-
1
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore, C., Lee, V. M., and Trojanowski, J. Q. (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci 8, 663-672.
-
(2007)
Nat. Rev. Neurosci
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
2
-
-
0037197836
-
Tau is essential to β-amyloid-induced neurotoxicity
-
Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P., and Ferreira, A. (2002) Tau is essential to β-amyloid-induced neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 99, 6364-6369.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
3
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., and Mucke, L. (2007) Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.-Q.8
Mucke, L.9
-
4
-
-
77957737750
-
Tau reduction prevents Aβ-induced defects in axonal transport
-
Vossel, K. A., Zhang, K., Brodbeck, J., Daub, A. C., Sharma, P., Finkbeiner, S., Cui, B., and Mucke, L. (2010) Tau reduction prevents Aβ-induced defects in axonal transport. Science 330, 198.
-
(2010)
Science
, vol.330
, pp. 198
-
-
Vossel, K.A.1
Zhang, K.2
Brodbeck, J.3
Daub, A.C.4
Sharma, P.5
Finkbeiner, S.6
Cui, B.7
Mucke, L.8
-
5
-
-
78651506630
-
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
-
Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., Palop, J. J., Noebels, J. L., and Mucke, L. (2011) Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J. Neurosci. 31, 700-711.
-
(2011)
J. Neurosci.
, vol.31
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
Yao, J.4
Chin, J.5
Yan, F.6
Wu, T.7
Hamto, P.8
Devidze, N.9
Yu, G.-Q.10
Palop, J.J.11
Noebels, J.L.12
Mucke, L.13
-
6
-
-
79551510136
-
Tau protein is required for amyloid β-induced impairment of hippocampal long-term potentiation
-
Shipton, O. A., Leitz, J. R., Dworzak, J., Acton, C. E. J., Tunbridge, E. M., Denk, F., Dawson, H. N., Vitek, M. P., Wade-Martins, R., Paulsen, O., and Vargas-Caballero, M. (2011) Tau protein is required for amyloid β-induced impairment of hippocampal long-term potentiation. J. Neurosci. 31, 1688-1692.
-
(2011)
J. Neurosci.
, vol.31
, pp. 1688-1692
-
-
Shipton, O.A.1
Leitz, J.R.2
Dworzak, J.3
Acton, C.E.J.4
Tunbridge, E.M.5
Denk, F.6
Dawson, H.N.7
Vitek, M.P.8
Wade-Martins, R.9
Paulsen, O.10
Vargas-Caballero, M.11
-
7
-
-
84894197205
-
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes
-
Abbondante, S., Baglietto-Vargas, D., Rodriguez-Ortiz, C. J., Estrada-Hernandez, T., Medeiros, R., and LaFerla, F. M. (2014) Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am. J. Pathol. 184, 819-826.
-
(2014)
Am. J. Pathol.
, vol.184
, pp. 819-826
-
-
Abbondante, S.1
Baglietto-Vargas, D.2
Rodriguez-Ortiz, C.J.3
Estrada-Hernandez, T.4
Medeiros, R.5
LaFerla, F.M.6
-
8
-
-
84872729419
-
Tau loss attenuates neuronal network hyperexcitability in mouse and drosophila genetic models of epilepsy
-
Holth, J. K., Bomben, V. C., Reed, J. G., Inoue, T., Younkin, L., Younkin, S. G., Pautler, R. G., Botas, J., and Noebels, J. L. (2013) Tau loss attenuates neuronal network hyperexcitability in mouse and drosophila genetic models of epilepsy. J. Neurosci. 33, 1651-1659.
-
(2013)
J. Neurosci.
, vol.33
, pp. 1651-1659
-
-
Holth, J.K.1
Bomben, V.C.2
Reed, J.G.3
Inoue, T.4
Younkin, L.5
Younkin, S.G.6
Pautler, R.G.7
Botas, J.8
Noebels, J.L.9
-
9
-
-
84880838441
-
Antisense reduction of tau in adult mice protects against seizures
-
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., Schuler, D. R., Maloney, S. E., Wozniak, D. F., Rigo, F., Bennett, C. F., Cirrito, J. R., Holtzman, D. M., and Miller, T. M. (2013) Antisense reduction of tau in adult mice protects against seizures. J. Neurosci. 33, 12887-12897.
-
(2013)
J. Neurosci.
, vol.33
, pp. 12887-12897
-
-
DeVos, S.L.1
Goncharoff, D.K.2
Chen, G.3
Kebodeaux, C.S.4
Yamada, K.5
Stewart, F.R.6
Schuler, D.R.7
Maloney, S.E.8
Wozniak, D.F.9
Rigo, F.10
Bennett, C.F.11
Cirrito, J.R.12
Holtzman, D.M.13
Miller, T.M.14
-
10
-
-
84897954587
-
Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles
-
Iqbal, K., Liu, F., and Gong, C.-X. (2014) Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles. Biochem. Pharmacol. 88, 631-639.
-
(2014)
Biochem. Pharmacol.
, vol.88
, pp. 631-639
-
-
Iqbal, K.1
Liu, F.2
Gong, C.-X.3
-
11
-
-
84875275094
-
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice
-
Morris, M., Hamto, P., Adame, A., Devidze, N., Masliah, E., and Mucke, L. (2013) Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice. Neurobiol. Aging 34, 1523-1529.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1523-1529
-
-
Morris, M.1
Hamto, P.2
Adame, A.3
Devidze, N.4
Masliah, E.5
Mucke, L.6
-
12
-
-
0028301455
-
Altered microtubule organization in small-calibre axons of mice lacking tau protein
-
Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, S., Ohshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T., and Hirokawa, N. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369, 488-491.
-
(1994)
Nature
, vol.369
, pp. 488-491
-
-
Harada, A.1
Oguchi, K.2
Okabe, S.3
Kuno, J.4
Terada, S.5
Ohshima, T.6
Sato-Yoshitake, R.7
Takei, Y.8
Noda, T.9
Hirokawa, N.10
-
13
-
-
0035067021
-
Inhibition of neuronal maturation in primary hippocampal neurons from τ deficient mice
-
Dawson, H. N., Ferreira, A., Eyster, M. V., Ghoshal, N., Binder, L. I., and Vitek, M. P. (2001) Inhibition of neuronal maturation in primary hippocampal neurons from τ deficient mice. J. Cell Sci. 114, 1179-1187.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 1179-1187
-
-
Dawson, H.N.1
Ferreira, A.2
Eyster, M.V.3
Ghoshal, N.4
Binder, L.I.5
Vitek, M.P.6
-
14
-
-
77953808475
-
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
-
Dawson, H. N., Cantillana, V., Jansen, M., Wang, H., Vitek, M. P., Wilcock, D. M., Lynch, J. R., and Laskowitz, D. T. (2010) Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience 169, 516-531.
-
(2010)
Neuroscience
, vol.169
, pp. 516-531
-
-
Dawson, H.N.1
Cantillana, V.2
Jansen, M.3
Wang, H.4
Vitek, M.P.5
Wilcock, D.M.6
Lynch, J.R.7
Laskowitz, D.T.8
-
15
-
-
84937558461
-
Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila
-
Bolkan, B. J., and Kretzschmar, D. (2014) Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila . Dev. Neurobiol., DOI: 10.1002/dneu.22199.
-
(2014)
Dev. Neurobiol.
-
-
Bolkan, B.J.1
Kretzschmar, D.2
-
16
-
-
84856708923
-
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
-
Lei, P., Ayton, S., Finkelstein, D. I., Spoerri, L., Ciccotosto, G. D., Wright, D. K., Wong, B. X. W., Adlard, P. A., Cherny, R. A., Lam, L. Q., Roberts, B. R., Volitakis, I., Egan, G. F., McLean, C. A., Cappai, R., Duce, J. A., and Bush, A. I. (2012) Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat. Med. 18, 291-295.
-
(2012)
Nat. Med.
, vol.18
, pp. 291-295
-
-
Lei, P.1
Ayton, S.2
Finkelstein, D.I.3
Spoerri, L.4
Ciccotosto, G.D.5
Wright, D.K.6
Wong, B.X.W.7
Adlard, P.A.8
Cherny, R.A.9
Lam, L.Q.10
Roberts, B.R.11
Volitakis, I.12
Egan, G.F.13
McLean, C.A.14
Cappai, R.15
Duce, J.A.16
Bush, A.I.17
-
17
-
-
0022896901
-
Tau protein function in living cells
-
Drubin, D. G., and Kirschner, M. W. (1986) Tau protein function in living cells. J. Cell Biol. 103, 2739-2746.
-
(1986)
J. Cell Biol.
, vol.103
, pp. 2739-2746
-
-
Drubin, D.G.1
Kirschner, M.W.2
-
18
-
-
0022365608
-
Distribution of tau in the mammalian central nervous system
-
Binder, L. I., Frankfurter, A., and Rebhun, L. I. (1985) Distribution of tau in the mammalian central nervous system. J. Cell Biol. 101, 1371-1378.
-
(1985)
J. Cell Biol.
, vol.101
, pp. 1371-1378
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
19
-
-
84859230759
-
Tau's role in the developing brain: Implications for intellectual disability
-
Sapir, T., Frotscher, M., Levy, T., Mandelkow, E.-M., and Reiner, O. (2012) Tau's role in the developing brain: implications for intellectual disability. Hum. Mol. Genet. 21, 1681-1692.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1681-1692
-
-
Sapir, T.1
Frotscher, M.2
Levy, T.3
Mandelkow, E.-M.4
Reiner, O.5
-
20
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., and Crowther, R. A. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3, 519-526.
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
21
-
-
0344653664
-
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
-
Gomez-Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E., and Hyman, B. T. (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann. Neurol. 41, 17-24.
-
(1997)
Ann. Neurol.
, vol.41
, pp. 17-24
-
-
Gomez-Isla, T.1
Hollister, R.2
West, H.3
Mui, S.4
Growdon, J.H.5
Petersen, R.C.6
Parisi, J.E.7
Hyman, B.T.8
-
22
-
-
0033624416
-
Do neuronal inclusions kill the cell?
-
Terry, R. D. (2000) Do neuronal inclusions kill the cell? J. Neural Transm., Suppl. 59, 91-93.
-
(2000)
J. Neural Transm., Suppl.
, vol.59
, pp. 91-93
-
-
Terry, R.D.1
-
23
-
-
44449136848
-
Non-tau based neuronal degeneration in Alzheimer's disease - An immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex
-
van de Nes, J. A., Nafe, R., and Schlote, W. (2008) Non-tau based neuronal degeneration in Alzheimer's disease - an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex. Brain Res. 1213, 152-165.
-
(2008)
Brain Res.
, vol.1213
, pp. 152-165
-
-
Van De Nes, J.A.1
Nafe, R.2
Schlote, W.3
-
24
-
-
0031691459
-
Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease
-
Vogt, B. A., Vogt, L. J., Vrana, K. E., Gioia, L., Meadows, R. S., Challa, V. R., Hof, P. R., and Van Hoesen, G. W. (1998) Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease. Exp. Neurol. 153, 8-22.
-
(1998)
Exp. Neurol.
, vol.153
, pp. 8-22
-
-
Vogt, B.A.1
Vogt, L.J.2
Vrana, K.E.3
Gioia, L.4
Meadows, R.S.5
Challa, V.R.6
Hof, P.R.7
Van Hoesen, G.W.8
-
25
-
-
84891945085
-
Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo
-
Kuchibhotla, K. V., Wegmann, S., Kopeikina, K. J., Hawkes, J., Rudinskiy, N., Andermann, M. L., Spires-Jones, T. L., Bacskai, B. J., and Hyman, B. T. (2014) Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proc. Natl. Acad. Sci. U.S.A. 111, 510-514.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 510-514
-
-
Kuchibhotla, K.V.1
Wegmann, S.2
Kopeikina, K.J.3
Hawkes, J.4
Rudinskiy, N.5
Andermann, M.L.6
Spires-Jones, T.L.7
Bacskai, B.J.8
Hyman, B.T.9
-
26
-
-
84921640576
-
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses
-
Rudinskiy, N., Hawkes, J., Wegmann, S., Kuchibhotla, K., Muzikansky, A., Betensky, R., Spires-Jones, T., and Hyman, B. (2014) Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. Acta Neuropathol. Commun. 2, 63.
-
(2014)
Acta Neuropathol. Commun.
, vol.2
, pp. 63
-
-
Rudinskiy, N.1
Hawkes, J.2
Wegmann, S.3
Kuchibhotla, K.4
Muzikansky, A.5
Betensky, R.6
Spires-Jones, T.7
Hyman, B.8
-
27
-
-
0041803006
-
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
-
Andorfer, C., Kress, Y., Espinoza, M., de Silva, R., Tucker, K. L., Barde, Y. A., Duff, K., and Davies, P. (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J. Neurochem. 86, 582-590.
-
(2003)
J. Neurochem.
, vol.86
, pp. 582-590
-
-
Andorfer, C.1
Kress, Y.2
Espinoza, M.3
De Silva, R.4
Tucker, K.L.5
Barde, Y.A.6
Duff, K.7
Davies, P.8
-
28
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S. M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., and Lee, V. M. (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
Saido, T.C.6
Maeda, J.7
Suhara, T.8
Trojanowski, J.Q.9
Lee, V.M.10
-
29
-
-
33646519920
-
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
-
Spires, T. L., Orne, J. D., SantaCruz, K., Pitstick, R., Carlson, G. A., Ashe, K. H., and Hyman, B. T. (2006) Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am. J. Pathol. 168, 1598-1607.
-
(2006)
Am. J. Pathol.
, vol.168
, pp. 1598-1607
-
-
Spires, T.L.1
Orne, J.D.2
SantaCruz, K.3
Pitstick, R.4
Carlson, G.A.5
Ashe, K.H.6
Hyman, B.T.7
-
30
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M., and Ashe, K. H. (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
SantaCruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
Guimaraes, A.7
DeTure, M.8
Ramsden, M.9
McGowan, E.10
Forster, C.11
Yue, M.12
Orne, J.13
Janus, C.14
Mariash, A.15
Kuskowski, M.16
Hyman, B.17
Hutton, M.18
Ashe, K.H.19
-
31
-
-
34147125835
-
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy
-
Berger, Z., Roder, H., Hanna, A., Carlson, A., Rangachari, V., Yue, M., Wszolek, Z., Ashe, K., Knight, J., Dickson, D., Andorfer, C., Rosenberry, T. L., Lewis, J., Hutton, M., and Janus, C. (2007) Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. J. Neurosci. 27, 3650-3662.
-
(2007)
J. Neurosci.
, vol.27
, pp. 3650-3662
-
-
Berger, Z.1
Roder, H.2
Hanna, A.3
Carlson, A.4
Rangachari, V.5
Yue, M.6
Wszolek, Z.7
Ashe, K.8
Knight, J.9
Dickson, D.10
Andorfer, C.11
Rosenberry, T.L.12
Lewis, J.13
Hutton, M.14
Janus, C.15
-
32
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
-
Wittmann, C. W., Wszolek, M. F., Shulman, J. M., Salvaterra, P. M., Lewis, J., Hutton, M., and Feany, M. B. (2001) Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293, 711-714.
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
Salvaterra, P.M.4
Lewis, J.5
Hutton, M.6
Feany, M.B.7
-
33
-
-
78149411188
-
Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo
-
Cowan, C. M., Bossing, T., Page, A., Shepherd, D., and Mudher, A. (2010) Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta Neuropathol. 120, 593-604.
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 593-604
-
-
Cowan, C.M.1
Bossing, T.2
Page, A.3
Shepherd, D.4
Mudher, A.5
-
34
-
-
33947691643
-
Granular tau oligomers as intermediates of tau filaments
-
Maeda, S., Sahara, N., Saito, Y., Murayama, M., Yoshiike, Y., Kim, H., Miyasaka, T., Murayama, S., Ikai, A., and Takashima, A. (2007) Granular tau oligomers as intermediates of tau filaments. Biochemistry 46, 3856-3861.
-
(2007)
Biochemistry
, vol.46
, pp. 3856-3861
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, M.4
Yoshiike, Y.5
Kim, H.6
Miyasaka, T.7
Murayama, S.8
Ikai, A.9
Takashima, A.10
-
35
-
-
33244456786
-
Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease
-
Maeda, S., Sahara, N., Saito, Y., Murayama, S., Ikai, A., and Takashima, A. (2006) Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci. Res. 54, 197-201.
-
(2006)
Neurosci. Res.
, vol.54
, pp. 197-201
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, S.4
Ikai, A.5
Takashima, A.6
-
36
-
-
79959571777
-
Characterization of prefibrillar tau oligomers in vitro and in Alzheimers disease
-
Patterson, K. R., Remmers, C., Fu, Y., Brooker, S., Kanaan, N. M., Vana, L., Ward, S., Reyes, J. F., Philibert, K., Glucksman, M. J., and Binder, L. I. (2011) Characterization of prefibrillar tau oligomers in vitro and in Alzheimers disease. J. Biol. Chem. 286, 23063-23076.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 23063-23076
-
-
Patterson, K.R.1
Remmers, C.2
Fu, Y.3
Brooker, S.4
Kanaan, N.M.5
Vana, L.6
Ward, S.7
Reyes, J.F.8
Philibert, K.9
Glucksman, M.J.10
Binder, L.I.11
-
37
-
-
84858965241
-
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
-
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R., and Kayed, R. (2012) Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J. 26, 1946-1959.
-
(2012)
FASEB J.
, vol.26
, pp. 1946-1959
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Sarmiento, J.4
Troncoso, J.5
Jackson, G.R.6
Kayed, R.7
-
38
-
-
84918519815
-
Characterization of tau oligomeric seeds in progressive supranuclear palsy
-
Gerson, J., Sengupta, U., Lasagna-Reeves, C., Guerrero-Munoz, M., Troncoso, J., and Kayed, R. (2014) Characterization of tau oligomeric seeds in progressive supranuclear palsy. Acta Neuropathol. Commun. 2, 73.
-
(2014)
Acta Neuropathol. Commun.
, vol.2
, pp. 73
-
-
Gerson, J.1
Sengupta, U.2
Lasagna-Reeves, C.3
Guerrero-Munoz, M.4
Troncoso, J.5
Kayed, R.6
-
39
-
-
79957913270
-
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wildtype mice
-
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R., and Kayed, R. (2011) Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wildtype mice. Mol. Neurodegener. 6, 39.
