-
1
-
-
84861313192
-
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
-
Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, et al. 2012. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci 32:7137-7145.
-
(2012)
J Neurosci
, vol.32
, pp. 7137-7145
-
-
Barten, D.M.1
Fanara, P.2
Andorfer, C.3
Hoque, N.4
Wong, P.Y.5
Husted, K.H.6
Cadelina, G.W.7
-
2
-
-
18244384190
-
Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila
-
Bettencourt da Cruz A, Schwarzel M, Schulze S, Niyyati M, Heisenberg M, Kretzschmar D. 2005. Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila. Mol Biol Cell 16:2433-2442.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 2433-2442
-
-
Bettencourt da Cruz, A.1
Schwarzel, M.2
Schulze, S.3
Niyyati, M.4
Heisenberg, M.5
Kretzschmar, D.6
-
3
-
-
84869029962
-
Beta-secretase cleavage of the fly amyloid precursor protein is required for glial survival
-
Bolkan BJ, Triphan T, Kretzschmar D. 2012. Beta-secretase cleavage of the fly amyloid precursor protein is required for glial survival. J Neurosci 32:16181-16192.
-
(2012)
J Neurosci
, vol.32
, pp. 16181-16192
-
-
Bolkan, B.J.1
Triphan, T.2
Kretzschmar, D.3
-
4
-
-
58149503769
-
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
-
Carmine-Simmen K, Proctor T, Tschape J, Poeck B, Triphan T, Strauss R, Kretzschmar D. 2009. Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol Dis 33:274-281.
-
(2009)
Neurobiol Dis
, vol.33
, pp. 274-281
-
-
Carmine-Simmen, K.1
Proctor, T.2
Tschape, J.3
Poeck, B.4
Triphan, T.5
Strauss, R.6
Kretzschmar, D.7
-
5
-
-
0242600546
-
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation
-
Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, et al. 2003. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol 162:1623-1627.
-
(2003)
Am J Pathol
, vol.162
, pp. 1623-1627
-
-
Cash, A.D.1
Aliev, G.2
Siedlak, S.L.3
Nunomura, A.4
Fujioka, H.5
Zhu, X.6
Raina, A.K.7
-
6
-
-
57649203362
-
Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model
-
Chatterjee S, Sang TK, Lawless GM, Jackson GR. 2009. Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet 18:164-177.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 164-177
-
-
Chatterjee, S.1
Sang, T.K.2
Lawless, G.M.3
Jackson, G.R.4
-
7
-
-
33744994326
-
Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila
-
Chau KW, Chan WY, Shaw PC, Chan HY. 2006. Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. Biochem Biophys Res Commun 346:150-159.
-
(2006)
Biochem Biophys Res Commun
, vol.346
, pp. 150-159
-
-
Chau, K.W.1
Chan, W.Y.2
Shaw, P.C.3
Chan, H.Y.4
-
8
-
-
77949721557
-
Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor
-
Chen G, League GP, Nam SC. 2010. Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor. PLoS One 5:e9480.
-
(2010)
PLoS One
, vol.5
, pp. e9480
-
-
Chen, G.1
League, G.P.2
Nam, S.C.3
-
9
-
-
68949101914
-
Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: A synchrotron x-ray scattering study
-
Choi MC, Raviv U, Miller HP, Gaylord MR, Kiris E, Ventimiglia D, Needleman DJ, et al. 2009. Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: A synchrotron x-ray scattering study. Biophys J 97:519-527.
-
(2009)
Biophys J
, vol.97
, pp. 519-527
-
-
Choi, M.C.1
Raviv, U.2
Miller, H.P.3
Gaylord, M.R.4
Kiris, E.5
Ventimiglia, D.6
Needleman, D.J.7
-
10
-
-
84868104221
-
FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions
-
Combs B, Gamblin TC. 2012. FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions. Biochemistry 51:8597-8607.
-
(2012)
Biochemistry
, vol.51
, pp. 8597-8607
-
-
Combs, B.1
Gamblin, T.C.2
-
11
-
-
0023915206
-
Expression of the mRNA for tau proteins during brain development and in cultured neurons and astroglial cells
-
Couchie D, Charriere-Bertrand C, Nunez J. 1988. Expression of the mRNA for tau proteins during brain development and in cultured neurons and astroglial cells. J Neurochem 50:1894-1899.
