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Volumn 51, Issue 9, 2013, Pages 605-618

Engineering subtle targeted mutations into the mouse genome

Author keywords

CRISPR Cas; Point mutation; TALEN; ZFN

Indexed keywords

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT PROTEIN; CRE RECOMBINASE; NUCLEASE; NUCLEIC ACID; RECOMBINASE; RNA; TRANSCIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; TRANSPOSASE; UNCLASSIFIED DRUG;

EID: 84884717093     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.22422     Document Type: Article
Times cited : (48)

References (94)
  • 1
    • 70349512750 scopus 로고    scopus 로고
    • Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    • Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A. 2009. Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev 126:882-897.
    • (2009) Mech Dev , vol.126 , pp. 882-897
    • Acampora, D.1    Di Giovannantonio, L.G.2    Di Salvio, M.3    Mancuso, P.4    Simeone, A.5
  • 3
    • 69049101229 scopus 로고    scopus 로고
    • AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice
    • Andley UP. 2009. AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice. BMC Ophthalmol 9:4.
    • (2009) BMC Ophthalmol , vol.9 , pp. 4
    • Andley, U.P.1
  • 4
    • 0032705186 scopus 로고    scopus 로고
    • Targeted mutagenesis of the endogenous mouse Mis gene promoter: In vivo definition of genetic pathways of vertebrate sexual development
    • Arango NA, Lovell-Badge R, Behringer RR. 1999. Targeted mutagenesis of the endogenous mouse Mis gene promoter: In vivo definition of genetic pathways of vertebrate sexual development. Cell 99:409-419.
    • (1999) Cell , vol.99 , pp. 409-419
    • Arango, N.A.1    Lovell-Badge, R.2    Behringer, R.R.3
  • 5
    • 0027316203 scopus 로고
    • Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy
    • Askew GR, Doetschman T, Lingrel JB. 1993. Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy. Mol Cell Biol 13:4115-4124.
    • (1993) Mol Cell Biol , vol.13 , pp. 4115-4124
    • Askew, G.R.1    Doetschman, T.2    Lingrel, J.B.3
  • 7
    • 0346503889 scopus 로고    scopus 로고
    • Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice
    • Branda CS, Dymecki SM. 2004. Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6:7-28.
    • (2004) Dev Cell , vol.6 , pp. 7-28
    • Branda, C.S.1    Dymecki, S.M.2
  • 10
    • 0024449118 scopus 로고
    • Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses
    • Cary LC, Goebel M, Corsaro BG, Wang HG, Rosen E, Fraser MJ. 1989. Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses. Virology 172:156-169.
    • (1989) Virology , vol.172 , pp. 156-169
    • Cary, L.C.1    Goebel, M.2    Corsaro, B.G.3    Wang, H.G.4    Rosen, E.5    Fraser, M.J.6
  • 11
    • 0035543861 scopus 로고    scopus 로고
    • Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy
    • Cearley JA, Detloff PJ. 2001. Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy. Transgenic Res 10:479-488.
    • (2001) Transgenic Res , vol.10 , pp. 479-488
    • Cearley, J.A.1    Detloff, P.J.2
  • 13
    • 23144431724 scopus 로고    scopus 로고
    • P-Match: transcription factor binding site search by combining patterns and weight matrices
    • Chekmenev DS, Haid C, Kel AE. 2005. P-Match: transcription factor binding site search by combining patterns and weight matrices. Nucleic Acids Res 33:W432-W437.
    • (2005) Nucleic Acids Res , vol.33
    • Chekmenev, D.S.1    Haid, C.2    Kel, A.E.3
  • 14
    • 77953183812 scopus 로고    scopus 로고
    • A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    • Cheloufi S, Santos Dos CO, Chong MMW, Hannon GJ. 2010. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465:584-589.
    • (2010) Nature , vol.465 , pp. 584-589
    • Cheloufi, S.1    Santos Dos, C.O.2    Chong, M.M.W.3    Hannon, G.J.4
  • 15
    • 84875298381 scopus 로고    scopus 로고
    • A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly
    • Chen S, Oikonomou G, Chiu CN, Niles BJ, Liu J, Lee DA, Antoshechkin I, Prober DA. 2013. A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly. Nucleic Acids Res 41:2769-2778.
    • (2013) Nucleic Acids Res , vol.41 , pp. 2769-2778
    • Chen, S.1    Oikonomou, G.2    Chiu, C.N.3    Niles, B.J.4    Liu, J.5    Lee, D.A.6    Antoshechkin, I.7    Prober, D.A.8
  • 17
    • 84874624936 scopus 로고    scopus 로고
    • Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    • Cho SW, Kim S, Kim JM, Kim J-S. 2013. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol 31:230-232.
    • (2013) Nat Biotechnol , vol.31 , pp. 230-232
    • Cho, S.W.1    Kim, S.2    Kim, J.M.3    Kim, J.-S.4
