-
2
-
-
0022550260
-
Defective brain microtubule assembly in Alzheimer's disease
-
Iqbal K, et al. (1986) Defective brain microtubule assembly in Alzheimer's disease. Lancet 2(8504):421-426.
-
(1986)
Lancet
, vol.2
, Issue.8504
, pp. 421-426
-
-
Iqbal, K.1
-
3
-
-
0027308924
-
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
-
Bramblett GT, et al. (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10(6):1089-1099.
-
(1993)
Neuron
, vol.10
, Issue.6
, pp. 1089-1099
-
-
Bramblett, G.T.1
-
4
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
Hong M, et al. (1998) Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282(5395):1914-1917.
-
(1998)
Science
, vol.282
, Issue.5395
, pp. 1914-1917
-
-
Hong, M.1
-
5
-
-
7944236911
-
The cytoskeleton in neurodegenerative diseases
-
Cairns NJ, Lee VM, Trojanowski JQ (2004) The cytoskeleton in neurodegenerative diseases. J Pathol 204(4):438-449.
-
(2004)
J Pathol
, vol.204
, Issue.4
, pp. 438-449
-
-
Cairns, N.J.1
Lee, V.M.2
Trojanowski, J.Q.3
-
6
-
-
0035882526
-
Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments
-
Ishihara T, et al. (2001) Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J Neurosci 21(16):6026-6035.
-
(2001)
J Neurosci
, vol.21
, Issue.16
, pp. 6026-6035
-
-
Ishihara, T.1
-
7
-
-
0036138044
-
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau
-
Tanemura K, et al. (2002) Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22(1):133-141.
-
(2002)
J Neurosci
, vol.22
, Issue.1
, pp. 133-141
-
-
Tanemura, K.1
-
8
-
-
19944429064
-
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
Zhang B, et al. (2005) Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci USA 102(1):227-231.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.1
, pp. 227-231
-
-
Zhang, B.1
-
9
-
-
77958065504
-
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
-
Brunden KR, et al. (2010) Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci 30(41): 13861-13866.
-
(2010)
J Neurosci
, vol.30
, Issue.41
, pp. 13861-13866
-
-
Brunden, K.R.1
-
10
-
-
84863230105
-
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
-
Zhang B, et al. (2012) The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32(11):3601-3611.
-
(2012)
J Neurosci
, vol.32
, Issue.11
, pp. 3601-3611
-
-
Zhang, B.1
-
11
-
-
70350716183
-
Optically resolving individual microtubules in live axons
-
Mudrakola HV, Zhang K, Cui B (2009) Optically resolving individual microtubules in live axons. Structure 17(11):1433-1441.
-
(2009)
Structure
, vol.17
, Issue.11
, pp. 1433-1441
-
-
Mudrakola, H.V.1
Zhang, K.2
Cui, B.3
-
12
-
-
67649202108
-
Drosophila tubulin-specific chaperone e functions at neuromuscular synapses and is required for microtubule network formation
-
Jin S, et al. (2009) Drosophila tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136(9): 1571-1581.
-
(2009)
Development
, vol.136
, Issue.9
, pp. 1571-1581
-
-
Jin, S.1
-
13
-
-
79951533987
-
Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria
-
Yao A, et al. (2011) Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. Hum Mol Genet 20(1):51-63.
-
(2011)
Hum Mol Genet
, vol.20
, Issue.1
, pp. 51-63
-
-
Yao, A.1
-
14
-
-
79955670132
-
The many faces of tau
-
Morris M, Maeda S, Vossel K, Mucke L (2011) The many faces of tau. Neuron 70(3): 410-426.
-
(2011)
Neuron
, vol.70
, Issue.3
, pp. 410-426
-
-
Morris, M.1
Maeda, S.2
Vossel, K.3
Mucke, L.4
-
15
-
-
78649660787
-
Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss
-
Kimura T, et al. (2010) Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss. J Biol Chem 285(49):38692-38699.
-
(2010)
J Biol Chem
, vol.285
, Issue.49
, pp. 38692-38699
-
-
Kimura, T.1
-
16
-
-
77954208049
-
Drosophila histone deacetylase 6 protects dopaminergic neurons against alpha-synuclein toxicity by promoting inclusion formation
-
Du GP, et al. (2010) Drosophila histone deacetylase 6 protects dopaminergic neurons against alpha-synuclein toxicity by promoting inclusion formation. Mol Biol Cell 21(13):2128-2137.
-
(2010)
Mol Biol Cell
, vol.21
, Issue.13
, pp. 2128-2137
-
-
Du, G.P.1
-
17
-
-
33947307791
-
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1
-
Thies E, Mandelkow EM (2007) Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci 27(11): 2896-2907.
-
(2007)
J Neurosci
, vol.27
, Issue.11
, pp. 2896-2907
-
-
Thies, E.1
Mandelkow, E.M.2
-
18
-
-
2442477424
-
New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants
-
Ruiz-Canada C, et al. (2004) New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants. Neuron 42(4):567-580.
