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Volumn 49, Issue 76, 2013, Pages 8441-8443

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration

(2) Kitson, Russell R A a Moody, Christopher J a

a UNIVERSITY OF NOTTINGHAM (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

19 IODOGELDANAMYCIN; 19 PHENYLGELDANAMYCIN; 2 NITROPHENYLGELDANAMYCIN DERIVATIVE; 4 ACETYLPHENYLGELDANAMYCIN DERIVATIVE; ALVESPIMYCIN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; TANESPIMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; PIGMENT EPITHELIUM; SUBSTITUTION REACTION; SUZUKI REACTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTINEOPLASTIC AGENTS; BENZOQUINONES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASMS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883428711 PISSN: 13597345 EISSN: 1364548X Source Type: Journal
DOI: 10.1039/c3cc43457e Document Type: Article

Times cited : (22)

References (44)

1
- 0014847819
- C. DeBoer, P. A. Meulman, R. J. Wnuk, D. H. Peterson, J. Antibiot., 1970, 23, 442-447
- (1970) J. Antibiot. , vol.23 , pp. 442-447
- Deboer, C.¹ Meulman, P.A.² Wnuk, R.J.³ Peterson, D.H.⁴

2
- 0028064940
- L. Whitesell, E. G. Mimnaugh, B. Decosta, C. E. Myers, L. M. Neckers, Proc. Natl. Acad. Sci. U. S. A., 1994, 91, 8324-8328
- (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 8324-8328
- Whitesell, L.¹ Mimnaugh, E.G.² Decosta, B.³ Myers, C.E.⁴ Neckers, L.M.⁵

3
- 84879294180
- R. R. A. Kitson, C. J. Moody, J. Org. Chem., 2013, 78, 5117-5141
- (2013) J. Org. Chem. , vol.78 , pp. 5117-5141
- Kitson, R.R.A.¹ Moody, C.J.²

4
- 33746377987
- E. McDonald, P. Workman, K. Jones, Curr. Top. Med. Chem., 2006, 6, 1091-1107
- (2006) Curr. Top. Med. Chem. , vol.6 , pp. 1091-1107
- McDonald, E.¹ Workman, P.² Jones, K.³

5
- 73649130290
- H. Adachi, M. Katsuno, M. Waza, M. Minamiyama, F. Tanaka, G. Sobue, Int. J. Hyperthermia, 2009, 25, 647-654
- (2009) Int. J. Hyperthermia , vol.25 , pp. 647-654
- Adachi, H.¹ Katsuno, M.² Waza, M.³ Minamiyama, M.⁴ Tanaka, F.⁵ Sobue, G.⁶

6
- 79955830308
- P. Aridon, F. Geraci, G. Turturici, M. D'Amelio, G. Savettieri, G. Sconzo, Neurodegener. Dis., 2011, 8, 155-168
- (2011) Neurodegener. Dis. , vol.8 , pp. 155-168
- Aridon, P.¹ Geraci, F.² Turturici, G.³ D'amelio, M.⁴ Savettieri, G.⁵ Sconzo, G.⁶

7
- 32844475529
- K. A. Gallo, Chem. Biol., 2006, 13, 115-116
- (2006) Chem. Biol. , vol.13 , pp. 115-116
- Gallo, K.A.¹

8
- 78649239916
- S. K. Kalia, L. V. Kalia, P. J. McLean, CNS Neurol. Disord.: Drug Targets, 2010, 9, 741-753
- (2010) CNS Neurol. Disord.: Drug Targets , vol.9 , pp. 741-753
- Kalia, S.K.¹ Kalia, L.V.² McLean, P.J.³

9
- 33846483687
- G.-R. Luo, S. Chen, W.-D. Le, Int. J. Biol. Sci., 2007, 3, 20-26
- (2007) Int. J. Biol. Sci. , vol.3 , pp. 20-26
- Luo, G.-R.¹ Chen, S.² Le, W.-D.³

10
- 77949877628
- M. U. Sajjad, B. Samson, A. Wyttenbach, Curr. Pharm. Biotechnol., 2010, 11, 198-215
- (2010) Curr. Pharm. Biotechnol. , vol.11 , pp. 198-215
- Sajjad, M.U.¹ Samson, B.² Wyttenbach, A.³

