메뉴 건너뛰기




Volumn 4, Issue 5, 2012, Pages

Oral curcumin for Alzheimer's disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(19)  Ringman, John M a   Frautschy, Sally A a,b   Teng, Edmond a,b   Begum, Aynun N a   Bardens, Jenny a   Beigi, Maryam a   Gylys, Karen H a,c   Badmaev, Vladimir d   Heath, Dennis D e   Apostolova, Liana G a   Porter, Verna a   Vanek, Zeba a   Marshall, Gad A f   Hellemann, Gerhard g   Sugar, Catherine g   Masterman, Donna L h   Montine, Thomas J i   Cummings, Jeffrey L j   Cole, Greg M a,b  


Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CURCUMIN; CURCUMIN C3 COMPLEX; DRUG METABOLITE; ISOPROSTANE DERIVATIVE; P TAU181 PROTEIN; PLACEBO; T TAU PROTEIN; TAU PROTEIN; TETRAHYDROCURCUMIN; UNCLASSIFIED DRUG;

EID: 84867901639     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/alzrt146     Document Type: Article
Times cited : (415)

References (26)
  • 1
    • 79952730699 scopus 로고    scopus 로고
    • 2011 Alzheimer's disease facts and figures
    • 21414557
    • 2011 Alzheimer's disease facts and figures. Thies W, Bleiler L, Alzheimers Dement 2011 7 208 244 21414557
    • (2011) Alzheimers Dement , vol.7 , pp. 208-244
    • Thies, W.1    Bleiler, L.2
  • 2
    • 0026711273 scopus 로고
    • Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes
    • 1588934
    • Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Reddy AC, Lokesh BR, Mol Cell Biochem 1992 111 117 124 1588934
    • (1992) Mol Cell Biochem , vol.111 , pp. 117-124
    • Reddy, A.C.1    Lokesh, B.R.2
  • 3
    • 16844382331 scopus 로고    scopus 로고
    • Evidence of increased oxidative damage in subjects with mild cognitive impairment
    • 10.1212/01.WNL.0000156156.13641.BA 15824339
    • Evidence of increased oxidative damage in subjects with mild cognitive impairment. Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfield DA, Markesbery WR, Neurology 2005 64 1152 1156 10.1212/01.WNL.0000156156.13641.BA 15824339
    • (2005) Neurology , vol.64 , pp. 1152-1156
    • Keller, J.N.1    Schmitt, F.A.2    Scheff, S.W.3    Ding, Q.4    Chen, Q.5    Butterfield, D.A.6    Markesbery, W.R.7
  • 5
  • 7
    • 0035957872 scopus 로고    scopus 로고
    • Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from βA(1-42) insult
    • DOI 10.1016/S0304-3940(01)01677-9, PII S0304394001016779
    • Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Kim DS, Park SY, Kim JK, Neurosci Lett 2001 303 57 61 10.1016/S0304-3940(01)01677-9 11297823 (Pubitemid 32285467)
    • (2001) Neuroscience Letters , vol.303 , Issue.1 , pp. 57-61
    • Kim, D.S.1    Park, S.-Y.2    Kim, J.-Y.3
  • 8
    • 1542364225 scopus 로고    scopus 로고
    • Curcumin Has Potent Anti-Amyloidogenic Effects for Alzheimer's β-Amyloid Fibrils In Vitro
    • DOI 10.1002/jnr.20025
    • Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M, J Neurosci Res 2004 75 742 750 10.1002/jnr.20025 14994335 (Pubitemid 38296087)
    • (2004) Journal of Neuroscience Research , vol.75 , Issue.6 , pp. 742-750
    • Ono, K.1    Hasegawa, K.2    Naiki, H.3    Yamada, M.4
  • 9
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM, J Neurosci 2001 21 8370 8377 11606625 (Pubitemid 33051435)
    • (2001) Journal of Neuroscience , vol.21 , Issue.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 10
    • 34547451145 scopus 로고    scopus 로고
    • Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model
    • DOI 10.1111/j.1471-4159.2007.04613.x
    • Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ, J Neurochem 2007 102 1095 1104 10.1111/j.1471-4159.2007.04613.x 17472706 (Pubitemid 47174225)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.4 , pp. 1095-1104
    • Garcia-Alloza, M.1    Borrelli, L.A.2    Rozkalne, A.3    Hyman, B.T.4    Bacskai, B.J.5
  • 12
    • 20844434618 scopus 로고
    • NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1). (Major Component 79%-85% Curcumin CAS No, 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • 12616304
    • NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1). (Major Component 79%-85% Curcumin CAS No, 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser 1993 427 1 275 12616304
    • (1993) Natl Toxicol Program Tech Rep ser , vol.427 , pp. 1-275
