Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy

Journal of Neuroscience

Volumn 30, Issue 41, 2010, Pages 13861-13866

  Brunden, Kurt R ^a   Zhang, Bin ^a   Carroll, Jenna ^a   Yao, Yuemang ^a   Potuzak, Justin S ^b   Hogan, Anne Marie L ^b   Iba, Michiyo ^a   James, Michael J ^a   Xie, Sharon X ^b   Ballatore, Carlo ^a,b   Smith III, Amos B ^b   Lee, Virginia M Y ^a   Trojanowski, John Q ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPOTHILONE D; TAU PROTEIN; DESOXYEPOTHILONE B; EPOTHILONE DERIVATIVE; TUBULIN MODULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; COGNITION; CONTROLLED STUDY; DRUG PENETRATION; EVALUATION; FOREBRAIN; MALE; MICROTUBULE; MOUSE; NERVE FIBER; NERVE FIBER DEGENERATION; NONHUMAN; PRIORITY JOURNAL; TAUOPATHY; TRANSGENIC MOUSE; ANIMAL; BRAIN; DRUG EFFECTS; ELECTRON MICROSCOPY; FEMALE; MAZE TEST; METABOLISM; MOTOR PERFORMANCE; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; RANDOMIZATION; ROTAROD TEST; TAUOPATHIES;

ANIMALS; AXONS; BRAIN; COGNITION; EPOTHILONES; FEMALE; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MICROTUBULES; MOTOR SKILLS; NEURONS; PHOSPHORYLATION; RANDOM ALLOCATION; ROTAROD PERFORMANCE TEST; TAU PROTEINS; TAUOPATHIES; TUBULIN MODULATORS;

EID: 77958065504     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3059-10.2010     Document Type: Article

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