-
(2004)
Neuron
, vol.42
, Issue.4
, pp. 567-580
-
-
Ruiz-Canada, C.1
-
19
-
-
13944280702
-
Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function
-
Sherwood NT, Sun Q, Xue M, Zhang B, Zinn K (2004) Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. PLoS Biol 2(12):e429.
-
(2004)
PLoS Biol
, vol.2
, Issue.12
-
-
Sherwood, N.T.1
Sun, Q.2
Xue, M.3
Zhang, B.4
Zinn, K.5
-
20
-
-
34047106848
-
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
-
Blard O, et al. (2007) Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Hum Mol Genet 16(5):555-566.
-
(2007)
Hum Mol Genet
, vol.16
, Issue.5
, pp. 555-566
-
-
Blard, O.1
-
21
-
-
27744600579
-
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
-
Chee FC, et al. (2005) Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiol Dis 20(3):918-928.
-
(2005)
Neurobiol Dis
, vol.20
, Issue.3
, pp. 918-928
-
-
Chee, F.C.1
-
22
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
Hubbert C, et al. (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417(6887):455-458.
-
(2002)
Nature
, vol.417
, Issue.6887
, pp. 455-458
-
-
Hubbert, C.1
-
23
-
-
12244295468
-
In vivo destabilization of dynamic microtubules by HDAC6- mediated deacetylation
-
Matsuyama A, et al. (2002) In vivo destabilization of dynamic microtubules by HDAC6- mediated deacetylation. EMBO J 21(24):6820-6831.
-
(2002)
EMBO J
, vol.21
, Issue.24
, pp. 6820-6831
-
-
Matsuyama, A.1
-
24
-
-
0030240325
-
Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease
-
Hempen B, Brion JP (1996) Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease. J Neuropathol Exp Neurol 55(9):964-972.
-
(1996)
J Neuropathol Exp Neurol
, vol.55
, Issue.9
, pp. 964-972
-
-
Hempen, B.1
Brion, J.P.2
-
25
-
-
49549083278
-
Histone deacetylase 6 interacts with the microtubule- associated protein tau
-
Ding H, Dolan PJ, Johnson GV (2008) Histone deacetylase 6 interacts with the microtubule- associated protein tau. J Neurochem 106(5):2119-2130.
-
(2008)
J Neurochem
, vol.106
, Issue.5
, pp. 2119-2130
-
-
Ding, H.1
Dolan, P.J.2
Johnson, G.V.3
-
26
-
-
0344640906
-
Domainselective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
-
Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL (2003) Domainselective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci USA 100(8):4389-4394.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.8
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
27
-
-
80054881600
-
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin
-
Kaluza D, et al. (2011) Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J 30(20):4142-4156.
-
(2011)
EMBO J
, vol.30
, Issue.20
, pp. 4142-4156
-
-
Kaluza, D.1
-
28
-
-
34047175919
-
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
-
Dompierre JP, et al. (2007) Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 27(13):3571-3583.
-
(2007)
J Neurosci
, vol.27
, Issue.13
, pp. 3571-3583
-
-
Dompierre, J.P.1
-
29
-
-
0346361872
-
Genetic modifiers of tauopathy in Drosophila
-
Shulman JM, Feany MB (2003) Genetic modifiers of tauopathy in Drosophila. Genetics 165(3):1233-1242.
-
(2003)
Genetics
, vol.165
, Issue.3
, pp. 1233-1242
-
-
Shulman, J.M.1
Feany, M.B.2
-
30
-
-
1542358895
-
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
-
Nishimura I, Yang Y, Lu B (2004) PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell 116(5): 671-682.
-
(2004)
Cell
, vol.116
, Issue.5
, pp. 671-682
-
-
Nishimura, I.1
Yang, Y.2
Lu, B.3
-
31
-
-
0032786370
-
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
-
Spittaels K, et al. (1999) Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol 155(6): 2153-2165.
-
(1999)
Am J Pathol
, vol.155
, Issue.6
, pp. 2153-2165
-
-
Spittaels, K.1
-
32
-
-
20044385920
-
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
-
Stokin GB, et al. (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307(5713):1282-1288.
-
(2005)
Science
, vol.307
, Issue.5713
, pp. 1282-1288
-
-
Stokin, G.B.1
-
33
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8(9):663-672.
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.9
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
34
-
-
0033230886
-
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
-
Ishihara T, et al. (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24(3): 751-762.
-
(1999)
Neuron
, vol.24
, Issue.3
, pp. 751-762
-
-
Ishihara, T.1
-
35
-
-
0242600546
-
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation
-
Cash AD, et al. (2003) Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol 162(5):1623-1627.