11
- 0035232359
- B. G. Brenner, Z. Wainberg, Expert Opin. Biol. Ther., 2001, 1, 67-77
- (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 67-77
- Brenner, B.G.¹ Wainberg, Z.²

12
- 84864628996
- F. Roesch, O. Meziane, A. Kula, S. Nisole, F. Porrot, I. Anderson, F. Mammano, A. Fassati, A. Marcello, M. Benkirane, O. Schwartz, PLoS Pathog., 2012, 8, e1002792
- (2012) O. Schwartz, Plos Pathog. , vol.8 , pp. e1002792
- Roesch, F.¹ Meziane, O.² Kula, A.³ Nisole, S.⁴ Porrot, F.⁵ Anderson, I.⁶ Mammano, F.⁷ Fassati, A.⁸ Marcello, A.⁹ Benkirane, M.¹⁰

13
- 78649867001
- L. Vozzolo, B. Loh, P. J. Gane, M. Tribak, L. H. Zhou, I. Anderson, E. Nyakatura, R. G. Jenner, D. Selwood, A. Fassati, J. Biol. Chem., 2010, 285, 39314-39328
- (2010) J. Biol. Chem. , vol.285 , pp. 39314-39328
- Vozzolo, L.¹ Loh, B.² Gane, P.J.³ Tribak, M.⁴ Zhou, L.H.⁵ Anderson, I.⁶ Nyakatura, E.⁷ Jenner, R.G.⁸ Selwood, D.⁹ Fassati, A.¹⁰

14
- 34247513586
- P. Acharya, R. Kumar, U. Tatu, Mol. Biochem. Parasitol., 2007, 153, 85-94
- (2007) Mol. Biochem. Parasitol. , vol.153 , pp. 85-94
- Acharya, P.¹ Kumar, R.² Tatu, U.³

15
- 0026704899
- Y. D. Sharma, Comp. Biochem. Physiol., B: Biochem. Mol. Biol., 1992, 102, 437-444
- (1992) Comp. Biochem. Physiol., B: Biochem. Mol. Biol. , vol.102 , pp. 437-444
- Sharma, Y.D.¹

16
- 59649092763
- D. Wider, M. P. Peli-Gulli, P. A. Briand, U. Tatu, D. Picard, Mol. Biochem. Parasitol., 2009, 164, 147-152
- (2009) Mol. Biochem. Parasitol. , vol.164 , pp. 147-152
- Wider, D.¹ Peli-Gulli, M.P.² Briand, P.A.³ Tatu, U.⁴ Picard, D.⁵

17
- 0029123128
- R. C. Schnur, M. L. Corman, R. J. Gallaschun, B. A. Cooper, M. F. Dee, J. L. Doty, M. L. Muzzi, C. I. DiOrio, E. G. Barbacci, J. Med. Chem., 1995, 38, 3813-3820
- (1995) J. Med. Chem. , vol.38 , pp. 3813-3820
- Schnur, R.C.¹ Corman, M.L.² Gallaschun, R.J.³ Cooper, B.A.⁴ Dee, M.F.⁵ Doty, J.L.⁶ Muzzi, M.L.⁷ Diorio, C.I.⁸ Barbacci, E.G.⁹

18
- 0029122080
- R. C. Schnur, M. L. Corman, R. J. Gallaschun, B. A. Cooper, M. F. Dee, J. L. Doty, M. L. Muzzi, J. D. Moyer, C. I. DiOrio, J. Med. Chem., 1995, 38, 3806-3812
- (1995) J. Med. Chem. , vol.38 , pp. 3806-3812
- Schnur, R.C.¹ Corman, M.L.² Gallaschun, R.J.³ Cooper, B.A.⁴ Dee, M.F.⁵ Doty, J.L.⁶ Muzzi, M.L.⁷ Moyer, J.D.⁸ Diorio, C.I.⁹

19
- 23044441106
- U. Banerji, A. O'Donnell, M. Scurr, S. Pacey, S. Stapleton, Y. Asad, L. Simmons, A. Maloney, F. Raynaud, M. Campbell, M. Walton, S. Lakhani, S. Kaye, P. Workman, I. Judson, J. Clin. Oncol., 2005, 23, 4152-4161
- (2005) J. Clin. Oncol. , vol.23 , pp. 4152-4161
- Banerji, U.¹ O'donnell, A.² Scurr, M.³ Pacey, S.⁴ Stapleton, S.⁵ Asad, Y.⁶ Simmons, L.⁷ Maloney, A.⁸ Raynaud, F.⁹ Campbell, M.¹⁰ Walton, M.¹¹ Lakhani, S.¹² Kaye, S.¹³ Workman, P.¹⁴ Judson, I.¹⁵

