메뉴 건너뛰기




Volumn 75, Issue , 2013, Pages 106-115

Gene × environment interactions in obesity: The state of the evidence

Author keywords

Gene environment interaction; Obesity; Statistical power; Systematic review

Indexed keywords

ARTICLE; BEVERAGE; BODY COMPOSITION; BODY WEIGHT; CARBOHYDRATE INTAKE; DIETARY FIBER; DIETARY INTAKE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EXERCISE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INTRAABDOMINAL FAT; LIFESTYLE; OBESITY; PHYSICAL ACTIVITY; PROTEIN INTAKE; REPLICATION STUDY; SAMPLE SIZE; SCIENTIFIC LITERATURE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; STANDARDIZATION; SUBCUTANEOUS FAT; SUGAR INTAKE; SYSTEMATIC REVIEW;

EID: 84885011484     PISSN: 00015652     EISSN: 14230062     Source Type: Journal    
DOI: 10.1159/000351070     Document Type: Article
Times cited : (26)

References (93)
  • 2
    • 38849145658 scopus 로고    scopus 로고
    • Evolutionary origins of obesity
    • Bellisari A: Evolutionary origins of obesity. Obes Rev 2008; 9: 165-180.
    • (2008) Obes Rev , vol.9 , pp. 165-180
    • Bellisari, A.1
  • 3
    • 53049097640 scopus 로고    scopus 로고
    • Seven models of population obesity
    • Ulijaszek SJ: Seven models of population obesity. Angiology 2008; 59(2 suppl):34S-8S.
    • (2008) Angiology , vol.59 , Issue.2 , pp. 34S-8S
    • Ulijaszek, S.J.1
  • 4
    • 33747412229 scopus 로고    scopus 로고
    • Unhealthy assimilation: Why do immigrants converge to American health status levels?
    • Antecol H, Bedard K: Unhealthy assimilation: why do immigrants converge to American health status levels? Demography 2006; 43: 337-360.
    • (2006) Demography , vol.43 , pp. 337-360
    • Antecol, H.1    Bedard, K.2
  • 5
    • 77951762127 scopus 로고    scopus 로고
    • The effect of rural-to-urban migration on obesity and diabetes in India: A cross-sectional study
    • Ebrahim S, et al: The effect of rural-to-urban migration on obesity and diabetes in India: a cross-sectional study. PLoS Med 2010; 7:e1000268.
    • (2010) PLoS Med , vol.7 , pp. e1000268
    • Ebrahim, S.1
  • 6
    • 33746607619 scopus 로고    scopus 로고
    • Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the US
    • Schulz LO, et al: Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the US. Diabetes Care 2006; 29: 1866-1871.
    • (2006) Diabetes Care , vol.29 , pp. 1866-1871
    • Schulz, L.O.1
  • 7
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, et al: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1
  • 8
    • 27744469119 scopus 로고    scopus 로고
    • Habitual physical activity in children: The role of genes and the environment
    • Franks PW, et al: Habitual physical activity in children: the role of genes and the environment. Am J Clin Nutr 2005; 82: 901-908.
    • (2005) Am J Clin Nutr , vol.82 , pp. 901-908
    • Franks, P.W.1
  • 9
    • 0030752118 scopus 로고    scopus 로고
    • Are genetic determinants of weight gain modified by leisure-time physical activity? A prospective study of Finnish twins
    • Heitmann BL, et al: Are genetic determinants of weight gain modified by leisure-time physical activity? A prospective study of Finnish twins. Am J Clin Nutr 1997; 66: 672-678.
    • (1997) Am J Clin Nutr , vol.66 , pp. 672-678
    • Heitmann, B.L.1
  • 10
    • 77952950739 scopus 로고    scopus 로고
    • The association of restrained eating with weight change over time in a community-based sample of twins
    • Schur EA, Heckbert SR, Goldberg JH: The association of restrained eating with weight change over time in a community-based sample of twins. Obesity 2010; 18: 1146-1152.