-
(2011)
Mol. Neurodegener.
, vol.6
, pp. 39
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Clos, A.L.4
Jackson, G.R.5
Kayed, R.6
-
40
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., and Binder, L. I. (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. U.S.A. 83, 4913-4917.
-
(1986)
Proc. Natl. Acad. Sci. U.S.A.
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
41
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal tau
-
Lee, V. M. Y., Balin, B. J., Otvos, L., Jr., and Trojanowski, J. Q. (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251, 675-678.
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.Y.1
Balin, B.J.2
Otvos, L.3
Trojanowski, J.Q.4
-
42
-
-
10944258455
-
Tau aggregation is driven by a transition from random coil to beta sheet structure
-
von Bergen, M., Barghorn, S., Biernat, J., Mandelkow, E.-M., and Mandelkow, E. (2005) Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochim. Biophys. Acta, Mol. Basis Dis. 1739, 158-166.
-
(2005)
Biochim. Biophys. Acta, Mol. Basis Dis.
, vol.1739
, pp. 158-166
-
-
Von Bergen, M.1
Barghorn, S.2
Biernat, J.3
Mandelkow, E.-M.4
Mandelkow, E.5
-
43
-
-
3142699791
-
Template-assisted filament growth by parallel stacking of tau
-
Margittai, M., and Langen, R. (2004) Template-assisted filament growth by parallel stacking of tau. Proc. Natl. Acad. Sci. U.S.A. 101, 10278-10283.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 10278-10283
-
-
Margittai, M.1
Langen, R.2
-
44
-
-
0026755755
-
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro
-
Wille, H., Drewes, G., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (1992) Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. J. Cell Biol. 118, 573-584.
-
(1992)
J. Cell Biol.
, vol.118
, pp. 573-584
-
-
Wille, H.1
Drewes, G.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
45
-
-
0033539689
-
Ligand-dependent tau filament formation: Implications for Alzheimer's disease progression
-
King, M. E., Ahuja, V., Binder, L. I., and Kuret, J. (1999) Ligand-dependent tau filament formation: implications for Alzheimer's disease progression. Biochemistry 38, 14851-14859.
-
(1999)
Biochemistry
, vol.38
, pp. 14851-14859
-
-
King, M.E.1
Ahuja, V.2
Binder, L.I.3
Kuret, J.4
-
46
-
-
0030923223
-
Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease
-
Wilson, D. M., and Binder, L. I. (1997) Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. Am. J. Pathol. 150, 2181-2195.
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 2181-2195
-
-
Wilson, D.M.1
Binder, L.I.2
-
47
-
-
0034023751
-
Differential assembly of human tau isoforms in the presence of arachidonic acid
-
King, M. E., Gamblin, T. C., Kuret, J., and Binder, L. I. (2000) Differential assembly of human tau isoforms in the presence of arachidonic acid. J. Neurochem. 74, 1749-1757.
-
(2000)
J. Neurochem.
, vol.74
, pp. 1749-1757
-
-
King, M.E.1
Gamblin, T.C.2
Kuret, J.3
Binder, L.I.4
-
48
-
-
0038152836
-
Anionic micelles and vesicles induce tau fibrillization in vitro
-
Chirita, C. N., Necula, M., and Kuret, J. (2003) Anionic micelles and vesicles induce tau fibrillization in vitro. J. Biol. Chem. 278, 25644-25650.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25644-25650
-
-
Chirita, C.N.1
Necula, M.2
Kuret, J.3
-
49
-
-
0037126688
-
Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments
-
Barghorn, S., and Mandelkow, E. (2002) Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments. Biochemistry 41, 14885-14896.
-
(2002)
Biochemistry
, vol.41
, pp. 14885-14896
-
-
Barghorn, S.1
Mandelkow, E.2
-
50
-
-
0034714351
-
Nucleated conformational conversion and the replication of conformational information by a prion determinant
-
Serio, T. R., Cashikar, A. G., Kowal, A. S., Sawicki, G. J., Moslehi, J. J., Serpell, L., Arnsdorf, M. F., and Lindquist, S. L. (2000) Nucleated conformational conversion and the replication of conformational information by a prion determinant. Science 289, 1317-1321.
-
(2000)
Science
, vol.289
, pp. 1317-1321
-
-
Serio, T.R.1
Cashikar, A.G.2
Kowal, A.S.3
Sawicki, G.J.4
Moslehi, J.J.5
Serpell, L.6
Arnsdorf, M.F.7
Lindquist, S.L.8
-
51
-
-
84860389674
-
Amyloid-beta forms fibrils by nucleated conformational conversion of oligomers
-
Lee, J., Culyba, E. K., Powers, E. T., and Kelly, J. W. (2011) Amyloid-beta forms fibrils by nucleated conformational conversion of oligomers. Nat. Chem. Biol. 7, 602-609.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 602-609
-
-
Lee, J.1
Culyba, E.K.2
Powers, E.T.3
Kelly, J.W.4
-
52
-
-
70349263251
-
The role of prefibrillar structures in the assembly of a peptide amyloid
-
Ruschak, A. M., and Miranker, A. D. (2009) The role of prefibrillar structures in the assembly of a peptide amyloid. J. Mol. Biol. 393, 214-226.
-
(2009)
J. Mol. Biol.
, vol.393
, pp. 214-226
-
-
Ruschak, A.M.1
Miranker, A.D.2
-
53
-
-
78649503285
-
Preparation and characterization of neurotoxic tau oligomers
-
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Guerrero-Muoz, M. J., Jackson, G. R., and Kayed, R. (2010) Preparation and characterization of neurotoxic tau oligomers. Biochemistry 49, 10039-10041.
-
(2010)
Biochemistry
, vol.49
, pp. 10039-10041
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Guerrero-Muoz, M.J.3
Jackson, G.R.4
Kayed, R.5
-
54
-
-
34249990083
-
Assembly of two distinct dimers and higher-order oligomers from full-length tau
-
Sahara, N., Maeda, S., Murayama, M., Suzuki, T., Dohmae, N., Yen, S.-H., and Takashima, A. (2007) Assembly of two distinct dimers and higher-order oligomers from full-length tau. Eur. J. Neurosci. 25, 3020-3029.
-
(2007)
Eur. J. Neurosci.
, vol.25
, pp. 3020-3029
-
-
Sahara, N.1
Maeda, S.2
Murayama, M.3
Suzuki, T.4
Dohmae, N.5
Yen, S.-H.6
Takashima, A.7
-
55
-
-
17144395539
-
Triggers of full-length tau aggregation: A role for partially folded intermediates
-
Chirita, C. N., Congdon, E. E., Yin, H., and Kuret, J. (2005) Triggers of full-length tau aggregation: a role for partially folded intermediates. Biochemistry 44, 5862-5872.
-
(2005)
Biochemistry
, vol.44
, pp. 5862-5872
-
-
Chirita, C.N.1
Congdon, E.E.2
Yin, H.3
Kuret, J.4
-
56
-
-
84872714502
-
Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
-
Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G., and Duff, K. E. (2013) Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J. Biol. Chem. 288, 1856-1870.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 1856-1870
-
-
Wu, J.W.1
Herman, M.2
Liu, L.3
Simoes, S.4
Acker, C.M.5
Figueroa, H.6
Steinberg, J.I.7
Margittai, M.8
Kayed, R.9
Zurzolo, C.10
Di Paolo, G.11
Duff, K.E.12
-
57
-
-
84868269943
-
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
-
Lasagna-Reeves, C., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R., and Kayed, R. (2012) Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci. Rep. 2, 1-7.
-
(2012)
Sci. Rep.
, vol.2
, pp. 1-7
-
-
Lasagna-Reeves, C.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Guerrero-Munoz, M.J.4
Kiritoshi, T.5
Neugebauer, V.6
Jackson, G.R.7
Kayed, R.8
-
58
-
-
84883502695
-
Formation and propagation of tau oligomeric seeds
-
Gerson, J. E., and Kayed, R. (2013) Formation and propagation of tau oligomeric seeds. Front. Neurol. 4, 93.
-
(2013)
Front. Neurol.
, vol.4
, pp. 93
-
-
Gerson, J.E.1
Kayed, R.2
-
59
-
-
84897954120
-
Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins
-
Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., and Kayed, R. (2014) Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins. Biochem. Pharmacol. 88, 468-478.
-
(2014)
Biochem. Pharmacol.
, vol.88
, pp. 468-478
-
-
Guerrero-Muñoz, M.J.1
Castillo-Carranza, D.L.2
Kayed, R.3
-
60
-
-
84883242375
-
Tau Aggregates as Immunotherapeutic Targets
-
Castillo-Carranza, D. L., Lasagna-Reeves, C. A., and Kayed, R. (2013) Tau aggregates as immunotherapeutic targets. Front. Biosci., Scholar Ed. 5, 426-438.
-
(2013)
Front. Biosci., Scholar Ed.
, vol.5
, pp. 426-438
-
-
Castillo-Carranza, D.L.1
Lasagna-Reeves, C.A.2
Kayed, R.3
-
61
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl, F. U., Bracher, A., and Hayer-Hartl, M. (2011) Molecular chaperones in protein folding and proteostasis. Nature 475, 324-332.
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
62
-
-
24144440041
-
In vivo evidence of CHIP up-regulation attenuating tau aggregation
-
Sahara, N., Murayama, M., Mizoroki, T., Urushitani, M., Imai, Y., Takahashi, R., Murata, S., Tanaka, K., and Takashima, A. (2005) In vivo evidence of CHIP up-regulation attenuating tau aggregation. J. Neurochem. 94, 1254-1263.
-
(2005)
J. Neurochem.
, vol.94
, pp. 1254-1263
-
-
Sahara, N.1
Murayama, M.2
Mizoroki, T.3
Urushitani, M.4
Imai, Y.5
Takahashi, R.6
Murata, S.7
Tanaka, K.8
Takashima, A.9
-
63
-
-
0025736490
-
Expression of heat shock proteins in Alzheimer's disease
-
Hamos, J. E. (1991) Expression of heat shock proteins in Alzheimer's disease. Neurology 41, 345-350.
-
(1991)
Neurology
, vol.41
, pp. 345-350
-
-
Hamos, J.E.1
-
64
-
-
0026091893
-
Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease
-
Perez, N., Sugar, J., Charya, S., Johnson, G., Merril, C., Bierer, L., Perl, D., Haroutunian, V., and Wallace, W. (1991) Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease. Mol. Brain Res. 11, 249-254.
-
(1991)
Mol. Brain Res.
, vol.11
, pp. 249-254
-
-
Perez, N.1
Sugar, J.2
Charya, S.3
Johnson, G.4
Merril, C.5
Bierer, L.6
Perl, D.7
Haroutunian, V.8
Wallace, W.9
-
65
-
-
0041026092
-
Interaction of Hsp70 chaperones with substrates
-
Rüdiger, S., Buchberger, A., and Bukau, B. (1997) Interaction of Hsp70 chaperones with substrates. Nat. Struct. Biol. 4, 342-349.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 342-349
-
-
Rudie1
diger, S.2
Buchberger, A.3
Bukau, B.4
-
66
-
-
33746364784
-
Structure and mechanism of the Hsp90 molecular chaperone machinery
-
Pearl, L. H., and Prodromou, C. (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu. Rev. Biochem. 75, 271-294.
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 271-294
-
-
Pearl, L.H.1
Prodromou, C.2
-
67
-
-
0035900793
-
CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
-
Jiang, J., Ballinger, C. A., Wu, Y., Dai, Q., Cyr, D. M., Höhfeld, J., and Patterson, C. (2001) CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J. Biol. Chem. 276, 42938-42944.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42938-42944
-
-
Jiang, J.1
Ballinger, C.A.2
Wu, Y.3
Dai, Q.4
Cyr, D.M.5
Höhfeld, J.6
Patterson, C.7
-
68
-
-
0033013126
-
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
-
Ballinger, C. A., Connell, P., Wu, Y., Hu, Z., Thompson, L. J., Yin, L.-Y., and Patterson, C. (1999) Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol. Cell. Biol. 19, 4535-4545.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4535-4545
-
-
Ballinger, C.A.1
Connell, P.2
Wu, Y.3
Hu, Z.4
Thompson, L.J.5
Yin, L.-Y.6
Patterson, C.7
-
69
-
-
11144356089
-
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
-
Petrucelli, L., Dickson, D., Kehoe, K., Taylor, J., Snyder, H., Grover, A., De Lucia, M., McGowan, E., Lewis, J., Prihar, G., Kim, J., Dillmann, W. H., Browne, S. E., Hall, A., Voellmy, R., Tsuboi, Y., Dawson, T. M., Wolozin, B., Hardy, J., and Hutton, M. (2004) CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum. Mol. Genet. 13, 703-714.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 703-714
-
-
Petrucelli, L.1
Dickson, D.2
Kehoe, K.3
Taylor, J.4
Snyder, H.5
Grover, A.6
De Lucia, M.7
McGowan, E.8
Lewis, J.9
Prihar, G.10
Kim, J.11
Dillmann, W.H.12
Browne, S.E.13
Hall, A.14
Voellmy, R.15
Tsuboi, Y.16
Dawson, T.M.17
Wolozin, B.18
Hardy, J.19
Hutton, M.20
more..
-
70
-
-
0037457966
-
Chaperones increase association of tau protein with microtubules
-
Dou, F., Netzer, W. J., Tanemura, K., Li, F., Hartl, F. U., Takashima, A., Gouras, G. K., Greengard, P., and Xu, H. (2003) Chaperones increase association of tau protein with microtubules. Proc. Natl. Acad. Sci. U.S.A. 100, 721-726.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 721-726
-
-
Dou, F.1
Netzer, W.J.2
Tanemura, K.3
Li, F.4
Hartl, F.U.5
Takashima, A.6
Gouras, G.K.7
Greengard, P.8
Xu, H.9
-
71
-
-
33745959291
-
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phosphoand caspase-3-cleaved tau species
-
Dickey, C. A., Yue, M., Lin, W.-L., Dickson, D. W., Dunmore, J. H., Lee, W. C., Zehr, C., West, G., Cao, S., Clark, A. M. K., Caldwell, G. A., Caldwell, K. A., Eckman, C., Patterson, C., Hutton, M., and Petrucelli, L. (2006) Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phosphoand caspase-3-cleaved tau species. J. Neurosci. 26, 6985-6996.
-
(2006)
J. Neurosci.
, vol.26
, pp. 6985-6996
-
-
Dickey, C.A.1
Yue, M.2
Lin, W.-L.3
Dickson, D.W.4
Dunmore, J.H.5
Lee, W.C.6
Zehr, C.7
West, G.8
Cao, S.9
Clark, A.M.K.10
Caldwell, G.A.11
Caldwell, K.A.12
Eckman, C.13
Patterson, C.14
Hutton, M.15
Petrucelli, L.16
-
72
-
-
84872526813
-
Tau triage decisions mediated by the chaperone network
-
Cook, C., and Petrucelli, L. (2013) Tau triage decisions mediated by the chaperone network. J. Alzheimer's Dis. 33, S145-S151.
-
(2013)
J. Alzheimer's Dis.
, vol.33
, pp. S145-S151
-
-
Cook, C.1
Petrucelli, L.2
-
73
-
-
84863508369
-
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
-
Cook, C., Gendron, T. F., Scheffel, K., Carlomagno, Y., Dunmore, J., DeTure, M., and Petrucelli, L. (2012) Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Hum. Mol. Genet. 21, 2936-2945.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2936-2945
-
-
Cook, C.1
Gendron, T.F.2
Scheffel, K.3
Carlomagno, Y.4
Dunmore, J.5
DeTure, M.6
Petrucelli, L.7
-
74
-
-
84989182910
-
Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition
-
Selenica, M.-L., Benner, L., Housley, S., Manchec, B., Lee, D., Nash, K., Kalin, J., Bergman, J., Kozikowski, A., Gordon, M., and Morgan, D. (2014) Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition. Alzheimer's Res. Ther. 6, 12.
-
(2014)
Alzheimer's Res. Ther.
, vol.6
, pp. 12
-
-
Selenica, M.-L.1
Benner, L.2
Housley, S.3
Manchec, B.4
Lee, D.5
Nash, K.6
Kalin, J.7
Bergman, J.8
Kozikowski, A.9
Gordon, M.10
Morgan, D.11
-
75
-
-
2342444942
-
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival
-
Shimura, H., Miura-Shimura, Y., and Kosik, K. S. (2004) Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. J. Biol. Chem. 279, 17957-17962.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 17957-17962
-
-
Shimura, H.1
Miura-Shimura, Y.2
Kosik, K.S.3
-
76
-
-
84896837095
-
Hsp90-tau complex reveals molecular basis for specificity in chaperone action
-
Karagöz, G. E., Duarte, A. M. S., Akoury, E., Ippel, H., Biernat, J., Morán Luengo, T., Radli, M., Didenko, T., Nordhues, B. A., Veprintsev, D. B., Dickey, C. A., Mandelkow, E., Zweckstetter, M., Boelens, R., Madl, T., and Rüdiger, S. G. D. (2014) Hsp90-tau complex reveals molecular basis for specificity in chaperone action. Cell 156, 963-974.
-
(2014)
Cell
, vol.156
, pp. 963-974
-
-
Karagodie1
z, G.E.2
Duarte, A.M.S.3
Akoury, E.4
Ippel, H.5
Biernat, J.6
Morán Luengo, T.7
Radli, M.8
Didenko, T.9
Nordhues, B.A.10
Veprintsev, D.B.11
Dickey, C.A.12
Mandelkow, E.13
Zweckstetter, M.14
Boelens, R.15
Madl, T.16
Rüdiger, S.G.D.17
-
77
-
-
33646246733
-
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
-
Dickey, C. A., Dunmore, J., Lu, B., Wang, J.-W., Lee, W. C., Kamal, A., Burrows, F., Eckman, C., Hutton, M., and Petrucelli, L. (2006) HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB J. 20, 753-755.
-
(2006)
FASEB J.
