Inducible expression of tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs

Journal of Biological Chemistry

Volumn 281, Issue 2, 2006, Pages 1205-1214

  Khlistunova, Inna ^a   Biernat, Jacek ^a   Wang, Yipeng ^a   Pickhardt, Marcus ^a   Von Bergen, Martin ^a   Gazova, Zuzana ^a   Mandelkow, Eckhard ^a   Mandelkow, Eva Maria ^a  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; ENZYME INHIBITION; ENZYME KINETICS; MATHEMATICAL MODELS; PROTEINS; TOXICITY;

INHIBITOR DRUGS; PHOSPHORYLATION; TAU PROTEIN;

CELL CULTURE;

DOXYCYCLINE; TAU PROTEIN; DNA FRAGMENT; ISOPROTEIN; PEPTIDE HYDROLASE; THIAZOLE DERIVATIVE; THIOFLAVINE; THROMBIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; FRONTOTEMPORAL DEMENTIA; NEUROBLASTOMA CELL; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TAUOPATHY; BIOLOGICAL MODEL; BRAIN; CELL LINE; CHEMICAL MODEL; CHEMISTRY; CHROMATOGRAPHY; DENSITY GRADIENT CENTRIFUGATION; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; GENE DELETION; HUMAN; MASS SPECTROMETRY; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; TIME; TUMOR CELL LINE;

ANIMALIA;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; BRAIN; CELL LINE; CELL LINE, TUMOR; CENTRIFUGATION, DENSITY GRADIENT; CHROMATOGRAPHY; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE DELETION; HUMANS; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MUTATION; NEURONS; PEPTIDE HYDROLASES; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; TAU PROTEINS; TAUOPATHIES; THIAZOLES; THROMBIN; TIME FACTORS;

EID: 33644851265     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507753200     Document Type: Article

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