    • (2010) Obesity , vol.18 , pp. 1146-1152
    • Schur, E.A.1    Heckbert, S.R.2    Goldberg, J.H.3
  • 11
    • 84355161792 scopus 로고    scopus 로고
    • Attenuated inheritance of body weight by running in monozygotic twins
    • Williams PT: Attenuated inheritance of body weight by running in monozygotic twins. Med Sci Sports Exerc 2012; 44: 98-103.
    • (2012) Med Sci Sports Exerc , vol.44 , pp. 98-103
    • Williams, P.T.1
  • 12
    • 67749084122 scopus 로고    scopus 로고
    • Childbirth moderates the genetic and environmental influences on BMI in adult twins
    • Rebollo-Mesa I, Ordonana JR: Childbirth moderates the genetic and environmental influences on BMI in adult twins. Obesity (Silver Spring) 2009; 17: 1646-1647.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1646-1647
    • Rebollo-Mesa, I.1    Ordonana, J.R.2
  • 13
    • 78651087342 scopus 로고    scopus 로고
    • The combined influence of genetic factors and sedentary activity on body mass changes from adolescence to young adulthood: The National Longitudinal Adolescent Health Study
    • Graff M, et al: The combined influence of genetic factors and sedentary activity on body mass changes from adolescence to young adulthood: the National Longitudinal Adolescent Health Study. Diabetes Metab Res Rev 2011; 27: 63-69.
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 63-69
    • Graff, M.1
  • 14
    • 79251648839 scopus 로고    scopus 로고
    • Education modifies genetic and environmental influences on BMI
    • Johnson W, et al: Education modifies genetic and environmental influences on BMI. PLoS One 2011; 6:e16290.
    • (2011) PLoS One , vol.6 , pp. e16290
    • Johnson, W.1
  • 15
    • 63649113482 scopus 로고    scopus 로고
    • Gene × environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
    • McCaffery JM, et al: Gene × environment interaction of vigorous exercise and body mass index among male Vietnam-era twins. Am J Clin Nutr 2009; 89: 1011-1018.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1011-1018
    • McCaffery, J.M.1
  • 16
    • 0031738113 scopus 로고    scopus 로고
    • Genes versus environment the relationship between dietary fat and total and central abdominal fat
    • Samaras K, et al: Genes versus environment. The relationship between dietary fat and total and central abdominal fat. Diabetes Care 1998; 21: 2069-2076.
    • (1998) Diabetes Care , vol.21 , pp. 2069-2076
    • Samaras, K.1
  • 17
    • 84856735797 scopus 로고    scopus 로고
    • Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: An international study of over 12, 000 twin pairs
    • Dubois L, et al: Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12, 000 twin pairs. PLoS One 2012; 7:e30153.
    • (2012) PLoS One , vol.7 , pp. e30153
    • Dubois, L.1
  • 18
    • 79952451185 scopus 로고    scopus 로고
    • Genetic regulation of pre-pubertal development of body mass index: A longitudinal study of Japanese twin boys and girls
    • Silventoinen K, Kaprio J, Yokoyama Y: Genetic regulation of pre-pubertal development of body mass index: a longitudinal study of Japanese twin boys and girls. Behav Genet 2011; 41: 234-241.
    • (2011) Behav Genet , vol.41 , pp. 234-241
    • Silventoinen, K.1    Kaprio, J.2    Yokoyama, Y.3
  • 19
    • 79959652910 scopus 로고    scopus 로고
    • Increased genetic variance of BMI with a higher prevalence of obesity
    • Rokholm B, et al: Increased genetic variance of BMI with a higher prevalence of obesity. PLoS One 2011; 6:e20816.
