Use of mouse models in studying type 2 diabetes mellitus

Expert Reviews in Molecular Medicine

Volumn 13, Issue , 2011, Pages

  Lee, Angela W S ^a   Cox, Roger D ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ETHYLNITROSOUREA; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN; LEPTIN RECEPTOR; GLUCOSE;

ADIPOSE TISSUE; ARTICLE; DISEASE COURSE; DISEASE MODEL; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SYNTHESIS; KNOCKOUT MOUSE; LOSS OF FUNCTION MUTATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OUTBRED STRAIN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; STRAIN DIFFERENCE; TRANSGENIC MOUSE; ANIMAL; COHORT ANALYSIS; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; REVIEW; TRANSLATIONAL RESEARCH;

ANIMALS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MICE; QUANTITATIVE TRAIT LOCI; SIGNAL TRANSDUCTION; TRANSLATIONAL RESEARCH;

EID: 79953752197     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S1462399410001729     Document Type: Article

References (147)

1. Roglic, G. et al. (2005) The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care 28, 2130-2135 (Pubitemid 41242456)
2. Donnelly, R. et al. (2000) ABCof arterial and venous disease: vascular complications of diabetes. British Medical Journal 320, 1062-1066 (Pubitemid 30198980)
3. Morrish, N.J. et al. (2001) Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia 44 (Supplement 2), S14-S21 (Pubitemid 32844108)
4. Song, S.H. and Hardisty, C.A. (2008) Early-onset type 2 diabetesmellitus: an increasing phenomenonof elevated cardiovascular risk. Expert Review of Cardiovascular Therapy 6, 315-322
5. Hatunic, M. et al. (2005) Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes. Diabetes and Vascular Disease Research 2, 73-75 (Pubitemid 40826999)
6. Steinberger, J. et al. (2001) Adiposity in childhood predicts obesity and insulin resistance in young adulthood. Jornal de Pediatria 138, 469-473 (Pubitemid 32319717)
7. Permutt, M.A., Wasson, J. and Cox, N. (2005) Genetic epidemiology of diabetes. Journal of Clinical Investigation 115, 1431-1439 (Pubitemid 40814647)
8. Stumvoll, M., Goldstein, B.J. and van Haeften, T.W. (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365, 1333-1346
9. Mills, G.W. et al. (2004) Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia 47, 732-738 (Pubitemid 38658376)
10. Vimaleswaran, K.S.and Loos, R.J. (2010) Progress in the genetics of common obesityand type 2 iabetes. Expert Reviews in Molecular Medicine 12, e7
11. Dupuis, J. et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics 42, 105-116
12. Saxena, R. et al. (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics 42, 142-148
13. Voight, B.F. et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics 42, 579-589
14. Soranzo, N. et al. (2010) Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes Sep 21; [Epub ahead of print]
15. Peters, L.L. et al. (2007) The mouse as a model for human biology: a resource guide for complex trait analysis. Nature Reviews. Genetics 8, 58-69 (Pubitemid 46006050)
16. Rosenthal, N. and Brown, S. (2007) The mouse ascending: perspectives for human-disease models. Nature Cell Biology 9, 993-999 (Pubitemid 47338136)
17. Fuchs, H. et al. (2009) The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Current Pharmaceutical Biotechnology 10, 236-243
18. Mallon, A.M., Blake, A. and Hancock, J.M. (2008) EuroPhenome and EMPReSS: online mouse phenotyping resource. Nucleic Acids Research 36, D715-D718 (Pubitemid 351149812)
19. Coleman, D.L. (1973) Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294-298
20. Halaas, J.L. et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546
21. Chen, H. et al. (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-495 (Pubitemid 26060722)
22. Lee, G.H. et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635
23. Asensio, C. et al. (2004) Changes in glycemia by leptin administration or high-fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis. Endocrinology 145, 2206-2213 (Pubitemid 38535049)
24. Srinivasan, K. and Ramarao, P. (2007) Animal models in type 2 diabetes research: an overview. Indian J Med Res 125, 451-472 (Pubitemid 46805458)
25. Chatzigeorgiou, A. et al. (2009) The use of animal models in the study of diabetes mellitus. In Vivo 23, 245-258