-
(1988)
J Neurochem
, vol.50
, pp. 1894-1899
-
-
Couchie, D.1
Charriere-Bertrand, C.2
Nunez, J.3
-
12
-
-
0035067021
-
Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
-
Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP. 2001. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci 114:1179-1187.
-
(2001)
J Cell Sci
, vol.114
, pp. 1179-1187
-
-
Dawson, H.N.1
Ferreira, A.2
Eyster, M.V.3
Ghoshal, N.4
Binder, L.I.5
Vitek, M.P.6
-
13
-
-
19744382953
-
The MAP2/Tau family of microtubule-associated proteins
-
Dehmelt L, Halpain S. 2005. The MAP2/Tau family of microtubule-associated proteins. Genome Biol 6:204.
-
(2005)
Genome Biol
, vol.6
, pp. 204
-
-
Dehmelt, L.1
Halpain, S.2
-
14
-
-
0030051269
-
MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth
-
DiTella MC, Feiguin F, Carri N, Kosik KS, Caceres A. 1996. MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. J Cell Sci 109 (Pt 2):467-477.
-
(1996)
J Cell Sci 109
, pp. 467-477
-
-
DiTella, M.C.1
Feiguin, F.2
Carri, N.3
Kosik, K.S.4
Caceres, A.5
-
15
-
-
0041827252
-
The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
-
Doerflinger H, Benton R, Shulman JM, St Johnston D. 2003. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development 130:3965-3975.
-
(2003)
Development
, vol.130
, pp. 3965-3975
-
-
Doerflinger, H.1
Benton, R.2
Shulman, J.M.3
St Johnston, D.4
-
16
-
-
77950940279
-
Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein
-
Feuillette S, Miguel L, Frebourg T, Campion D, Lecourtois M. 2010. Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein. J Neurochem 113:895-903.
-
(2010)
J Neurochem
, vol.113
, pp. 895-903
-
-
Feuillette, S.1
Miguel, L.2
Frebourg, T.3
Campion, D.4
Lecourtois, M.5
-
17
-
-
0032428153
-
A nucleated assembly mechanism of Alzheimer paired helical filaments
-
Friedhoff P, von Bergen M, Mandelkow EM, Davies P, Mandelkow E. 1998. A nucleated assembly mechanism of Alzheimer paired helical filaments. Proc Natl Acad Sci USA 95:15712-15717.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15712-15717
-
-
Friedhoff, P.1
von Bergen, M.2
Mandelkow, E.M.3
Davies, P.4
Mandelkow, E.5
-
18
-
-
0026166253
-
Growth cones: the mechanism of neurite advance
-
Gordon-Weeks PR. 1991. Growth cones: the mechanism of neurite advance. Bioessays 13:235-239.
-
(1991)
Bioessays
, vol.13
, pp. 235-239
-
-
Gordon-Weeks, P.R.1
-
19
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. 1986. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089.
-
(1986)
J Biol Chem
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
20
-
-
80054995024
-
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain
-
Hama H, Kurokawa H, Kawano H, Ando R, Shimogori T, Noda H, Fukami K, Sakaue-Sawano A, Miyawaki A 2011. Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci 14:1481-1488.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1481-1488
-
-
Hama, H.1
Kurokawa, H.2
Kawano, H.3
Ando, R.4
Shimogori, T.5
Noda, H.6
Fukami, K.7
Sakaue-Sawano, A.8
Miyawaki, A.9
-
21
-
-
0028301455
-
Altered microtubule organization in small-calibre axons of mice lacking tau protein
-
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, et al. 1994. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369:488-491.
-
(1994)
Nature
, vol.369
, pp. 488-491
-
-
Harada, A.1
Oguchi, K.2
Okabe, S.3
Kuno, J.4
Terada, S.5
Ohshima, T.6
Sato-Yoshitake, R.7
-
22
-
-
0034814018
-
Identification and characterization of the Drosophila tau homolog
-
Heidary G, Fortini ME. 2001. Identification and characterization of the Drosophila tau homolog. Mech Dev 108:171-178.
-
(2001)
Mech Dev
, vol.108
, pp. 171-178
-
-
Heidary, G.1
Fortini, M.E.2
-
23
-
-
0033680949
-
Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
-
Hummel T, Krukkert K, Roos J, Davis G, Klambt C. 2000. Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development. Neuron 26:357-370.