    • (2011) PLoS One , vol.6 , pp. e20816
    • Rokholm, B.1
  • 20
    • 0344874261 scopus 로고    scopus 로고
    • Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: Evidence for geneenvironment interaction
    • Greenfield JR, et al: Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: evidence for geneenvironment interaction. J Clin Endocrinol Metab 2003; 88: 5381-5386.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5381-5386
    • Greenfield, J.R.1
  • 21
    • 70349786824 scopus 로고    scopus 로고
    • Modification effects of physical activity and protein intake on heritability of body size and composition
    • Silventoinen K, et al: Modification effects of physical activity and protein intake on heritability of body size and composition. Am J Clin Nutr 2009; 90: 1096-1103.
    • (2009) Am J Clin Nutr , vol.90 , pp. 1096-1103
    • Silventoinen, K.1
  • 22
    • 58149482427 scopus 로고    scopus 로고
    • Physical activity reduces the influence of genetic effects on BMI and waist circumference: A study in young adult twins
    • Mustelin L, et al: Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes 2009; 33: 29-36.
    • (2009) Int J Obes , vol.33 , pp. 29-36
    • Mustelin, L.1
  • 23
    • 33846256812 scopus 로고    scopus 로고
    • Physical activity, diet and gene-environment interactions in relation to body mass index and waist circumference: The Swedish Young Male Twins Study
    • Karnehed N, et al: Physical activity, diet and gene-environment interactions in relation to body mass index and waist circumference: the Swedish Young Male Twins Study. Public Health Nutr 2006; 9: 851-858.
    • (2006) Public Health Nutr , vol.9 , pp. 851-858
    • Karnehed, N.1
  • 24
    • 58149528039 scopus 로고    scopus 로고
    • Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G × E) interaction
    • Cornes BK, et al: Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G × E) interaction. Int J Obes 2009; 33: 75-79.
    • (2009) Int J Obes , vol.33 , pp. 75-79
    • Cornes, B.K.1
  • 25
    • 84860643113 scopus 로고    scopus 로고
    • Sleep duration and body mass index in twins: A gene-environment interaction
    • Watson NF, et al: Sleep duration and body mass index in twins: a gene-environment interaction. Sleep 2012; 35: 597-603.
    • (2012) Sleep , vol.35 , pp. 597-603
    • Watson, N.F.1
  • 26
    • 0017669906 scopus 로고
    • Familial resemblance of body weight and weight/height in 374 homes with adopted children
    • Biron P, Mongeau JG, Bertrand D: Familial resemblance of body weight and weight/height in 374 homes with adopted children. J Pediatr 1977; 91: 555-558.
    • (1977) J Pediatr , vol.91 , pp. 555-558
    • Biron, P.1    Mongeau, J.G.2    Bertrand, D.3
  • 27
    • 0026738994 scopus 로고
    • Childhood body mass index-Genetic and familial environmental influences assessed in a longitudinal adoption study
    • Sorensen TI, Holst C, Stunkard AJ: Childhood body mass index-genetic and familial environmental influences assessed in a longitudinal adoption study. Int J Obes Relat Metab Disord 1992; 16: 705-714.
    • (1992) Int J Obes Relat Metab Disord , vol.16 , pp. 705-714
    • Sorensen, T.I.1    Holst, C.2    Stunkard, A.J.3
  • 28
    • 0025293894 scopus 로고
    • The body-mass index of twins who have been reared apart
    • Stunkard AJ, et al: The body-mass index of twins who have been reared apart. N Engl J Med 1990; 322: 1483-1487.
    • (1990) N Engl J Med , vol.322 , pp. 1483-1487
    • Stunkard, A.J.1
  • 29
    • 25844442493 scopus 로고    scopus 로고
    • Association of melanin-concentrating hormone receptor 1 5 ′ polymorphism with early-onset extreme obesity
    • Bell CG, et al: Association of melanin-concentrating hormone receptor 1 5 ′ polymorphism with early-onset extreme obesity. Diabetes 2005; 54: 3049-3055.