-
(2003)
Am J Pathol
, vol.162
, Issue.5
, pp. 1623-1627
-
-
Cash, A.D.1
-
36
-
-
16244366803
-
Class II histone deacetylases: From sequence to function, regulation, and clinical implication
-
Yang XJ, Grégoire S (2005) Class II histone deacetylases: From sequence to function, regulation, and clinical implication. Mol Cell Biol 25(8):2873-2884.
-
(2005)
Mol Cell Biol
, vol.25
, Issue.8
, pp. 2873-2884
-
-
Yang, X.J.1
Grégoire, S.2
-
37
-
-
44649158252
-
HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions
-
Valenzuela-Fernández A, Cabrero JR, Serrador JM, Sánchez-Madrid F (2008) HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol 18(6):291-297.
-
(2008)
Trends Cell Biol
, vol.18
, Issue.6
, pp. 291-297
-
-
Valenzuela-Fernández, A.1
Cabrero, J.R.2
Serrador, J.M.3
Sánchez-Madrid, F.4
-
38
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y, et al. (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115(6):727-738.
-
(2003)
Cell
, vol.115
, Issue.6
, pp. 727-738
-
-
Kawaguchi, Y.1
-
39
-
-
77649337122
-
HDAC6 controls autophagosome maturation essential for ubiquitin- selective quality-control autophagy
-
Lee JY, et al. (2010) HDAC6 controls autophagosome maturation essential for ubiquitin- selective quality-control autophagy. EMBO J 29(5):969-980.
-
(2010)
EMBO J
, vol.29
, Issue.5
, pp. 969-980
-
-
Lee, J.Y.1
-
40
-
-
28844475400
-
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
-
Iwata A, Riley BE, Johnston JA, Kopito RR (2005) HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem 280(48): 40282-40292.
-
(2005)
J Biol Chem
, vol.280
, Issue.48
, pp. 40282-40292
-
-
Iwata, A.1
Riley, B.E.2
Johnston, J.A.3
Kopito, R.R.4
-
41
-
-
34548851476
-
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
-
Olzmann JA, et al. (2007) Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol 178(6):1025-1038.
-
(2007)
J Cell Biol
, vol.178
, Issue.6
, pp. 1025-1038
-
-
Olzmann, J.A.1
-
42
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey UB, et al. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447(7146):859-863.
-
(2007)
Nature
, vol.447
, Issue.7146
, pp. 859-863
-
-
Pandey, U.B.1
-
43
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs JJ, et al. (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 18(5):601-607.
-
(2005)
Mol Cell
, vol.18
, Issue.5
, pp. 601-607
-
-
Kovacs, J.J.1
-
44
-
-
84863508369
-
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
-
Cook C, et al. (2012) Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Hum Mol Gene 21(13):2936-2945.
-
(2012)
Hum Mol Gene
, vol.21
, Issue.13
, pp. 2936-2945
-
-
Cook, C.1
-
45
-
-
77953046399
-
Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts
-
Sudo H, Baas PW (2010) Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. J Neurosci 30(21):7215-7226.
-
(2010)
J Neurosci
, vol.30
, Issue.21
, pp. 7215-7226
-
-
Sudo, H.1
Baas, P.W.2
-
46
-
-
5444273804
-
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
-
Mandelkow EM, Thies E, Trinczek B, Biernat J, Mandelkow E (2004) MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol 167(1): 99-110.
-
(2004)
J Cell Biol
, vol.167
, Issue.1
, pp. 99-110
-
-
Mandelkow, E.M.1
Thies, E.2
Trinczek, B.3
Biernat, J.4
Mandelkow, E.5
-
47
-
-
33750618516
-
Microtubule acetylation promotes kinesin-1 binding and transport
-
Reed NA, et al. (2006) Microtubule acetylation promotes kinesin-1 binding and transport. Curr Biol 16(21):2166-2172.
-
(2006)
Curr Biol
, vol.16
, Issue.21
, pp. 2166-2172
-
-
Reed, N.A.1
-
48
-
-
70450239488
-
Kinesin-1 regulates microtubule dynamics via a c-Jun N-terminal kinase-dependent mechanism
-
Daire V, et al. (2009) Kinesin-1 regulates microtubule dynamics via a c-Jun N-terminal kinase-dependent mechanism. J Biol Chem 284(46):31992-32001.
-
(2009)
J Biol Chem
, vol.284
, Issue.46
, pp. 31992-32001
-
-
Daire, V.1
-
49
-
-
40749161986
-
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally
-
Zhang Y, et al. (2008) Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol 28(5):1688-1701.
-
(2008)
Mol Cell Biol
, vol.28
, Issue.5
, pp. 1688-1701
-
-
Zhang, Y.1
-
50
-
-
77955355838
-
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
-
Butler KV, et al. (2010) Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc 132(31):10842-10846.
-
(2010)
J Am Chem Soc
, vol.132
, Issue.31
, pp. 10842-10846
-
-
Butler, K.V.1
|