, vol.20
, pp. 753-755
-
-
Dickey, C.A.1
Dunmore, J.2
Lu, B.3
Wang, J.-W.4
Lee, W.C.5
Kamal, A.6
Burrows, F.7
Eckman, C.8
Hutton, M.9
Petrucelli, L.10
-
78
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
Dickey, C. A., Kamal, A., Lundgren, K., Klosak, N., Bailey, R. M., Dunmore, J., Ash, P., Shoraka, S., Zlatkovic, J., Eckman, C. B., Patterson, C., Dickson, D. W., Nahman, N. S., Jr., Hutton, M., Burrows, F., and Petrucelli, L. (2007) The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J. Clin. Invest. 117, 648-658.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
Patterson, C.11
Dickson, D.W.12
Nahman, N.S.13
Hutton, M.14
Burrows, F.15
Petrucelli, L.16
-
79
-
-
84872482226
-
Intracellular degradation of misfolded tau protein induced by geldanamycin is associated with activation of proteasome
-
Opattova, A., Filipcik, P., Cente, M., and Novak, M. (2013) Intracellular degradation of misfolded tau protein induced by geldanamycin is associated with activation of proteasome. J. Alzheimer's Dis. 33, 339-348.
-
(2013)
J. Alzheimer's Dis.
, vol.33
, pp. 339-348
-
-
Opattova, A.1
Filipcik, P.2
Cente, M.3
Novak, M.4
-
80
-
-
24944546195
-
Heat shock protein 90 indirectly regulates ERK activity by affecting raf protein metabolism
-
Dou, F., Yuan, L.-D., and Zhu, J.-J. (2005) Heat shock protein 90 indirectly regulates ERK activity by affecting raf protein metabolism. Acta Biochim. Biophys. Sin. 37, 501-505.
-
(2005)
Acta Biochim. Biophys. Sin.
, vol.37
, pp. 501-505
-
-
Dou, F.1
Yuan, L.-D.2
Zhu, J.-J.3
-
81
-
-
84883428711
-
An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors - potential therapeutics in cancer and neurodegeneration
-
Kitson, R. R. A., and Moody, C. J. (2013) An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors - potential therapeutics in cancer and neurodegeneration. Chem. Commun. 49, 8441-8443.
-
(2013)
Chem. Commun.
, vol.49
, pp. 8441-8443
-
-
Kitson, R.R.A.1
Moody, C.J.2
-
82
-
-
42149111606
-
Akt and CHIP coregulate tau degradation through coordinated interactions
-
Dickey, C. A., Koren, J., Zhang, Y.-J., Xu, Y.-f., Jinwal, U. K., Birnbaum, M. J., Monks, B., Sun, M., Cheng, J. Q., Patterson, C., Bailey, R. M., Dunmore, J., Soresh, S., Leon, C., Morgan, D., and Petrucelli, L. (2008) Akt and CHIP coregulate tau degradation through coordinated interactions. Proc. Natl. Acad. Sci. U.S.A. 105, 3622-3627.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 3622-3627
-
-
Dickey, C.A.1
Koren, J.2
Zhang, Y.-J.3
Xu, Y.-F.4
Jinwal, U.K.5
Birnbaum, M.J.6
Monks, B.7
Sun, M.8
Cheng, J.Q.9
Patterson, C.10
Bailey, R.M.11
Dunmore, J.12
Soresh, S.13
Leon, C.14
Morgan, D.15
Petrucelli, L.16
-
83
-
-
84873665973
-
Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease
-
Sinadinos, C., Quraishe, S., Sealey, M., Samson, P. B., Mudher, A., and Wyttenbach, A. (2013) Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease. J. Alzheimer's Dis. 33, 1117-1133.
-
(2013)
J. Alzheimer's Dis.
, vol.33
, pp. 1117-1133
-
-
Sinadinos, C.1
Quraishe, S.2
Sealey, M.3
Samson, P.B.4
Mudher, A.5
Wyttenbach, A.6
-
84
-
-
84893639934
-
Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment
-
Chen, Y., Wang, B., Liu, D., Li, J. J., Xue, Y., Sakata, K., Zhu, L.-q., Heldt, S. A., Xu, H., and Liao, F.-F. (2014) Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J. Neurosci. 34, 2464-2470.
-
(2014)
J. Neurosci.
, vol.34
, pp. 2464-2470
-
-
Chen, Y.1
Wang, B.2
Liu, D.3
Li, J.J.4
Xue, Y.5
Sakata, K.6
Zhu, L.-Q.7
Heldt, S.A.8
Xu, H.9
Liao, F.-F.10
-
85
-
-
84872178269
-
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun
-
No. e00102
-
Li, C., Ma, J., Zhao, H., Blagg, B. S. J., and Dobrowsky, R. T. (2012) Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. ASN Neuro 4, No. e00102.
-
(2012)
ASN Neuro
, vol.4
-
-
Li, C.1
Ma, J.2
Zhao, H.3
Blagg, B.S.J.4
Dobrowsky, R.T.5
-
86
-
-
60049098351
-
Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line
-
Lu, Y., Ansar, S., Michaelis, M. L., and Blagg, B. S. J. (2009) Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line. Bioorg. Med. Chem. 17, 1709-1715.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 1709-1715
-
-
Lu, Y.1
Ansar, S.2
Michaelis, M.L.3
Blagg, B.S.J.4
-
87
-
-
33847660142
-
A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity
-
Ansar, S., Burlison, J. A., Hadden, M. K., Yu, X. M., Desino, K. E., Bean, J., Neckers, L., Audus, K. L., Michaelis, M. L., and Blagg, B. S. J. (2007) A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity. Bioorg. Med. Chem. Lett. 17, 1984-1990.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 1984-1990
-
-
Ansar, S.1
Burlison, J.A.2
Hadden, M.K.3
Yu, X.M.4
Desino, K.E.5
Bean, J.6
Neckers, L.7
Audus, K.L.8
Michaelis, M.L.9
Blagg, B.S.J.10
-
88
-
-
84885054226
-
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
-
Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., III, Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N., and Dickey, C. A. (2013) Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J. Clin. Invest. 123, 4158-4169.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 4158-4169
-
-
Blair, L.J.1
Nordhues, B.A.2
Hill, S.E.3
Scaglione, K.M.4
O'Leary, J.C.5
Fontaine, S.N.6
Breydo, L.7
Zhang, B.8
Li, P.9
Wang, L.10
Cotman, C.11
Paulson, H.L.12
Muschol, M.13
Uversky, V.N.14
Klengel, T.15
Binder, E.B.16
Kayed, R.17
Golde, T.E.18
Berchtold, N.19
Dickey, C.A.20
more..
-
89
-
-
0032701913
-
Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells
-
Kim, H. R., Kang, H. S., and Kim, H. D. (1999) Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells. IUBMB Life 48, 429-433.
-
(1999)
IUBMB Life
, vol.48
, pp. 429-433
-
-
Kim, H.R.1
Kang, H.S.2
Kim, H.D.3
-
90
-
-
25844466597
-
Heat shock response modulators as therapeutic tools for diseases of protein conformation
-
Westerheide, S. D., and Morimoto, R. I. (2005) Heat shock response modulators as therapeutic tools for diseases of protein conformation. J. Biol. Chem. 280, 33097-33100.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33097-33100
-
-
Westerheide, S.D.1
Morimoto, R.I.2
-
91
-
-
84878752125
-
Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of purkinje cells in Alzheimer's disease
-
Jiang, Y.-Q., Wang, X.-L., Cao, X.-H., Ye, Z.-Y., Li, L., and Cai, W.-Q. (2013) Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of purkinje cells in Alzheimer's disease. Brain Res. 1519, 105-111.
-
(2013)
Brain Res.
, vol.1519
, pp. 105-111
-
-
Jiang, Y.-Q.1
Wang, X.-L.2
Cao, X.-H.3
Ye, Z.-Y.4
Li, L.5
Cai, W.-Q.6
-
92
-
-
84877358032
-
Reconstructing the Hsp90/tau machine
-
Jinwal, U. K., Koren, J., III, and Dickey, CA (2013) Reconstructing the Hsp90/tau machine. Curr. Enzyme Inhib. 9, 41-45.
-
(2013)
Curr. Enzyme Inhib.
, vol.9
, pp. 41-45
-
-
Jinwal, U.K.1
Koren, J.2
Dickey, C.A.3
-
93
-
-
74949110831
-
The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules
-
Jinwal, U. K., Koren, J., III, Borysov, S. I., Schmid, A. B., Abisambra, J. F., Blair, L. J., Johnson, A. G., Jones, J. R., Shults, C. L., O'Leary, J. C., Jin, Y., Buchner, J., Cox, M. B., and Dickey, C. A. (2010) The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules. J. Neurosci. 30, 591-599.
-
(2010)
J. Neurosci.
, vol.30
, pp. 591-599
-
-
Jinwal, U.K.1
Koren, J.2
Borysov, S.I.3
Schmid, A.B.4
Abisambra, J.F.5
Blair, L.J.6
Johnson, A.G.7
Jones, J.R.8
Shults, C.L.9
O'Leary, J.C.10
Jin, Y.11
Buchner, J.12
Cox, M.B.13
Dickey, C.A.14
-
94
-
-
60849092552
-
The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule
-
Carrettiero, D. C., Hernandez, I., Neveu, P., Papagiannakopoulos, T., and Kosik, K. S. (2009) The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule. J. Neurosci. 29, 2151-2161.
-
(2009)
J. Neurosci.
, vol.29
, pp. 2151-2161
-
-
Carrettiero, D.C.1
Hernandez, I.2
Neveu, P.3
Papagiannakopoulos, T.4
Kosik, K.S.5
-
95
-
-
84867809427
-
Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation
-
Thompson, A. D., Scaglione, K. M., Prensner, J., Gillies, A. T., Chinnaiyan, A., Paulson, H. L., Jinwal, U. K., Dickey, C. A., and Gestwicki, J. E. (2012) Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chem. Biol. 7, 1677-1686.
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1677-1686
-
-
Thompson, A.D.1
Scaglione, K.M.2
Prensner, J.3
Gillies, A.T.4
Chinnaiyan, A.5
Paulson, H.L.6
Jinwal, U.K.7
Dickey, C.A.8
Gestwicki, J.E.9
-
96
-
-
84856477398
-
Hsp70 alters tau function and aggregation in an isoform specific manner
-
Voss, K., Combs, B., Patterson, K. R., Binder, L. I., and Gamblin, T. C. (2012) Hsp70 alters tau function and aggregation in an isoform specific manner. Biochemistry 51, 888-898.
-
(2012)
Biochemistry
, vol.51
, pp. 888-898
-
-
Voss, K.1
Combs, B.2
Patterson, K.R.3
Binder, L.I.4
Gamblin, T.C.5
-
97
-
-
81855190900
-
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport
-
Patterson, K. R., Ward, S. M., Combs, B., Voss, K., Kanaan, N. M., Morfini, G., Brady, S. T., Gamblin, T. C., and Binder, L. I. (2011) Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry 50, 10300-10310.
-
(2011)
Biochemistry
, vol.50
, pp. 10300-10310
-
-
Patterson, K.R.1
Ward, S.M.2
Combs, B.3
Voss, K.4
Kanaan, N.M.5
Morfini, G.6
Brady, S.T.7
Gamblin, T.C.8
Binder, L.I.9
-
98
-
-
84879767467
-
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels
-
Miyata, Y., Li, X., Lee, H.-F., Jinwal, U. K., Srinivasan, S. R., Seguin, S. P., Young, Z. T., Brodsky, J. L., Dickey, C. A., Sun, D., and Gestwicki, J. E. (2013) Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem. Neurosci. 4, 930-939.
-
(2013)
ACS Chem. Neurosci.
, vol.4
, pp. 930-939
-
-
Miyata, Y.1
Li, X.2
Lee, H.-F.3
Jinwal, U.K.4
Srinivasan, S.R.5
Seguin, S.P.6
Young, Z.T.7
Brodsky, J.L.8
Dickey, C.A.9
Sun, D.10
Gestwicki, J.E.11
-
99
-
-
84869988993
-
Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70
-
Miyata, Y., Rauch, J. N., Jinwal, U. K., Thompson, A. D., Srinivasan, S., Dickey, C. A., and Gestwicki, J. E. (2012) Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem. Biol. 19, 1391-1399.
-
(2012)
Chem. Biol.
, vol.19
, pp. 1391-1399
-
-
Miyata, Y.1
Rauch, J.N.2
Jinwal, U.K.3
Thompson, A.D.4
Srinivasan, S.5
Dickey, C.A.6
Gestwicki, J.E.7
-
100
-
-
84862281225
-
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
-
Congdon, E. E., Wu, J. W., Myeku, N., Figueroa, Y. H., Herman, M., Marinec, P. S., Gestwicki, J. E., Dickey, C. A., Yu, W. H., and Duff, K. E. (2012) Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy 8, 609-622.
-
(2012)
Autophagy
, vol.8
, pp. 609-622
-
-
Congdon, E.E.1
Wu, J.W.2
Myeku, N.3
Figueroa, Y.H.4
Herman, M.5
Marinec, P.S.6
Gestwicki, J.E.7
Dickey, C.A.8
Yu, W.H.9
Duff, K.E.10
-
101
-
-
70349617699
-
Chemical manipulation of Hsp70 ATPase activity regulates tau stability
-
Jinwal, U. K., Miyata, Y., Koren, J., III, Jones, J. R., Trotter, J. H., Chang, L., O'Leary, J., Morgan, D., Lee, D. C., Shults, C. L., Rousaki, A., Weeber, E. J., Zuiderweg, E. R. P., Gestwicki, J. E., and Dickey, C. A. (2009) Chemical manipulation of Hsp70 ATPase activity regulates tau stability. J. Neurosci. 29, 12079-12088.
-
(2009)
J. Neurosci.
, vol.29
, pp. 12079-12088
-
-
Jinwal, U.K.1
Miyata, Y.2
Koren, J.3
Jones, J.R.4
Trotter, J.H.5
Chang, L.6
O'Leary, J.7
Morgan, D.8
Lee, D.C.9
Shults, C.L.10
Rousaki, A.11
Weeber, E.J.12
Zuiderweg, E.R.P.13
Gestwicki, J.E.14
Dickey, C.A.15
-
102
-
-
84875755553
-
Imbalance of Hsp70 family variants fosters tau accumulation
-
Jinwal, U. K., Akoury, E., Abisambra, J. F., O'Leary, J. C., Thompson, A. D., Blair, L. J., Jin, Y., Bacon, J., Nordhues, B. A., Cockman, M., Zhang, J., Li, P., Zhang, B., Borysov, S., Uversky, V. N., Biernat, J., Mandelkow, E., Gestwicki, J. E., Zweckstetter, M., and Dickey, C. A. (2013) Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J. 27, 1450-1459.
-
(2013)
FASEB J.
, vol.27
, pp. 1450-1459
-
-
Jinwal, U.K.1
Akoury, E.2
Abisambra, J.F.3
O'Leary, J.C.4
Thompson, A.D.5
Blair, L.J.6
Jin, Y.7
Bacon, J.8
Nordhues, B.A.9
Cockman, M.10
Zhang, J.11
Li, P.12
Zhang, B.13
Borysov, S.14
Uversky, V.N.15
Biernat, J.16
Mandelkow, E.17
Gestwicki, J.E.18
Zweckstetter, M.19
Dickey, C.A.20
more..
-
103
-
-
84882250523
-
Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau
-
Abisambra, J., Jinwal, U. K., Miyata, Y., Rogers, J., Blair, L., Li, X., Seguin, S. P., Wang, L., Jin, Y., Bacon, J., Brady, S., Cockman, M., Guidi, C., Zhang, J., Koren, J., III, Young, Z. T., Atkins, C. A., Zhang, B., Lawson, L. Y., Weeber, E. J., Brodsky, J. L., Gestwicki, J. E., and Dickey, C. A. (2013) Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau. Biol. Psychiatry 74, 367-374.
-
(2013)
Biol. Psychiatry
, vol.74
, pp. 367-374
-
-
Abisambra, J.1
Jinwal, U.K.2
Miyata, Y.3
Rogers, J.4
Blair, L.5
Li, X.6
Seguin, S.P.7
Wang, L.8
Jin, Y.9
Bacon, J.10
Brady, S.11
Cockman, M.12
Guidi, C.13
Zhang, J.14
Koren, J.15
Young, Z.T.16
Atkins, C.A.17
Zhang, B.18
Lawson, L.Y.19
Weeber, E.J.20
Brodsky, J.L.21
Gestwicki, J.E.22
Dickey, C.A.23
more..
-
104
-
-
84864285399
-
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau
-
Abisambra, J. F., Jinwal, U. K., Suntharalingam, A., Arulselvam, K., Brady, S., Cockman, M., Jin, Y., Zhang, B., and Dickey, C. A. (2012) DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. J. Mol. Biol. 421, 653-661.
-
(2012)
J. Mol. Biol.
, vol.421
, pp. 653-661
-
-
Abisambra, J.F.1
Jinwal, U.K.2
Suntharalingam, A.3
Arulselvam, K.4
Brady, S.5
Cockman, M.6
Jin, Y.7
Zhang, B.8
Dickey, C.A.9
-
105
-
-
2942722444
-
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
-
Shorter, J., and Lindquist, S. (2004) Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science 304, 1793-1797.
-
(2004)
Science
, vol.304
, pp. 1793-1797
-
-
Shorter, J.1
Lindquist, S.2
-
106
-
-
33746405081
-
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities
-
Shorter, J., and Lindquist, S. (2006) Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol. Cell 23, 425-438.
-
(2006)
Mol. Cell
, vol.23
, pp. 425-438
-
-
Shorter, J.1
Lindquist, S.2
-
107
-
-
51349150684
-
Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
-
Lo Bianco, C., Shorter, J., Régulier, E., Lashuel, H., Iwatsubo, T., Lindquist, S., and Aebischer, P. (2008) Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. J. Clin. Invest. 118, 3087-3097.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3087-3097
-
-
Lo Bianco, C.1
Shorter, J.2
Régulier, E.3
Lashuel, H.4
Iwatsubo, T.5
Lindquist, S.6
Aebischer, P.7
-
108
-
-
75349089072
-
Applying Hsp104 to protein-misfolding disorders
-
Vashist, S., Cushman, M., and Shorter, J. (2010) Applying Hsp104 to protein-misfolding disorders. Biochem. Cell Biol. 88, 1-13.