    • (2005) Diabetes , vol.54 , pp. 3049-3055
    • Bell, C.G.1
  • 30
    • 15644369364 scopus 로고    scopus 로고
    • Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes
    • Hinney A, et al: Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes. J Clin Endocrinol Metab 1998; 83: 3737-3741.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3737-3741
    • Hinney, A.1
  • 31
    • 79955940395 scopus 로고    scopus 로고
    • The genetic epidemiology of melanocortin 4 receptor variants
    • Loos RJ: The genetic epidemiology of melanocortin 4 receptor variants. Eur J Pharmacol 2011; 660: 156-164.
    • (2011) Eur J Pharmacol , vol.660 , pp. 156-164
    • Loos, R.J.1
  • 32
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, et al: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726.
    • (2007) Nat Genet , vol.39 , pp. 724-726
    • Dina, C.1
  • 33
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1
  • 34
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • Scuteri A, et al: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3:e115.
    • (2007) PLoS Genet , vol.3 , pp. e115
    • Scuteri, A.1
  • 35
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken T, et al: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-1472.
    • (2007) Science , vol.318 , pp. 1469-1472
    • Gerken, T.1
  • 36
    • 33645825830 scopus 로고    scopus 로고
    • A common genetic variant is associated with adult and childhood obesity
    • Herbert A, et al: A common genetic variant is associated with adult and childhood obesity. Science 2006; 312: 279-283.
    • (2006) Science , vol.312 , pp. 279-283
    • Herbert, A.1
  • 37
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, et al: Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010; 42: 937-948.
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1
  • 38
    • 67651216024 scopus 로고    scopus 로고
    • NRXN3 is a novel locus for waist circumference: A genome-wide association study from the CHARGE Consortium
    • Heard-Costa NL, et al: NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 2009; 5:e1000539.
    • (2009) PLoS Genet , vol.5 , pp. e1000539
    • Heard-Costa, N.L.1
  • 39
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • Willer CJ, et al: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1
  • 40
    • 79957588287 scopus 로고    scopus 로고
    • Genome partitioning of genetic variation for complex traits using common SNPs
    • Yang J, et al: Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet 2011; 43: 519-525.
    • (2011) Nat Genet , vol.43 , pp. 519-525
    • Yang, J.1
  • 41
    • 79951715822 scopus 로고    scopus 로고
    • Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    • de Miguel-Yanes JM, et al: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care 2011; 34: 121-125.
    • (2011) Diabetes Care , vol.34 , pp. 121-125
    • De Miguel-Yanes, J.M.1
  • 42
    • 84858273254 scopus 로고    scopus 로고
    • Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program
    • Delahanty LM, et al: Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care 2012; 35: 363-366.
    • (2012) Diabetes Care , vol.35 , pp. 363-366
    • Delahanty, L.M.1
  • 43
    • 64549158008 scopus 로고    scopus 로고
    • Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    • Renstrm F, et al: Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 2009; 18: 1489-1496.
    • (2009) Hum Mol Genet , vol.18 , pp. 1489-1496
    • Renstrm, F.1
  • 45
    • 0242300570 scopus 로고    scopus 로고
    • Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
    • Mizuno TM, et al: Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 2003; 52: 2675-2683.
    • (2003) Diabetes , vol.52 , pp. 2675-2683
    • Mizuno, T.M.1
  • 46
    • 33846822094 scopus 로고    scopus 로고
    • Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
    • Ren D, et al: Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest 2007; 117: 397-406.
    • (2007) J Clin Invest , vol.117 , pp. 397-406
    • Ren, D.1
  • 47
    • 0038141363 scopus 로고    scopus 로고
    • The role of melanocortin signalling in the control of body weight: Evidence from human and murine genetic models
    • Yeo GS, et al: The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models. QJM 2000; 93: 7-14.
    • (2000) QJM , vol.93 , pp. 7-14
    • Yeo, G.S.1
  • 48
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • Farooqi IS, et al: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003; 348: 1085-1095.
    • (2003) N Engl J Med , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1
  • 49
    • 0037456733 scopus 로고    scopus 로고
    • Binge eating as a major phenotype of melanocortin 4 receptor gene mutations
    • Branson R, et al: Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 2003; 348: 1096-1103.
