Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease

Experimental Neurology

Volumn 153, Issue 1, 1998, Pages 8-22

  Vogt, Brent A ^c,d   Vogt, Leslie J ^c,d   Vrana, Kent E ^c,d   Gioia, Lynda ^c,d   Meadows, Robert S ^c,d   Challa, Venkat R ^c,d   Hof, Patrick R ^a   Van Hoesen, Gary W ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c Cingulum NeuroSciences Institute   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Apolipoprotein E genotype; Eigenvector projections; Neocortex; Senile plaques; Tau immunohistochemistry

Indexed keywords

AGING; ALZHEIMER DISEASE; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENOTYPE; GLUCOSE METABOLISM; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; SENILE PLAQUE;

EID: 0031691459     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6852     Document Type: Article

References (91)

1. Armstrong, R. A., L. Wood, D. Myers, and C. U. M. Smith. 1996. The use of multivariate methods in the identification of subtypes of Alzheimer's disease: A comparison of principal components and cluster analysis. Dementia 7: 215-220.
2. Arriagada, P. V., J. H. Growdon, E. T. Hedley-Whyte, and B. T. Hyman. 1992. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639.
3. Bálint, R. 1909. Seelenlähmung des "Schauens," optische Ataxie, räumliche Störung der Aufmerksamkeit. Mschr. Psychiatr. Neurol. 25: 51-81.
4. Bennett, D. A., E. J. Cochran, C. B. Saper, J. B. Leverenz, D. W. Gilley, and R. S. Wilson. 1993. Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease. Neurobiol. Aging 14: 589-596.
5. Benson, D. F., R. J. Davis, and D. B. Snyder. 1988. Posterior cortical atrophy. Arch. Neurol. 45: 789-793.
6. Bird, T. D., S. Stranaham, S. M. Sumi, and M. Radkind. 1983. Alzheimer's disease: Choline acetyltransferase activity in brain tissue from clinical and pathological subtypes. Ann. Neurol. 14: 284-293.
7. Blacker, D., J. L. Haines, L. Rodes, R. H. Terwedow, L. E. Harrell, R. T. Perry, S. S. Bassett, D. Meyers, M. S. Albert, and R. Tanzi. 1997. ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative. Neurology 48: 139-147.
8. Bondareff, W., C. Q. Mountjoy, and M. Roth. 1982. Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia. Neurology 32: 164-168.
9. Bouras, C., P. R. Hof, P. Giannakopoulos, J. P. Michael, and J. H. Morrisson. 1994. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly individuals: A quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb. Cortex 4: 138-150.
10. Braak, H., and E. Braak. 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82: 239-259.
11. Braak, H., and E. Braak. 1993. Alzheimer neuropathology and limbic circuits. In Neurobiology of Cingulate Cortex and Limbic Thalamus (B. A. Vogt and M. Gabriel, Eds.), pp. 606-626. Birkhäuser, Boston.
12. Brun, A., and E. Englund. 1981. Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading. Histopathology 5: 549-564.
13. Buée-Scherrer, V., O. Conamines, C. Mourton-Gilles, R. Jakes, M. Goedert, B. Pau, and A. Delacourte. 1996. AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease. Mol. Brain Res. 39: 79-88.
14. Chui, H. C., E. L. Tneg, V. W. Henderson, and A. C. Moy. 1985. Clinical subtypes of dementia of the Alzheimer type. Neurology 35: 1544-1550.
15. Crystal, H., D. Dickson, P. Fuld, D. Masur, R. Scott, M. Mehler, J. Masdeu, C. Kawas, M. Aronson, and L. Wolfson. 1988. Clinico-pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 38: 1682-1687.
16. Dawson, V. L., D. S. Bredt, D. S. Fotuhi, P. M. Hwang, and S. H. Snyder. 1991. Nitric oxide synthase and neuronal NADPH-diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA 88: 7797-7801.
17. Dawson, V. L., T. M. Dawson, E. D. London, D. S. Bredt, and S. H. Snyder. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88: 6368-6371.
18. Filley, C. M., J. Kelly, and R. K. Heaton. 1986. Neuropsychiatric features of early- and late-onset Alzheimer's disease. Arch. Neurol. 43: 574-576.