-
(2010)
Biochem. Cell Biol.
, vol.88
, pp. 1-13
-
-
Vashist, S.1
Cushman, M.2
Shorter, J.3
-
109
-
-
84869017593
-
Operational plasticity enables Hsp104 to disaggregate diverse amyloid and nonamyloid clients
-
DeSantis, M. E., Leung, E. H., Sweeny, E. A., Jackrel, M. E., Cushman-Nick, M., Neuhaus-Follini, A., Vashist, S., Sochor, M. A., Knight, M. N., and Shorter, J. (2012) Operational plasticity enables Hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell 151, 778-793.
-
(2012)
Cell
, vol.151
, pp. 778-793
-
-
DeSantis, M.E.1
Leung, E.H.2
Sweeny, E.A.3
Jackrel, M.E.4
Cushman-Nick, M.5
Neuhaus-Follini, A.6
Vashist, S.7
Sochor, M.A.8
Knight, M.N.9
Shorter, J.10
-
110
-
-
70349987102
-
Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing
-
Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., and Mandelkow, E. (2009) Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum. Mol. Genet. 18, 4153-4170.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4153-4170
-
-
Wang, Y.1
Martinez-Vicente, M.2
Krüger, U.3
Kaushik, S.4
Wong, E.5
Mandelkow, E.-M.6
Cuervo, A.M.7
Mandelkow, E.8
-
111
-
-
84862285881
-
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
-
Krüger, U., Wang, Y., Kumar, S., and Mandelkow, E.-M. (2012) Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol. Aging 33, 2291-2305.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2291-2305
-
-
Krudie1
ger, U.2
Wang, Y.3
Kumar, S.4
Mandelkow, E.-M.5
-
112
-
-
84864956245
-
Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications
-
Andreu, C. I., Woehlbier, U., Torres, M., and Hetz, C. (2012) Protein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applications. FEBS Lett. 586, 2826-2834.
-
(2012)
FEBS Lett.
, vol.586
, pp. 2826-2834
-
-
Andreu, C.I.1
Woehlbier, U.2
Torres, M.3
Hetz, C.4
-
113
-
-
77955653927
-
Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease
-
Honjo, Y., Ito, H., Horibe, T., Takahashi, R., and Kawakami, K. (2010) Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease. Brain Res. 1349, 90-96.
-
(2010)
Brain Res.
, vol.1349
, pp. 90-96
-
-
Honjo, Y.1
Ito, H.2
Horibe, T.3
Takahashi, R.4
Kawakami, K.5
-
114
-
-
84884894382
-
Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization
-
Xu, L.-R., Liu, X.-L., Chen, J., and Liang, Y. (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8, e76657.
-
(2013)
PLoS One
, vol.8
, pp. e76657
-
-
Xu, L.-R.1
Liu, X.-L.2
Chen, J.3
Liang, Y.4
-
115
-
-
84855368532
-
NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
-
Ali, Y. O., Ruan, K., and Zhai, R. G. (2012) NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum. Mol. Genet. 21, 237-250.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 237-250
-
-
Ali, Y.O.1
Ruan, K.2
Zhai, R.G.3
-
116
-
-
33745096194
-
Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism
-
Porat, Y., Abramowitz, A., and Gazit, E. (2006) Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism. Chem. Biol. Drug Des. 67, 27-37.
-
(2006)
Chem. Biol. Drug Des.
, vol.67
, pp. 27-37
-
-
Porat, Y.1
Abramowitz, A.2
Gazit, E.3
-
117
-
-
70349617699
-
Chemical manipulation of hsp70 ATPase activity regulates tau stability
-
Jinwal, U., Miyata, Y., Koren, J., III, Jones, J., Trotter, J., Chang, L., O'Leary, J., Morgan, D., Lee, D., Shults, C., Rousaki, A., Weeber, E., Zuiderweg, E., Gestwicki, J., and Dickey, C. (2009) Chemical manipulation of hsp70 ATPase activity regulates tau stability. J. Neurosci. 29, 12079-12088.
-
(2009)
J. Neurosci.
, vol.29
, pp. 12079-12088
-
-
Jinwal, U.1
Miyata, Y.2
Koren, J.3
Jones, J.4
Trotter, J.5
Chang, L.6
O'Leary, J.7
Morgan, D.8
Lee, D.9
Shults, C.10
Rousaki, A.11
Weeber, E.12
Zuiderweg, E.13
Gestwicki, J.14
Dickey, C.15
-
118
-
-
84893118788
-
Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway
-
Huang, H.-C., Tang, D., Xu, K., and Jiang, Z.-F. (2014) Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway. J. Recept. Signal Transduction 34, 26-37.
-
(2014)
J. Recept. Signal Transduction
, vol.34
, pp. 26-37
-
-
Huang, H.-C.1
Tang, D.2
Xu, K.3
Jiang, Z.-F.4
-
119
-
-
84883278654
-
Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway
-
Hoppe, J. B., Coradini, K., Frozza, R. L., Oliveira, C. M., Meneghetti, A. B., Bernardi, A., Pires, E. S., Beck, R. C. R., and Salbego, C. G. (2013) Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway. Neurobiol. Learn. Mem. 106, 134-144.
-
(2013)
Neurobiol. Learn. Mem.
, vol.106
, pp. 134-144
-
-
Hoppe, J.B.1
Coradini, K.2
Frozza, R.L.3
Oliveira, C.M.4
Meneghetti, A.B.5
Bernardi, A.6
Pires, E.S.7
Beck, R.C.R.8
Salbego, C.G.9
-
120
-
-
84884724033
-
Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons
-
Patil, S. P., Tran, N., Geekiyanage, H., Liu, L., and Chan, C. (2013) Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons. Neurosci. Lett. 554, 121-125.
-
(2013)
Neurosci. Lett.
, vol.554
, pp. 121-125
-
-
Patil, S.P.1
Tran, N.2
Geekiyanage, H.3
Liu, L.4
Chan, C.5
-
121
-
-
77950811222
-
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples
-
Mohorko, N., Repovš, G., Popovic, M., Kovacs, G. G., and Bresjanac, M. (2010) Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples. J. Neuropathol. Exp. Neurol. 69, 405-414.
-
(2010)
J. Neuropathol. Exp. Neurol.
, vol.69
, pp. 405-414
-
-
Mohorko, N.1
Repovš, G.2
Popovic, M.3
Kovacs, G.G.4
Bresjanac, M.5
-
122
-
-
84873687399
-
Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice
-
Ma, Q.-L., Zuo, X., Yang, F., Ubeda, O. J., Gant, D. J., Alaverdyan, M., Teng, E., Hu, S., Chen, P.-P., Maiti, P., Teter, B., Cole, G. M., and Frautschy, S. A. (2013) Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J. Biol. Chem. 288, 4056-4065.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 4056-4065
-
-
Ma, Q.-L.1
Zuo, X.2
Yang, F.3
Ubeda, O.J.4
Gant, D.J.5
Alaverdyan, M.6
Teng, E.7
Hu, S.8
Chen, P.-P.9
Maiti, P.10
Teter, B.11
Cole, G.M.12
Frautschy, S.A.13
-
123
-
-
63249086235
-
Curcumin blocks brain tumor formation
-
Purkayastha, S., Berliner, A., Fernando, S. S., Ranasinghe, B., Ray, I., Tariq, H., and Banerjee, P. (2009) Curcumin blocks brain tumor formation. Brain Res. 1266, 130-138.
-
(2009)
Brain Res.
, vol.1266
, pp. 130-138
-
-
Purkayastha, S.1
Berliner, A.2
Fernando, S.S.3
Ranasinghe, B.4
Ray, I.5
Tariq, H.6
Banerjee, P.7
-
124
-
-
84867901639
-
Oral curcumin for Alzheimer's disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
-
Ringman, J., Frautschy, S., Teng, E., Begum, A., Bardens, J., Beigi, M., Gylys, K., Badmaev, V., Heath, D., Apostolova, L., Porter, V., Vanek, Z., Marshall, G., Hellemann, G., Sugar, C., Masterman, D., Montine, T., Cummings, J., and Cole, G. (2012) Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimer's Res. Ther. 4, 43.
-
(2012)
Alzheimer's Res. Ther.
, vol.4
, pp. 43
-
-
Ringman, J.1
Frautschy, S.2
Teng, E.3
Begum, A.4
Bardens, J.5
Beigi, M.6
Gylys, K.7
Badmaev, V.8
Heath, D.9
Apostolova, L.10
Porter, V.11
Vanek, Z.12
Marshall, G.13
Hellemann, G.14
Sugar, C.15
Masterman, D.16
Montine, T.17
Cummings, J.18
Cole, G.19
-
125
-
-
84555177564
-
"Clicked"sugar - curcumin conjugate: Modulator of amyloid-β and tau peptide aggregation at ultralow concentrations
-
Dolai, S., Shi, W., Corbo, C., Sun, C., Averick, S., Obeysekera, D., Farid, M., Alonso, A., Banerjee, P., and Raja, K. (2011) "Clicked"sugar - curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations. ACS Chem. Neurosci. 2, 694-699.
-
(2011)
ACS Chem. Neurosci.
, vol.2
, pp. 694-699
-
-
Dolai, S.1
Shi, W.2
Corbo, C.3
Sun, C.4
Averick, S.5
Obeysekera, D.6
Farid, M.7
Alonso, A.8
Banerjee, P.9
Raja, K.10
-
126
-
-
48149099777
-
Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?
-
Narlawar, R., Pickhardt, M., Leuchtenberger, S., Baumann, K., Krause, S., Dyrks, T., Weggen, S., Mandelkow, E., and Schmidt, B. (2008) Curcumin-derived pyrazoles and isoxazoles: swiss army knives or blunt tools for Alzheimer's disease? ChemMedChem. 3, 165-172.
-
(2008)
ChemMedChem.
, vol.3
, pp. 165-172
-
-
Narlawar, R.1
Pickhardt, M.2
Leuchtenberger, S.3
Baumann, K.4
Krause, S.5
Dyrks, T.6
Weggen, S.7
Mandelkow, E.8
Schmidt, B.9
-
127
-
-
44249116000
-
Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
-
Rezai-Zadeh, K., Arendash, G. W., Hou, H., Fernandez, F., Jensen, M., Runfeldt, M., Shytle, R. D., and Tan, J. (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res. 1214, 177-187.
-
(2008)
Brain Res.
, vol.1214
, pp. 177-187
-
-
Rezai-Zadeh, K.1
Arendash, G.W.2
Hou, H.3
Fernandez, F.4
Jensen, M.5
Runfeldt, M.6
Shytle, R.D.7
Tan, J.8
-
128
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., Puigserver, P., Sinclair, D. A., and Tsai, L. H. (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 26, 3169-3179.
-
(2007)
EMBO J.
, vol.26
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
Rodgers, J.T.6
Delalle, I.7
Baur, J.A.8
Sui, G.9
Armour, S.M.10
Puigserver, P.11
Sinclair, D.A.12
Tsai, L.H.13
-
129
-
-
64049092736
-
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
-
Julien, C., Tremblay, C., É mond, V., Lebbadi, M., Salem, N. J., Bennett, D. A., and Calon, F. (2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 68, 48-58.
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, pp. 48-58
-
-
Julien, C.1
Tremblay, C.2
Émond, V.3
Lebbadi, M.4
Salem, N.J.5
Bennett, D.A.6
Calon, F.7
-
130
-
-
84898873423
-
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi
-
Du, L.-L., Xie, J.-Z., Cheng, X.-S., Li, X.-H., Kong, F.-L., Jiang, X., Ma, Z.-W., Wang, J.-Z., Chen, C., and Zhou, X.-W. (2014) Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age 36, 613-623.
-
(2014)
Age
, vol.36
, pp. 613-623
-
-
Du, L.-L.1
Xie, J.-Z.2
Cheng, X.-S.3
Li, X.-H.4
Kong, F.-L.5
Jiang, X.6
Ma, Z.-W.7
Wang, J.-Z.8
Chen, C.9
Zhou, X.-W.10
-
131
-
-
84890126689
-
Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol
-
Lee, H. R., Shin, H. K., Park, S. Y., Kim, H. Y., Lee, W. S., Rhim, B. Y., Hong, K. W., and Kim, C. D. (2014) Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol. J. Neurosci. Res. 92, 206-217.
-
(2014)
J. Neurosci. Res.
, vol.92
, pp. 206-217
-
-
Lee, H.R.1
Shin, H.K.2
Park, S.Y.3
Kim, H.Y.4
Lee, W.S.5
Rhim, B.Y.6
Hong, K.W.7
Kim, C.D.8
-
132
-
-
84892623174
-
Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8
-
Porquet, D., Casadesús, G., Bayod, S., Vicente, A., Canudas, A., Vilaplana, J., Pelegrí, C., Sanfeliu, C., Camins, A., Pallàs, M., and del Valle, J. (2013) Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age 35, 1851-1865.
-
(2013)
Age
, vol.35
, pp. 1851-1865
-
-
Porquet, D.1
Casadesús, G.2
Bayod, S.3
Vicente, A.4
Canudas, A.5
Vilaplana, J.6
Pelegrí, C.7
Sanfeliu, C.8
Camins, A.9
Pallàs, M.10
Del Valle, J.11
-
133
-
-
84892715064
-
Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: An exploratory study
-
Varamini, B., Sikalidis, A. K., and Bradford, K. L. (2013) Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study. Int. J. Food Sci. Nutr. 65, 89-96.
-
(2013)
Int. J. Food Sci. Nutr.
, vol.65
, pp. 89-96
-
-
Varamini, B.1
Sikalidis, A.K.2
Bradford, K.L.3
-
134
-
-
27844497059
-
Resveratrol promotes clearance of Alzheimer's disease amyloid-β peptides
-
Marambaud, P., Zhao, H., and Davies, P. (2005) Resveratrol promotes clearance of Alzheimer's disease amyloid-β peptides. J. Biol. Chem. 280, 37377-37382.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37377-37382
-
-
Marambaud, P.1
Zhao, H.2
Davies, P.3
-
135
-
-
77954907699
-
Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aβ into off-pathway conformers
-
Ladiwala, A. R. A., Lin, J. C., Bale, S. S., Marcelino-Cruz, A. M., Bhattacharya, M., Dordick, J. S., and Tessier, P. M. (2010) Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aβ into off-pathway conformers. J. Biol. Chem. 285, 24228-24237.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 24228-24237
-
-
Ladiwala, A.R.A.1
Lin, J.C.2
Bale, S.S.3
Marcelino-Cruz, A.M.4
Bhattacharya, M.5
Dordick, J.S.6
Tessier, P.M.7
-
136
-
-
67649999248
-
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
-
Almeida, L., Vaz-da-Silva, M., Falcão, A., Soares, E., Costa, R., Loureiro, A. I., Fernandes-Lopes, C., Rocha, J.-F., Nunes, T., Wright, L., and Soares-da-Silva, P. (2009) Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol. Nutr. Food Res. 53, S7-S15.
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. S7-S15
-
-
Almeida, L.1
Vaz-da-Silva, M.2
Falcão, A.3
Soares, E.4
Costa, R.5
Loureiro, A.I.6
Fernandes-Lopes, C.7
Rocha, J.-F.8
Nunes, T.9
Wright, L.10
Soares-da-Silva, P.11
-
137
-
-
67651160771
-
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau
-
Li, W., Sperry, J. B., Crowe, A., Trojanowski, J. Q., Smith Iii, A. B., and Lee, V. M. Y. (2009) Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau. J. Neurochem. 110, 1339-1351.
-
(2009)
J. Neurochem.
, vol.110
, pp. 1339-1351
-
-
Li, W.1
Sperry, J.B.2
Crowe, A.3
Trojanowski, J.Q.4
Smith, A.B.5
Lee, V.M.Y.6
-
138
-
-
79953707326
-
Oleuropein and derivatives from olives as Tau aggregation inhibitors
-
Daccache, A., Lion, C., Sibille, N., Gerard, M., Slomianny, C., Lippens, G., and Cotelle, P. (2011) Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem. Int. 58, 700-707.
-
(2011)
Neurochem. Int.
, vol.58
, pp. 700-707
-
-
Daccache, A.1
Lion, C.2
Sibille, N.3
Gerard, M.4
Slomianny, C.5
Lippens, G.6
Cotelle, P.7
-
139
-
-
62749155335
-
Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection
-
Wu, Y.-T., Lin, L.-C., and Tsai, T.-H. (2009) Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection. J. Chromatogr. A 1216, 3501-3507.
-
(2009)
J. Chromatogr. A
, vol.1216
, pp. 3501-3507
-
-
Wu, Y.-T.1
Lin, L.-C.2
Tsai, T.-H.3
-
140
-
-
0037128935
-
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
-
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., and Mandelkow, E.-M. (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J. Cell Biol. 156, 1051-1063.
-
(2002)
J. Cell Biol.
, vol.156
, pp. 1051-1063
-
-
Stamer, K.1
Vogel, R.2
Thies, E.3
Mandelkow, E.4
Mandelkow, E.-M.5
-
141
-
-
84887973794
-
Potential synergy between tau aggregation inhibitors and tau chaperone modulators
-
Blair, L. J., Z, B., and Dickey, C. A. (2013) Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimer's Res. Ther. 5, 41.
-
(2013)
Alzheimer's Res. Ther.
, vol.5
, pp. 41
-
-
Blair, L.J.1
Z, B.2
Dickey, C.A.3
-
142
-
-
0032514682
-
Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines
-
Caughey, W. S., Raymond, L. D., Horiuchi, M., and Caughey, B. (1998) Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proc. Natl. Acad. Sci. U.S.A. 95, 12117-12122.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 12117-12122
-
-
Caughey, W.S.1
Raymond, L.D.2
Horiuchi, M.3
Caughey, B.4
-
143
-
-
59449092235
-
Amyloid fibrillar meshwork formation of iron-induced oligomeric species of Aβ40 with phthalocyanine tetrasulfonate and its toxic consequences
-
Park, J.-W., Ahn, J. S., Lee, J.-H., Bhak, G., Jung, S., and Paik, S. R. (2008) Amyloid fibrillar meshwork formation of iron-induced oligomeric species of Aβ40 with phthalocyanine tetrasulfonate and its toxic consequences. ChemBioChem 9, 2602-2605.