-
(2000)
Neuron
, vol.26
, pp. 357-370
-
-
Hummel, T.1
Krukkert, K.2
Roos, J.3
Davis, G.4
Klambt, C.5
-
24
-
-
67349142329
-
Mechanisms of tau-induced neurodegeneration
-
Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I. 2009. Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 118:53-69.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 53-69
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
Alonso Adel, C.4
Grundke-Iqbal, I.5
-
25
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
Jackson GR, Wiedau-Pazos M, Sang TK, Wagle N, Brown CA, Massachi S, Geschwind DH. 2002. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34:509-519.
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
Wiedau-Pazos, M.2
Sang, T.K.3
Wagle, N.4
Brown, C.A.5
Massachi, S.6
Geschwind, D.H.7
-
26
-
-
84863689574
-
Lessons from tau-deficient mice
-
Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J, Ittner A, et al. 2012. Lessons from tau-deficient mice. Int J Alzheimers Dis 2012:873270.
-
(2012)
Int J Alzheimers Dis
, vol.2012
, pp. 873270
-
-
Ke, Y.D.1
Suchowerska, A.K.2
van der Hoven, J.3
De Silva, D.M.4
Wu, C.W.5
van Eersel, J.6
Ittner, A.7
-
27
-
-
31944434543
-
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
-
Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. 2006. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol 16:230-241.
-
(2006)
Curr Biol
, vol.16
, pp. 230-241
-
-
Khurana, V.1
Lu, Y.2
Steinhilb, M.L.3
Oldham, S.4
Shulman, J.M.5
Feany, M.B.6
-
28
-
-
0030864464
-
The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila
-
Kretzschmar D, Hasan G, Sharma S, Heisenberg M, Benzer S. 1997. The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. J Neurosci 17:7425-7432.
-
(1997)
J Neurosci
, vol.17
, pp. 7425-7432
-
-
Kretzschmar, D.1
Hasan, G.2
Sharma, S.3
Heisenberg, M.4
Benzer, S.5
-
29
-
-
77953444868
-
The circadian clock gene period extends healthspan in aging Drosophila melanogaster
-
Albany NY
-
Krishnan N, Kretzschmar D, Rakshit K, Chow E, Giebultowicz JM. 2009. The circadian clock gene period extends healthspan in aging Drosophila melanogaster. Aging (Albany NY) 1:937-948.
-
(2009)
Aging
, vol.1
, pp. 937-948
-
-
Krishnan, N.1
Kretzschmar, D.2
Rakshit, K.3
Chow, E.4
Giebultowicz, J.M.5
-
30
-
-
79959211894
-
Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor
-
League GP, Nam SC. 2011. Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor. PLoS One 6:e21218.
-
(2011)
PLoS One
, vol.6
, pp. e21218
-
-
League, G.P.1
Nam, S.C.2
-
31
-
-
61349120799
-
FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action
-
LeBoeuf AC, Levy SF, Gaylord M, Bhattacharya A, Singh AK, Jordan MA, Wilson L, et al. 2008. FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action. J Biol Chem 283:36406-36415.
-
(2008)
J Biol Chem
, vol.283
, pp. 36406-36415
-
-
LeBoeuf, A.C.1
Levy, S.F.2
Gaylord, M.3
Bhattacharya, A.4
Singh, A.K.5
Jordan, M.A.6
Wilson, L.7
-
33
-
-
84856708923
-
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
-
Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, et al. 2012. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med 18:291-295.
-
(2012)
Nat Med
, vol.18
, pp. 291-295
-
-
Lei, P.1
Ayton, S.2
Finkelstein, D.I.3
Spoerri, L.4
Ciccotosto, G.D.5
Wright, D.K.6
Wong, B.X.7
-
34
-
-
0026778182
-
Degeneration of photoreceptors in rhodopsin mutants of Drosophila
-
Leonard DS, Bowman VD, Ready DF, Pak WL. 1992. Degeneration of photoreceptors in rhodopsin mutants of Drosophila. J Neurobiol 23:605-626.
-
(1992)
J Neurobiol
, vol.23
, pp. 605-626
-
-
Leonard, D.S.1
Bowman, V.D.2
Ready, D.F.3
Pak, W.L.4
-
35
-
-
34247574162
-
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau
-
Li B, Chohan MO, Grundke-Iqbal I, Iqbal K. 2007. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta Neuropathol 113:501-511.