19. Fisher, N. J., B. P. Rourke, L. Bieliauskas, B. Giordani, S. Berent, and N. Foster. 1996. Neuropsychological subgroups of patients with Alzheimer's disease. J. Clin. Exp. Neuropsychol. 18: 349-370.
20. Fletcher, W. A. 1994. Ophthalmological aspects of Alzheimer's disease. Curr. Opin. Ophthalmol. 5: 38-44.
21. Fletcher, W. A., and J. A. Sharpe. 1988. Smooth pursuit dysfunction in Alzheimer's disease. Neurology 38: 272-277.
22. Foster, N. L., T. N. Chase, P. Fedio, N. J. Petronsas, R. A. Brooks, and G. DiChiro. 1983. Alzheimer's disease: Focal cortical changes shown by positron emission tomography. Neurology 33: 961-965.
23. Furey-Kurkjian, M. L., P. Pietriyni, N. R. Graff-Radford, G. E. Alexander, U. Freo, J. Szczepanik, and M. B. Schapiro. 1996. Visual variant of Alzheimer's disease: Distinctive neuropsychological features. Neuropsychology 10: 294-300.
24. Gioia, L., L. J. Vogt, W. M. Freeman, B. A. Vogt, and K. E. Vrana. 1998. PCR-based apolipoprotein E genotype analysis from archival fixed brain. J. Neurosci. Methods 80: 209-214.
25. Gómez-Isla, T., J. L. Price, D. W. McKeel Jr., J. C. Morris, J. H. Growdon, and B. T. Hyman. 1996. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16: 4491-4500.
26. Gouras, G. K., N. R. Relkin, D. Sweeney, D. G. Munoz, I. R. Mackenzie, and S. Gandy. 1997. Increased apolipoprotein E ∈4 in epilepsy with senile plaques. Ann. Neurol. 41: 402-404.
27. Grady, C. L., J. V. Haxby, M. B. Shapiro, A. Kumar, M. J. Ball, L. Heston, and S. I. Rapoport. 1990. Subgroups in dementia of the Alzheimer type identified using positron emission tomography. J. Neuropsychiatr. 2: 373-384.
28. Grasby, P. M., C. D. Frith, K. J. Friston, C. Bench, R. S. J. Frackowiak, and R. J. Dolan. 1993. Functional mapping of brain areas implicated in auditory-verbal memory function. Brain 116: 1-20.
29. Grünthal, E. 1928. Hirnpathologischen Analyse der Alzheimerschen Krankheir. Psychiat.-Neurol. Wschr. 36: 401-407.
30. Hardy, J. 1996. New insights into the genetics of Alzheimer's disease. Ann. Med. 28: 255-258.
31. Haxby, J. V., R. Duara, C. L. Grady, N. R. Culter, and S. I. Rapoport. 1985. Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease. J. Cereb. Blood Flow Metab. 5: 193-200.
32. Haxby, J. V., C. L. Grady, and E. Koss. 1988. Heterogeneous anterior-posterior metabolic patterns in dementia of the Alzheimer type. Neurology 38: 1053-1063.
33. Hirano, A., and H. M. Zimmerman. 1962. Alzheimer's neurofibrillary changes; A topographic study. Arch. Neurol. 7: 227-242.
34. Hirono, N., E. Mori, K. Ishii, Y. Ikejiri, T. Imamura, T. Shimomura, M. Hashimoto, H. Yamashita, and M. Sasaki. 1998. Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatr. 64: 552-554.
35. Hof, P. R., N. Archin, A. P. Osmand, A. P. Dougherty, C. Wells, C. Bouras, and J. H. Morrison. 1993. Posterior cortical atrophy in Alzheimer's disease: Analysis of a new case and re-evaluation of a historical report. Acta Neuropathol. 86: 215-223.
36. Hof, P. R., L. M. Bierer, D. P. Perl, A. Delacourte, L. Buée, C. Bouras, and J. H. Morrison. 1992. Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Arch. Neurol. 49: 946-953.
37. Hof, P. R., C. Bouras, J. Constantinidis, and J. H. Morrison. 1989. Bálint's syndrome in Alzheimer's disease: Specific disruption of the occipitoparietal visual pathway. Brain Res. 493: 368-375.
