Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

Journal of Neurochemistry

Volumn 110, Issue 4, 2009, Pages 1339-1351

  Li, Wenkai ^a   Sperry, Jeffrey B ^b   Crowe, Alex ^a   Trojanowski, John Q ^a   Smith Iii, Amos B ^b,c   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

Aldehyde; Fibrillization; Lysine; Neurodegeneration; Oleocanthal; Tau

Indexed keywords

ALDEHYDE; AMYLOID BETA PROTEIN; GLUTAMINE; HEXAPEPTIDE; IBUPROFEN; ISOLEUCINE; LYSINE; NATURAL PRODUCT; OLEOCANTHAL; OLIVE OIL; SCHIFF BASE; TAU PROTEIN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; MICROTUBULE ASSEMBLY; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN AGGREGATION; STRUCTURE ACTIVITY RELATION; TAUOPATHY;

ALDEHYDES; AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-INFLAMMATORY AGENTS; BRAIN; ENCEPHALITIS; HUMANS; LYSINE; MOLECULAR STRUCTURE; NEUROFIBRILLARY TANGLES; NEUROFIBRILS; NEUROPROTECTIVE AGENTS; PEPTIDES; PHENOLS; PROTEIN FOLDING; SCHIFF BASES; TAU PROTEINS; TAUOPATHIES;

EID: 67651160771     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06224.x     Document Type: Article

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