Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Neuropharmacology

Volumn 64, Issue , 2013, Pages 81-96

  Fass, Daniel M ^a,b   Reis, Surya A ^a,b   Ghosh, Balaram ^a,b   Hennig, Krista M ^a,b   Joseph, Nadine F ^c   Zhao, Wen Ning ^a,b   Nieland, Thomas J F ^b   Guan, Ji Song ^c   Groves Kuhnle, Chelsea E ^a,b   Tang, Weiping ^b   Barker, Douglas D ^b   Mazitschek, Ralph ^a   Schreiber, Stuart L ^b   Tsai, Li Huei ^b,c   Haggarty, Stephen J ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Acetylation; Chromatin; Cognitive enhancer; CREB; Epigenetic; Histone deacetylases

Indexed keywords

CREBINOSTAT; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 9; HISTONE H3; HISTONE H4; NOOTROPIC AGENT; SYNAPSIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; BRAIN NERVE CELL; CHROMATIN; CONTROLLED STUDY; DENDRITE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG IDENTIFICATION; EARLY GROWTH RESPONSE 1 GENE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE EXPRESSION; GRANULIN GENE; HIPPOCAMPUS; HISTONE ACETYLATION; IN VITRO STUDY; MALE; MAPT GENE; MEMORY; MOLECULAR MECHANICS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SYNAPSE; UPREGULATION;

ACETYLATION; ANIMALS; ANIMALS, NEWBORN; BIPHENYL COMPOUNDS; CELLS, CULTURED; DENDRITES; DRUG DISCOVERY; EMBRYO, MAMMALIAN; GENES, REPORTER; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; HYDRAZINES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; NEURONS; NOOTROPIC AGENTS; PROSENCEPHALON; RECOMBINANT PROTEINS;

EID: 84866387948     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.06.043     Document Type: Review

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