mortality. Obes Rev 4: 257-290.
-
(2003)
Obes Rev
, vol.4
, pp. 257-290
-
-
Katzmarzyk, P.T.1
Janssen, I.2
Ardern, C.I.3
-
7
-
-
0032010796
-
Current estimates of the economic cost of obesity in the United States
-
Wolf AM, Colditz GA (1998) Current estimates of the economic cost of obesity in the United States. Obes Res 6: 97-106.
-
(1998)
Obes Res
, vol.6
, pp. 97-106
-
-
Wolf, A.M.1
Colditz, G.A.2
-
8
-
-
0032805065
-
The direct health care costs of obesity in the United States
-
Allison DB, Zannolli R, Narayan KM (1999) The direct health care costs of obesity in the United States. Am J Public Health 89: 1194-1199.
-
(1999)
Am J Public Health
, vol.89
, pp. 1194-1199
-
-
Allison, D.B.1
Zannolli, R.2
Narayan, K.M.3
-
9
-
-
0032577404
-
Environmental contributions to the obesity epidemic
-
Hill JO, Peters JC (1998) Environmental contributions to the obesity epidemic. Science 280: 1371-1374.
-
(1998)
Science
, vol.280
, pp. 1371-1374
-
-
Hill, J.O.1
Peters, J.C.2
-
10
-
-
0032577309
-
The search for human obesity genes
-
Comuzzie AG, Allison DB (1998) The search for human obesity genes. Science 280: 1374-1377.
-
(1998)
Science
, vol.280
, pp. 1374-1377
-
-
Comuzzie, A.G.1
Allison, D.B.2
-
11
-
-
85047697648
-
Twins and virtual twins: Bases of relative body weight revisited
-
Segal NL, Allison DB (2002) Twins and virtual twins: Bases of relative body weight revisited. Int J Obes Relat Metab Disord 26: 437-441.
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, pp. 437-441
-
-
Segal, N.L.1
Allison, D.B.2
-
12
-
-
0026849567
-
Positional cloning: Let's not call it reverse anymore
-
Collins FS (1992) Positional cloning: Let's not call it reverse anymore. Nat Genet 1: 3-6.
-
(1992)
Nat Genet
, vol.1
, pp. 3-6
-
-
Collins, F.S.1
-
13
-
-
0037373275
-
Discovering genotypes underlying human phenotypes: Past successes for Mendelian disease, future approaches for complex disease
-
Botstein D, Risch N (2003) Discovering genotypes underlying human phenotypes: Past successes for Mendelian disease, future approaches for complex disease. Nat Genet 33 Suppl: 228-237.
-
(2003)
Nat Genet
, vol.33
, Issue.SUPPL.
, pp. 228-237
-
-
Botstein, D.1
Risch, N.2
-
14
-
-
13144306071
-
Genome-wide association studies for common diseases and complex traits
-
Hirschhorn JN, Daly MJ (2005) Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6: 95-108.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 95-108
-
-
Hirschhorn, J.N.1
Daly, M.J.2
-
15
-
-
13144265739
-
Genome-wide association studies: Theoretical and practical concerns
-
Wang WY, Barratt BJ, Clayton DG, Todd JA (2005) Genome-wide association studies: Theoretical and practical concerns. Nat Rev Genet 6: 109-118.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 109-118
-
-
Wang, W.Y.1
Barratt, B.J.2
Clayton, D.G.3
Todd, J.A.4
-
16
-
-
33745237158
-
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
-
Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, et al. (2006) A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 38: 644-651.
-
(2006)
Nat Genet
, vol.38
, pp. 644-651
-
-
Arking, D.E.1
Pfeufer, A.2
Post, W.3
Kao, W.H.4
Newton-Cheh, C.5
-
17
-
-
20244380171
-
Complement factor H polymorphism in age-related macular degeneration
-
Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, et al. (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308: 385-389.
-
(2005)
Science
, vol.308
, pp. 385-389
-
-
Klein, R.J.1
Zeiss, C.2
Chew, E.Y.3
Tsai, J.Y.4
Sackler, R.S.5
-
18
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science: 314: 1461-1463.