    • (2003) N Engl J Med , vol.348 , pp. 1096-1103
    • Branson, R.1
  • 50
    • 84878795484 scopus 로고    scopus 로고
    • Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology
    • Bernhard F, et al: Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia 2013; 56: 311-322.
    • (2013) Diabetologia , vol.56 , pp. 311-322
    • Bernhard, F.1
  • 51
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • Heid IM, et al: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010, 42: 949-960.
    • (2010) Nat Genet , vol.42 , pp. 949-960
    • Heid, I.M.1
  • 52
    • 84863684047 scopus 로고    scopus 로고
    • Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
    • Fox CS, et al: Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet 2012; 8:e1002695.
    • (2012) PLoS Genet , vol.8 , pp. e1002695
    • Fox, C.S.1
  • 53
    • 82255186505 scopus 로고    scopus 로고
    • Pharmacogenetics in type 2 diabetes: Potential implications for clinical practice
    • Huang C, Florez JC: Pharmacogenetics in type 2 diabetes: potential implications for clinical practice. Genome Med 2011; 3: 76.
    • (2011) Genome Med , vol.3 , pp. 76
    • Huang, C.1    Florez, J.C.2
  • 54
    • 63349109584 scopus 로고    scopus 로고
    • Pharmacogenetics in diabetes
    • Pearson ER: Pharmacogenetics in diabetes. Curr Diab Rep 2009; 9: 172-181.
    • (2009) Curr Diab Rep , vol.9 , pp. 172-181
    • Pearson, E.R.1
  • 55
    • 77958548114 scopus 로고    scopus 로고
    • Invited commentary: Gene × lifestyle interactions and complex disease traits-Inferring cause and effect from observational data, sine qua non
    • discussion 998-999
    • Franks PW, Nettleton JA: Invited commentary: gene × lifestyle interactions and complex disease traits-inferring cause and effect from observational data, sine qua non. Am J Epidemiol 2010; 172: 992-997; discussion 998-999.
    • (2010) Am J Epidemiol , vol.172 , pp. 992-997
    • Franks, P.W.1    Nettleton, J.A.2
  • 56
    • 33748797136 scopus 로고    scopus 로고
    • Genes, environment and the value of prospective cohort studies
    • Manolio TA, Bailey-Wilson JE, Collins FS: Genes, environment and the value of prospective cohort studies. Nat Rev Genet 2006; 7: 812-820.
    • (2006) Nat Rev Genet , vol.7 , pp. 812-820
    • Manolio, T.A.1    Bailey-Wilson, J.E.2    Collins, F.S.3
  • 57
    • 84885897931 scopus 로고    scopus 로고
    • The interplay of lifestyle and genetic susceptibility in type 2 diabetes risk
    • Franks PW, Shungin D: The interplay of lifestyle and genetic susceptibility in type 2 diabetes risk. Diabetes Manag 2011; 1: 299-307.
    • (2011) Diabetes Manag , vol.1 , pp. 299-307
    • Franks, P.W.1    Shungin, D.2
  • 58
    • 79960025383 scopus 로고    scopus 로고
    • Gene-lifestyle and gene-pharmacotherapy interactions in obesity and its cardiovascular consequences
    • Franks PW, Poveda A: Gene-lifestyle and gene-pharmacotherapy interactions in obesity and its cardiovascular consequences. Curr Vasc Pharmacol 2011; 9: 401-456.
    • (2011) Curr Vasc Pharmacol , vol.9 , pp. 401-456
    • Franks, P.W.1    Poveda, A.2
  • 59
    • 38449098674 scopus 로고    scopus 로고
    • Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    • Andreasen CH, et al: Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57: 95-101.
    • (2008) Diabetes , vol.57 , pp. 95-101
    • Andreasen, C.H.1
  • 60
    • 51649099799 scopus 로고    scopus 로고
    • Physical activity and the association of common FTO gene variants with body mass index and obesity
    • Rampersaud E, et al: Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 2008; 168: 1791-1797.