38. Hof, P. R., C. Bouras, J. Constantinidis, and J. H. Morrison. 1990. Selective disconnection of specific visual association pathways in cases of Alzheimer's disease presenting with Bálint's syndrome. J. Neuropathol. Exp. Neurol. 49: 168-184.
39. Hof, P. R., and J. H. Morrison. 1991. Neocortical neuronal subpopulations labeled by a monoclonal antibody to calbindin exhibit differential vulnerability in Alzheimer's disease. Exp. Neurol. 111: 293-301.
40. Hof, P. R., E. A. Nimchinsky, M. R. Celio, C. Bouras, and J. H. Morrison. 1993. Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease. Neurosci. Lett. 152: 145-149.
41. Hof, P. R., B. A. Vogt, C. Bouras, and J. H. Morrison. 1997. Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: A review of lesion distribution and circuit disconnection in cortical visual pathways. Vision Res 37: 3609-3625.
42. Hyman, B. T., K. Marzloff, and P. V. Arriagada. 1993. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J. Neuropathol. Exp. Neurol. 52: 594-600.
43. Hyman, B. T., H. L. West, T. Gomez-Isla, and S. Mui. 1995. Quantitative neuropathology in Alzheimer's disease: Neuronal loss in high-order association cortex paralleles dementia. In Research Advances in Alzheimer's Disease and Relatedc Disorders (K. Iqbal, J. A. Mortimer, and H. M. Wisniewski, eds.), pp. 453-460. Wiley, New York.
44. Katzman, R., R. Terry, R. DeTeresa, T. Brown, P. Davies, P. Fuld, X. Renbing, and A. Peck. 1988. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Ann. Neurol. 23: 138-144.
45. Khachaturian, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch. Neurol. 42: 1097-1105.
46. Kiyosawa, M., T. M. Bosley, J. Chawluk, D. Jamieson, N. J. Schatz, P. J. Savino, R. C. Sergott, M. Reivich, and A. Alavi. 1989. Alzheimer's disease with prominent visual symptoms. Ophthalmology 96: 1077-1086.
47. Kurylo, D. D., S. Corkin, R. P. Dolan, J. F. Rizzo III, S. W. Parker, and J. H. Growdon. 1994. Broad-band visual capacities are not selectively impaired in Alzheimer's disease. Neurobiol. Aging 15: 305-311.
48. Lippa, C. F., A. M. Saunders, T. W. Smith, J. M. Swearer, D. A. Drachman, B. Ghetti, L. Nee, D. Pulaski-Salo, D. Dickson, Y. Robitaille, C. Bergeron, B. Crain, M. D. Benson, M. Farlow, B. T. Hyman, P. St. George-Hyslop, A. D. Roses, and D. A. Pollen. 1996. Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway. Neurology 46: 406-412.
49. Lippa, C. F., T. W. Smith, and J. M. Swearer. 1994. Alzheimer's disease and Lewy body disease: A comparative clinicopathological study. Ann. Neurol. 35: 81-88.
50. Mann, D. M. A., B. Marcyniuk, P. O. Yates, D. Neary, and J. S. Snowden. 1988. The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined at biopsy and at autopsy. Neuropathol. Appl. Neurobiol. 14: 177-195.
51. Mann, D. M. A., P. O. Yates, and B. Marcyniuk. 1985. Some morphometric observations on the cerebral cortex in presenile Alzheimer's disease and Down's syndrome in middle age. J. Neurol. Sci. 69: 139-159.
52. Martin, A. 1987. Representation of semantic and spatial knowledge in Alzheimer's patients: Implications for models of preserved learning and amnesia. J. Clin. Exp. Neuropsychol. 9: 191-224.
53. Martin, A. 1990. Neuropsychology of Alzheimer's disease: The case for subgroups. In Modular Deficits in Alzheimer-type Dementia (M. Schwartz, Ed.), pp. 145-175. MIT Press, Cambridge, MA.
54. 14C]2-deoxy-D-glucose uptake into retrosplenial cortex and other memory-related structures of the monkey during a delayed response. Brain Res. Bull. 22: 829-838.
55. McKeith, I. G., D. Galasko, K. Kosaka, et al. 1996. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies. Neurology 47: 1113-1124.
