Evidence of a Novel Quantitative-Trait Locus for Obesity on Chromosome 4p in Mexican Americans

American Journal of Human Genetics

Volumn 74, Issue 2, 2004, Pages 272-282

  Arya, Rector ^a,d   Duggirala, Ravindranath ^b   Jenkinson, Christopher P ^a   Almasy, Laura ^b   Blangero, John ^b   O'Connell, Peter ^c   Stern, Michael P ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ARTICLE; BODY FAT; BODY MASS; CHROMOSOME 4P; DIABETES MELLITUS; ETHNIC GROUP; FEMALE; GENE LOCATION; GENOME ANALYSIS; HUMAN; LINKAGE ANALYSIS; LOWEST INCOME GROUP; MAJOR CLINICAL STUDY; MALE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RACE DIFFERENCE; RECEPTOR GENE;

EID: 0842264056     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/381717     Document Type: Article

References (80)

1. Adeyemo A, Luke A, Cooper R, Wu X, Tayo B, Zhu X, Rotimi C, Bouzekri N, Ward R (2003) A genome-wide scan for body mass index among Nigerian families. Obes Res 11: 266-273
2. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
3. Amos CI (1994) Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54: 535-543
4. Arya R, Blangero J, Almasy L, O'Connell P, Stern MP, Duggirala R (2001a) A major locus for body mass index (BMI) on chromosome 4p in Mexican Americans. Obes Res Suppl 9:70S
5. Arya R, Duggirala R, Almasy L, Rainwater DL, Mahaney MC, Cole S, Dyer TD, Williams K, Leach RJ, Hixson JE, MacCluer JW, O'Connell P, Stern MP, Blangero J (2002) Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans. Nat Genet 30:102-105
6. Arya R, Duggirala R, Williams JT, Almasy L, Blangero J (2001b) Power to localize the major gene for disease liability is increased after accounting for the effects of related quantitative phenotypes. Genet Epidemiol Suppl 21:S774-S778
7. Atwood LD, Heard-Costa NL, Cupples LA, Jaquish CE, Wilson PW, D'Agostino RB (2002) Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet 71:1044-1050
8. Barsh GS, Farooqi IS, O'Rahilly S (2000) Genetics of body-weight regulation. Nature 404:644-651
9. Beglinger C, Degen L, Matzinger D, D'Amato M, Drewe J (2001) Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Am J Physiol Regul Integr Comp Physiol 280:R1149-R1154
10. Blangero J, Almasy L (1997) Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol 14:959-964
11. Blangero J, Williams JT, Almasy L (2001) Variance component methods for detecting complex trait loci. Adv Genet 42:151-181
12. Blangero J, Williams JT, Iturria SJ, Almasy L (1999) Oligogenic model selection using the Bayesian Information Criterion: linkage analysis of the P300 Cz event-related brain potential. Genet Epidemiol Suppl 17:S67-S72
13. Borecki IB, Higgins M, Schreiner PJ, Arnett DK, Mayer-Davis E, Hunt SC, Province MA (1998) Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. Obes Res 6: 107-114
14. Bouchard C (1997) Genetics of human obesity: recent results from linkage studies. J Nutr 127:1887S-1890S
15. Chagnon YC, Rankinen T, Snyder EE, Weisnagel SJ, Perusse L, Bouchard C (2003) The human obesity gene map: the 2002 update. Obes Res 11:313-367
16. Comuzzie AG, Allison DB (1998) The search for human obesity genes. Science 280:1374-1377
17. Comuzzie AG, Hixson JE, Almasy L, Mitchell BD, Mahaney MC, Dyer TD, Stern MP, MacCluer JW, Blangero J (1997) A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 15:273-276
18. Comuzzie AG, Williams JT, Martin LJ, Blangero J (2001) Searching for genes underlying normal variation in human adiposity. J Mol Med 79:57-70
19. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295
20. de Weerth A, Pisegna JR, Huppi K, Wank SA (1993) Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. Biochem Biophys Res Commun 194:811-818
21. Diehl AK, Stern MP (1989) Special health problems of Mexican-Americans: obesity, gallbladder disease, diabetes mellitus, and cardiovascular disease. Adv Intern Med 34:73-96
22. Donahue RP, Prineas RJ, Donahue RD, Zimmet P, Bean JA, De Court, Collier G, Goldberg RB, Skyler JS, Schneiderman N (1999) Is fasting leptin associated with insulin resistance among nondiabetic individuals? The Miami Community Health Study. Diabetes Care 22:1092-1096
23. Drewe J, Gadient A, Rovati LC, Beglinger C (1992) Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans. Gastroenterology 102: 1654-1659
24. Duggirala R, Dodd G, Fowler S, Schneider J, Arya R, Diehl AK, Almasy L, O'Connell P, Stern MP, Blangero J (2003) A major susceptibility locus for gallbladder disease is on chromosome 11p in Mexican Americans. Am J Hum Genet Suppl 73:195