-
(2008)
ChemBioChem
, vol.9
, pp. 2602-2605
-
-
Park, J.-W.1
Ahn, J.S.2
Lee, J.-H.3
Bhak, G.4
Jung, S.5
Paik, S.R.6
-
144
-
-
14844303721
-
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
-
Taniguchi, S., Suzuki, N., Masuda, M., Hisanaga, S., Iwatsubo, T., Goedert, M., and Hasegawa, M. (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J. Biol. Chem. 280, 7614-7623.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7614-7623
-
-
Taniguchi, S.1
Suzuki, N.2
Masuda, M.3
Hisanaga, S.4
Iwatsubo, T.5
Goedert, M.6
Hasegawa, M.7
-
145
-
-
84874027197
-
Inhibition of tau filament formation by conformational modulation
-
Akoury, E., Gajda, M., Pickhardt, M., Biernat, J., Soraya, P., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2013) Inhibition of tau filament formation by conformational modulation. J. Am. Chem. Soc. 135, 2853-2862.
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 2853-2862
-
-
Akoury, E.1
Gajda, M.2
Pickhardt, M.3
Biernat, J.4
Soraya, P.5
Griesinger, C.6
Mandelkow, E.7
Zweckstetter, M.8
-
146
-
-
77953521942
-
Exebryl-1: A novel small molecule currently in human clinical trials as a disease-modifying drug for the treatment of Alzheimer's disease
-
Snow, A. D., Cummings, J., Lake, T., Hu, Q., Esposito, L., Cam, J., Hudson, M., Smith, E., and Runnels, S. (2009) Exebryl-1: a novel small molecule currently in human clinical trials as a disease-modifying drug for the treatment of Alzheimer's disease. Alzheimer's Dementia 5, P418.
-
(2009)
Alzheimer's Dementia
, vol.5
, pp. 418
-
-
Snow, A.D.1
Cummings, J.2
Lake, T.3
Hu, Q.4
Esposito, L.5
Cam, J.6
Hudson, M.7
Smith, E.8
Runnels, S.9
-
147
-
-
84891102304
-
A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease
-
Song, J. M., DiBattista, A. M., Sung, Y. M., Ahn, J. M., Turner, R. S., Yang, J., Pak, D. T. S., Lee, H.-K., and Hoe, H.-S. (2014) A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease. Exp. Neurol. 252, 105-113.
-
(2014)
Exp. Neurol.
, vol.252
, pp. 105-113
-
-
Song, J.M.1
DiBattista, A.M.2
Sung, Y.M.3
Ahn, J.M.4
Turner, R.S.5
Yang, J.6
Pak, D.T.S.7
Lee, H.-K.8
Hoe, H.-S.9
-
148
-
-
84875182760
-
Mechanistic basis of phenothiazine-driven inhibition of tau aggregation
-
Akoury, E., Pickhardt, M., Gajda, M., Biernat, J., Mandelkow, E., and Zweckstetter, M. (2013) Mechanistic basis of phenothiazine-driven inhibition of tau aggregation. Angew. Chem., Int. Ed. 52, 3511-3515.
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 3511-3515
-
-
Akoury, E.1
Pickhardt, M.2
Gajda, M.3
Biernat, J.4
Mandelkow, E.5
Zweckstetter, M.6
-
149
-
-
84876588286
-
Aminothienopyridazines and methylene blue affect tau fibrillization via cysteine oxidation
-
Crowe, A., James, M. J., Lee, V. M.-Y., Smith, A. B., Trojanowski, J. Q., Ballatore, C., and Brunden, K. R. (2013) Aminothienopyridazines and methylene blue affect tau fibrillization via cysteine oxidation. J. Biol. Chem. 288, 11024-11037.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11024-11037
-
-
Crowe, A.1
James, M.J.2
Lee, V.M.-Y.3
Smith, A.B.4
Trojanowski, J.Q.5
Ballatore, C.6
Brunden, K.R.7
-
150
-
-
47749108256
-
Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain
-
Hattori, M., Sugino, E., Minoura, K., In, Y., Sumida, M., Taniguchi, T., Tomoo, K., and Ishida, T. (2008) Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. Biochem. Biophys. Res. Commun. 374, 158-163.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.374
, pp. 158-163
-
-
Hattori, M.1
Sugino, E.2
Minoura, K.3
In, Y.4
Sumida, M.5
Taniguchi, T.6
Tomoo, K.7
Ishida, T.8
-
151
-
-
84871446624
-
Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice
-
Hosokawa, M., Arai, T., Masuda-Suzukake, M., Nonaka, T., Yamashita, M., Akiyama, H., and Hasegawa, M. (2012) Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice. PLoS One 7, e52389.
-
(2012)
PLoS One
, vol.7
, pp. e52389
-
-
Hosokawa, M.1
Arai, T.2
Masuda-Suzukake, M.3
Nonaka, T.4
Yamashita, M.5
Akiyama, H.6
Hasegawa, M.7
-
152
-
-
84865074623
-
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
-
Fatouros, C., Pir, G. J., Biernat, J., Koushika, S. P., Mandelkow, E., Mandelkow, E.-M., Schmidt, E., and Baumeister, R. (2012) Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Hum. Mol. Genet. 21, 3587-3603.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 3587-3603
-
-
Fatouros, C.1
Pir, G.J.2
Biernat, J.3
Koushika, S.P.4
Mandelkow, E.5
Mandelkow, E.-M.6
Schmidt, E.7
Baumeister, R.8
-
153
-
-
77954954324
-
Methylene blue fails to inhibit tau and polyglutamine protein dependent toxicity in zebrafish
-
van Bebber, F., Paquet, D., Hruscha, A., Schmid, B., and Haass, C. (2010) Methylene blue fails to inhibit tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiol. Dis. 39, 265-271.
-
(2010)
Neurobiol. Dis.
, vol.39
, pp. 265-271
-
-
Van Bebber, F.1
Paquet, D.2
Hruscha, A.3
Schmid, B.4
Haass, C.5
-
154
-
-
84893473873
-
Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy
-
Spires-Jones, T. L., Friedman, T., Pitstick, R., Polydoro, M., Roe, A., Carlson, G. A., and Hyman, B. T. (2014) Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci. Lett. 562, 63-68.
-
(2014)
Neurosci. Lett.
, vol.562
, pp. 63-68
-
-
Spires-Jones, T.L.1
Friedman, T.2
Pitstick, R.3
Polydoro, M.4
Roe, A.5
Carlson, G.A.6
Hyman, B.T.7
-
155
-
-
77958566761
-
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
-
O'Leary, J., Li, Q., Marinec, P., Blair, L., Congdon, E., Johnson, A., Jinwal, U., Koren, J., Jones, J., Kraft, C., Peters, M., Abisambra, J., Duff, K., Weeber, E., Gestwicki, J., and Dickey, C. (2010) Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Mol. Neurodegener. 5, 45.
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 45
-
-
O'Leary, J.1
Li, Q.2
Marinec, P.3
Blair, L.4
Congdon, E.5
Johnson, A.6
Jinwal, U.7
Koren, J.8
Jones, J.9
Kraft, C.10
Peters, M.11
Abisambra, J.12
Duff, K.13
Weeber, E.14
Gestwicki, J.15
Dickey, C.16
-
156
-
-
84902953435
-
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity
-
Stack, C., Jainuddin, S., Elipenahli, C., Gerges, M., Starkova, N., Starkov, A. A., Jové, M., Portero-Otin, M., Launay, N., Pujol, A., Kaidery, N. A., Thomas, B., Tampellini, D., Beal, M. F., and Dumont, M. (2014) Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity. Hum. Mol. Genet. 23, 3716-3732.
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 3716-3732
-
-
Stack, C.1
Jainuddin, S.2
Elipenahli, C.3
Gerges, M.4
Starkova, N.5
Starkov, A.A.6
Jové, M.7
Portero-Otin, M.8
Launay, N.9
Pujol, A.10
Kaidery, N.A.11
Thomas, B.12
Tampellini, D.13
Beal, M.F.14
Dumont, M.15
-
157
-
-
79251555689
-
Methylene blue reduces Aβ levels and rescues early cognitive deficit by increasing proteasome activity
-
Medina, D. X., Caccamo, A., and Oddo, S. (2011) Methylene blue reduces Aβ levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol. 21, 140-149.
-
(2011)
Brain Pathol.
, vol.21
, pp. 140-149
-
-
Medina, D.X.1
Caccamo, A.2
Oddo, S.3
-
158
-
-
51349134160
-
Hope in Alzheimer's fight emerges from unexpected places
-
T, G. (2008) Hope in Alzheimer's fight emerges from unexpected places. Nat. Med. 14, 894.
-
(2008)
Nat. Med.
, vol.14
, pp. 894
-
-
T, G.1
-
159
-
-
33644851265
-
Inducible expression of tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs
-
Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen, M., Gazova, Z., Mandelkow, E., and Mandelkow, E.-M. (2006) Inducible expression of tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. J. Biol. Chem. 281, 1205-1214.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1205-1214
-
-
Khlistunova, I.1
Biernat, J.2
Wang, Y.3
Pickhardt, M.4
Von Bergen, M.5
Gazova, Z.6
Mandelkow, E.7
Mandelkow, E.-M.8
-
160
-
-
34548691220
-
N-Phenylamine derivatives as aggregation inhibitors in cell models of tauopathy
-
Pickhardt, M., B, J., Khlistunova, I., Wang, Y. P., Gazova, Z., Mandelkow, E. M., and Mandelkow, E. (2007) N-Phenylamine derivatives as aggregation inhibitors in cell models of tauopathy. Curr. Alzheimer Res. 4, 397-402.
-
(2007)
Curr. Alzheimer Res.
, vol.4
, pp. 397-402
-
-
Pickhardt, M.1
B, J.2
Khlistunova, I.3
Wang, Y.P.4
Gazova, Z.5
Mandelkow, E.M.6
Mandelkow, E.7
-
161
-
-
34548502687
-
Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of τaggregation and toxicity in vitro and in cells
-
Pickhardt, M., Larbig, G., Khlistunova, I., Coksezen, A., Meyer, B., Mandelkow, E.-M., Schmidt, B., and Mandelkow, E. (2007) Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of τaggregation and toxicity in vitro and in cells. Biochemistry 46, 10016-10023.
-
(2007)
Biochemistry
, vol.46
, pp. 10016-10023
-
-
Pickhardt, M.1
Larbig, G.2
Khlistunova, I.3
Coksezen, A.4
Meyer, B.5
Mandelkow, E.-M.6
Schmidt, B.7
Mandelkow, E.8
-
162
-
-
78650392793
-
3D QSAR CoMFA study on phenylthiazolylhydrazide (PTH) derivatives as tau protein aggregation inhibitors
-
Park, H., Kim, M. K., Kim, D. W., Choo, I. L. H., and Chong, Y. (2010) 3D QSAR CoMFA study on phenylthiazolylhydrazide (PTH) derivatives as tau protein aggregation inhibitors. Bull. Korean Chem. Soc. 31, 3838-3841.
-
(2010)
Bull. Korean Chem. Soc.
, vol.31
, pp. 3838-3841
-
-
Park, H.1
Kim, M.K.2
Kim, D.W.3
Choo, I.L.H.4
Chong, Y.5
-
163
-
-
13544251748
-
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
Pickhardt, M., Gazova, Z., von Bergen, M., Khlistunova, I., Wang, Y., Hascher, A., Mandelkow, E.-M., Biernat, J., and Mandelkow, E. (2005) Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J. Biol. Chem. 280, 3628-3635.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3628-3635
-
-
Pickhardt, M.1
Gazova, Z.2
Von Bergen, M.3
Khlistunova, I.4
Wang, Y.5
Hascher, A.6
Mandelkow, E.-M.7
Biernat, J.8
Mandelkow, E.9
-
164
-
-
77952081276
-
Discovery of brain-penetrant, orally bioavailable amino-thienopyridazine inhibitors of tau aggregation
-
Ballatore, C., Brunden, K. R., Piscitelli, F., James, M. J., Crowe, A., Yao, Y., Hyde, E., Trojanowski, J. Q., Lee, V. M. Y., and Smith, A. B. (2010) Discovery of brain-penetrant, orally bioavailable amino-thienopyridazine inhibitors of tau aggregation. J. Med. Chem. 53, 3739-3747.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 3739-3747
-
-
Ballatore, C.1
Brunden, K.R.2
Piscitelli, F.3
James, M.J.4
Crowe, A.5
Yao, Y.6
Hyde, E.7
Trojanowski, J.Q.8
Lee, V.M.Y.9
Smith, A.B.10
-
165
-
-
84863202528
-
Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure - activity relationship leads to selection of candidates with desirable in vivo properties
-
Ballatore, C., Crowe, A., Piscitelli, F., James, M., Lou, K., Rossidivito, G., Yao, Y., Trojanowski, J. Q., Lee, V. M. Y., Brunden, K. R., and Smith Iii, A. B. (2012) Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure - activity relationship leads to selection of candidates with desirable in vivo properties. Bioorg. Med. Chem. 20, 4451-4461.
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 4451-4461
-
-
Ballatore, C.1
Crowe, A.2
Piscitelli, F.3
James, M.4
Lou, K.5
Rossidivito, G.6
Yao, Y.7
Trojanowski, J.Q.8
Lee, V.M.Y.9
Brunden, K.R.10
Smith Iii, A.B.11
-
166
-
-
68849086671
-
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening
-
Crowe, A., Huang, W., Ballatore, C., Johnson, R. L., Hogan, A.-M. L., Huang, R., Wichterman, J., McCoy, J., Huryn, D., Auld, D. S., Smith, A. B., Inglese, J., Trojanowski, J. Q., Austin, C. P., Brunden, K. R., and Lee, V. M. Y. (2009) Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry 48, 7732-7745.
-
(2009)
Biochemistry
, vol.48
, pp. 7732-7745
-
-
Crowe, A.1
Huang, W.2
Ballatore, C.3
Johnson, R.L.4
Hogan, A.-M.L.5
Huang, R.6
Wichterman, J.7
McCoy, J.8
Huryn, D.9
Auld, D.S.10
Smith, A.B.11
Inglese, J.12
Trojanowski, J.Q.13
Austin, C.P.14
Brunden, K.R.15
Lee, V.M.Y.16
-
167
-
-
33746456027
-
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: The 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial
-
Hotta, N., Akanuma, Y., Kawamori, R., Matsuoka, K., Oka, Y., Shichiri, M., Toyota, T., Nakashima, M., Yoshimura, I., Sakamoto, N., Shigeta, Y., and Group, t. A. S. (2006) Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial. Diabetes Care 29, 1538-1544.
-
(2006)
Diabetes Care
, vol.29
, pp. 1538-1544
-
-
Hotta, N.1
Akanuma, Y.2
Kawamori, R.3
Matsuoka, K.4
Oka, Y.5
Shichiri, M.6
Toyota, T.7
Nakashima, M.8
Yoshimura, I.9
Sakamoto, N.10
Shigeta, Y.11
-
168
-
-
37349128195
-
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy
-
Bulic, B., Pickhardt, M., Khlistunova, I., Biernat, J., Mandelkow, E.-M., Mandelkow, E., and Waldmann, H. (2007) Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angew. Chem., Int. Ed. 46, 9215-9219.
-
(2007)
Angew. Chem., Int. Ed.
, vol.46
, pp. 9215-9219
-
-
Bulic, B.1
Pickhardt, M.2
Khlistunova, I.3
Biernat, J.4
Mandelkow, E.-M.5
Mandelkow, E.6
Waldmann, H.7
-
169
-
-
84873438430
-
Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors
-
Messing, L., Decker, J. M., Joseph, M., Mandelkow, E., and Mandelkow, E.-M. (2013) Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiol. Aging 34, 1343-1354.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1343-1354
-
-
Messing, L.1
Decker, J.M.2
Joseph, M.3
Mandelkow, E.4
Mandelkow, E.-M.5
-
170
-
-
0029114196
-
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments
-
Schweers, O., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (1995) Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proc. Natl. Acad. Sci. U.S.A. 92, 8463-8467.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 8463-8467
-
-
Schweers, O.1
Mandelkow, E.M.2
Biernat, J.3
Mandelkow, E.4
-
171
-
-
71749113077
-
Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322
-
Mo, Z.-Y., Zhu, Y.-Z., Zhu, H.-L., Fan, J.-B., Chen, J., and Liang, Y. (2009) Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322. J. Biol. Chem. 284, 34648-34657.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 34648-34657
-
-
Mo, Z.-Y.1
Zhu, Y.-Z.2
Zhu, H.-L.3
Fan, J.-B.4
Chen, J.5
Liang, Y.6
-
172
-
-
84865663663
-
β-Sheet core of tau paired helical filaments revealed by solid-state NMR
-
Daebel, V., Chinnathambi, S., Biernat, J., Schwalbe, M., Habenstein, B., Loquet, A., Akoury, E., Tepper, K., Müller, H., Baldus, M., Griesinger, C., Zweckstetter, M., Mandelkow, E., Vijayan, V., and Lange, A. (2012) β-Sheet core of tau paired helical filaments revealed by solid-state NMR. J. Am. Chem. Soc. 134, 13982-13989.
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 13982-13989
-
-
Daebel, V.1
Chinnathambi, S.2
Biernat, J.3
Schwalbe, M.4
Habenstein, B.5
Loquet, A.6
Akoury, E.7
Tepper, K.8
Müller, H.9
Baldus, M.10
Griesinger, C.11
Zweckstetter, M.12
Mandelkow, E.13
Vijayan, V.14
Lange, A.15
-
173
-
-
84858595119
-
Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations
-
Walker, S., Ullman, O., and Stultz, C. M. (2012) Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations. J. Biol. Chem. 287, 9591-9600.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 9591-9600
-
-
Walker, S.1
Ullman, O.2
Stultz, C.M.3
-
174
-
-
84924991419
-
Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide crosslinking
-
Haque, M. M., Kim, D., Yu, Y. H., Lim, S., Kim, D. J., Chang, Y.-T., Ha, H.-H., and Kim, Y. K. (2014) Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide crosslinking. Amyloid, 1-7.
