Antisense reduction of tau in adult mice protects against seizures

Journal of Neuroscience

Volumn 33, Issue 31, 2013, Pages 12887-12897

  DeVos, Sarah L ^a   Goncharoff, Dustin K ^a   Chen, Guo ^a   Kebodeaux, Carey S ^a   Yamada, Kaoru ^a   Stewart, Floy R ^a   Schuler, Dorothy R ^a   Maloney, Susan E ^b   Wozniak, David F ^b   Rigo, Frank ^c   Bennett, C Frank ^c   Cirrito, John R ^a   Holtzman, David M ^a   Miller, Timothy M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ANTISENSE OLIGONUCLEOTIDE; PENTETRAZOLE; PICROTOXIN; TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; HIPPOCAMPUS; IN VIVO STUDY; LOCOMOTION; MALE; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SEIZURE; SENSORIMOTOR FUNCTION; SPATIAL LEARNING;

AGE FACTORS; ANIMALS; ANTICONVULSANTS; CENTRAL NERVOUS SYSTEM; CONVULSANTS; DISEASE MODELS, ANIMAL; GAIT DISORDERS, NEUROLOGIC; GENE EXPRESSION REGULATION; INFUSIONS, INTRAVENTRICULAR; LACTIC ACID; LOCOMOTION; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRODIALYSIS; OLIGONUCLEOTIDES, ANTISENSE; PENTYLENETETRAZOLE; PICROTOXIN; SEIZURES; TAU PROTEINS;

EID: 84880838441     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2107-13.2013     Document Type: Article

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