    • (2008) Arch Intern Med , vol.168 , pp. 1791-1797
    • Rampersaud, E.1
  • 61
    • 55649096648 scopus 로고    scopus 로고
    • Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program
    • Franks PW, et al: Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia 2008; 51: 2214-2223.
    • (2008) Diabetologia , vol.51 , pp. 2214-2223
    • Franks, P.W.1
  • 62
    • 67349234146 scopus 로고    scopus 로고
    • Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15, 925 Swedish and 2, 511 Finnish adults
    • Jonsson A, et al: Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15, 925 Swedish and 2, 511 Finnish adults. Diabetologia 2009; 52: 1334-1338.
    • (2009) Diabetologia , vol.52 , pp. 1334-1338
    • Jonsson, A.1
  • 63
    • 82455175773 scopus 로고    scopus 로고
    • Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218, 166 adults and 19, 268 children
    • Kilpelinen TO, et al: Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218, 166 adults and 19, 268 children. PLoS Med 2011; 8:e1001116.
    • (2011) PLoS Med , vol.8 , pp. e1001116
    • Kilpelinen, T.O.1
  • 64
    • 77952909940 scopus 로고    scopus 로고
    • Challenges in the use of literature-based meta-analysis to examine geneenvironment interactions
    • Palla L, et al: Challenges in the use of literature-based meta-analysis to examine geneenvironment interactions. Am J Epidemiol 2010; 171: 1225-1232.
    • (2010) Am J Epidemiol , vol.171 , pp. 1225-1232
    • Palla, L.1
  • 65
    • 84876802154 scopus 로고    scopus 로고
    • Gene-environment and gene-treatment interactions in type 2 diabetes: Progress, pitfalls, and prospects
    • Franks PW, Pearson ER, Florez JC: Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects. Diabetes Care 2013; 36: 1413-1421.
    • (2013) Diabetes Care , vol.36 , pp. 1413-1421
    • Franks, P.W.1    Pearson, E.R.2    Florez, J.C.3
  • 66
    • 77956798214 scopus 로고    scopus 로고
    • Physical activity attenuates the genetic predisposition to obesity in 20, 000 men and women from EPIC-Norfolk prospective population study
    • Li S, et al: Physical activity attenuates the genetic predisposition to obesity in 20, 000 men and women from EPIC-Norfolk prospective population study. PLoS Med 2010; 7:e1000332.
    • (2010) PLoS Med , vol.7 , pp. e1000332
    • Li, S.1
  • 67
    • 84867261218 scopus 로고    scopus 로고
    • Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men
    • Qi Q, et al: Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. Circulation 2012; 126: 1821-1827.
    • (2012) Circulation , pp. 1821-1827
    • Qi, Q.1
  • 68
    • 84867222127 scopus 로고    scopus 로고
    • Sugar-sweetened beverages and genetic risk of obesity
    • Qi Q, et al: Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 2012; 367: 1387-1396.
    • (2012) N Engl J Med , vol.367 , pp. 1387-1396
    • Qi, Q.1
  • 69
    • 84857589505 scopus 로고    scopus 로고
    • Attenuating effect of vigorous physical activity on the risk for inherited obesity: A study of 47, 691 runners
    • Williams PT: Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47, 691 runners. PLoS One 2012; 7:e31436.
    • (2012) PLoS One , vol.7 , pp. e31436
    • Williams, P.T.1
  • 70
    • 34547170053 scopus 로고    scopus 로고
    • The spread of obesity in a large social network over 32 years
    • Christakis NA, Fowler JH: The spread of obesity in a large social network over 32 years. N Engl J Med 2007; 357: 370-379.
    • (2007) N Engl J Med , vol.357 , pp. 370-379
    • Christakis, N.A.1    Fowler, J.H.2
  • 71
    • 69449093447 scopus 로고    scopus 로고
    • Association of variants in the PCSK1 gene with obesity in the EPICNorfolk study
    • Kilpelinen TO, et al: Association of variants in the PCSK1 gene with obesity in the EPICNorfolk study. Hum Mol Genet 2009; 18: 3496-3501.