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
Rioux, J.D.4
Silverberg, M.S.5
-
19
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
Sladek R, Rocheleau G, Rung J, Dina C, Shen L, et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445: 881-885.
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
Dina, C.4
Shen, L.5
-
20
-
-
33748039452
-
Heritability of cardiovascular and personality traits in 6,148 Sardinians
-
doi:10.1371/journal.pgen.0020132
-
Pilia G, Chen WM, Scuteri A, Orru M, Albai G, et al. (2006) Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2: e132. doi:10.1371/journal.pgen.0020132
-
(2006)
PLoS Genet
, vol.2
-
-
Pilia, G.1
Chen, W.M.2
Scuteri, A.3
Orru, M.4
Albai, G.5
-
21
-
-
0032707163
-
Population choice in mapping genes for complex diseases
-
Wright AF, Carothers AD, Pirastu M (1999) Population choice in mapping genes for complex diseases. Nat Genet 23: 397-404.
-
(1999)
Nat Genet
, vol.23
, pp. 397-404
-
-
Wright, A.F.1
Carothers, A.D.2
Pirastu, M.3
-
22
-
-
0034574603
-
Use of population isolates for mapping complex traits
-
Peltonen L, Palotie A, Lange K (2000) Use of population isolates for mapping complex traits. Nat Rev Genet 1: 182-190.
-
(2000)
Nat Rev Genet
, vol.1
, pp. 182-190
-
-
Peltonen, L.1
Palotie, A.2
Lange, K.3
-
24
-
-
34547628858
-
Family Based Association Tests for Genome Wide Association Scans
-
In press
-
Chen WM, Abecasis GR (2007) Family Based Association Tests for Genome Wide Association Scans. Am J Hum Genet. In press.
-
(2007)
Am J Hum Genet
-
-
Chen, W.M.1
Abecasis, G.R.2
-
25
-
-
0000803318
-
Construction of multilocus genetic linkage maps in humans
-
Lander ES, Green P (1987) Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A 84: 2363-2367.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 2363-2367
-
-
Lander, E.S.1
Green, P.2
-
26
-
-
0036338150
-
Merlin-rapid analysis of dense genetic maps using sparse gene flow trees
-
Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30: 97-101.
-
(2002)
Nat Genet
, vol.30
, pp. 97-101
-
-
Abecasis, G.R.1
Cherny, S.S.2
Cookson, W.O.3
Cardon, L.R.4
-
29
-
-
0032714352
-
Genomic control for association studies
-
Devlin B, Roeder K (1999) Genomic control for association studies. Biometrics 55: 997-1004.
-
(1999)
Biometrics
, vol.55
, pp. 997-1004
-
-
Devlin, B.1
Roeder, K.2
-
30
-
-
0001677717
-
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
-
Benjamini Y, Hochberg Y (1995) Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc Ser B Stat Methodol 57: 289-300.
-
(1995)
J R Stat Soc Ser B Stat Methodol
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
31
-
-
0032886705
-
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation
-
Peters T, Ausmeier K, Ruther U (1999) Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome 10: 983-986.
-
(1999)
Mamm Genome
, vol.10
, pp. 983-986
-
-
Peters, T.1
Ausmeier, K.2
Ruther, U.3
-
32
-
-
33645489353
-
Genome scan for body mass index and height in the Framingham Heart Study
-
Geller F, Dempfle A, Gorg T (2003) Genome scan for body mass index and height in the Framingham Heart Study. BMC Genet 4 Suppl 1: S91.