26. Yoshioka, M. et al. (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894 (Pubitemid 27188269)
27. Mathews, C.E., Langley, S.H. and Leiter, E.H. (2002) New mouse model to study islet transplantation in insulin-dependent diabetes mellitus. Transplantation 73, 1333-1336 (Pubitemid 34454284)
28. Lakso, M. et al. (1992) Targeted oncogene activation by site-specific recombination in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 89, 6232-6236
29. Orban, P.C., Chui, D. and Marth, J.D. (1992) Tissueand site-specific DNA recombination in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 89, 6861-6865
30. Akagi, K. et al. (1997) Cre-mediated somatic sitespecific recombination in mice. Nucleic Acids Research 25, 1766-1773 (Pubitemid 27303358)
31. Feil, R. et al. (1997) Regulation of Cre recombinase activity by mutated estrogen receptor ligandbinding domains. Biochemical and Biophysical Research Communications 237, 752-757 (Pubitemid 27434760)
32. Kim, J.E., Nakashima, K. and de Crombrugghe, B. (2004) Transgenic mice expressing a ligandinducible cre recombinase in osteoblasts and odontoblasts: a newtool to examine physiologyand disease of postnatal bone and tooth. American Journal of Pathology 165, 1875-1882 (Pubitemid 39578367)
33. Hayashi, S. and McMahon, A.P. (2002) Efficient recombination in diverse tissues by a tamoxifeninducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Developmental Biology 244, 305-318 (Pubitemid 34450645)
34. Remedi,M.S. et al. (2009) Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metabolism 9, 140-151
35. Koch, L. et al. (2008) Central insulin action regulates peripheral glucose and fat metabolism in mice. Journal of Clinical Investigation 118, 2132-2147 (Pubitemid 351872332)
36. Ernst, M.B. et al. (2009) Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. Journal of Neuroscience 29, 11582-11593
37. Girard, C.A. et al. (2009) Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. Journal of Clinical Investigation 119, 80-90
38. Soriano, P. (1999) Generalized lacZ expression with theROSA26 Cre reporter strain.Nature Genetics 21, 70-71 (Pubitemid 29036285)
39. Belgardt, B.F. et al. (2008) PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metabolism 7, 291-301 (Pubitemid 351467391)
40. Justice, M.J. et al. (1999) Mouse ENU mutagenesis. Human Molecular Genetics 8, 1955-1963 (Pubitemid 29458674)
41. Hitotsumachi, S., Carpenter, D.A. and Russell,W.L. (1985) Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proceedings of the National Academy of Sciences of the United States of America 82, 6619-6621 (Pubitemid 16228871)
42. Frayling, T.M. et al. (2007)A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (Pubitemid 46764279)
43. Church, C. et al. (2009) A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genetics 5, e1000599
44. Fischer, J. et al. (2009) Inactivation of the Fto gene protects from obesity. Nature 458, 894-898
45. Nolan, P.M. et al. (2000) A systematic, genomewide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nature Genetics 25, 440-443 (Pubitemid 32983439)
46. Hrabe de Angelis, M.H. et al. (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genetics 25, 444-447
47. Aigner, B. et al. (2008) Diabetes models by screen for hyperglycaemia in phenotype-driven ENU mouse mutagenesis projects. American Journal of Physiology. Endocrinology and Metabolism 294, E232-240 (Pubitemid 351231449)
48. Toye, A.A. et al. (2004) A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes 53, 1577-1583 (Pubitemid 38697672)
49. Grupe, A. et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83, 69-78
50. Bali, D. et al. (1995) Animal model for maturityonset diabetes of the young generated by disruption of the mouse glucokinase gene. Journal of Biological Chemistry 270, 21464-21467
51. Goldsworthy, M. et al. (2008) Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57, 2234-2244
52. Nandi, A. et al. (2004) Mouse models of insulin resistance. Physiological Reviews 84, 623-647 (Pubitemid 38365494)
53. Pirola, L., Johnston, A.M. and Van Obberghen, E. (2004) Modulation of insulin action. Diabetologia 47, 170-184 (Pubitemid 38315353)
54. Nakae, J., Kido, Y. and Accili, D. (2001) Distinct and overlapping functions of insulin and IGF-I receptors. Endocrine Reviews 22, 818-835 (Pubitemid 34214297)