20
- 20044384168
- M. P. Goetz, D. Toft, J. Reid, M. Ames, B. Stensgard, S. Safgren, A. A. Adjei, J. Sloan, P. Atherton, V. Vasile, S. Salazaar, A. Adjei, G. Croghan, C. Erlichman, J. Clin. Oncol., 2005, 23, 1078-1087
- (2005) J. Clin. Oncol. , vol.23 , pp. 1078-1087
- Goetz, M.P.¹ Toft, D.² Reid, J.³ Ames, M.⁴ Stensgard, B.⁵ Safgren, S.⁶ Adjei, A.A.⁷ Sloan, J.⁸ Atherton, P.⁹ Vasile, V.¹⁰ Salazaar, S.¹¹ Adjei, A.¹² Croghan, G.¹³ Erlichman, C.¹⁴

21
- 20944444881
- R. K. Ramanathan, D. L. Trump, J. L. Eiseman, C. P. Belani, S. S. Agarwala, E. G. Zuhowski, J. Lan, D. M. Potter, S. P. Ivy, S. Ramalingam, A. M. Brufsky, M. K. K. Wong, S. Tutchko, M. J. Egorin, Clin. Cancer Res., 2005, 11, 3385-3391
- (2005) Clin. Cancer Res. , vol.11 , pp. 3385-3391
- Ramanathan, R.K.¹ Trump, D.L.² Eiseman, J.L.³ Belani, C.P.⁴ Agarwala, S.S.⁵ Zuhowski, E.G.⁶ Lan, J.⁷ Potter, D.M.⁸ Ivy, S.P.⁹ Ramalingam, S.¹⁰ Brufsky, A.M.¹¹ Wong, M.K.K.¹² Tutchko, S.¹³ Egorin, M.J.¹⁴

22
- 0141596326
- E. A. Sausville, J. E. Tomaszewski, P. Ivy, Curr. Cancer Drug Targets, 2003, 3, 377-383
- (2003) Curr. Cancer Drug Targets , vol.3 , pp. 377-383
- Sausville, E.A.¹ Tomaszewski, J.E.² Ivy, P.³

23
- 67649380752
- J. E. H. Day, A. J. Blake, C. J. Moody, Synlett, 2009, 1567-1570
- (2009) Synlett , pp. 1567-1570
- Day, J.E.H.¹ Blake, A.J.² Moody, C.J.³

24
- 84859716448
- J. E. H. Day, S. Y. Sharp, M. G. Rowlands, W. Aherne, A. Hayes, F. I. Raynaud, W. Lewis, S. M. Roe, C. Prodromou, L. H. Pearl, P. Workman, C. J. Moody, ACS Chem. Biol., 2011, 6, 1339-1347
- (2011) ACS Chem. Biol. , vol.6 , pp. 1339-1347
- Day, J.E.H.¹ Sharp, S.Y.² Rowlands, M.G.³ Aherne, W.⁴ Hayes, A.⁵ Raynaud, F.I.⁶ Lewis, W.⁷ Roe, S.M.⁸ Prodromou, C.⁹ Pearl, L.H.¹⁰ Workman, P.¹¹ Moody, C.J.¹²

25
- 77956429649
- J. E. H. Day, S. Y. Sharp, M. G. Rowlands, W. Aherne, W. Lewis, S. M. Roe, C. Prodromou, L. H. Pearl, P. Workman, C. J. Moody, Chem.–Eur. J., 2010, 16, 10366-10372
- (2010) Chem.–Eur. J. , vol.16 , pp. 10366-10372
- Day, J.E.H.¹ Sharp, S.Y.² Rowlands, M.G.³ Aherne, W.⁴ Lewis, W.⁵ Roe, S.M.⁶ Prodromou, C.⁷ Pearl, L.H.⁸ Workman, P.⁹ Moody, C.J.¹⁰