25. Duggirala R, Blangero J, Almasy L, Arya R, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP (2001) A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet 68:1149-1164
26. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP (1999) Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64:1127-1140
27. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP (2000) A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet 66:1237-1245
28. Duggirala R, Stern MP, Mitchell BD, Reinhart LJ, Shipman PA, Uresandi OC, Chung WK, Leibel RL, Hales CN, O'Connell P, Blangero J (1996) Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Genet 59:694-703
29. Esterbauer H, Oberkofler H, Linnemayr V, Iglseder B, Hedegger M, Wolfsgruber P, Paulweber B, Fastner G, Krempler F, Patsch W (2002) Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. Diabetes 51:1281-1286
30. Funakoshi A, Miyasaka K, Matsumoto H, Yamamori S, Takiguchi S, Kataoka K, Takata Y, Matsusue K, Kono A, Shimokata H (2000) Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism. FEBS Lett 466:264-266
31. Geary N (1996) Failure of pulsatile infusion to increase glucagon's satiating potency. Physiol Behav 59:613-616
32. Green P, Falls K, Crooks S (1990) Documentation for CRIMAP. Department of Genetics, School of Medicine, Washington University, St. Louis
33. Gutzwiller JP, Drewe J, Ketterer S, Hildebrand P, Krautheim A, Beglinger C (2000) Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans. Am J Physiol Regul Integr Comp Physiol 279:R189-R195
34. Gutzwiller JP, Goke B, Drewe J, Hildebrand P, Ketterer S, Handschin D, Winterhalder R, Conen D, Beglinger C (1999) Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 44:81-86
35. Haffner SM, Hazuda HP, Mitchell BD, Patterson JK, Stern MP (1991) Increased incidence of type II diabetes mellitus in Mexican Americans. Diabetes Care 14:102-108
36. Haffner SM, Stern MP, Hazuda HP, Pugh J, Patterson JK, Malina R (1986) Upper body and centralized adiposity in Mexican Americans and non-Hispanic whites: relationship to body mass index and other behavioral and demographic variables. Int J Obes 10:493-502
37. Haffner SM, Stern MP, Miettinen H, Wei M, Gingerich RL (1996) Leptin concentrations in diabetic and nondiabetic Mexican Americans. Diabetes 45:822-824
38. Hager J, Dina C, Francke S, Dubois S, Houari M, Vatin V, Vaillant E, Lorentz N, Basdevant A, Clement K, Guy-Grand B, Froguel P (1998) A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat Genet 20:304-308
39. Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, Timberlake D, Foroud T, Kobes S, Baier L, Burns DK, Almasy L, Blangero J, Garvey WT, Bennett PH, Knowler WC (1998) An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet 63:1130-1138
40. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413:179-183
41. Hinney A, Remschmidt H, Hebebrand J (2000) Candidate gene polymorphisms in eating disorders. Eur J Pharmacol 410:147-159
42. Huppi K, Siwarski D, Pisegna JR, Wank S (1995) Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse. Genomics 25:727-729
43. Inoue H, Iannotti CA, Welling CM, Veile R, Donis-Keller H, Permutt MA (1997) Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM). Genomics 42:331-335
44. Joos SK, Mueller WH, Hanis CL, Schull WJ (1984) Diabetes alert study: weight history and upper body obesity in diabetic and non-diabetic Mexican American adults. Ann Hum Biol 11:167-171
45. Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473-481
46. Kaplan LM (2000) Genetics of obesity and body weight regulation. Curr Opin Endocrinol Diab 7:218-224
47. Kopelman PG (2000) Obesity as a medical problem. Nature 404:635-643
48. Larrouy D, Vidal H, Andreelli F, Laville M, Langin D (1999) Cloning and mRNA tissue distribution of human PPAR-gamma coactivator-1. Int J Obes Relat Metab Disord 23: 1327-1332
49. Lieverse RJ, Jansen JB, Masclee AM, Lamers CB (1994) Satiety effects of cholecystokinin in humans. Gastroenterology 106: 1451-1454
50. Lowell BB (1998) Adaptive thermogenesis: turning on the heat. Curr Biol 8:R517-R520
51. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, and Landt M (1996) Radioimmunoassay of leptin in human plasma. Clin Chem 42:942-946
52. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 11:1155-1161