-
(2014)
Amyloid
, pp. 1-7
-
-
Haque, M.M.1
Kim, D.2
Yu, Y.H.3
Lim, S.4
Kim, D.J.5
Chang, Y.-T.6
Ha, H.-H.7
Kim, Y.K.8
-
175
-
-
79952263121
-
Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide
-
Zheng, J., Liu, C., Sawaya, M. R., Vadla, B., Khan, S., Woods, R. J., Eisenberg, D., Goux, W. J., and Nowick, J. S. (2011) Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J. Am. Chem. Soc. 133, 3144-3157.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 3144-3157
-
-
Zheng, J.1
Liu, C.2
Sawaya, M.R.3
Vadla, B.4
Khan, S.5
Woods, R.J.6
Eisenberg, D.7
Goux, W.J.8
Nowick, J.S.9
-
176
-
-
84887440374
-
Structural determinants of tau aggregation inhibitor potency
-
Schafer, K. N., Cisek, K., Huseby, C. J., Chang, E., and Kuret, J. (2013) Structural determinants of tau aggregation inhibitor potency. J. Biol. Chem. 288, 32599-32611.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 32599-32611
-
-
Schafer, K.N.1
Cisek, K.2
Huseby, C.J.3
Chang, E.4
Kuret, J.5
-
177
-
-
34548258322
-
Accelerating amyloid-βfibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
-
Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., Puoliväli, J., Lesné, S., Ashe, K. H., Muchowski, P. J., and Mucke, L. (2007) Accelerating amyloid-βfibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J. Biol. Chem. 282, 23818-23828.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23818-23828
-
-
Cheng, I.H.1
Scearce-Levie, K.2
Legleiter, J.3
Palop, J.J.4
Gerstein, H.5
Bien-Ly, N.6
Puoliväli, J.7
Lesné, S.8
Ashe, K.H.9
Muchowski, P.J.10
Mucke, L.11
-
178
-
-
79952105548
-
Posttranslational modifications of tau protein: Implications for Alzheimer's disease
-
Martin, L., Latypova, X., and Terro, F. (2011) Posttranslational modifications of tau protein: implications for Alzheimer's disease. Neurochem. Int. 58, 458-471.
-
(2011)
Neurochem. Int.
, vol.58
, pp. 458-471
-
-
Martin, L.1
Latypova, X.2
Terro, F.3
-
179
-
-
0033596946
-
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
-
Schneider, A., Biernat, J., von Bergen, M., Mandelkow, E., and Mandelkow, E. M. (1999) Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38, 3549-3558.
-
(1999)
Biochemistry
, vol.38
, pp. 3549-3558
-
-
Schneider, A.1
Biernat, J.2
Von Bergen, M.3
Mandelkow, E.4
Mandelkow, E.M.5
-
180
-
-
0033677809
-
C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease
-
Abraha, A., Ghoshal, N., Gamblin, T. C., Cryns, V., Berry, R. W., Kuret, J., and Binder, L. I. (2000) C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J. Cell Sci. 113, 3737-3745.
-
(2000)
J. Cell Sci.
, vol.113
, pp. 3737-3745
-
-
Abraha, A.1
Ghoshal, N.2
Gamblin, T.C.3
Cryns, V.4
Berry, R.W.5
Kuret, J.6
Binder, L.I.7
-
181
-
-
1642280378
-
Pseudophosphorylation of tau protein alters its ability for self-aggregation
-
Haase, C., Stieler, J. T., Arendt, T., and Holzer, M. (2004) Pseudophosphorylation of tau protein alters its ability for self-aggregation. J. Neurochem. 88, 1509-1520.
-
(2004)
J. Neurochem.
, vol.88
, pp. 1509-1520
-
-
Haase, C.1
Stieler, J.T.2
Arendt, T.3
Holzer, M.4
-
182
-
-
36949040819
-
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation
-
Liu, F., Li, B., Tung, E. J., Grundke-Iqbal, I., Iqbal, K., and Gong, C.-X. (2007) Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. Eur. J. Neurosci. 26, 3429-3436.
-
(2007)
Eur. J. Neurosci.
, vol.26
, pp. 3429-3436
-
-
Liu, F.1
Li, B.2
Tung, E.J.3
Grundke-Iqbal, I.4
Iqbal, K.5
Gong, C.-X.6
-
183
-
-
43449128899
-
Biochemistry of tau in Alzheimer's disease and related neurological disorders
-
Sergeant, N., Bretteville, A., Hamdane, M., Caillet-Boudin, M.-L., Grognet, P., Bombois, S., Blum, D., Delacourte, A., Pasquier, F., Vanmechelen, E., Schraen-Maschke, S., and Buée, L. (2008) Biochemistry of tau in Alzheimer's disease and related neurological disorders. Expert Rev. Proteomics 5, 207-224.
-
(2008)
Expert Rev. Proteomics
, vol.5
, pp. 207-224
-
-
Sergeant, N.1
Bretteville, A.2
Hamdane, M.3
Caillet-Boudin, M.-L.4
Grognet, P.5
Bombois, S.6
Blum, D.7
Delacourte, A.8
Pasquier, F.9
Vanmechelen, E.10
Schraen-Maschke, S.11
Buée, L.12
-
184
-
-
34250818767
-
Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles
-
Caccamo, A., Oddo, S., Tran, L. X., and LaFerla, F. M. (2007) Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles. Am. J. Pathol. 170, 1669-1675.
-
(2007)
Am. J. Pathol.
, vol.170
, pp. 1669-1675
-
-
Caccamo, A.1
Oddo, S.2
Tran, L.X.3
LaFerla, F.M.4
-
185
-
-
33845530335
-
Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert
-
Engel, T., Goñi-Oliver, P., Lucas, J. J., Avila, J., and Hernández, F. (2006) Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J. Neurochem. 99, 1445-1455.
-
(2006)
J. Neurochem.
, vol.99
, pp. 1445-1455
-
-
Engel, T.1
Goñi-Oliver, P.2
Lucas, J.J.3
Avila, J.4
Hernández, F.5
-
186
-
-
28844481487
-
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies
-
Nakashima, H., Ishihara, T., Suguimoto, P., Yokota, O., Oshima, E., Kugo, A., Terada, S., Hamamura, T., Trojanowski, J., Lee, V. Y., and Kuroda, S. (2005) Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta Neuropathol. 110, 547-556.
-
(2005)
Acta Neuropathol.
, vol.110
, pp. 547-556
-
-
Nakashima, H.1
Ishihara, T.2
Suguimoto, P.3
Yokota, O.4
Oshima, E.5
Kugo, A.6
Terada, S.7
Hamamura, T.8
Trojanowski, J.9
Lee, V.Y.10
Kuroda, S.11
-
187
-
-
68149150844
-
A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
-
Serenó, L., Coma, M., Rodríguez, M., Sánchez-Ferrer, P., Sánchez, M. B., Gich, I., Agulló, J. M., Pérez, M., Avila, J., Guardia-Laguarta, C., Clarimón, J., Lleó, A., and Gómez-Isla, T. (2009) A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiol. Dis. 35, 359-367.
-
(2009)
Neurobiol. Dis.
, vol.35
, pp. 359-367
-
-
Serenó, L.1
Coma, M.2
Rodríguez, M.3
Sánchez-Ferrer, P.4
Sánchez, M.B.5
Gich, I.6
Agulló, J.M.7
Pérez, M.8
Avila, J.9
Guardia-Laguarta, C.10
Clarimón, J.11
Lleó, A.12
Gómez-Isla, T.13
-
188
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
Noble, W., Planel, E., Zehr, C., Olm, V., Meyerson, J., Suleman, F., Gaynor, K., Wang, L., LaFrancois, J., Feinstein, B., Burns, M., Krishnamurthy, P., Wen, Y., Bhat, R., Lewis, J., Dickson, D., and Duff, K. (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc. Natl. Acad. Sci. U.S.A. 102, 6990-6995.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
Suleman, F.6
Gaynor, K.7
Wang, L.8
LaFrancois, J.9
Feinstein, B.10
Burns, M.11
Krishnamurthy, P.12
Wen, Y.13
Bhat, R.14
Lewis, J.15
Dickson, D.16
Duff, K.17
-
189
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu, F., Grundke-Iqbal, I., Iqbal, K., and Gong, C.-X. (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur. J. Neurosci. 22, 1942-1950.
-
(2005)
Eur. J. Neurosci.
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.-X.4
-
190
-
-
33846212717
-
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
-
Wang, J.-Z., Grundke-Iqbal, I., and Iqbal, K. (2007) Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur. J. Neurosci. 25, 59-68.
-
(2007)
Eur. J. Neurosci.
, vol.25
, pp. 59-68
-
-
Wang, J.-Z.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
191
-
-
81155126062
-
Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation
-
Jung, M.-S., Park, J.-H., Ryu, Y. S., Choi, S.-H., Yoon, S.-H., Kwen, M.-Y., Oh, J. Y., Song, W.-J., and Chung, S.-H. (2011) Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J. Biol. Chem. 286, 40401-40412.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 40401-40412
-
-
Jung, M.-S.1
Park, J.-H.2
Ryu, Y.S.3
Choi, S.-H.4
Yoon, S.-H.5
Kwen, M.-Y.6
Oh, J.Y.7
Song, W.-J.8
Chung, S.-H.9
-
192
-
-
51349109221
-
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
-
Liu, F., Liang, Z., Wegiel, J., Hwang, Y.-W., Iqbal, K., Grundke-Iqbal, I., Ramakrishna, N., and Gong, C.-X. (2008) Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J. 22, 3224-3233.
-
(2008)
FASEB J.
, vol.22
, pp. 3224-3233
-
-
Liu, F.1
Liang, Z.2
Wegiel, J.3
Hwang, Y.-W.4
Iqbal, K.5
Grundke-Iqbal, I.6
Ramakrishna, N.7
Gong, C.-X.8
-
193
-
-
0035340295
-
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: Potential role for DYRK as a glycogen synthase kinase 3-priming kinase
-
Woods, Y. L., Cohen, P., Becker, W., Jakes, R., Goedert, M., Wang, X., and Proud, C. G. (2001) The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochem. J. 355, 609-615.
-
(2001)
Biochem. J.
, vol.355
, pp. 609-615
-
-
Woods, Y.L.1
Cohen, P.2
Becker, W.3
Jakes, R.4
Goedert, M.5
Wang, X.6
Proud, C.G.7
-
194
-
-
57649134248
-
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in down syndrome
-
Shi, J., Zhang, T., Zhou, C., Chohan, M. O., Gu, X., Wegiel, J., Zhou, J., Hwang, Y.-W., Iqbal, K., Grundke-Iqbal, I., Gong, C.-X., and Liu, F. (2008) Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in down syndrome. J. Biol. Chem. 283, 28660-28669.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 28660-28669
-
-
Shi, J.1
Zhang, T.2
Zhou, C.3
Chohan, M.O.4
Gu, X.5
Wegiel, J.6
Zhou, J.7
Hwang, Y.-W.8
Iqbal, K.9
Grundke-Iqbal, I.10
Gong, C.-X.11
Liu, F.12
-
195
-
-
84865756788
-
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted tau exon 10 inclusion
-
Yin, X., Jin, N., Gu, J., Shi, J., Zhou, J., Gong, C.-X., Iqbal, K., Grundke-Iqbal, I., and Liu, F. (2012) Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted tau exon 10 inclusion. J. Biol. Chem. 287, 30497-30506.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 30497-30506
-
-
Yin, X.1
Jin, N.2
Gu, J.3
Shi, J.4
Zhou, J.5
Gong, C.-X.6
Iqbal, K.7
Grundke-Iqbal, I.8
Liu, F.9
-
196
-
-
39749196069
-
Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: Evidence for a functional link between Down Syndrome and Alzheimer's disease
-
Ryoo, S.-R., Cho, H.-J., Lee, H.-W., Jeong, H. K., Radnaabazar, C., Kim, Y.-S., Kim, M.-J., Son, M.-Y., Seo, H., Chung, S.-H., and Song, W.-J. (2008) Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down Syndrome and Alzheimer's disease. J. Neurochem. 104, 1333-1344.
-
(2008)
J. Neurochem.
, vol.104
, pp. 1333-1344
-
-
Ryoo, S.-R.1
Cho, H.-J.2
Lee, H.-W.3
Jeong, H.K.4
Radnaabazar, C.5
Kim, Y.-S.6
Kim, M.-J.7
Son, M.-Y.8
Seo, H.9
Chung, S.-H.10
Song, W.-J.11
-
197
-
-
78651063834
-
Dyrk1A-mediated phosphorylation of presenilin 1: A functional link between Down Syndrome and Alzheimer's disease
-
Ryu, Y. S., Park, S. Y., Jung, M.-S., Yoon, S.-H., Kwen, M.-Y., Lee, S.-Y., Choi, S.-H., Radnaabazar, C., Kim, M.-K., Kim, H., Kim, K., Song, W.-J., and Chung, S.-H. (2010) Dyrk1A-mediated phosphorylation of presenilin 1: a functional link between Down Syndrome and Alzheimer's disease. J. Neurochem. 115, 574-584.
-
(2010)
J. Neurochem.
, vol.115
, pp. 574-584
-
-
Ryu, Y.S.1
Park, S.Y.2
Jung, M.-S.3
Yoon, S.-H.4
Kwen, M.-Y.5
Lee, S.-Y.6
Choi, S.-H.7
Radnaabazar, C.8
Kim, M.-K.9
Kim, H.10
Kim, K.11
Song, W.-J.12
Chung, S.-H.13
-
198
-
-
26944433068
-
Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down Syndrome, Pick disease, and related transgenic models
-
Ferrer, I., Barrachina, M., Puig, B., Martínez de Lagrán, M., Martí, E., Avila, J., and Dierssen, M. (2005) Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down Syndrome, Pick disease, and related transgenic models. Neurobiol. Dis. 20, 392-400.
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 392-400
-
-
Ferrer, I.1
Barrachina, M.2
Puig, B.3
Martínez De Lagrán, M.4
Martí, E.5
Avila, J.6
Dierssen, M.7
-
199
-
-
84869782889
-
Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: A new avenue for a disease modifying treatment of Alzheimer's?
-
Smith, B., Medda, F., Gokhale, V., Dunckley, T., and Hulme, C. (2012) Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's? ACS Chem. Neurosci. 3, 857-872.
-
(2012)
ACS Chem. Neurosci.
, vol.3
, pp. 857-872
-
-
Smith, B.1
Medda, F.2
Gokhale, V.3
Dunckley, T.4
Hulme, C.5
-
200
-
-
79955827792
-
β-Carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites
-
Frost, D., Meechoovet, B., Wang, T., Gately, S., Giorgetti, M., Shcherbakova, I., and Dunckley, T. (2011) β-Carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites. PLoS One 6, e19264.
-
(2011)
PLoS One
, vol.6
, pp. e19264
-
-
Frost, D.1
Meechoovet, B.2
Wang, T.3
Gately, S.4
Giorgetti, M.5
Shcherbakova, I.6
Dunckley, T.7
-
201
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain, J., McLauchlan, H., Elliott, M., and Cohen, P. (2003) The specificities of protein kinase inhibitors: an update. Biochem. J. 371, 199-204.
-
(2003)
Biochem. J.
, vol.371
, pp. 199-204
-
-
Bain, J.1
McLauchlan, H.2
Elliott, M.3
Cohen, P.4
-
202
-
-
84864280635
-
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A
-
Guedj, F., Sébrié, C., Rivals, I., Ledru, A., Paly, E., Bizot, J. C., Smith, D., Rubin, E., Gillet, B., Arbones, M., and Delabar, J. M. (2009) Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. PLoS One 4, e4606.
-
(2009)
PLoS One
, vol.4
, pp. e4606
-
-
Guedj, F.1
Sébrié, C.2
Rivals, I.3
Ledru, A.4
Paly, E.5
Bizot, J.C.6
Smith, D.7
Rubin, E.8
Gillet, B.9
Arbones, M.10
Delabar, J.M.11
-
203
-
-
68249130300
-
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2
-
Cozza, G., M, M., Papinutto, E., Bain, J., Elliott, M., di Maira, G., Gianoncelli, A., Pagano, M. A., Sarno, S., Ruzzene, M., Battistutta, R., Meggio, F., Moro, S., Zagotto, G., and Pinna, L. A. (2009) Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem. J. 421, 387-395.
-
(2009)
Biochem. J.
, vol.421
, pp. 387-395
-
-
Cozza, G.1
M, M.2
Papinutto, E.3
Bain, J.4
Elliott, M.5
Di Maira, G.6
Gianoncelli, A.7
Pagano, M.A.8
Sarno, S.9
Ruzzene, M.10
Battistutta, R.11
Meggio, F.12
Moro, S.13
Zagotto, G.14
Pinna, L.A.15
-
204
-
-
77956504025
-
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy
-
Bhaskar, K., Hobbs, G. A., Yen, S. H., and Lee, G. (2010) Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathol. Appl. Neurobiol. 36, 462-477.
-
(2010)
Neuropathol. Appl. Neurobiol.
, vol.36
, pp. 462-477
-
-
Bhaskar, K.1
Hobbs, G.A.2
Yen, S.H.3
Lee, G.4
-
205
-
-
84869992747
-
The complex PrPc-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease
-
Larson, M., Sherman, M. A., Amar, F., Nuvolone, M., Schneider, J. A., Bennett, D. A., Aguzzi, A., and Lesné, S. E. (2012) The complex PrPc-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease. J. Neurosci. 32, 16857-16871.
-
(2012)
J. Neurosci.
, vol.32
, pp. 16857-16871
-
-
Larson, M.1
Sherman, M.A.2
Amar, F.3
Nuvolone, M.4
Schneider, J.A.5
Bennett, D.A.6
Aguzzi, A.7
Lesné, S.E.8
-
206
-
-
0036469248
-
Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein tau
-
Klein, C., Krämer, E.-M., Cardine, A.-M., Schraven, B., Brandt, R., and Trotter, J. (2002) Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein tau. J. Neurosci. 22, 698-707.