  • 14
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM, Neurology 1984 34 939 944 10.1212/WNL.34.7.939 6610841 (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 15
    • 0030814418 scopus 로고    scopus 로고
    • Development of cognitive instruments for use in clinical trials of antidementia drugs: Additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study
    • 9236948
    • Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study. Mohs RC, Knopman D, Petersen RC, Ferris SH, Ernesto C, Grundman M, Sano M, Bieliauskas L, Geldmacher D, Clark C, Thal LJ, Alzheimer Dis Assoc Disord 1997 11 Suppl 2 13 21 9236948
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.SUPPL. 2 , pp. 1913-1921
    • Mohs, R.C.1    Knopman, D.2    Petersen, R.C.3    Ferris, S.H.4    Ernesto, C.5    Grundman, M.6    Sano, M.7    Bieliauskas, L.8    Geldmacher, D.9    Clark, C.10    Thal, L.J.11
  • 16
    • 0027985334 scopus 로고
    • The neuropsychiatric inventory: Comprehensive assessment of psychopathology in dementia
    • The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J, Neurology 1994 44 2308 2314 10.1212/WNL.44.12.2308 7991117 (Pubitemid 24382728)
    • (1994) Neurology , vol.44 , Issue.12 , pp. 2308-2314
    • Cummings, J.L.1    Mega, M.2    Gray, K.3    Rosenberg-Thompson, S.4    Carusi, D.A.5    Gornbein, J.6
  • 17
    • 0030771116 scopus 로고    scopus 로고
    • An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study
    • 9236950
    • An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M, Ferris S, Alzheimer Dis Assoc Disord 1997 11 Suppl 2 33 39 9236950
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.SUPPL. 2 , pp. 1933-1939
    • Galasko, D.1    Bennett, D.2    Sano, M.3    Ernesto, C.4    Thomas, R.5    Grundman, M.6    Ferris, S.7
  • 18
    • 27644574348 scopus 로고    scopus 로고
    • 4-neuroprostanes from excitotoxicity and innate immune response in vivo by α- Or γ-tocopherol
    • DOI 10.1016/j.jchromb.2005.03.037, PII S1570023205002382, Analysis of Antioxidants and Biomarkers of Oxidative Stress
    • Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol. Milatovic D, VanRollins M, Li K, Montine KS, Montine TJ, J Chromatogr B Analyt Technol Biomed Life Sci 2005 827 88 93 10.1016/j.jchromb. 2005.03.037 16260380 (Pubitemid 41551601)
    • (2005) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.827 , Issue.1 , pp. 88-93
    • Milatovic, D.1    VanRollins, M.2    Li, K.3    Montine, K.S.4    Montine, T.J.5
  • 21
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • 10101144
    • Biotransformation of curcumin through reduction and glucuronidation in mice. Pan MH, Huang TM, Lin JK, Drug Metab Dispos 1999 27 486 494 10101144
    • (1999) Drug Metab Dispos , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 22
    • 0035686083 scopus 로고    scopus 로고
    • Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
    • DOI 10.1016/S0197-4580(01)00300-1, PII S0197458001003001
    • Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM, Neurobiol Aging 2001 22 993 1005 10.1016/S0197-4580(01)00300-1 11755008 (Pubitemid 34070638)
    • (2001) Neurobiology of Aging , vol.22 , Issue.6 , pp. 993-1005
    • Frautschy, S.A.1    Hu, W.2    Kim, P.3    Miller, S.A.4    Chu, T.5    Harris-White, M.E.6    Cole, G.M.7
  • 24
    • 58149084882 scopus 로고    scopus 로고
    • A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin
    • 10.4103/0250-474X.44591 20046768
    • A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S, Indian J Pharm Sci 2008 70 445 449 10.4103/0250-474X.44591 20046768
    • (2008) Indian J Pharm Sci , vol.70 , pp. 445-449
    • Antony, B.1    Merina, B.2    Iyer, V.S.3    Judy, N.4    Lennertz, K.5    Joyal, S.6
  • 26
    • 67649805281 scopus 로고    scopus 로고
    • Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions
    • 10.1016/j.jalz.2009.03.002 19560104
    • Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions. Kokjohn TA, Roher AE, Alzheimers Dement 2009 5 340 347 10.1016/j.jalz.2009.03.002 19560104
    • (2009) Alzheimers Dement , vol.5 , pp. 340-347
    • Kokjohn, T.A.1    Roher, A.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.