-
1
-
-
0033664539
-
Insulin receptors and insulin action in the brain: Review and clinical implications
-
Schulingkamp R, Pagano D, Hung D, Raffa R: Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci Biobehavioral Rev 24:855-872, 2000
-
(2000)
Neurosci Biobehavioral Rev
, vol.24
, pp. 855-872
-
-
Schulingkamp, R.1
Pagano, D.2
Hung, D.3
Raffa, R.4
-
2
-
-
0037303635
-
Brain insulin: Regulation, mechanisms of action and functions
-
Kyriaki G: Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol 23:1-25, 2003
-
(2003)
Cell Mol Neurobiol
, vol.23
, pp. 1-25
-
-
Kyriaki, G.1
-
3
-
-
0031752685
-
Global burden of diabetes, 1995-2025: Prevalence, numerical estimates and projections
-
King H, Aubert RE, Herman WH: Global burden of diabetes, 1995-2025: prevalence, numerical estimates and projections. Diabetes Care 21:1414-1431, 1998
-
(1998)
Diabetes Care
, vol.21
, pp. 1414-1431
-
-
King, H.1
Aubert, R.E.2
Herman, W.H.3
-
4
-
-
0034333018
-
Cognition and synaptic plasticity in diabetes mellitus
-
Gispen WH, Biessels GJ: Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 23:542-549, 2000
-
(2000)
Trends Neurosci
, vol.23
, pp. 542-549
-
-
Gispen, W.H.1
Biessels, G.J.2
-
5
-
-
13944272576
-
The role of insulin receptor signaling in the brain
-
Plum L, Schubert M, Bruning J: The role of insulin receptor signaling in the brain. Trends Endo Metab 16:59-65, 2005
-
(2005)
Trends Endo Metab
, vol.16
, pp. 59-65
-
-
Plum, L.1
Schubert, M.2
Bruning, J.3
-
6
-
-
0031907459
-
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype
-
Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D Jr: Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 50:164-168, 1998
-
(1998)
Neurology
, vol.50
, pp. 164-168
-
-
Craft, S.1
Peskind, E.2
Schwartz, M.W.3
Schellenberg, G.D.4
Raskind, M.5
Porte Jr., D.6
-
7
-
-
0031928535
-
Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
-
Hoyer S: Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J Neural Transm 105:415-422, 1998
-
(1998)
J Neural Transm
, vol.105
, pp. 415-422
-
-
Hoyer, S.1
-
8
-
-
0032764016
-
Diabetes mellitus and the risk of dementia: The Rotterdam Study
-
Ott A, Stolk RP, van Harskamp F, Pols A, Hofman A, Breteler M: Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology 53:1937-1942, 1999
-
(1999)
Neurology
, vol.53
, pp. 1937-1942
-
-
Ott, A.1
Stolk, R.P.2
Van Harskamp, F.3
Pols, A.4
Hofman, A.5
Breteler, M.6
-
9
-
-
0036591657
-
Does insulin dysfunction play a role in Alzheimer's disease?
-
Gasparini L, Netzer WJ, Greengard P, Xu H: Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci 23:288-293, 2002
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 288-293
-
-
Gasparini, L.1
Netzer, W.J.2
Greengard, P.3
Xu, H.4
-
10
-
-
8844257940
-
Diabetes mellitus in midlife and the risk of dementia three decades later
-
Beeri M, Goldbourt U, Silverman J, Noy S, Schmeidler J, Ravona-Springer R, Sverdlick A, Davidson M: Diabetes mellitus in midlife and the risk of dementia three decades later. Neurology 63:1902-1907, 2004
-
(2004)
Neurology
, vol.63
, pp. 1902-1907
-
-
Beeri, M.1
Goldbourt, U.2
Silverman, J.3
Noy, S.4
Schmeidler, J.5
Ravona-Springer, R.6
Sverdlick, A.7
Davidson, M.8
-
11
-
-
0842309993
-
Increased risk of type 2 diabetes in Alzheimer disease
-
Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC: Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 53:474-481, 2004
-
(2004)
Diabetes
, vol.53
, pp. 474-481
-
-
Janson, J.1
Laedtke, T.2
Parisi, J.E.3
O'Brien, P.4
Petersen, R.C.5
Butler, P.C.6
-
12
-
-
12344323961
-
Tau phosphorylation in neuronal cell function and dysfunction
-
Johnson G, Stoothoff W: Tau phosphorylation in neuronal cell function and dysfunction. J Cell Sci 117:5721-5729, 2004
-
(2004)
J Cell Sci
, vol.117
, pp. 5721-5729
-
-
Johnson, G.1
Stoothoff, W.2
-
13
-
-
2442718788
-
Tangling with hypothermia
-
Avila J, Diaz-Nido J: Tangling with hypothermia. Nat Med 10:460-461, 2004
-
(2004)
Nat Med
, vol.10
, pp. 460-461
-
-
Avila, J.1
Diaz-Nido, J.2
-
14
-
-
0030748390
-
Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
-