-
(2002)
J. Neurosci.
, vol.22
, pp. 698-707
-
-
Klein, C.1
Krämer, E.-M.2
Cardine, A.-M.3
Schraven, B.4
Brandt, R.5
Trotter, J.6
-
207
-
-
82755189704
-
Dynamic association of tau with neuronal membranes is regulated by phosphorylation
-
Pooler, A., Usardi, A., Evans, C., Philpott, K., Noble, W., and Hanger, D. (2012) Dynamic association of tau with neuronal membranes is regulated by phosphorylation. Neurobiol. Aging 33, 431.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 431
-
-
Pooler, A.1
Usardi, A.2
Evans, C.3
Philpott, K.4
Noble, W.5
Hanger, D.6
-
208
-
-
27444437758
-
Disease-related modifications in tau affect the interaction between Fyn and Tau
-
Bhaskar, K., Yen, S.-H., and Lee, G. (2005) Disease-related modifications in tau affect the interaction between Fyn and Tau. J. Biol. Chem. 280, 35119-35125.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35119-35125
-
-
Bhaskar, K.1
Yen, S.-H.2
Lee, G.3
-
209
-
-
0041888516
-
Trafficking of prion proteins through a caveolae-mediated endosomal pathway
-
Peters, P. J., Mironov, A., Peretz, D., van Donselaar, E., Leclerc, E., Erpel, S., DeArmond, S. J., Burton, D. R., Williamson, R. A., Vey, M., and Prusiner, S. B. (2003) Trafficking of prion proteins through a caveolae-mediated endosomal pathway. J. Cell Biol. 162, 703-717.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 703-717
-
-
Peters, P.J.1
Mironov, A.2
Peretz, D.3
Van Donselaar, E.4
Leclerc, E.5
Erpel, S.6
DeArmond, S.J.7
Burton, D.R.8
Williamson, R.A.9
Vey, M.10
Prusiner, S.B.11
-
210
-
-
79551677684
-
Cells respond to mechanical stress by rapid disassembly of caveolae
-
Sinha, B., Köster, D., Ruez, R., Gonnord, P., Bastiani, M., Abankwa, D., Stan, R. V., Butler-Browne, G., Vedie, B., Johannes, L., Morone, N., Parton, R. G., Raposo, G., Sens, P., Lamaze, C., and Nassoy, P. (2011) Cells respond to mechanical stress by rapid disassembly of caveolae. Cell 144, 402-413.
-
(2011)
Cell
, vol.144
, pp. 402-413
-
-
Sinha, B.1
Köster, D.2
Ruez, R.3
Gonnord, P.4
Bastiani, M.5
Abankwa, D.6
Stan, R.V.7
Butler-Browne, G.8
Vedie, B.9
Johannes, L.10
Morone, N.11
Parton, R.G.12
Raposo, G.13
Sens, P.14
Lamaze, C.15
Nassoy, P.16
-
211
-
-
79957803165
-
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: A randomised, placebo-controlled phase 2 trial
-
Piette, F., Belmin, J., Vincent, H., Schmidt, N., Pariel, S., Verny, M., Marquis, C., Mely, J., Hugonot-Diener, L., Kinet, J.-P., Dubreuil, P., Moussy, A., and Hermine, O. (2011) Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial. Alzheimer's Res. Ther. 3, 16.
-
(2011)
Alzheimer's Res. Ther.
, vol.3
, pp. 16
-
-
Piette, F.1
Belmin, J.2
Vincent, H.3
Schmidt, N.4
Pariel, S.5
Verny, M.6
Marquis, C.7
Mely, J.8
Hugonot-Diener, L.9
Kinet, J.-P.10
Dubreuil, P.11
Moussy, A.12
Hermine, O.13
-
212
-
-
84893832278
-
Fyn kinase inhibition as a novel therapy for Alzheimer's disease
-
Nygaard, H. B., v, D. C., and Strittmatter, S. M. (2014) Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimer's Res. Ther. 6, 8.
-
(2014)
Alzheimer's Res. Ther.
, vol.6
, pp. 8
-
-
Nygaard, H.B.1
V, D.C.2
Strittmatter, S.M.3
-
213
-
-
56149091270
-
Small molecule, non-peptide p75NTR ligands inhibit Aβ-induced neurodegeneration and synaptic impairment
-
Yang, T., Knowles, J. K., Lu, Q., Zhang, H., Arancio, O., Moore, L. A., Chang, T., Wang, Q., Andreasson, K., Rajadas, J., Fuller, G. G., Xie, Y., Massa, S. M., and Longo, F. M. (2008) Small molecule, non-peptide p75NTR ligands inhibit Aβ-induced neurodegeneration and synaptic impairment. PLoS One 3, e3604.
-
(2008)
PLoS One
, vol.3
, pp. e3604
-
-
Yang, T.1
Knowles, J.K.2
Lu, Q.3
Zhang, H.4
Arancio, O.5
Moore, L.A.6
Chang, T.7
Wang, Q.8
Andreasson, K.9
Rajadas, J.10
Fuller, G.G.11
Xie, Y.12
Massa, S.M.13
Longo, F.M.14
-
214
-
-
84908006750
-
Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPPL/S transgenic mice
-
in press
-
Nguyen, T.-V.; Shen, L.; Vander Griend, L.; Quach, L. N.; Belichenko, N. P.; Saw, N.; Yang, T.; Shamloo, M.; Wyss-Coray, T.; Massa, S. M.; Longo, F. M. (2014) Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPPL/S transgenic mice. J. Alzheimer's Dis., DOI: 10.3233/JAD-140036, in press.
-
(2014)
J. Alzheimer's Dis.
-
-
Nguyen, T.-V.1
Shen, L.2
Vander Griend, L.3
Quach, L.N.4
Belichenko, N.P.5
Saw, N.6
Yang, T.7
Shamloo, M.8
Wyss-Coray, T.9
Massa, S.M.10
Longo, F.M.11
-
215
-
-
57049125529
-
Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin
-
Jolivalt, C. G., Lee, C. A., Beiswenger, K. K., Smith, J. L., Orlov, M., Torrance, M. A., and Masliah, E. (2008) Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J. Neurosci. Res. 86, 3265-3274.
-
(2008)
J. Neurosci. Res.
, vol.86
, pp. 3265-3274
-
-
Jolivalt, C.G.1
Lee, C.A.2
Beiswenger, K.K.3
Smith, J.L.4
Orlov, M.5
Torrance, M.A.6
Masliah, E.7
-
216
-
-
33845515523
-
Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency
-
Clodfelder-Miller, B. J., Zmijewska, A. A., Johnson, G. V. W., and Jope, R. S. (2006) Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes 55, 3320-3325.
-
(2006)
Diabetes
, vol.55
, pp. 3320-3325
-
-
Clodfelder-Miller, B.J.1
Zmijewska, A.A.2
Johnson, G.V.W.3
Jope, R.S.4
-
217
-
-
84892690389
-
The neuroprotection of liraglutide on alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice
-
Xiong, H., Zheng, C., Wang, J., Song, J., Zhao, G., Shen, H., and Deng, Y. (2013) The neuroprotection of liraglutide on alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. J. Alzheimer's Dis. 37, 623-635.
-
(2013)
J. Alzheimer's Dis.
, vol.37
, pp. 623-635
-
-
Xiong, H.1
Zheng, C.2
Wang, J.3
Song, J.4
Zhao, G.5
Shen, H.6
Deng, Y.7
-
218
-
-
84881162103
-
Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes
-
Kang, M. J., Kim, C., Jeong, H., Cho, B. K., Ryou, A. L., Hwang, D., Mook-Jung, I., and Yi, E. C. (2013) Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes. Exp. Mol. Med. 45, e29.
-
(2013)
Exp. Mol. Med.
, vol.45
, pp. e29
-
-
Kang, M.J.1
Kim, C.2
Jeong, H.3
Cho, B.K.4
Ryou, A.L.5
Hwang, D.6
Mook-Jung, I.7
Yi, E.C.8
-
219
-
-
67650072530
-
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease
-
Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., and Gong, C.-X. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-1832.
-
(2009)
Brain
, vol.132
, pp. 1820-1832
-
-
Liu, F.1
Shi, J.2
Tanimukai, H.3
Gu, J.4
Gu, J.5
Grundke-Iqbal, I.6
Iqbal, K.7
Gong, C.-X.8
-
220
-
-
0037454755
-
Evidence of a balance between phosphorylation and OGlcNAc glycosylation of tau proteins - A role in nuclear localization
-
Lefebvre, T., Ferreira, S., Dupont-Wallois, L., Bussière, T., Dupire, M.-J., Delacourte, A., Michalski, J.-C., and Caillet-Boudin, M.-L. (2003) Evidence of a balance between phosphorylation and OGlcNAc glycosylation of tau proteins - a role in nuclear localization. Biochim. Biophys. Acta, Gen. Subj. 1619, 167-176.
-
(2003)
Biochim. Biophys. Acta, Gen. Subj.
, vol.1619
, pp. 167-176
-
-
Lefebvre, T.1
Ferreira, S.2
Dupont-Wallois, L.3
Bussière, T.4
Dupire, M.-J.5
Delacourte, A.6
Michalski, J.-C.7
Caillet-Boudin, M.-L.8
-
221
-
-
84859819548
-
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation
-
Yu, Y., Zhang, L., Li, X., Run, X., Liang, Z., Li, Y., Liu, Y., Lee, M. H., Grundke-Iqbal, I., Iqbal, K., Vocadlo, D. J., Liu, F., and Gong, C.-X. (2012) Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PLoS One 7, e35277.
-
(2012)
PLoS One
, vol.7
, pp. e35277
-
-
Yu, Y.1
Zhang, L.2
Li, X.3
Run, X.4
Liang, Z.5
Li, Y.6
Liu, Y.7
Lee, M.H.8
Grundke-Iqbal, I.9
Iqbal, K.10
Vocadlo, D.J.11
Liu, F.12
Gong, C.-X.13
-
222
-
-
84897117088
-
O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers
-
Yuzwa, S. A., Cheung, A. H., Okon, M., McIntosh, L. P., and Vocadlo, D. J. (2014) O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers. J. Mol. Biol. 426, 1736-1752.
-
(2014)
J. Mol. Biol.
, vol.426
, pp. 1736-1752
-
-
Yuzwa, S.A.1
Cheung, A.H.2
Okon, M.3
McIntosh, L.P.4
Vocadlo, D.J.5
-
223
-
-
84880450188
-
Effect of xixin decoction on O-linked N-acetylglucosamine glycosylation of tau proteins in rat brain with sporadic Alzheimer disease
-
Diwu, Y., Tian, J., and Shi, J. (2013) Effect of xixin decoction on O-linked N-acetylglucosamine glycosylation of tau proteins in rat brain with sporadic Alzheimer disease. J. Tradit. Chin. Med. 33, 367-372.
-
(2013)
J. Tradit. Chin. Med.
, vol.33
, pp. 367-372
-
-
Diwu, Y.1
Tian, J.2
Shi, J.3
-
224
-
-
47649117312
-
Turning down tau phosphorylation
-
Fischer, P. (2008) Turning down tau phosphorylation. Nat. Chem. Biol. 4, 448-449.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 448-449
-
-
Fischer, P.1
-
225
-
-
0033526623
-
An immunochemical study on tau glycation in paired helical filaments
-
Ko, L.-w., Ko, E. C., Nacharaju, P., Liu, W.-K., Chang, E., Kenessey, A., and Yen, S.-H. C. (1999) An immunochemical study on tau glycation in paired helical filaments. Brain Res. 830, 301-313.
-
(1999)
Brain Res.
, vol.830
, pp. 301-313
-
-
Ko, L.-W.1
Ko, E.C.2
Nacharaju, P.3
Liu, W.-K.4
Chang, E.5
Kenessey, A.6
Yen, S.-H.C.7
-
226
-
-
34147135482
-
Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation
-
Kuhla, B., Haase, C., Flach, K., Lüth, H.-J., Arendt, T., and Münch, G. (2007) Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation. J. Biol. Chem. 282, 6984-6991.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6984-6991
-
-
Kuhla, B.1
Haase, C.2
Flach, K.3
Lüth, H.-J.4
Arendt, T.5
Münch, G.6
-
227
-
-
9644273963
-
Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro
-
Necula, M., and Kuret, J. (2004) Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro. J. Biol. Chem. 279, 49694-49703.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49694-49703
-
-
Necula, M.1
Kuret, J.2
-
228
-
-
0029076397
-
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide
-
Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M. A., Perry, G., Godman, G. C., Nawroth, P., Zweier, J. L., and Stern, D. (1995) Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide. Nat. Med. 1, 693-699.
-
(1995)
Nat. Med.
, vol.1
, pp. 693-699
-
-
Yan, S.D.1
Yan, S.F.2
Chen, X.3
Fu, J.4
Chen, M.5
Kuppusamy, P.6
Smith, M.A.7
Perry, G.8
Godman, G.C.9
Nawroth, P.10
Zweier, J.L.11
Stern, D.12
-
229
-
-
67650995472
-
D-Ribosylated tau forms globular aggregates with high cytotoxicity
-
Chen, L., Wei, Y., Wang, X., and He, R. (2009) D-Ribosylated tau forms globular aggregates with high cytotoxicity. Cell. Mol. Life Sci. 66, 2559-2571.
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 2559-2571
-
-
Chen, L.1
Wei, Y.2
Wang, X.3
He, R.4
-
230
-
-
84900556648
-
Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal tau protein
-
Kamah, A., Huvent, I., Cantrelle, F.-X., Qi, H., Lippens, G., Landrieu, I., and Smet-Nocca, C. (2014) Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal tau protein. Biochemistry 53, 3020-3032.
-
(2014)
Biochemistry
, vol.53
, pp. 3020-3032
-
-
Kamah, A.1
Huvent, I.2
Cantrelle, F.-X.3
Qi, H.4
Lippens, G.5
Landrieu, I.6
Smet-Nocca, C.7
-
231
-
-
84890357149
-
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
-
Cook, C., Carlomagno, Y., Gendron, T. F., Dunmore, J., Scheffel, K., Stetler, C., Davis, M., Dickson, D., Jarpe, M., DeTure, M., and Petrucelli, L. (2014) Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum. Mol. Genet. 23, 104-116.
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 104-116
-
-
Cook, C.1
Carlomagno, Y.2
Gendron, T.F.3
Dunmore, J.4
Scheffel, K.5
Stetler, C.6
Davis, M.7
Dickson, D.8
Jarpe, M.9
DeTure, M.10
Petrucelli, L.11
-
232
-
-
84875241051
-
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
-
Xiong, Y., Zhao, K., Wu, J., Xu, Z., Jin, S., and Zhang, Y. Q. (2013) HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 110, 4604-4609.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 4604-4609
-
-
Xiong, Y.1
Zhao, K.2
Wu, J.3
Xu, Z.4
Jin, S.5
Zhang, Y.Q.6
-
233
-
-
84866387948
-
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatinmediated neuroplasticity
-
Fass, D. M., Reis, S. A., Ghosh, B., Hennig, K. M., Joseph, N. F., Zhao, W.-N., Nieland, T. J. F., Guan, J.-S., Groves Kuhnle, C. E., Tang, W., Barker, D. D., Mazitschek, R., Schreiber, S. L., Tsai, L.-H., and Haggarty, S. J. (2013) Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatinmediated neuroplasticity. Neuropharmacology 64, 81-96.
-
(2013)
Neuropharmacology
, vol.64
, pp. 81-96
-
-
Fass, D.M.1
Reis, S.A.2
Ghosh, B.3
Hennig, K.M.4
Joseph, N.F.5
Zhao, W.-N.6
Nieland, T.J.F.7
Guan, J.-S.8
Groves Kuhnle, C.E.9
Tang, W.10
Barker, D.D.11
Mazitschek, R.12
Schreiber, S.L.13
Tsai, L.-H.14
Haggarty, S.J.15
-
234
-
-
67349220155
-
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model
-
Ricobaraza, A., Cuadrado-Tejedor, M., Pérez-Mediavilla, A., Frechilla, D., Del Río, J., and García-Osta, A. (2009) Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology 34, 1721-1732.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 1721-1732
-
-
Ricobaraza, A.1
Cuadrado-Tejedor, M.2
Pérez-Mediavilla, A.3
Frechilla, D.4
Del Río, J.5
García-Osta, A.6
-
235
-
-
84878937633
-
The microtubule-associated tau protein has intrinsic acetyltransferase activity
-
Cohen, T. J., Friedmann, D., Hwang, A. W., Marmorstein, R., and Lee, V. M. Y. (2013) The microtubule-associated tau protein has intrinsic acetyltransferase activity. Nat. Struct. Mol. Biol. 20, 756-762.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 756-762
-
-
Cohen, T.J.1
Friedmann, D.2
Hwang, A.W.3
Marmorstein, R.4
Lee, V.M.Y.5
-
236
-
-
84893803744
-
HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes
-
Noack, M., Leyk, J., and Richter-Landsberg, C. (2014) HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. Glia 62, 535-547.
-
(2014)
Glia
, vol.62
, pp. 535-547
-
-
Noack, M.1
Leyk, J.2
Richter-Landsberg, C.3
-
237
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
Cohen, T. J., G, J., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q., and Lee, V. M. (2011) The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat. Commun. 2, 252.
-
(2011)
Nat. Commun.
, vol.2
, pp. 252
-
-
Cohen, T.J.1
G, J.2
Hurtado, D.E.3
Kwong, L.K.4
Mills, I.P.5
Trojanowski, J.Q.6
Lee, V.M.7
-
238
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min, S.-W., Cho, S.-H., Zhou, Y., Schroeder, S., Haroutunian, V., Seeley, W. W., Huang, E. J., Shen, Y., Masliah, E., Mukherjee, C., Meyers, D., Cole, P. A., Ott, M., and Gan, L. (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67, 953-966.
-
(2010)
Neuron
, vol.67
, pp. 953-966
-
-
Min, S.-W.1
Cho, S.-H.2
Zhou, Y.3
Schroeder, S.4
Haroutunian, V.5
Seeley, W.W.6
Huang, E.J.7
Shen, Y.8
Masliah, E.9
Mukherjee, C.10
Meyers, D.11
Cole, P.A.12
Ott, M.13
Gan, L.14
-
239
-
-
46149114114
-
SUMO-1 immunoreactivity co-localizes with phospho-tau in APP transgenic mice but not in mutant Tau transgenic mice
-
Takahashi, K., Ishida, M., Komano, H., and Takahashi, H. (2008) SUMO-1 immunoreactivity co-localizes with phospho-tau in APP transgenic mice but not in mutant Tau transgenic mice. Neurosci. Lett. 441, 90-93.