  • 21
    • 84875531751 scopus 로고    scopus 로고
    • Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes
    • Davies B, Davies G, Preece C, Puliyadi R, Szumska D, Bhattacharya S. 2013. Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes. PLoS ONE 8:e60216.
    • (2013) PLoS ONE , vol.8
    • Davies, B.1    Davies, G.2    Preece, C.3    Puliyadi, R.4    Szumska, D.5    Bhattacharya, S.6
  • 22
    • 0025320906 scopus 로고
    • A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    • DeChiara TM, Efstratiadis A, Robertson EJ. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78-80.
    • (1990) Nature , vol.345 , pp. 78-80
    • DeChiara, T.M.1    Efstratiadis, A.2    Robertson, E.J.3
  • 26
    • 23744479962 scopus 로고    scopus 로고
    • Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
    • Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. 2005. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122:473-483.
    • (2005) Cell , vol.122 , pp. 473-483
    • Ding, S.1    Wu, X.2    Li, G.3    Han, M.4    Zhuang, Y.5    Xu, T.6
  • 27
    • 0024205183 scopus 로고
    • Targeted mutation of the Hprt gene in mouse embryonic stem cells
    • Doetschman T, Maeda N, Smithies O. 1988. Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci USA 85:8583-8587.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8583-8587
    • Doetschman, T.1    Maeda, N.2    Smithies, O.3
  • 29
    • 84859727275 scopus 로고    scopus 로고
    • The Mouse Genome Database (MGD): Comprehensive resource for genetics and genomics of the laboratory mouse
    • Mouse Genome Database Group.
    • Eppig JT, Blake JA, Bult CJ, Kadin JA, Richardson JE, Mouse Genome Database Group. 2012. The Mouse Genome Database (MGD): Comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res 40:D881-D886.
    • (2012) Nucleic Acids Res , vol.40
    • Eppig, J.T.1    Blake, J.A.2    Bult, C.J.3    Kadin, J.A.4    Richardson, J.E.5
  • 33
    • 7644239147 scopus 로고    scopus 로고
    • The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome
    • Gao F, Maiti S, Sun G, Ordonez NG, Udtha M, Deng JM, Behringer RR, Huff V. 2004. The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome. Mol Cell Biol 24:9899-9910.
    • (2004) Mol Cell Biol , vol.24 , pp. 9899-9910
    • Gao, F.1    Maiti, S.2    Sun, G.3    Ordonez, N.G.4    Udtha, M.5    Deng, J.M.6    Behringer, R.R.7    Huff, V.8
  • 34
    • 0031830673 scopus 로고    scopus 로고
    • Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: A comparison of homologous recombination methods
    • Gschwind M, Huber G. 1998. Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: A comparison of homologous recombination methods. Mol Cell Biol 18:4651-4658.
    • (1998) Mol Cell Biol , vol.18 , pp. 4651-4658
    • Gschwind, M.1    Huber, G.2
  • 35
    • 77956566519 scopus 로고    scopus 로고
    • A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency
    • Guo G, Smith A. 2010. A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development 137:3185-3192.
    • (2010) Development , vol.137 , pp. 3185-3192
    • Guo, G.1    Smith, A.2
  • 37
    • 0026429190 scopus 로고
    • Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
    • Hasty P, Ramírez-Solis R, Krumlauf R, Bradley A. 1991. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350:243-246.
    • (1991) Nature , vol.350 , pp. 243-246
    • Hasty, P.1    Ramírez-Solis, R.2    Krumlauf, R.3    Bradley, A.4
  • 39
    • 43449132366 scopus 로고    scopus 로고
    • Multisite phosphorylation regulates Bim stability and apoptotic activity
    • Hübner A, Barrett T, Flavell RA, Davis RJ. 2008. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell 30:415-425.
    • (2008) Mol Cell , vol.30 , pp. 415-425
    • Hübner, A.1    Barrett, T.2    Flavell, R.A.3    Davis, R.J.4
  • 41
  • 43
    • 64749111225 scopus 로고    scopus 로고
    • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    • Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. 2009. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771-775.
    • (2009) Nature , vol.458 , pp. 771-775
    • Kaji, K.1    Norrby, K.2    Paca, A.3    Mileikovsky, M.4    Mohseni, P.5    Woltjen, K.6
  • 45
    • 0030032063 scopus 로고    scopus 로고
    • Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain
    • Kim YG, Cha J, Chandrasegaran S. 1996. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci USA 93:1156-1160.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1156-1160
    • Kim, Y.G.1    Cha, J.2    Chandrasegaran, S.3
  • 46
    • 0024409025 scopus 로고
    • Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination
    • Koller BH, Smithies O. 1989. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci USA 86:8932-8935.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 8932-8935
    • Koller, B.H.1    Smithies, O.2
  • 47
    • 74949133880 scopus 로고    scopus 로고
    • Targeted chromosomal deletions in human cells using zinc finger nucleases
    • Lee HJ, Kim E, Kim J-S. 2010. Targeted chromosomal deletions in human cells using zinc finger nucleases. Genome Res 20:81-89.
    • (2010) Genome Res , vol.20 , pp. 81-89
    • Lee, H.J.1    Kim, E.2    Kim, J.-S.3
  • 49
    • 13544262560 scopus 로고    scopus 로고
    • piggyBac internal sequences are necessary for efficient transformation of target genomes
    • Li X, Harrell RA, Handler AM, Beam T, Hennessy K, Fraser MJ. 2005. piggyBac internal sequences are necessary for efficient transformation of target genomes. Insect Mol Biol 14:17-30.
    • (2005) Insect Mol Biol , vol.14 , pp. 17-30
    • Li, X.1    Harrell, R.A.2    Handler, A.M.3    Beam, T.4    Hennessy, K.5    Fraser, M.J.6
  • 50
    • 70349176337 scopus 로고    scopus 로고
    • Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons
    • Liang Q, Kong J, Stalker J, Bradley A. 2009. Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons. Genesis 47:404-408.
    • (2009) Genesis , vol.47 , pp. 404-408
    • Liang, Q.1    Kong, J.2    Stalker, J.3    Bradley, A.4
  • 51
    • 79952302385 scopus 로고    scopus 로고
    • De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks
    • Mahfouz MM, Li L, Shamimuzzaman M, Wibowo A, Fang X, Zhu J-K. 2011. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci USA 108:2623-2628.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2623-2628
    • Mahfouz, M.M.1    Li, L.2    Shamimuzzaman, M.3    Wibowo, A.4    Fang, X.5    Zhu, J.-K.6
  • 53
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour SL, Thomas KR, Capecchi MR. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes. Nature 336:348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 54
    • 77749273530 scopus 로고    scopus 로고
    • Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases
    • Mashimo T, Takizawa A, Voigt B, Yoshimi K, Hiai H, Kuramoto T, Serikawa T. 2010. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS ONE 5:e8870.
    • (2010) PLoS ONE , vol.5
    • Mashimo, T.1    Takizawa, A.2    Voigt, B.3    Yoshimi, K.4    Hiai, H.5    Kuramoto, T.6    Serikawa, T.7
  • 57
    • 77957005768 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
    • Meyer M, de Angelis MH, Wurst W, Kühn R. 2010. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci USA 107:15022-15026.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15022-15026
    • Meyer, M.1    de Angelis, M.H.2    Wurst, W.3    Kühn, R.4
  • 59
    • 64049118040 scopus 로고    scopus 로고
    • Short motif sequences determine the targets of the prokaryotic CRISPR defence system
    • Mojica FJM, Diez-Villasenor C, Garcia-Martinez J, Almendros C. 2009. Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology 155:733-740.
    • (2009) Microbiology , vol.155 , pp. 733-740
    • Mojica, F.J.M.1    Diez-Villasenor, C.2    Garcia-Martinez, J.3    Almendros, C.4
  • 61
    • 0029993449 scopus 로고    scopus 로고
    • Know your neighbors: Three phenotypes in null Mutants of the myogenic bHLH gene MRF4
    • Olson EN, Arnold HH, Rigby PW, Wold BJ. 1996. Know your neighbors: Three phenotypes in null Mutants of the myogenic bHLH gene MRF4. Cell 85:1-4.
    • (1996) Cell , vol.85 , pp. 1-4
    • Olson, E.N.1    Arnold, H.H.2    Rigby, P.W.3    Wold, B.J.4
  • 64
    • 84860380381 scopus 로고    scopus 로고
    • Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases
    • Perez-Pinera P, Ousterout DG, Brown MT, Gersbach CA. 2012. Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases. Nucleic Acids Res 40:3741-3752.
    • (2012) Nucleic Acids Res , vol.40 , pp. 3741-3752
    • Perez-Pinera, P.1    Ousterout, D.G.2    Brown, M.T.3    Gersbach, C.A.4
  • 68
    • 0024473608 scopus 로고
    • Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells
    • Schwartzberg PL, Goff SP, Robertson EJ. 1989. Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science 246:799-803.
    • (1989) Science , vol.246 , pp. 799-803
    • Schwartzberg, P.L.1    Goff, S.P.2    Robertson, E.J.3
  • 70
    • 0028158627 scopus 로고
    • Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice
    • Stacey A, Schnieke A, McWhir J, Cooper J, Colman A, Melton DW. 1994. Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol Cell Biol 14:1009-1016.
    • (1994) Mol Cell Biol , vol.14 , pp. 1009-1016