-
(2003)
BMC Genet
, vol.4
, Issue.SUPPL. 1
-
-
Geller, F.1
Dempfle, A.2
Gorg, T.3
-
33
-
-
0036234398
-
A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program
-
Wu X, Cooper RS, Borecki I, Hanis C, Bray M, et al. (2002) A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hum Genet 70: 1247-1256.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 1247-1256
-
-
Wu, X.1
Cooper, R.S.2
Borecki, I.3
Hanis, C.4
Bray, M.5
-
34
-
-
0033678517
-
Anisomastia associated with interstitial duplication of Chromosome 16, mental retardation, obesity, dysmorphic facies, and digital anomalies: Molecular mapping of a new syndrome by fluorescent in situ hybridization and microsatellites to 16q13 (D16S419-D16S503)
-
Stratakis CA, Lafferty A, Taymans SE, Gafni RI, Meck JM, et al. (2000) Anisomastia associated with interstitial duplication of Chromosome 16, mental retardation, obesity, dysmorphic facies, and digital anomalies: Molecular mapping of a new syndrome by fluorescent in situ hybridization and microsatellites to 16q13 (D16S419-D16S503). J Clin Endocrinol Metab 85: 3396-3401.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 3396-3401
-
-
Stratakis, C.A.1
Lafferty, A.2
Taymans, S.E.3
Gafni, R.I.4
Meck, J.M.5
-
35
-
-
0020995915
-
Isozymes of human phosphofructokinase: Biochemical and genetic aspects
-
Vora S (1983) Isozymes of human phosphofructokinase: Biochemical and genetic aspects. Isozymes Curr Top Biol Med Res 11: 3-23.
-
(1983)
Isozymes Curr Top Biol Med Res
, vol.11
, pp. 3-23
-
-
Vora, S.1
-
36
-
-
0037312921
-
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
-
Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33: 177-182.
-
(2003)
Nat Genet
, vol.33
, pp. 177-182
-
-
Lohmueller, K.E.1
Pearce, C.L.2
Pike, M.3
Lander, E.S.4
Hirschhorn, J.N.5
-
37
-
-
12244297741
-
A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans
-
Thiel BA, Chakravarti A, Cooper RS, Luke A, Lewis S, et al. (2003) A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens 16: 151-153.
-
(2003)
Am J Hypertens
, vol.16
, pp. 151-153
-
-
Thiel, B.A.1
Chakravarti, A.2
Cooper, R.S.3
Luke, A.4
Lewis, S.5
-
38
-
-
0035337657
-
Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE)
-
McKenzie CA, Abecasis GR, Keavney B, Forrester T, Ratcliffe PJ, et al. (2001) Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE). Hum Mol Genet 10: 1077-1084.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1077-1084
-
-
McKenzie, C.A.1
Abecasis, G.R.2
Keavney, B.3
Forrester, T.4
Ratcliffe, P.J.5
-
39
-
-
20044390391
-
Fine-mapping gene-by-diet interactions on Chromosome 13 in a LG/J x SM/J murine model of obesity
-
Ehrich TH, Hrbek T, Kenney-Hunt JP, Pletscher LS, Wang B, et al. (2005) Fine-mapping gene-by-diet interactions on Chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes 54: 1863-1872.
-
(2005)
Diabetes
, vol.54
, pp. 1863-1872
-
-
Ehrich, T.H.1
Hrbek, T.2
Kenney-Hunt, J.P.3
Pletscher, L.S.4
Wang, B.5
-
40
-
-
21344471889
-
Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish
-
Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, et al. (2005) Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes 54: 2245-2250.
-
(2005)
Diabetes
, vol.54
, pp. 2245-2250
-
-
Damcott, C.M.1
Ott, S.H.2
Pollin, T.I.3
Reinhart, L.J.4
Wang, J.5
-
41
-
-
0028853880
-
Interaction of the lipoprotein lipase asparagine 291->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: A study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults
-
Fisher RM, Mailly F, Peacock RE, Hamsten A, Seed M, et al. (1995) Interaction of the lipoprotein lipase asparagine 291->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults. J Lipid Res 36: 2104-2112.
-
(1995)
J Lipid Res
, vol.36
, pp. 2104-2112
-
-
Fisher, R.M.1
Mailly, F.2
Peacock, R.E.3
Hamsten, A.4
Seed, M.5
-
42
-
-
11144358198
-
A gene atlas of the mouse and human protein-encoding transcriptomes
-
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, et al. (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A 101: 6062-6067.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 6062-6067
-
-
Su, A.I.1
Wiltshire, T.2
Batalov, S.3
Lapp, H.4
Ching, K.A.5
-
43
-
-
0036083007
-
Phosphofructo-kinase deficiency; past, present and future
-
Nakajima H, Raben N, Hamaguchi T, Yamasaki T (2002) Phosphofructo-kinase deficiency; past, present and future. Curr Mol Med 2: 197-212.