-
(2007)
Acta Neuropathol
, vol.113
, pp. 501-511
-
-
Li, B.1
Chohan, M.O.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
36
-
-
0029884047
-
Isolation and sequencing of the 5' end of the rat microtubule-associated protein (MAP1B)-encoding cDNA
-
Liu D, Fischer I. 1996. Isolation and sequencing of the 5' end of the rat microtubule-associated protein (MAP1B)-encoding cDNA. Gene 171:307-308.
-
(1996)
Gene
, vol.171
, pp. 307-308
-
-
Liu, D.1
Fischer, I.2
-
37
-
-
0025352661
-
Microtubule-associated proteins and the determination of neuronal form
-
Matus A. 1990. Microtubule-associated proteins and the determination of neuronal form. J Physiol (Paris) 84:134-137.
-
(1990)
J Physiol (Paris)
, vol.84
, pp. 134-137
-
-
Matus, A.1
-
38
-
-
3142592230
-
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
-
Mudher A, Shepherd D, Newman TA, Mildren P, Jukes JP, Squire A, Mears A, et al. 2004. GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Mol Psychiatry 9:522-530.
-
(2004)
Mol Psychiatry
, vol.9
, pp. 522-530
-
-
Mudher, A.1
Shepherd, D.2
Newman, T.A.3
Mildren, P.4
Jukes, J.P.5
Squire, A.6
Mears, A.7
-
39
-
-
33845622415
-
Identification of core promoter modules in Drosophila and their application in accurate transcription start site prediction
-
Ohler U. 2006. Identification of core promoter modules in Drosophila and their application in accurate transcription start site prediction. Nucleic Acids Res 34:5943-5950.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 5943-5950
-
-
Ohler, U.1
-
40
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. e45
-
-
Pfaffl, M.W.1
-
41
-
-
0023871829
-
Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human
-
Reinke R, Krantz DE, Yen D, Zipursky SL. 1988. Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human. Cell 52:291-301.
-
(1988)
Cell
, vol.52
, pp. 291-301
-
-
Reinke, R.1
Krantz, D.E.2
Yen, D.3
Zipursky, S.L.4
-
42
-
-
0034605045
-
Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
-
Takei Y, Teng J, Harada A, Hirokawa N. 2000. Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes. J Cell Biol 150:989-1000.
-
(2000)
J Cell Biol
, vol.150
, pp. 989-1000
-
-
Takei, Y.1
Teng, J.2
Harada, A.3
Hirokawa, N.4
-
43
-
-
0025201210
-
The roles of microtubule-associated proteins in brain morphogenesis: A review
-
Tucker RP. 1990. The roles of microtubule-associated proteins in brain morphogenesis: A review. Brain Res Brain Res Rev 15:101-120.
-
(1990)
Brain Res Brain Res Rev
, vol.15
, pp. 101-120
-
-
Tucker, R.P.1
-
44
-
-
33847194237
-
Hereditary frontotemporal dementia caused by Tau gene mutations
-
van Swieten J, Spillantini MG. 2007. Hereditary frontotemporal dementia caused by Tau gene mutations. Brain Pathol 17:63-73.
-
(2007)
Brain Pathol
, vol.17
, pp. 63-73
-
-
van Swieten, J.1
Spillantini, M.G.2
-
46
-
-
0034716223
-
Tau and tau reporters disrupt central projections of sensory neurons in Drosophila
-
Williams DW, Tyrer M, Shepherd D. 2000. Tau and tau reporters disrupt central projections of sensory neurons in Drosophila. J Comp Neurol 428:630-640.
-
(2000)
J Comp Neurol
, vol.428
, pp. 630-640
-
-
Williams, D.W.1
Tyrer, M.2
Shepherd, D.3
-
48
-
-
0035958642
-
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
-
Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB. 2001. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293:711-714.
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
Salvaterra, P.M.4
Lewis, J.5
Hutton, M.6
Feany, M.B.7
-
49
-
-
84863230105
-
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
-
Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, et al. 2012. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32:3601-3611.
-
(2012)
J Neurosci
, vol.32
, pp. 3601-3611
-
-
Zhang, B.1
Carroll, J.2
Trojanowski, J.Q.3
Yao, Y.4
Iba, M.5
Potuzak, J.S.6
Hogan, A.M.7
|