55. Shepherd, P.R., Withers, D.J. and Siddle, K. (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochemical Journal 333 (Pt 3), 471-490 (Pubitemid 28398511)
56. Thorens, B. (1996) Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. American Journal of Physiology 270, G541-553
57. Accili, D. et al. (1996) Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genetics 12, 106-109 (Pubitemid 26013160)
58. Joshi, R.L. et al. (1996) Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO Journal 15, 1542-1547 (Pubitemid 26112375)
59. Kim, J.K. et al. (2000) Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. Journal of Clinical Investigation 105, 1791-1797 (Pubitemid 30421760)
60. Bruning, J.C. et al. (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Molecular Cell 2, 559-569 (Pubitemid 128379082)
61. Bluher, M. et al. (2002) Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Developmental Cell 3, 25-38 (Pubitemid 34778393)
62. Bluher, M. et al. (2004) Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knockout mice is associated with differences in patterns of gene expression. Journal of Biological Chemistry 279, 31891-31901 (Pubitemid 39037862)
63. Bluher, M., Kahn, B.B. and Kahn, C.R. (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574 (Pubitemid 36135156)
64. Lauro, D. et al. (1998) Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nature Genetics 20, 294-298 (Pubitemid 28507678)
65. Michael, M.D. et al. (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Molecular Cell 6, 87-97
66. Bruning, J.C. et al. (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122-2125
67. Fernandez, A.M. et al. (2001) Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes and Development 15, 1926-1934 (Pubitemid 32738622)
68. Bruning, J.C. et al. (1997) Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561-572 (Pubitemid 27154421)
69. Araki, E. et al. (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186-190 (Pubitemid 24347839)
70. Tamemoto, H. et al. (1994) Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182-186 (Pubitemid 24347838)
71. Withers, D.J. et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904 (Pubitemid 28157668)
72. Carvalho, E. et al. (2005) Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. American Journal of Physiology. Endocrinology and Metabolism 289, E551-561 (Pubitemid 41356075)
73. Zisman, A. et al. (2000) Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nature Medicine 6, 924-928 (Pubitemid 30644753)
74. Kim,Y.B. et al. (2005) Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Molecular and Cellular Biology 25, 9713-9723
75. Abel, E.D. et al. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409, 729-733 (Pubitemid 32144519)
76. Kotani, K. et al. (2004) GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. Journal of Clinical Investigation 114, 1666-1675 (Pubitemid 40385558)
77. Katz, E.B. et al. (1995) Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377, 151-155
78. Stenbit, A.E. et al. (1997) GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Medicine 3, 1096-1101 (Pubitemid 27444450)
79. Ren, J.M. et al. (1995) Overexpression of Glut4 protein in muscle increases basal and insulinstimulated whole body glucose disposal in conscious mice. Journal of Clinical Investigation 95, 429-432
80. Gibbs, E.M. et al. (1995) Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). Journal of Clinical Investigation 95, 1512-1518
81. Cho, H. et al. (2001) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292, 1728-1731 (Pubitemid 32506248)
82. Terauchi,Y. et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nature Genetics 21, 230-235 (Pubitemid 29070374)
83. Aoki, K. et al. (2009) Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice. American Journal of Physiology. Endocrinology and Metabolism 296, E842-853
84. Mauvais-Jarvis, F. et al. (2002) Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation 109, 141-149 (Pubitemid 34052550)
85. Elchebly, M. et al. (1999) Increased insulin sensitivityand obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544-1548
86. Klaman, L.D. et al. (2000) Increased energy expenditure, decreased adiposity, and tissuespecific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Molecular and Cellular Biology 20, 5479-5489 (Pubitemid 30482885)
