Dyrk1A-mediated phosphorylation of Presenilin 1: A functional link between Down syndrome and Alzheimer's disease

Journal of Neurochemistry

Volumn 115, Issue 3, 2010, Pages 574-584

  Ryu, Young Shin ^a   Park, So Young ^a   Jung, Min Su ^a   Yoon, Song Hee ^a   Kwen, Mi Yang ^a   Lee, Sun Young ^a   Choi, Sun Hee ^a   Radnaabazar, Chinzorig ^a   Kim, Mi Kyoung ^a   Kim, Hangun ^b   Kim, Kwonseop ^b   Song, Woo Joo ^a   Chung, Sul Hee ^a  

^a Inje University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Alzheimer's disease; Down syndrome; Dyrk1A; Phosphorylation; Presenilin 1.

Indexed keywords

AMYLOID BETA PROTEIN; DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1A; GAMMA SECRETASE; PRESENILIN 1; PROTEIN KINASE; THREONINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN SYNDROME; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSGENIC MOUSE; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; DOWN SYNDROME; HALF-LIFE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PLASMIDS; PRESENILIN-1; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RNA, SMALL INTERFERING;

MAMMALIA; MUS MUSCULUS;

EID: 78651063834     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06769.x     Document Type: Article

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