-
(2008)
Neurosci. Lett.
, vol.441
, pp. 90-93
-
-
Takahashi, K.1
Ishida, M.2
Komano, H.3
Takahashi, H.4
-
240
-
-
17644393495
-
Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity
-
Zhang, Y. J., Xu, Y. F., Chen, X. Q., Wang, X. C., and Wang, J.-Z. (2005) Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity. FEBS Lett. 579, 2421-2427.
-
(2005)
FEBS Lett.
, vol.579
, pp. 2421-2427
-
-
Zhang, Y.J.1
Xu, Y.F.2
Chen, X.Q.3
Wang, X.C.4
Wang, J.-Z.5
-
241
-
-
33645546784
-
Peroxynitrite-mediated τ modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms
-
Reynolds, M. R., Lukas, T. J., Berry, R. W., and Binder, L. I. (2006) Peroxynitrite-mediated τ modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms. Biochemistry 45, 4314-4326.
-
(2006)
Biochemistry
, vol.45
, pp. 4314-4326
-
-
Reynolds, M.R.1
Lukas, T.J.2
Berry, R.W.3
Binder, L.I.4
-
242
-
-
84862300056
-
Structure and pathology of tau protein in Alzheimer disease
-
Kolarova, M., García-Sierra, F., Bartos, A., Ricny, J., and Ripova, D. (2012) Structure and pathology of tau protein in Alzheimer disease. Int. J. Alzheimer's Dis. 2012, 13.
-
(2012)
Int. J. Alzheimer's Dis.
, vol.2012
, pp. 13
-
-
Kolarova, M.1
García-Sierra, F.2
Bartos, A.3
Ricny, J.4
Ripova, D.5
-
243
-
-
3242749074
-
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
-
Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., Vitek, M. P., LaFerla, F. M., Rohn, T. T., and Cotman, C. W. (2004) Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J. Clin. Invest. 114, 121-130.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 121-130
-
-
Rissman, R.A.1
Poon, W.W.2
Blurton-Jones, M.3
Oddo, S.4
Torp, R.5
Vitek, M.P.6
LaFerla, F.M.7
Rohn, T.T.8
Cotman, C.W.9
-
244
-
-
20844432024
-
Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease
-
Hampel, H., Bürger, K., Pruessner, J. C., Zinkowski, R., DeBernardis, J., Kerkman, D., Leinsinger, G., Evans, A. C., Davies, P., Möller, H. J., and Teipel, S. J. (2005) Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease. Arch Neurol. 62, 770-773.
-
(2005)
Arch Neurol.
, vol.62
, pp. 770-773
-
-
Hampel, H.1
Bürger, K.2
Pruessner, J.C.3
Zinkowski, R.4
DeBernardis, J.5
Kerkman, D.6
Leinsinger, G.7
Evans, A.C.8
Davies, P.9
Möller, H.J.10
Teipel, S.J.11
-
245
-
-
0037197836
-
Tau is essential to beta-amyloid-induced neurotoxicity
-
Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P., and Ferreira, A. (2002) Tau is essential to beta-amyloid-induced neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 99, 6364-6369.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
246
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G. Q., and Mucke, L. (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
247
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Paul Murphy, M., Baker, M., Yu, X., Duff, K., Hardy, J., Corral, A., Lin, W. L., Yen, S. H., Dickson, D. W., Davies, P., and Hutton, M. (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet. 25, 402-405.
-
(2000)
Nat. Genet.
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul Murphy, M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
248
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni, A. A., Boutajangout, A., Quartermain, D., and Sigurdsson, E. M. (2007) Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J. Neurosci. 27, 9115-9129.
-
(2007)
J. Neurosci.
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
249
-
-
78650065372
-
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
-
Boutajangout, A., Quartermain, D., and Sigurdsson, E. M. (2010) Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J. Neurosci. 30, 16559-16566.
-
(2010)
J. Neurosci.
, vol.30
, pp. 16559-16566
-
-
Boutajangout, A.1
Quartermain, D.2
Sigurdsson, E.M.3
-
250
-
-
82955194797
-
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
-
Bi, M., Ittner, A., Ke, Y. D., Gotz, J., and Ittner, L. M. (2011) Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One 6, e26860.
-
(2011)
PLoS One
, vol.6
, pp. e26860
-
-
Bi, M.1
Ittner, A.2
Ke, Y.D.3
Gotz, J.4
Ittner, L.M.5
-
251
-
-
84922479255
-
Efficacy and safety of a liposome-based vaccine against protein tau, assessed in tau.P301L mice that model tauopathy
-
Theunis, C., Crespo-Biel, N., Gafner, V., Pihlgren, M., Lopez- Deber, M. P., Reis, P., Hickman, D. T., Adolfsson, O., Chuard, N., Ndao, D. M., Borghgraef, P., Devijver, H., Van Leuven, F., Pfeifer, A., and Muhs, A. (2013) Efficacy and safety of a liposome-based vaccine against protein tau, assessed in tau.P301L mice that model tauopathy. PLoS One 8, e72301.
-
(2013)
PLoS One
, vol.8
, pp. e72301
-
-
Theunis, C.1
Crespo-Biel, N.2
Gafner, V.3
Pihlgren, M.4
Lopez-Deber, M.P.5
Reis, P.6
Hickman, D.T.7
Adolfsson, O.8
Chuard, N.9
Ndao, D.M.10
Borghgraef, P.11
Devijver, H.12
Van Leuven, F.13
Pfeifer, A.14
Muhs, A.15
-
252
-
-
77954656871
-
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
-
Boimel, M., Grigoriadis, N., Lourbopoulos, A., Haber, E., Abramsky, O., and Rosenmann, H. (2010) Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp. Neurol. 224, 472-485.
-
(2010)
Exp. Neurol.
, vol.224
, pp. 472-485
-
-
Boimel, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Haber, E.4
Abramsky, O.5
Rosenmann, H.6
-
253
-
-
84860531636
-
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: A suitable therapeutic approach
-
Troquier, L., Caillierez, R., Burnouf, S., Fernandez-Gomez, F. J., Grosjean, M. E., Zommer, N., Sergeant, N., Schraen-Maschke, S., Blum, D., and Buee, L. (2012) Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Curr. Alzheimer Res. 9, 397-405.
-
(2012)
Curr. Alzheimer Res.
, vol.9
, pp. 397-405
-
-
Troquier, L.1
Caillierez, R.2
Burnouf, S.3
Fernandez-Gomez, F.J.4
Grosjean, M.E.5
Zommer, N.6
Sergeant, N.7
Schraen-Maschke, S.8
Blum, D.9
Buee, L.10
-
254
-
-
33749614555
-
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
-
Rosenmann, H., Grigoriadis, N., Karussis, D., Boimel, M., Touloumi, O., Ovadia, H., and Abramsky, O. (2006) Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. Arch Neurol. 63, 1459-1467.
-
(2006)
Arch Neurol.
, vol.63
, pp. 1459-1467
-
-
Rosenmann, H.1
Grigoriadis, N.2
Karussis, D.3
Boimel, M.4
Touloumi, O.5
Ovadia, H.6
Abramsky, O.7
-
255
-
-
84882793431
-
Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation
-
Rozenstein-Tsalkovich, L., Grigoriadis, N., Lourbopoulos, A., Nousiopoulou, E., Kassis, I., Abramsky, O., Karussis, D., and Rosenmann, H. (2013) Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation. Exp. Neurol. 248, 451-456.
-
(2013)
Exp. Neurol.
, vol.248
, pp. 451-456
-
-
Rozenstein-Tsalkovich, L.1
Grigoriadis, N.2
Lourbopoulos, A.3
Nousiopoulou, E.4
Kassis, I.5
Abramsky, O.6
Karussis, D.7
Rosenmann, H.8
-
256
-
-
79960563632
-
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
-
Boutajangout, A., Ingadottir, J., Davies, P., and Sigurdsson, E. M. (2011) Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J. Neurochem 118, 658-667.
-
(2011)
J. Neurochem
, vol.118
, pp. 658-667
-
-
Boutajangout, A.1
Ingadottir, J.2
Davies, P.3
Sigurdsson, E.M.4
-
257
-
-
80053202160
-
Passive immunization with anti-tau antibodies in two transgenic models: Reduction of tau pathology and delay of disease progression
-
Chai, X., Wu, S., Murray, T. K., Kinley, R., Cella, C. V., Sims, H., Buckner, N., Hanmer, J., Davies, P., O'Neill, M. J., Hutton, M. L., and Citron, M. (2011) Passive immunization with anti-tau antibodies in two transgenic models: reduction of tau pathology and delay of disease progression. J. Biol. Chem. 286, 34457-34467.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 34457-34467
-
-
Chai, X.1
Wu, S.2
Murray, T.K.3
Kinley, R.4
Cella, C.V.5
Sims, H.6
Buckner, N.7
Hanmer, J.8
Davies, P.9
O'Neill, M.J.10
Hutton, M.L.11
Citron, M.12
-
258
-
-
84902524301
-
p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice
-
Walls, K. C., Ager, R. R., Vasilevko, V., Cheng, D., Medeiros, R., and LaFerla, F. M. (2014) p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neurosci. Lett. 575, 96-100.
-
(2014)
Neurosci. Lett.
, vol.575
, pp. 96-100
-
-
Walls, K.C.1
Ager, R.R.2
Vasilevko, V.3
Cheng, D.4
Medeiros, R.5
LaFerla, F.M.6
-
259
-
-
84885783467
-
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
-
Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I., and Holtzman, D. M. (2013) Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 80, 402-414.
-
(2013)
Neuron
, vol.80
, pp. 402-414
-
-
Yanamandra, K.1
Kfoury, N.2
Jiang, H.3
Mahan, T.E.4
Ma, S.5
Maloney, S.E.6
Wozniak, D.F.7
Diamond, M.I.8
Holtzman, D.M.9
-
260
-
-
84896269359
-
Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles
-
Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Estes, D. M., Barrett, A. D., Dineley, K. T., Jackson, G. R., and Kayed, R. (2014) Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J. Neurosci. 34, 4260-4272.
-
(2014)
J. Neurosci.
, vol.34
, pp. 4260-4272
-
-
Castillo-Carranza, D.L.1
Sengupta, U.2
Guerrero-Munoz, M.J.3
Lasagna-Reeves, C.A.4
Gerson, J.E.5
Singh, G.6
Estes, D.M.7
Barrett, A.D.8
Dineley, K.T.9
Jackson, G.R.10
Kayed, R.11
-
261
-
-
84901776466
-
Specific targeting of tau oligomers in htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds
-
Castillo-Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero-Munoz, M. J., Lasagna-Reeves, C. A., and Kayed, R. (2014) Specific targeting of tau oligomers in htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. J. Alzheimer's Dis 40, S97-S111.
-
(2014)
J. Alzheimer's Dis
, vol.40
, pp. S97-S111
-
-
Castillo-Carranza, D.L.1
Gerson, J.E.2
Sengupta, U.3
Guerrero-Munoz, M.J.4
Lasagna-Reeves, C.A.5
Kayed, R.6
-
262
-
-
84925883347
-
Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease
-
in press
-
Brunden, K. R.; Trojanowski, J. Q.; Smith, A. B.; Lee, V. M.; Ballatore, C. (2014) Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease.Bioorg. Med. Chem., DOI: 10.1016/j.bmc.2013.12.046, in press.
-
(2014)
Bioorg. Med. Chem.
-
-
Brunden, K.R.1
Trojanowski, J.Q.2
Smith, A.B.3
Lee, V.M.4
Ballatore, C.5
-
263
-
-
64649097649
-
NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model
-
Shiryaev, N., Jouroukhin, Y., Giladi, E., Polyzoidou, E., Grigoriadis, N. C., Rosenmann, H., and Gozes, I. (2009) NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. Neurobiol. Dis. 34, 381-388.
-
(2009)
Neurobiol. Dis.
, vol.34
, pp. 381-388
-
-
Shiryaev, N.1
Jouroukhin, Y.2
Giladi, E.3
Polyzoidou, E.4
Grigoriadis, N.C.5
Rosenmann, H.6
Gozes, I.7
-
264
-
-
35548974346
-
Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model
-
Vulih-Shultzman, I., Pinhasov, A., Mandel, S., Grigoriadis, N., Touloumi, O., Pittel, Z., and Gozes, I. (2007) Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. J. Pharmacol. Exp. Ther. 323, 438-449.
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.323
, pp. 438-449
-
-
Vulih-Shultzman, I.1
Pinhasov, A.2
Mandel, S.3
Grigoriadis, N.4
Touloumi, O.5
Pittel, Z.6
Gozes, I.7
-
265
-
-
84863230105
-
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
-
Zhang, B., Carroll, J., Trojanowski, J. Q., Yao, Y., Iba, M., Potuzak, J. S., Hogan, A.-M. L., Xie, S. X., Ballatore, C., Smith, A. B., Lee, V. M.-Y., and Brunden, K. R. (2012) The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J. Neurosci. 32, 3601-3611.
-
(2012)
J. Neurosci.
, vol.32
, pp. 3601-3611
-
-
Zhang, B.1
Carroll, J.2
Trojanowski, J.Q.3
Yao, Y.4
Iba, M.5
Potuzak, J.S.6
Hogan, A.-M.L.7
Xie, S.X.8
Ballatore, C.9
Smith, A.B.10
Lee, V.M.-Y.11
Brunden, K.R.12
-
266
-
-
41149175575
-
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
-
Matsuoka, Y., Jouroukhin, Y., Gray, A. J., Ma, L., Hirata-Fukae, C., Li, H.-F., Feng, L., Lecanu, L., Walker, B. R., Planel, E., Arancio, O., Gozes, I., and Aisen, P. S. (2008) A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J. Pharmacol. Exp. Ther. 325, 146-153.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.325
, pp. 146-153
-
-
Matsuoka, Y.1
Jouroukhin, Y.2
Gray, A.J.3
Ma, L.4
Hirata-Fukae, C.5
Li, H.-F.6
Feng, L.7
Lecanu, L.8
Walker, B.R.9
Planel, E.10
Arancio, O.11
Gozes, I.12
Aisen, P.S.13
-
267
-
-
84879412186
-
NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy
-
Quraishe, S., C, C., and Mudher, A. (2013) NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol. Psychiatry 18, 834-842.
-
(2013)
Mol. Psychiatry
, vol.18
, pp. 834-842
-
-
Quraishe, S.1
C, C.2
Mudher, A.3
-
268
-
-
79955952344
-
Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel
-
Shemesh, O. A., and Spira, M. E. (2011) Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel. Neurobiol. Dis. 43, 163-175.
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 163-175
-
-
Shemesh, O.A.1
Spira, M.E.2
-
269
-
-
84893647317
-
Rescue of tau-induced synaptic transmission pathology by paclitaxel
-
Erez, H., Shemesh, O. A., and Spira, M. E. (2014) Rescue of tau-induced synaptic transmission pathology by paclitaxel. Front. Cell. Neurosci. 8, 34.
-
(2014)
Front. Cell. Neurosci.
, vol.8
, pp. 34
-
-
Erez, H.1
Shemesh, O.A.2
Spira, M.E.3
-
270
-
-
84861906161
-
Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation
-
Das, V., and Miller, J. H. (2012) Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation. Eur. J. Neurosc. 35, 1705-1717.
-
(2012)
Eur. J. Neurosc.
, vol.35
, pp. 1705-1717
-
-
Das, V.1
Miller, J.H.2
-
271
-
-
84861313192
-
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
-
Barten, D. M., Fanara, P., Andorfer, C., Hoque, N., Wong, P. Y. A., Husted, K. H., Cadelina, G. W., DeCarr, L. B., Yang, L., Liu, V., Fessler, C., Protassio, J., Riff, T., Turner, H., Janus, C. G., Sankaranarayanan, S., Polson, C., Meredith, J. E., Gray, G., Hanna, A., Olson, R. E., Kim, S.-H., Vite, G. D., Lee, F. Y., and Albright, C. F. (2012) Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J. Neurosci. 32, 7137-7145.
-
(2012)
J. Neurosci.
, vol.32
, pp. 7137-7145
-
-
Barten, D.M.1
Fanara, P.2
Andorfer, C.3
Hoque, N.4
Wong, P.Y.A.5
Husted, K.H.6
Cadelina, G.W.7
DeCarr, L.B.8
Yang, L.9
Liu, V.10
Fessler, C.11
Protassio, J.12
Riff, T.13
Turner, H.14
Janus, C.G.15
Sankaranarayanan, S.16
Polson, C.17
Meredith, J.E.18
Gray, G.19
Hanna, A.20
Olson, R.E.21
Kim, S.-H.22
Vite, G.D.23
Lee, F.Y.24
Albright, C.F.25
more..
-
272
-
-
77958065504
-
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
-
Brunden, K. R., Zhang, B., Carroll, J., Yao, Y., Potuzak, J. S., Hogan, A.-M. L., Iba, M., James, M. J., Xie, S. X., Ballatore, C., Smith, A. B., Lee, V. M.-Y., and Trojanowski, J. Q. (2010) Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J. Neurosci. 30, 13861-13866.
-
(2010)
J. Neurosci.
, vol.30
, pp. 13861-13866
-
-
Brunden, K.R.1
Zhang, B.2
Carroll, J.3
Yao, Y.4
Potuzak, J.S.5
Hogan, A.-M.L.6
Iba, M.7
James, M.J.8
Xie, S.X.9
Ballatore, C.10
Smith, A.B.11
Lee, V.M.-Y.12
Trojanowski, J.Q.13
-
273
-
-
84864395349
-
Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies
-
Brunden, K. R., Ballatore, C., Lee, V. M., Smith, A. B., 3rd, and Trojanowski, J. Q. (2012) Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochem. Soc. Trans. 40, 661-666.
-
(2012)
Biochem. Soc. Trans.
, vol.40
, pp. 661-666
-
-
Brunden, K.R.1
Ballatore, C.2
Lee, V.M.3
Smith, A.B.4
Trojanowski, J.Q.5
-
274
-
-
85030640434
-
Targeting mRNA for Alzheimer's and related dementias
-
Wolfe, M. S. (2014) Targeting mRNA for Alzheimer's and related dementias. Scientifica 2014, 13.
-
(2014)
Scientifica
, vol.2014
, pp. 13
-
-
Wolfe, M.S.1
|