3D QSAR CoMFA study on phenylthiazolylhydrazide (PTH) derivataives as tau protein aggregation inhibitors

Bulletin of the Korean Chemical Society

Volumn 31, Issue 12, 2010, Pages 3838-3841

  Park, Hye Ri ^a   Kim, Mi Kyoung ^a   Kim, Dong Woon ^b   Il, Han Choo ^c   Chong, Youhoon ^a  

^a Konkuk University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Seoul National University Hospital   (South Korea)

Author keywords

3D QSAR; Alzheimer; CoMFA; Tau protein

Indexed keywords

EID: 78650392793     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2010.31.12.3838     Document Type: Article

References (20)

1. Hardy, J.; Selkoe, D. J. Science 2002, 297, 353.
2. Vieira, M. N.; Forny-Germano, L.; Saraiva, L. M.; Sebollela, A.; Martinez, A. M.; Houzel, J. C.; De Felice, F. G.; Ferreira, S. T. J. Neurochem. 2007, 103, 736.
3. Leroy, K.; Bretteville, A.; Schindowski, K.; Gilissen, E.; Authelet, M.; De Decker, R.; Yilmaz, Z.; Buee, L.; Brion, J. P. Am. J. Pathol. 2007, 171, 976.
4. Ballatore, C.; Lee, V. M.; Trojanowski, J. Q. Nat. Rev. Neurosci. 2007, 8, 663.
5. Xia, W. Curr. Opin. Investig. Drugs. 2003, 4, 55.
6. Wischik, C. M.; Bentham, P.; Wischik, D. J.; Seng, K. M. Alzheimer's and Dementia 2008, 4, T167.
7. Bulic, B.; Pickhardt, M.; Khlistunova, I.; Biernat, J.; Mandelkow, E. M.; Mandelkow, E.; Waldmann, H. Angew. Chem. Int. Ed. 2007, 46, 9215.
8. Pickhardt, M.; von Bergen, M.; Gazova, Z.; Hascher, A.; Biernat, J.; Mandelkow, E.-M.; Mandelkow, E. Curr. Alzheimer Res. 2005, 2, 219.
9. Larbig, G.; Pickhardt, M.; Lloyd, D. G.; Schmidt, B.; Mandelkow, E. Curr. Alzheimer Res. 2007, 4, 315.
10. Pickhardt, M.; Larbig, G.; Khlistunova, I.; Coksezen, A.; Meyer, B.; Mandelkow, E.-M.; Schmidt, N.; Mandelkow, E. Biochemistry 2007, 46, 10016.
11. Pickhardt, M.; Biernat, J.; Khlistunova, I.; Wang, Y. P.; Gazova, Z.; Mandelkow, E. M.; Mandelkow, E. Curr. Alzhemier Res. 2007, 4, 397.
12. Pickhardt, M.; Gazova, Z.; von Bergen, M.; Khlistunova, I.; Wang, Y.; Hascher, A.; Mandelkow, E. M.; Biernat, J.; Mandelkow, E. J. Biol. Chem. 2005, 280, 3628.
13. Necula, M.; Chirita, C. M.; Kuret, J. Biochemistry 2005, 44, 10227.
14. Taniguchi, S.; Suzuki, N.; Masuda, M.; Hisanaga, S.; Iwatsubo, T.; Goedert, M.; Hasegawa, M. J. Biol. Chem. 2005, 280, 7614.
15. Kazius, J.; McGuire, R.; Bursi, R. J. Med. Chem. 2005, 48, 312.
16. SYBYL 7.2 Tripos International, 1699 South Hanley Rd., St. Louis, Missouri, 63144, USA.
17. Cramer, M.; Cramer, R. D.; Jones, D. M. J. Am. Chem. Soc. 1988, 110, 5959.
18. Kim, J.; Lee, M.; Kang, S. -Y.; Park, J.; Lim, Y.; Koh, D.; Park, K. H.; Chong, Y. Bull. Korean Chem. Soc. 2006, 27, 1025.
19. Klebe, G.; Abraham, U.; Mietzner, T. J. Med. Chem. 1994, 37, 4130.
20. Kim, J.; Han, J. H.; Chong, Y. Bull. Korean Chem. Soc. 2006, 27, 1919.