Tau reduction prevents Aβ-induced defects in axonal transport

Science

Volumn 330, Issue 6001, 2010, Pages

  Vossel, Keith A ^a,b   Zhang, Kai ^c   Brodbeck, Jens ^a   Daub, Aaron C ^a   Sharma, Punita ^a   Finkbeiner, Steven ^a,b   Cui, Bianxiao ^c   Mucke, Lennart ^a,b  

^a GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; PROTEIN TYROSINE KINASE A;

ENZYME; MITOCHONDRION; NERVOUS SYSTEM DISORDER; PATHOGENICITY; PEPTIDE; PROTEIN;

ALZHEIMER DISEASE; CELL MOTILITY; GENOTYPE; MICROTUBULE; MITOCHONDRION; NERVE FIBER TRANSPORT; NONHUMAN; PLASMID; PRIORITY JOURNAL; REDUCTION; SHORT SURVEY; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; CYTOLOGY; HIPPOCAMPUS; METABOLISM; MOUSE; NERVE CELL;

AMYLOID BETA-PROTEIN; ANIMALS; AXONAL TRANSPORT; CELLS, CULTURED; HIPPOCAMPUS; MICE; MITOCHONDRIA; NEURONS; PEPTIDE FRAGMENTS; RECEPTOR, TRKA; TAU PROTEINS; AMYLOID BETA-PEPTIDES;

EID: 77957737750     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1194653     Document Type: Short Survey

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14. We thank A. Chung, K. Ho, E. LaDow, H. Solanoy, X. Wang, and G. Yu for excellent technical support and advice; Y. Huang for helpful discussions on mitochondrial transport; Y. Yoon for the mito-RFP plasmid; H. M. Brown for the TrkA-mCherry plasmid; M. Vitek and H. Dawson for tau knockout mice; A. Holloway for statistical support; S. Ordway for editorial review; J. Carroll for graphics support; and M. Dela Cruz for administrative assistance. L.M. has received research funding from Elan Pharmaceuticals for other projects and serves on the Scientific Advisory Boards of AgeneBio, iPierian, and Probiodrug. This work was supported by NIH grants AG011385 and NS041787 (L.M.) and NS057906 (B.C.) and the McBean Family Foundation (K.A.V.). The animal care facility was partly supported by an NIH Extramural Research Facilities Improvement Program Project (C06 RR018928).