Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

Human Molecular Genetics

Volumn 23, Issue 1, 2014, Pages 104-116

  Cook, Casey ^a   Carlomagno, Yari ^a   Gendron, Tania F ^a   Dunmore, Judy ^a   Scheffel, Kristyn ^a   Stetler, Caroline ^a   Davis, Mary ^a   Dickson, Dennis ^a   Jarpe, Matthew ^b   DeTure, Michael ^a   Petrucelli, Leonard ^a  

^a MAYO CLINIC   (United States)

^b Acetylon Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACY 738; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; TAU PROTEIN; TRICHOSTATIN A; TUBACIN; TUBASTATIN A; UNCLASSIFIED DRUG;

ACETYLATION; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DEACETYLATION; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; TAUOPATHY; WILD TYPE;

ACETYLATION; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMINO ACID MOTIFS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HEK293 CELLS; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MALE; MICE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PYRIMIDINES; TAU PROTEINS;

EID: 84890357149     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt402     Document Type: Article

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