53. Mahaney MC, Blangero J, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW (1995) Plasma HDL cholesterol, triglycerides, and adiposity: a quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study. Circulation 92:3240-3248
54. Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM (2001) Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci USA 98:3820-3825
55. Mitchell BD, Stern MP, Haffner SM, Hazuda HP, Patterson JK (1990) Risk factors for cardiovascular mortality in Mexican Americans and non-Hispanic whites. San Antonio Heart Study. Am J Epidemiol 131:423-433
56. Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, and Spiegelman BM (2000) Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell 6:307-316
57. Moran TH, Katz LF, Plata-Salaman CR, Schwartz GJ (1998) Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am J Physiol 274:R618-R625
58. Nadler ST, Attie AD (2001) Please pass the chips: genomic insights into obesity and diabetes. J Nutr 131:2078-2081
59. Nadler ST, Stoehr JP, Schueler KL, Tanimoto G, Yandell BS, Attie AD (2000) The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci USA 97:11371-11376
60. Norman RA, Tataranni PA, Pratley R, Thompson DB, Hanson RL, Prochazka M, Baier L, Ehm MG, Sakul H, Foroud T, Garvey WT, Burns D, Knowler WC, Bennett PH, Bogardus C, Ravussin E (1998) Autosomal genomic'scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet 62:659-668
61. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100:8466-8471
62. Perusse L, Rice T, Chagnon YC, Despres JP, Lemieux S, Roy S, Lacaille M, Ho-Kim MA, Chagnon M, Province MA, Rao DC, Bouchard C (2001) A genome-wide scan for abdominal fat assessed by computed tomography in the Quebec Family Study. Diabetes 50:614-621
63. Platte P, Papanicolaou GJ, Johnston J, Klein CM, Doheny KF, Pugh EW, Roy-Gagnon MH, Stunkard AJ, Francomano CA, Wilson AF (2003) A study of linkage and association of body mass index in the Old Order Amish. Am J Med Genet 121:71-80
64. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
65. Rice T, Despres JP, Perusse L, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C (1997) Segregation analysis of abdominal visceral fat: the HERITAGE Family Study. Obes Res 5:417-424
66. Self SG, Liang K-Y (1987) Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under non-standard conditions. J Am Stat Assoc 82:605-610
67. Sobel E, Sengul H, Weeks DE (2001) Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. Hum Hered 52: 121-131
68. Spiegelman BM, Puigserver P, Wu Z (2000) Regulation of adipogenesis and energy balance by PPAR-γ and PGC-1. Int J Obes Relat Metab Disord Suppl 24:S8-S10
69. Stern MP, Haffner SM (1990) Type II diabetes and its complications in Mexican Americans. Diabetes Metab Rev 6: 29-45
70. Stern MP, Morales PA, Valdez RA, Monterrosa A, Haffner SM, Mitchell BD, Hazuda HP (1993) Predicting diabetes: moving beyond impaired glucose tolerance. Diabetes 42: 706-714
71. Stern MP, Patterson JK, Haffner SM, Hazuda HP, Mitchell BD (1989) Lack of awareness and treatment of hyperlipidemia in type II diabetes in a community survey. JAMA 262:360-364
72. Stern MP, Patterson JK, Mitchell BD, Haffner SM, Hazuda HP (1990) Overweight and mortality in Mexican Americans. Int J Obes 14:623-629
73. Stone S, Abkevich V, Hunt SC, Gutin A, Russell DL, Neff CD, Riley R, Frech GC, Hensel CH, Jammulapati S, Potter J, Sexton D, Tran T, Gibbs D, Iliev D, Gress R, Bloomquist B, Amatruda J, Rae PM, Adams TD, Skolnick MH, Shattuck D (2002) A major predisposition locus for severe obesity, at 4p15-p14. Am J Hum Genet 70:1459-1468
74. Tritos NA, Mantzoros CS (1997) Leptin: its role in obesity and beyond. Diabetologia 40:1371-1379
75. Vega RB, Huss JM, Kelly DP (2000) The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20:1868-1876
76. World Health Organization, Department of Noncommunicable Disease Surveillance (1999) Definition, diagnosis, and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1: Diagnosis and classification of diabetes mellitus. World Health Organization, Geneva
77. Wu X, Cooper RS, Borecki I, Hanis C, Bray M, Lewis CE, Zhu X, Kan D, Luke A, Curb D (2002) A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hum Genet 70:1247-1256
78. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999a) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124
79. Wu Z, Puigserver P, Spiegelman BM (1999b) Transcriptional activation of adipogenesis. Curr Opin Cell Biol 11:689-694
80. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138