Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L)tau protein

Nature Genetics

Volumn 25, Issue 4, 2000, Pages 402-405

  Lewis, Jada ^a   McGowan, Eileen ^a   Rockwood, Julia ^b   Melrose, Heather ^a   Nacharaju, Parimala ^a   Van Slegtenhorst, Marjon ^a   Gwinn Hardy, Katrina ^a   Murphy, M P ^a   Baker, Matt ^a   Yu, Xin ^a   Duff, Karen ^a   Hardy, John ^a   Corral, Anthony ^a   Lin, Wen Lang ^a   Yen, Shu Hui ^a   Dickson, Dennis W ^a   Davies, Peter ^b   Hutton, Mike ^a  

^a MAYO CLINIC   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 17; CONTROLLED STUDY; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; MICROTUBULE; MOTOR DYSFUNCTION; MOUSE; MUSCLE ATROPHY; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PARKINSONISM; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMINO ACID SUBSTITUTION; ANIMALS; BRACHIAL PLEXUS NEURITIS; BRAIN STEM; CELL COUNT; GENE EXPRESSION; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MOVEMENT DISORDERS; MUSCLE, SKELETAL; MUTATION; NEUROFIBRILLARY TANGLES; NEURONS; SPINAL CORD; TAU PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0034426011     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/78078     Document Type: Article

References (23)

1. Neurodegenerative diseases with cytoskeletal pathology: A biochemical classification
2. Missense and splicing mutations in tau associated with FTDP-17: Multiple pathogenic mechanisms
3. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
4. Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism
5. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands
6. A vector for expressing foreign genes in the brains and hearts of transgenic mice
7. Transgenic models of tauopathies and synucleinopathies
8. Developmentally regulated expression of specific tau sequences
9. A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis
10. Tau pathology in a family with dementia and a P301L mutation in tau
11. The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains
12. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
13. Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease
14. Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies
15. Tau protein pathology in neurodegenerative diseases
16. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
17. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
18. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
19. Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
20. Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: Tau pathologies with exclusively "exon 10" isoforms
21. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis
22. Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
23. Widespread cytoskeletal pathology characterizes corticobasal degeneration