56. Mirra, S. S., A. Heyman, and D. McKeel. 1991. The consortium to establish a registry for Alzheimer's disease (CERAD). Neurology 41: 479-486.
57. Minoshima, S., N. L. Foster, and D. E. Kuhl. 1994. Posterior cingulate cortex in Alzheimer's disease. Lancet 344: 895.
58. Minoshima, S., B. Giordani, S. Berent, K. A. Frey, N. L. Foster, and D. E. Kuhl. 1997. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann. Neurol. 42: 85-94.
59. Morel, F. 1945. Les aires striée, parastriée et péristriée dans les troubles de la fonction visuelle au cours de la maladie d'Alzheimer. Confin. Neurol. 6: 238-242.
60. Mountjoy, C. Q., M. Roth, N. J. R. Evans, and H. M. Evans. 1983. Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol. Aging 4: 1-11.
61. Murray, E. A., M. Davidson, D. Gaffan, D. S. Olton, and S. Suomi. 1989. Effects of fornix transection and cingulate cortical ablation on spatial memory in rhesus monkeys. Exp. Brain Res. 74: 173-186.
62. Nagy, Z., M. M. Esiri, K. A. Jobst, J. H. Morris, E. King, B. McDonal, S. Litchfield, A. Smith, L. Barnetson, and A. D. Smith. 1995. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria. Dementia 6: 21-31.
63. Neary, D., and J. S. Snowden. 1987. Perceptuospatial disorder in Alzheimer's disease. Semin. Ophthalmol. 2: 151-158.
64. Neary, D., J. S. Snowden, D. M. A. Mann, D. M. Bowen, N. R. Sims, B. Northen, P. O. Yates, and A. N. Davison. 1986. Alzheimer's disease: A correlative study. J. Neurol. Neurosurg. Psych. 49: 229-237.
65. Nimchinsky, E. A., B. A. Vogt, J. H. Morrison, and P. R. Hof. 1997. Neurofilament and calcium-binding proteins in the human cingulate cortex. J. Comp. Neurol. 384: 597-620.
66. Olson, C. R., S. Y. Musil, and M. E. Goldberg. 1993. Posterior cingulate cortex and visuospatial cognition: Properties of single neurons in the behaving monkey. In Neurobiology of Cingulate Cortex and Limbic Thalamus (B. A. Vogt and M. Gabriel, Eds.), pp. 366-380. Birkhäuser, Boston.
67. Olson, C. R., S. Y. Musil, and M. E. Goldberg. 1996. Single neurons in posterior cingulate cortex of behaving macaque: Eye movement signals. J. Neurophysiol. 76: 3285-3300.
68. Paik, Y. K., D. J. Chang, C. A. Reardon, G. E. Davies, R. W. Mahley, and J. M. Taylor. 1985. Nucleotide sequence and structure of the human apolipoprotein E gene. Proc. Natl. Acad. Sci. USA 82: 3445-3449.
69. Pearson, R. C. A., M. M. Esiri, R. W. Hiorns, G. K. Wilcock, and T. P. S. Powell. 1985. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc. Natl. Acad. Sci. USA 82: 4531-4534.
70. Pietrini, P., M. L. Furey, N. Graff-Radford, U. Freo, G. E. Alexander, C. L. Grady, A. Dani, M. J. Mentis, and M. B. Shapiro. 1996. Preferential metabolic involvement of visual cortical areas in a subtype of Alzheimer's disease: Clinical implications. Am. J. Psych. 153: 1261-1268.
71. Procter, A. W., S. L. Lowe, A. M. Palmer, P. T. Francis, M. M. Esiri, G. C. Stratmann, A. Najlerahim, A. J. Patel, A. Hunt, and D. M. Bowen. 1988. Topographical distribution of neurochemical changes in Alzheimer's disease. J. Neurol. Sci. 84: 125-140.
72. Rossor, M. N., N. J. Garrett, A. L. Johnson, C. Q. Mountjoy, R. Roth, and L. L. Iversen. 1982. A post-mortem study of cholinergic and GABA systems in senile dementia. Brain 105: 313-330.