26
- 77149140097
- J. E. H. Day, S. Y. Sharp, M. G. Rowlands, W. Aherne, P. Workman, C. J. Moody, Chem.–Eur. J., 2010, 16, 2758-2763
- (2010) Chem.–Eur. J. , vol.16 , pp. 2758-2763
- Day, J.E.H.¹ Sharp, S.Y.² Rowlands, M.G.³ Aherne, W.⁴ Workman, P.⁵ Moody, C.J.⁶

27
- 33846509183
- C. S. P. McErlean, N. Proisy, C. J. Davis, N. A. Boland, S. Y. Sharp, K. Boxall, A. M. Z. Slawin, P. Workman, C. J. Moody, Org. Biomol. Chem., 2007, 5, 531-546
- (2007) Org. Biomol. Chem. , vol.5 , pp. 531-546
- McErlean, C.S.P.¹ Proisy, N.² Davis, C.J.³ Boland, N.A.⁴ Sharp, S.Y.⁵ Boxall, K.⁶ Slawin, A.M.Z.⁷ Workman, P.⁸ Moody, C.J.⁹

28
- 33750986790
- N. Proisy, S. Y. Sharp, K. Boxall, S. Connelly, S. M. Roe, C. Prodromou, A. M. Z. Slawin, L. H. Pearl, P. Workman, C. J. Moody, Chem. Biol., 2006, 13, 1203-1215
- (2006) Chem. Biol. , vol.13 , pp. 1203-1215
- Proisy, N.¹ Sharp, S.Y.² Boxall, K.³ Connelly, S.⁴ Roe, S.M.⁵ Prodromou, C.⁶ Slawin, A.M.Z.⁷ Pearl, L.H.⁸ Workman, P.⁹ Moody, C.J.¹⁰

29
- 84883401173
- R. R. A. Kitson, C.-H. Chuan, R. Xiong, H. E. L. Williams, A. L. Davis, W. Lewis, D. L. Dehn, D. Siegel, S. M. Roe, C. Prodromou, D. Ross, C. J. Moody, Nat. Chem., 2013, 307-314
- (2013) Nat. Chem. , pp. 307-314
- Kitson, R.R.A.¹ Chuan, C.-H.² Xiong, R.³ Williams, H.E.L.⁴ Davis, A.L.⁵ Lewis, W.⁶ Dehn, D.L.⁷ Siegel, D.⁸ Roe, S.M.⁹ Prodromou, C.¹⁰ Ross, D.¹¹ Moody, C.J.¹²

30
- 33645471864
- R. L. Cysyk, R. J. Parker, J. J. Barchi, P. S. Steeg, N. R. Hartman, J. A. Strong, Chem. Res. Toxicol., 2006, 19, 376-381
- (2006) Chem. Res. Toxicol. , vol.19 , pp. 376-381
- Cysyk, R.L.¹ Parker, R.J.² Barchi, J.J.³ Steeg, P.S.⁴ Hartman, N.R.⁵ Strong, J.A.⁶

31
- 52949096836
- W. Guo, P. Reigan, D. Siegel, D. Ross, Drug Metab. Dispos., 2008, 36, 2050-2057
- (2008) Drug Metab. Dispos. , vol.36 , pp. 2050-2057
- Guo, W.¹ Reigan, P.² Siegel, D.³ Ross, D.⁴

32
- 33845956606
- W. S. Lang, G. W. Caldwell, J. Li, G. C. Leo, W. J. Jones, J. A. Masucci, Drug Metab. Dispos., 2007, 35, 21-29
- (2007) Drug Metab. Dispos. , vol.35 , pp. 21-29
- Lang, W.S.¹ Caldwell, G.W.² Li, J.³ Leo, G.C.⁴ Jones, W.J.⁵ Masucci, J.A.⁶

33
- 0344511727
- J. M. Jez, J. C. H. Chen, G. Rastelli, R. M. Stroud, D. V. Santi, Chem. Biol., 2003, 10, 361-368
- (2003) Chem. Biol. , vol.10 , pp. 361-368
- Jez, J.M.¹ Chen, J.C.H.² Rastelli, G.³ Stroud, R.M.⁴ Santi, D.V.⁵

34
- 3242893125
- Y. S. Lee, M. G. Marcu, L. Neckers, Chem. Biol., 2004, 11, 991-998
- (2004) Chem. Biol. , vol.11 , pp. 991-998
- Lee, Y.S.¹ Marcu, M.G.² Neckers, L.³