-
(2002)
Curr Mol Med
, vol.2
, pp. 197-212
-
-
Nakajima, H.1
Raben, N.2
Hamaguchi, T.3
Yamasaki, T.4
-
44
-
-
13644270555
-
Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines
-
Hannemann A, Jandrig B, Gaunitz F, Eschrich K, Bigl M (2005) Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines. Gene 345: 237-247.
-
(2005)
Gene
, vol.345
, pp. 237-247
-
-
Hannemann, A.1
Jandrig, B.2
Gaunitz, F.3
Eschrich, K.4
Bigl, M.5
-
45
-
-
33644859289
-
Obesity as compared with physical activity in predicting risk of coronary heart disease in women
-
Li TY, Rana JS, Manson JE, Willett WC, Stampfer MJ, et al. (2006) Obesity as compared with physical activity in predicting risk of coronary heart disease in women. Circulation 113: 499-506.
-
(2006)
Circulation
, vol.113
, pp. 499-506
-
-
Li, T.Y.1
Rana, J.S.2
Manson, J.E.3
Willett, W.C.4
Stampfer, M.J.5
-
46
-
-
33747870163
-
Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old
-
Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, et al. (2006) Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 355: 763-778.
-
(2006)
N Engl J Med
, vol.355
, pp. 763-778
-
-
Adams, K.F.1
Schatzkin, A.2
Harris, T.B.3
Kipnis, V.4
Mouw, T.5
-
47
-
-
1842574410
-
The SU.VI.MAX Study: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
-
Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, et al. (2004) The SU.VI.MAX Study: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164: 2335-2342.
-
(2004)
Arch Intern Med
, vol.164
, pp. 2335-2342
-
-
Hercberg, S.1
Galan, P.2
Preziosi, P.3
Bertrais, S.4
Mennen, L.5
-
48
-
-
0032145872
-
A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: The SU.VI.MAX study-design, methods, and participant characteristics. SUpplementation en VItamines et Mineraux AntioXydants
-
Hercberg S, Preziosi P, Briancon S, Galan P, Triol I, et al. (1998) A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study-design, methods, and participant characteristics. SUpplementation en VItamines et Mineraux AntioXydants. Control Clin Trials 19: 336-351.
-
(1998)
Control Clin Trials
, vol.19
, pp. 336-351
-
-
Hercberg, S.1
Preziosi, P.2
Briancon, S.3
Galan, P.4
Triol, I.5
-
49
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
-
50
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
Dina C, Meyre D, Gallina S, Durand E, Korner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724-726.
-
(2007)
Nat Genet
, vol.39
, pp. 724-726
-
-
Dina, C.1
Meyre, D.2
Gallina, S.3
Durand, E.4
Korner, A.5
-
52
-
-
0033909546
-
A general test of association for quantitative traits in nuclear families
-
Abecasis GR, Cardon LR, Cookson WOC (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66: 279-292.
-
(2000)
Am J Hum Genet
, vol.66
, pp. 279-292
-
-
Abecasis, G.R.1
Cardon, L.R.2
Cookson, W.O.C.3
-
53
-
-
33749017409
-
-
Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, et al. (2006) The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14: 529-644.
-
Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, et al. (2006) The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14: 529-644.
-
-
-
-
54
-
-
34447577485
-
The International HapMap Project
-
The International HapMap Consortium
-
The International HapMap Consortium (2005) The International HapMap Project. Nature 437: 1299-1320
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
55
-
-
0034017850
-
GOLD - Graphical overview of linkage disequilibrium
-
Abecasis GR, Cookson WOC (2000) GOLD - Graphical overview of linkage disequilibrium. Bioinformatics 16: 182-183.
-
(2000)
Bioinformatics
, vol.16
, pp. 182-183
-
-
Abecasis, G.R.1
Cookson, W.O.C.2
|