Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

Neurobiology of Aging

Volumn 34, Issue 5, 2013, Pages 1343-1354

  Messing, Lars ^a   Decker, Jochen Martin ^a   Joseph, Maria ^a   Mandelkow, Eckhard ^a,b,c   Mandelkow, Eva Maria ^a,b,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^c MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Aggregation; Aggregation inhibitory drugs; Hippocampus; Organotypic slice culture; Tau pathology

Indexed keywords

CASPASE 3; COMPOUND BB14; NEUROPROTECTIVE AGENT; PROTEIN INHIBITOR; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ACTIVATION; CELL DEATH; CELL LOSS; CELL SURVIVAL; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC SPINE; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IN VITRO STUDY; MICROGLIA; MOLECULAR PATHOLOGY; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; TAUOPATHY; TRANSGENIC MOUSE;

ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; DIMERIZATION; HIPPOCAMPUS; MICE; MICE, TRANSGENIC; NEURONS; TAU PROTEINS; TAUOPATHIES;

EID: 84873438430     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.10.024     Document Type: Article

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