87. Nakae, J. et al. (2002) Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nature Genetics 32, 245-253
88. He, W. et al. (2003) Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proceedings of the National Academy ofSciences of the United States of America 100, 15712-15717 (Pubitemid 38021055)
89. Zhang, J. et al. (2004) Selective disruption of PPARgamma2 impairs the development of adipose tissue and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America 101, 10703-10708 (Pubitemid 38955806)
90. Yang, C. et al. (2001) Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. Journal of Clinical Investigation 107, 1311-1318 (Pubitemid 32494548)
91. Wojtaszewski, J.F. et al. (1999) Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. Journal of Clinical Investigation 104, 1257-1264 (Pubitemid 29536296)
92. Samuel, V., Petersen, K. and Shulman, G.I. (2010) Lipid-induced insulin resistance: unravelling the mechanism. The Lancet 375, 2267-2277
93. Jones, J.R. et al. (2005) Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proceedings of theNational Academyof Sciences of the United States of America 102, 6207-6212 (Pubitemid 40594279)
94. Okamoto, H. et al. (2004) Transgenic rescue of insulin receptor-deficient mice. Journal of Clinical Investigation 114, 214-223 (Pubitemid 39071626)
95. Kubota, N. et al. (2000) Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49, 1880-1889
96. Ravichandran, L.V. et al. (2001) Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. Molecular Endocrinology 15, 1768-1780 (Pubitemid 32939307)
97. Nakae, J. et al. (2003) The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Developmental Cell 4, 119-129 (Pubitemid 36105338)
98. Chang-Chen, K.J., Mullur, R. and Bernal-Mizrachi, E. (2008) Beta-cell failure as a complication of diabetes. Reviews in Endocrine and Metabolic Disorder 9, 329-343
99. Guillam, M.T. et al. (1997) Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nature Genetics 17, 327-330
100. Postic, C. et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. Journal of Biological Chemistry 274, 305-315 (Pubitemid 29035064)
101. Remedi, M.S. et al. (2005)ATP-sensitiveK+channel signaling in glucokinase-deficient diabetes. Diabetes 54, 2925-2931
102. Terauchi, Y. et al. (1997) Development of noninsulin- dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. Journal of Clinical Investigation 99, 861-866 (Pubitemid 27123622)
103. Freeman, H.C. et al. (2006) Deletion of nicotinamide nucleotide transhydrogenase: anewquantitive trait locus accounting for glucose intolerance in C57BL/ 6J mice. Diabetes 55, 2153-2156 (Pubitemid 44514958)
104. Huang, T.T. et al. (2006) Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Human Molecular Genetics 15, 1187-1194
105. Toye, A.A. et al. (2005) A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48, 675-686 (Pubitemid 40591223)
106. Miki, T. et al. (1998) Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 95, 10402-10406
107. Remedi, M.S. et al. (2006) Hyperinsulinism in mice with heterozygous loss of K(ATP) channels. Diabetologia 49, 2368-2378 (Pubitemid 44359098)
108. Koster, J.C. et al. (2002) Hyperinsulinism induced by targeted suppression of beta cellKATP channels. Proceedings of the National Academyof Sciences of the United States of America 99, 16992-16997 (Pubitemid 36034086)
109. Koster, J.C. et al. (2000) Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell 100, 645-654
110. Koster, J.C. et al. (2006) Expression of ATPinsensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes. Diabetes 55, 2957-2964 (Pubitemid 44923632)
111. Shiota, C. et al. (2002) Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. Journal of Biological Chemistry 277, 37176-37183
112. Seghers, V. et al. (2000) Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion. Journal of Biological Chemistry 275, 9270-9277 (Pubitemid 30185147)
113. Kulkarni, R.N. et al. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339 (Pubitemid 29077587)
114. Pound, L.D. et al. (2009) Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochemical Journal 421, 371-376
115. Ahlgren, U. et al. (1998) Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes and Development 12, 1763-1768 (Pubitemid 28304328)