73. Rossor, M. N., L. L. Iversen, G. P. Reynolds, C. Q. Mountjoy, and M. Roth. 1984. Neurochemical characteristics of early and late onset types of Alzheimer's disease. Br. Med. J. 288: 961-964.
74. Schmechel, D. E., A. M. Saunders, W. J. Strittmater, B. J. Crain, S. H. Joo, M. A. Pericak-Vance, D. Goldgaber, and A. D. Roses. 1993. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90: 9649-9653.
75. Sparks, D. L., J. C. III, Hunsaker, S. W. Scheff, R. J. Kryscio, J. L. Hensen, and W. R. Markesbery. 1990. Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease. Neurobiol. Aging 11: 601-607.
76. Sparks, D. L., S. W. Scheff, H. Liu, T. Landers, F. Danner, C. M. Coyne, and J. C. Hunsker III. 1996. Increased density of senile plaques, but not neurofibrillary tangles in non-demented individuals with the apolipoprotein E4 allele: Comparison to confirmed Alzheimer's disease patients. J. Neurol. Sci. 138: 97-104.
77. Terry, R. D., A. Peck, R. DeTeresa, R. Schechter, and D. S. Horoupian. 1981. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann. Neurol. 10: 184-192.
78. Valenstein, E., D. Bowers, M. Verfaellie, K. M. Heilman, A. Day, and R. T. Watson. 1987. Retrosplenial amnesia. Brain 110: 1631-1646.
79. Van Hoesen, G. W., B. T. Hyman, and A. R. Damasio. 1991. Entorhinal cortex pathology in Alzheimer's disease. Hippocampus 1: 1-8.
80. Vickers, J. C., B. M. Riederer, R. A. Marugg, V. Buée-Scherrer, L. Buée, A. Delacourte, and J. H. Morrison. 1994. Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience 62: 1-13.
81. Victoroff, J., W. Ross, D. F. Benson, M. A. Verity, and H. V. Vinters. 1994. Posterior cortical atrophy - Neuropathologic correlations. Arch. Neurol. 51: 269-274.
82. Vogt, B. A., P. B. Crino, and L. J. Vogt. 1992. Reorganization of cingulate cortex in Alzheimer's disease: Neuron loss, neuritic plaques, and muscarinic receptor binding. Cereb. Cortex 2: 526-535.
83. Vogt, B. A., P. B. Crino, and L. Volicer. 1991. Laminar alterations in gamma-aminobutyric acidA, muscarinic and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease. J. Neurochem. 57: 282-290.
84. Vogt, B. A., D. M. Finch, and C. R. Olson. 1992. Functional heterogeneity in cingulate cortex: The anterior executive and posterior evaluative regions. Cereb. Cortex 2: 435-443.
85. Vogt, B. A., and M. Gabriel. 1993. Neurobiology of Cingulate Cortex and Limbic Thalamus. Birkhäuser, Boston.
86. Vogt, B. A., A. Martin, K. E. Vrana, J. R. Absher, L. J. Vogt, and P. R. Hof. 1998. Multifocal cortical neurodegeneration in Alzheimer's disease. In Cerebral Cortex (A. Peters and J. H. Morrison, Eds.). Plenum Press: New York.
87. Vogt, B. A., E. A. Nimchinsky, L. J. Vogt, and P. R. Hof. 1995. Human cingulate cortex: Surface features, flat maps, and cytoarchitecture. J. Comp. Neurol. 359: 490-506.
88. Vogt, B. A., and D. N. Pandya. 1987. Cingulate cortex of the rhesus monkey. II. Cortical afferents. J. Comp. Neurol. 262: 271-289.
89. Vogt, B. A., G. W. Van Hoesen, and L. J. Vogt. 1990. Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease. Acta Neuropathol. 80: 581-589.
90. Vogt, B. A., L. J. Vogt, E. A. Nimchinsky, and P. R. Hof. 1997. Primate cingulate cortex chemoarchitecture and its disruption in Alzheimer's disease. In Handbook of Chemical Neuroanatomy. Vol. 13. The Primate Nervous System, Part 1. (F. E. Bloom, A. Björklund, and T. Hökfelt, Eds.), Part 1, pp. 455-528. Elsevier, Amsterdam.
91. Yankner, B. A. 1995. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16: 921-932.