    • (2009) Hum Mol Genet , vol.18 , pp. 3496-3501
    • Kilpelinen, T.O.1
  • 72
    • 0024595312 scopus 로고
    • Competing risks bias arising from an omitted risk factor
    • Schatzkin A, Slud E: Competing risks bias arising from an omitted risk factor. Am J Epidemiol 1989; 129: 850-856.
    • (1989) Am J Epidemiol , vol.129 , pp. 850-856
    • Schatzkin, A.1    Slud, E.2
  • 73
    • 51449116347 scopus 로고    scopus 로고
    • Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18, 014 Danes
    • Andreasen CH, et al: Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18, 014 Danes. PLoS One 2008; 3:e2872.
    • (2008) PLoS One , vol.3 , pp. e2872
    • Andreasen, C.H.1
  • 74
    • 34247576412 scopus 로고    scopus 로고
    • The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    • Lyon HN, et al: The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet 2007; 3:e61.
    • (2007) PLoS Genet , vol.3 , pp. e61
    • Lyon, H.N.1
  • 75
    • 73449085512 scopus 로고    scopus 로고
    • Meta-analysis of the INSIG2 association with obesity including 74 345 individuals: Does heterogeneity of estimates relate to study design?
    • Heid IM, et al: Meta-analysis of the INSIG2 association with obesity including 74, 345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet 2009; 5:e1000694.
    • (2009) PLoS Genet , vol.5 , pp. e1000694
    • Heid, I.M.1
  • 76
    • 80051594894 scopus 로고    scopus 로고
    • Association between fat intake, physical activity and mortality depending on genetic variation in FTO
    • Sonestedt E, et al: Association between fat intake, physical activity and mortality depending on genetic variation in FTO. Int J Obes 2011; 35: 1041-1049.
    • (2011) Int J Obes , vol.35 , pp. 1041-1049
    • Sonestedt, E.1
  • 77
    • 70350686380 scopus 로고    scopus 로고
    • Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
    • Sonestedt E, et al: Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 2009; 90: 1418-1425.
    • (2009) Am J Clin Nutr , vol.90 , pp. 1418-1425
    • Sonestedt, E.1
  • 78
    • 84864351302 scopus 로고    scopus 로고
    • Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial
    • Peter I, et al: Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial. Obesity 2012; 20: 1675-1682.
    • (2012) Obesity , vol.20 , pp. 1675-1682
    • Peter, I.1
  • 79
    • 80051548943 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial
    • Qi Q, et al: Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. Circulation 2011; 124: 563-571.
    • (2011) Circulation , vol.124 , pp. 563-571
    • Qi, Q.1
  • 80
    • 38749153653 scopus 로고    scopus 로고
    • Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study
    • Kilpelinen TO, et al: Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: the Finnish Diabetes Prevention Study. Metabolism 2008; 57: 428-436.
    • (2008) Metabolism , vol.57 , pp. 428-436
    • Kilpelinen, T.O.1
  • 81
    • 77956183756 scopus 로고    scopus 로고
    • Lifestyle modifies the relationship between body composition and adrenergic receptor genetic polymorphisms, ADRB2, ADRB3 and ADRA2B: A secondary analysis of a randomized controlled trial of physical activity among postmenopausal women
    • Bea JW, et al: Lifestyle modifies the relationship between body composition and adrenergic receptor genetic polymorphisms, ADRB2, ADRB3 and ADRA2B: a secondary analysis of a randomized controlled trial of physical activity among postmenopausal women. Behav Genet 2010; 40: 649-659.
