Genetic models in applied physiology: Invited review: Identifying new mouse models of cardiovascular disease: A review of high-throughput screens of mutagenized and inbred strains

Journal of Applied Physiology

Volumn 94, Issue 4, 2003, Pages 1650-1659

  Svenson, Karen L ^a   Bogue, Molly A ^a   Peters, Luanne L ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

Mouse Phenome Project; Mutagenesis

Indexed keywords

ATHEROSCLEROSIS; BLOOD; BLOOD DISEASE; CARDIOVASCULAR DISEASE; GENETIC ENGINEERING; HEART; HYPERTENSION; LUNG; LUNG DISEASE; MUTAGENESIS; NONHUMAN; OBESITY; PHENOTYPE; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SLEEP DISORDER; THROMBOSIS; ANIMAL; DISEASE MODEL; GENETIC SCREENING; GENETICS; HUMAN; MOUSE; MOUSE STRAIN;

ANIMALS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; GENETIC SCREENING; HUMANS; MICE; MICE, INBRED STRAINS; MUTAGENESIS; PHENOTYPE;

EID: 0142087920     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01029.2003     Document Type: Review

References (44)

1. Adami S, Zamberlan N, Gatti D, Zanfisi C, Braga V, Broggini M, and Rossini M. Computed radiographic absorptiometry and morphometry in the assessment of postmenopausal bone loss. Osteoporos Int 6: 8-13, 1996.
2. Arnesen H. Introduction: the metabolic cardiovascular syndrome. J Cardiovasc Pharmacol 20: S1-S4, 1992.
3. Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C, and Chomka EV. Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 62: 209-213, 1998.
4. Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, and Fisher EM. Genealogies of mouse inbred strains. Nat Genet 24: 23-25, 2000.
5. Belknap JK, Hitzemann A, Crabbe JC, Phillips TJ, Buck KJ, and Williams RW. QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits. Behav Genet 31: 5-15, 2001.
6. Berg K. Risk factor variability and coronary heart disease. Acta Genet Med Gemellol (Roma) 39: 15-24, 1990.
7. Bodary PF, Westrick RJ, Wickenheiser KJ, Shen Y, and Eitzman DT. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 287: 1706-1709, 2002.
8. Brown SD and Balling R. Systematic approaches to mouse mutagenesis. Curr Opin Genet Dev 11: 268-273, 2001.
9. Chen Y, Yee D, Dains K, Chatterjee A, Cavalcoli J, Schneider E, Om J, Woychik RP, and Magnuson T. Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nat Genet 24: 314-317, 2000.
10. Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, and Kane JP. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 9: 936-949, 1999.
11. Chu V, Otero JM, Lopez O, Morgan JP, Amende I, and Hampton TG. Method for non-invasively recording electrocardiograms in conscious mice. BMC Physiol 1: 6, 2001.
12. Clark ATGD, Takahashi JS, Vitaterna MH, Siepkas SM, Peters LL, Frankel WN, Carlson GA, Nadeau J, and Justice MJ. A summary of ENU mutagenesis activities in North America. Genetica In press.
13. Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, and Friedman JM. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108: 1113-1121, 2001.
14. Davis AP and Justice MJ. An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis. Genetics 148: 7-12, 1998.
15. Drake TA, Schadt E, Hannani K, Kabo JM, Krass K, Colinayo V, Greaser LE, Goldin J III, and Lusis AJ. Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics 5: 205-215, 2001.
16. Festing M. Origins and characteristics of inbred strains of mice. In: Genetic Variants and Strains of the Laboratory Mouse (3rd ed.), edited by Lyon MF, Roston S, and Brown SDM. New York: Oxford Univ. Press, 1996, vol. 2, p. 1537-1576.
17. Ford ES, Giles WH, and Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Jama 287: 356-359, 2002.
18. Franken P, Malafosse A, and Tafti M. Genetic determinants of sleep regulation in inbred mice. Sleep 22: 155-169, 1999.
19. Glass CK and Witztum JI. Atherosclerosis: the road ahead. Cell 104: 503-516, 2001.
20. Grundy SM. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 83: 25F-29F, 1999.
21. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, and Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes 41: 715-722, 1992.
22. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, and Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
23. Hampton TGPB and Seburn KL. Cardiac characterization. MPD:17. Mouse Phenome Database [Online]. The Jackson Laboratory, Bar Harbor, ME. http://www.jax.org/phenome.
24. Hrabe de Angelis M and Strivens M. Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans. Brief Bioinform 2: 170-180, 2001.
25. Huber R, Deboer T, and Tobler I. Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations. Brain Res 857: 8-19, 2000.
26. Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, and Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92: 883-893, 1993.
27. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, and Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24: 683-689, 2001.
28. Krege JH, Hodgin JB, Hagaman JR, and Smithies O. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25: 1111-1115, 1995.
29. Lanfranchi P and Somers VK. Obstructive sleep apnea and vascular disease. Respir Res 2: 315-319, 2001.
30. Lusis AJ. Genetic factors affecting blood lipoproteins: the candidate gene approach. J Lipid Res 29: 397-429, 1988.
31. Matsuzawa Y, Funahashi T, and Nakamura T. Molecular mechanism of vascular disease in metabolic syndrome X. J Diabetes Complications 16: 17-18, 2002.
32. a.Moore KJ and Nagle DL. Complex trait analysis in the mouse: the strengths, the limitations, and the promise yet to come. Annu Rev Genet 34: 653-686, 2000.
33. Nishina PMWJ, Toyofuku W, Kuypers FA, Ishida BY, and Paigen B. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28: 599-605, 1993.
34. Noveroske JK, Weber JS, and Justice MJ. The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm Genome 11: 478-483, 2000.
35. Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, WynshawBoris A, Yanagisawa M, et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420: 563-573, 2002.
36. Paigen BGH and Naggert JK. Atherosclerosis, plasma lipids, blood pressure, and heart rate. MPD:99, Mouse Phenome Database [Online]. The Jackson Laboratory, Bar Harbor ME. http://www.jax.org/phenome.
37. Paigen K and Eppig JT, A mouse phenome project. Mamm Genome 11: 715-717, 2000.
38. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, and Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA 89: 4471-4475, 1992.
39. Rajaraman S, Davis WS, Mahakali-Zama A, Evans HK, Russell LB, and Bedell MA. An allelic series of mutations in the kit ligand gene of mice. II. Effects of ethylnitrosoureainduced kitl point mutations on survival and peripheral blood cells of kitl (steel) mice. Genetics 162: 341-353, 2002.
40. Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH, and Bogardus C. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 3: 238-240, 1997.
41. Soukas A, Cohen P, Socci ND, and Friedman JM. Leptinspecific patterns of gene expression in white adipose tissue. Genes Dev 14: 963-980, 2000.
42. Stanford WL, Cohn JB, and Cordes SP. Gene-trap mutagenesis: past, present and beyond. Nat Rev Genet 2: 756-768, 2001.
43. Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, and Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res 10: 473-482, 2000.
44. Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, and Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71: 70-77, 2001.