Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels

ACS Chemical Neuroscience

Volumn 4, Issue 6, 2013, Pages 930-939

  Miyata, Yoshinari ^a   Li, Xiaokai ^a   Lee, Hsiu Fang ^a   Jinwal, Umesh K ^c   Srinivasan, Sharan R ^a   Seguin, Sandlin P ^d   Young, Zapporah T ^a   Brodsky, Jeffrey L ^d   Dickey, Chad A ^c   Sun, Duxin ^a   Gestwicki, Jason E ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Allosteric inhibitors; Alzheimer's disease; microtubule associated protein tau (MAPT); protein quality control; proteostasis; rhodacyanines; tauopathy

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; HEAT SHOCK PROTEIN 70; PROTEIN INHIBITOR; PYRIDINE; PYRIDINIUM DERIVATIVE; TAU PROTEIN; UNCLASSIFIED DRUG; YM 01; YM 08; BENZOTHIAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; THIAZOLIDINE DERIVATIVE; YM-08 COMPOUND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; BRAIN SLICE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTERFEROMETRY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CAPILLARY PERMEABILITY; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; FEMALE; LIVER MICROSOME; MCF 7 CELL LINE; METABOLISM; PHYSIOLOGY; PROCEDURES; SYNTHESIS;

MUS;

ANIMALS; BENZOTHIAZOLES; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MCF-7 CELLS; MICE; MICROSOMES, LIVER; PYRIDINES; TAU PROTEINS; THIAZOLES; THIAZOLIDINES;

EID: 84879767467     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn300210g     Document Type: Article

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