    • (2010) Behav Genet , vol.40 , pp. 649-659
    • Bea, J.W.1
  • 82
    • 24344504484 scopus 로고    scopus 로고
    • Obese subjects carrying the 11482G A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
    • Corella D, et al: Obese subjects carrying the 11482G A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab 2005; 90: 5121-5126.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5121-5126
    • Corella, D.1
  • 83
    • 35848936503 scopus 로고    scopus 로고
    • The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program
    • Franks PW, et al: The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia 2007; 50: 2451-2460.
    • (2007) Diabetologia , vol.50 , pp. 2451-2460
    • Franks, P.W.1
  • 84
    • 77957601724 scopus 로고    scopus 로고
    • Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program
    • Jablonski KA, et al: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes 2010; 59: 2672-2681.
    • (2010) Diabetes , vol.59 , pp. 2672-2681
    • Jablonski, K.A.1
  • 85
    • 50049128467 scopus 로고    scopus 로고
    • Extension of type 2 diabetes genome-wide association scan results in the Diabetes Prevention Program
    • Moore AF, et al: Extension of type 2 diabetes genome-wide association scan results in the Diabetes Prevention Program. Diabetes 2008; 57: 2503-2510.
    • (2008) Diabetes , vol.57 , pp. 2503-2510
    • Moore, A.F.1
  • 86
    • 80755135540 scopus 로고    scopus 로고
    • Gene × environment interactions in type 2 diabetes
    • Franks PW: Gene × environment interactions in type 2 diabetes. Curr Diab Rep 2011; 11: 552-561.
    • (2011) Curr Diab Rep , vol.11 , pp. 552-561
    • Franks, P.W.1
  • 87
    • 78650332973 scopus 로고    scopus 로고
    • Meta-analysis of gene-environment interaction: Joint estimation of SNP and SNP × environment regression coefficients
    • Manning AK, et al: Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients. Genet Epidemiol 2011; 35: 11-18.
    • (2011) Genet Epidemiol , vol.35 , pp. 11-18
    • Manning, A.K.1
  • 88
    • 33847059098 scopus 로고    scopus 로고
    • Exploiting gene-environment interaction to detect genetic associations
    • Kraft P, et al: Exploiting gene-environment interaction to detect genetic associations. Hum Hered 2007; 63: 111-119.
    • (2007) Hum Hered , vol.63 , pp. 111-119
    • Kraft, P.1
  • 89
    • 84861614905 scopus 로고    scopus 로고
    • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
    • Manning AK, et al: A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012; 44: 659-669.
    • (2012) Nat Genet , vol.44 , pp. 659-669
    • Manning, A.K.1
  • 90
    • 36949009909 scopus 로고    scopus 로고
    • Investigating gene environment interaction in complex diseases: Increasing power by selective sampling for environmental exposure
    • Boks MP, et al: Investigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure. Int J Epidemiol 2007; 36: 1363-1369.
    • (2007) Int J Epidemiol , vol.36 , pp. 1363-1369
    • Boks, M.P.1
  • 91
    • 77954157546 scopus 로고    scopus 로고
    • On the use of variance per genotype as a tool to identify quantitative trait interaction effects: A report from the Womens Genome Health Study
    • Pare G, et al: On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Womens Genome Health Study. PLoS Genet 2010; 6:e1000981.
    • (2010) PLoS Genet , vol.6 , pp. e1000981
    • Pare, G.1
  • 92
    • 84867330691 scopus 로고    scopus 로고
    • FTO genotype is associated with phenotypic variability of body mass index
    • Yang J, et al: FTO genotype is associated with phenotypic variability of body mass index. Nature 2012; 490: 267-272.
    • (2012) Nature , vol.490 , pp. 267-272
    • Yang, J.1
  • 93
    • 84880838336 scopus 로고    scopus 로고
    • Gene × physical activity interactions in obesity: Combined analysis of 111, 421 individuals of European ancestry
    • Ahmad S, et al: Gene × physical activity interactions in obesity: combined analysis of 111, 421 individuals of European ancestry. PLoS Genet 2013; 9:e1003607.
    • (2013) PLoS Genet , vol.9 , pp. e1003607
    • Ahmad, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.