35
- 34547933867
- S. C. Onuoha, S. R. Mukund, E. T. Coulstock, B. Serengova, J. Shaw, S. H. McLaughlin, S. E. Jackson, J. Mol. Biol., 2007, 372, 287-297
- (2007) J. Mol. Biol. , vol.372 , pp. 287-297
- Onuoha, S.C.¹ Mukund, S.R.² Coulstock, E.T.³ Serengova, B.⁴ Shaw, J.⁵ McLaughlin, S.H.⁶ Jackson, S.E.⁷

36
- 79955042825
- P. Reigan, D. Siegel, W. C. Guo, D. Ross, Mol. Pharmacol., 2011, 79, 823-832
- (2011) Mol. Pharmacol. , vol.79 , pp. 823-832
- Reigan, P.¹ Siegel, D.² Guo, W.C.³ Ross, D.⁴

37
- 33947427870
- P. Thepchatri, T. Eliseo, D. O. Cicero, D. Myles, J. P. Snyder, J. Am. Chem. Soc., 2007, 129, 3127-3134
- (2007) Chem. Soc. , vol.129 , pp. 3127-3134
- Thepchatri, P.¹ Eliseo, T.² Cicero, D.O.³ Myles, D.⁴ Snyder, J.P.⁵ Am, J.⁶

38
- 84883436792
- 3006097
- K. Sasaki and Y. Inoue, German Patent No. Ger. Offen., 3006097, 1980
- (1980) German Patent No. Ger. Offen.
- Sasaki, K.¹ Inoue, Y.²

39
- 49249152617
- N. Miyaura, K. Yamada, A. Suzuki, Tetrahedron Lett., 1979, 20, 3437-3440
- (1979) Tetrahedron Lett. , vol.20 , pp. 3437-3440
- Miyaura, N.¹ Yamada, K.² Suzuki, A.³

40
- 0037195653
- G. A. Molander, B. W. Katona, F. Machrouhi, J. Org. Chem., 2002, 67, 8416-8423
- (2002) J. Org. Chem. , vol.67 , pp. 8416-8423
- Molander, G.A.¹ Katona, B.W.² Machrouhi, F.³

41
- 70149117010
- D. M. Knapp, E. P. Gillis, M. D. Burke, J. Am. Chem. Soc., 2009, 131, 6961-6963
- (2009) Chem. Soc. , vol.131 , pp. 6961-6963
- Knapp, D.M.¹ Gillis, E.P.² Burke, M.D.³ Am, J.⁴

42
- 3142545683
- J.-Y. Le Brazidec, A. Kamal, D. Busch, L. Thao, L. Zhang, G. Timony, R. Grecko, K. Trent, R. Lough, T. Salazar, S. Khan, F. Burrows, M. F. Boehm, J. Med. Chem., 2004, 47, 3865-3873
- (2004) J. Med. Chem. , vol.47 , pp. 3865-3873
- Le Brazidec, J.-Y.¹ Kamal, A.² Busch, D.³ Thao, L.⁴ Zhang, L.⁵ Timony, G.⁶ Grecko, R.⁷ Trent, K.⁸ Lough, R.⁹ Salazar, T.¹⁰ Khan, S.¹¹ Burrows, F.¹² Boehm, M.F.¹³

43
- 0032488615
- D. A. Neel, M. R. Jirousek, J. H. McDonald, Bioorg. Med. Chem. Lett., 1998, 8, 47-50
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 47-50
- Neel, D.A.¹ Jirousek, M.R.² McDonald, J.H.³

44
- 77955829634
- D. C. Harrowven, D. P. Curran, S. L. Kostiuk, I. L. Wallis-Guy, S. Whiting, K. J. Stenning, B. Tang, E. Packard, L. Nanson, Chem. Commun., 2010, 46, 6335-6337
- (2010) Chem. Commun. , vol.46 , pp. 6335-6337
- Harrowven, D.C.¹ Curran, D.P.² Kostiuk, S.L.³ Wallis-Guy, I.L.⁴ Whiting, S.⁵ Stenning, K.J.⁶ Tang, B.⁷ Packard, E.⁸ Nanson, L.⁹

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