    • Stacey, A.1    Schnieke, A.2    McWhir, J.3    Cooper, J.4    Colman, A.5    Melton, D.W.6
  • 73
    • 79959319829 scopus 로고    scopus 로고
    • CRISPR-based adaptive immune systems
    • Terns MP, Terns RM. 2011. CRISPR-based adaptive immune systems. Curr Opin Microbiol 14:321-327.
    • (2011) Curr Opin Microbiol , vol.14 , pp. 321-327
    • Terns, M.P.1    Terns, R.M.2
  • 74
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas KR, Capecchi MR. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 76
    • 0026100231 scopus 로고
    • Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells
    • Valancius V, Smithies O. 1991. Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol Cell Biol 11:1402-1408.
    • (1991) Mol Cell Biol , vol.11 , pp. 1402-1408
    • Valancius, V.1    Smithies, O.2
  • 77
    • 0032079829 scopus 로고    scopus 로고
    • Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system
    • Vazquez JC, Nogues C, Rucker EB, Piedrahita JA. 1998. Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system. Transgenic Res 7:181-193.
    • (1998) Transgenic Res , vol.7 , pp. 181-193
    • Vazquez, J.C.1    Nogues, C.2    Rucker, E.B.3    Piedrahita, J.A.4
  • 78
    • 0037180505 scopus 로고    scopus 로고
    • An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells
    • Vivian JL, Chen Y, Yee D, Schneider E, Magnuson T. 2002. An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells. Proc Natl Acad Sci USA 99: 15542-15547.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15542-15547
    • Vivian, J.L.1    Chen, Y.2    Yee, D.3    Schneider, E.4    Magnuson, T.5
  • 79
    • 71649101421 scopus 로고    scopus 로고
    • Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analagous to the human IDUA_W402X mutation
    • Wang D, Shukla C, Liu X, Schoeb TR, Clarke LA, Bedwell DM, Keeling KM. 2010. Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analagous to the human IDUA_W402X mutation. Mol Genet Metab 99:62-71.
    • (2010) Mol Genet Metab , vol.99 , pp. 62-71
    • Wang, D.1    Shukla, C.2    Liu, X.3    Schoeb, T.R.4    Clarke, L.A.5    Bedwell, D.M.6    Keeling, K.M.7
  • 81
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R. 2013b. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153:910-918.
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6    Jaenisch, R.7
  • 86
    • 0030806247 scopus 로고    scopus 로고
    • Introduction of precise alterations into the mouse genome with high efficiency by stable tag-exchange gene targeting: Implications for gene targeting in ES cells
    • Whyatt LM, Rathjen PD. 1997. Introduction of precise alterations into the mouse genome with high efficiency by stable tag-exchange gene targeting: Implications for gene targeting in ES cells. Nucleic Acids Res 25:2381-2388.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2381-2388
    • Whyatt, L.M.1    Rathjen, P.D.2
  • 88
    • 0028333746 scopus 로고
    • Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells
    • Wu H, Liu X, Jaenisch R. 1994. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci USA 91:2819-2823.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2819-2823
    • Wu, H.1    Liu, X.2    Jaenisch, R.3
  • 90
    • 80555139701 scopus 로고    scopus 로고
    • Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells
    • Xu D, Liu X, Yu W-M, Meyerson HJ, Guo C, Gerson SL, Qu C-K. 2011. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med 208:1977-1988.
    • (2011) J Exp Med , vol.208 , pp. 1977-1988
    • Xu, D.1    Liu, X.2    Yu, W.-M.3    Meyerson, H.J.4    Guo, C.5    Gerson, S.L.6    Qu, C.-K.7
  • 91
    • 0031571681 scopus 로고    scopus 로고
    • Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus
    • Yoon JK, Olson EN, Arnold HH, Wold BJ. 1997. Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus. Dev Biol 188:349-362.
    • (1997) Dev Biol , vol.188 , pp. 349-362
    • Yoon, J.K.1    Olson, E.N.2    Arnold, H.H.3    Wold, B.J.4
  • 92
    • 65449154892 scopus 로고    scopus 로고
    • Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
    • Yusa K, Rad R, Takeda J, Bradley A. 2009. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Meth 6:363-369.
    • (2009) Nat Meth , vol.6 , pp. 363-369
    • Yusa, K.1    Rad, R.2    Takeda, J.3    Bradley, A.4
  • 94
    • 0024420342 scopus 로고
    • Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    • Zijlstra M, Li E, Sajjadi F, Subramani S, Jaenisch R. 1989. Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438.
    • (1989) Nature , vol.342 , pp. 435-438
    • Zijlstra, M.1    Li, E.2    Sajjadi, F.3    Subramani, S.4    Jaenisch, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.