116. Gupta, R.K. et al. (2005) The MODY1 gene HNF- 4alpha regulates selected genes involved in insulin secretion. Journal of Clinical Investigation 115, 1006-1015 (Pubitemid 40489405)
117. Miura, A. et al. (2006) Hepatocyte nuclear factor- 4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. Journal of Biological Chemistry 281, 5246-5257 (Pubitemid 43847789)
118. Lee, Y.H., Sauer, B. and Gonzalez, F.J. (1998) Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Molecular and Cellular Biology 18, 3059-3068 (Pubitemid 28183474)
119. Pontoglio, M. et al. (1998) Defective insulin secretion in hepatocyte nuclear factor 1alphadeficient mice. Journal of Clinical Investigation 101, 2215-2222 (Pubitemid 28244105)
120. Wang, L. et al. (2004) Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release. Endocrinology 145, 3941-3949 (Pubitemid 39037583)
121. Naya, F.J. et al. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes and Development 11, 2323-2334 (Pubitemid 27408530)
122. Vaxillaire, M. and Froguel, P. (2009) Monogenic forms of diabetes mellitus: an update. Endocrinol Nutr 56 (Supplement 4), 26-29
123. Vaxillaire, M. and Froguel, P. (2008) Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocrine Reviews 29, 254-264 (Pubitemid 351679698)
124. Aguilar-Bryan, L. et al. (1998) Toward understanding the assembly and structure of KATP channels. Physiological Reviews 78, 227-245 (Pubitemid 28070980)
125. Flanagan, S.E. et al. (2009) Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Human Mutation 30, 170-180
126. Shimomura, K. et al. (2009) Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism.EMBOMolecular Medicine 1, 166-177
127. Gloyn, A.L. et al. (2004) Activating mutations in the gene encoding the ATP-sensitive potassiumchannel subunit Kir6.2 and permanent neonatal diabetes. New England Journal of Medicine 350, 1838-1849 (Pubitemid 38917250)
128. Nestorowicz, A. et al. (1997) A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism. Diabetes 46, 1743-1748 (Pubitemid 27456405)
129. Huopio, H. et al. (2002) K(ATP) channels and insulin secretion disorders. American Journal of Physiology. Endocrinology and Metabolism 283, E207-216 (Pubitemid 34827434)
130. Hugill, A. et al. (2010) A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse. Diabetologia 53, 2352-2356
131. Zeggini, E. et al. (2007) Replication of genomewide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341 (Pubitemid 46871654)
132. Sladek, R. et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885
133. Grant, S.F. et al. (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics 38, 320-323
134. Shao, S. et al. (2009) Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells. Biochemical and Biophysical Research Communications 384, 401-404
135. Fajans, S.S., Bell, G.I. and Polonsky, K.S. (2001) Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New England Journal of Medicine 345, 971-980
136. Schmidt, C. et al. (2008) A meta-analysis of QTL for diabetes-related traits in rodents. Physiological Genomics 34, 42-53
137. Kim, J.H. et al. (2001) Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics 74, 273-286 (Pubitemid 32675351)
138. Kim, J.H. et al. (2005) Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity. Physiological Genomics 22, 171-181 (Pubitemid 41356350)
139. Frazer, K.A. et al. (2007) A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448, 1050-1053 (Pubitemid 47345584)
140. Valdar, W. et al. (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nature Genetics 38, 879-887 (Pubitemid 44141655)
141. Churchill, G.A. et al. (2004) The collaborative cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36, 1133-1137
142. Mott, R. et al. (2000) A method for fine mapping quantitative trait loci in outbred animal stocks. Proceedings of theNational Academyof Sciences of the United States of America 97, 12649-12654
143. Ghazalpour, A. et al. (2008) High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genetics 4, e1000149
144. Newgard, C.B. and Attie, A.D. (2010) Getting biological about the genetics of diabetes. Nature Medicine 16, 388-391
145. Ingelsson, E. et al. (2010) Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes 59, 1266-1275
146. Grubb, S.C. et al. (2009) Mouse phenome database. Nucleic Acids Research 37, D720-730
147. Colagiuri, S. (2010) Diabesity: therapeutic options. Diabetes Obesity and Metabolism 12, 463-473