Hong M, Lee VMY: Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 272:19547-19553, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 19547-19553
-
-
Hong, M.1
Lee, V.M.Y.2
-
15
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.1
-
16
-
-
12144289492
-
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: Implications for Alzheimer's disease
-
Planel E, Miyasaka T, Launery T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A: Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J Neurosci 24:2401-2411, 2004
-
(2004)
J Neurosci
, vol.24
, pp. 2401-2411
-
-
Planel, E.1
Miyasaka, T.2
Launery, T.3
Chui, D.H.4
Tanemura, K.5
Sato, S.6
Murayama, O.7
Ishiguro, K.8
Tatebayashi, Y.9
Takashima, A.10
-
17
-
-
28844493414
-
Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3
-
Clodfelder-Miller B, De Sarno P, Zmijewska A, Song L, Jope R: Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3. J Biol Chem 280:39723-39731, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 39723-39731
-
-
Clodfelder-Miller, B.1
De Sarno, P.2
Zmijewska, A.3
Song, L.4
Jope, R.5
-
18
-
-
27644478606
-
Contribution of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grunke-Iqbal I, Iqbal K, Gong CX: Contribution of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neur 22:1942-1950, 2005
-
(2005)
Eur J Neur
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grunke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
19
-
-
12144290448
-
Role for neuronal insulin resistance in neurodegenerative diseases
-
Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Kustermann E, Arndt S, Jacobs A, Krone W, Kahn C, Bruning J: Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 101:3100-3105, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3100-3105
-
-
Schubert, M.1
Gautam, D.2
Surjo, D.3
Ueki, K.4
Baudler, S.5
Schubert, D.6
Kondo, T.7
Alber, J.8
Galldiks, N.9
Kustermann, E.10
Arndt, S.11
Jacobs, A.12
Krone, W.13
Kahn, C.14
Bruning, J.15
-
20
-
-
23044481208
-
The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse
-
Schechter R, Beju D, Miller K: The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse. Biochem Biophys Res Commun 334:979-986, 2005
-
(2005)
Biochem Biophys Res Commun
, vol.334
, pp. 979-986
-
-
Schechter, R.1
Beju, D.2
Miller, K.3
-
21
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
Schubert M, Brazil D, Burks D, Kushner J, Ye J, Flint C, Farhand-Fallah J, Dikkes P, Warot X, Rio C, Corfas G, White M: Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23:7084-7092, 2003
-
(2003)
J Neurosci
, vol.23
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.2
Burks, D.3
Kushner, J.4
Ye, J.5
Flint, C.6
Farhand-Fallah, J.7
Dikkes, P.8
Warot, X.9
Rio, C.10
Corfas, G.11
White, M.12
-
22
-
-
0029569152
-
Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatases
-
Trojanowski J, Lee VM: Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases. FASEB J 15:1570-1576, 1995
-
(1995)
FASEB J
, vol.15
, pp. 1570-1576
-
-
Trojanowski, J.1
Lee, V.M.2
-
23
-
-
10944246574
-
Pinning down phosphorylated tau and tauopathies
-
Lim J, Lu K: Pinning down phosphorylated tau and tauopathies. Biochim Biophys Acta 1739:311-322, 2005
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 311-322
-
-
Lim, J.1
Lu, K.2
-
24
-
-
0026784416
-
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1: Implications for Alzheimer's disease
-
Goedert M, Cohen E, Jakes R, Cohen P: p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1: implications for Alzheimer's disease. FEBS Lett 312:95-99, 1992
-
(1992)
FEBS Lett
, vol.312
, pp. 95-99
-
-
Goedert, M.1
Cohen, E.2
Jakes, R.3
Cohen, P.4
-
25
-
-
0030813929
-
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons
-
Merrick S, Trojanowski J, Lee V: Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons. J Neurosci 15:5726-5737, 1997
-
(1997)
J Neurosci
, vol.15
, pp. 5726-5737
-
-
Merrick, S.1
Trojanowski, J.2
Lee, V.3
-
26
-
-
0033520355
-
Molecular interactions among protein phosphatase 2A, tau, and microtubules: Implications for the regulation of tau phosphorylation and the development of tauopathies
-
Sontag E, Nunbhakdi-Craig V, Lee G, Brandt R, Kamibayashi C, Kuret J, White CL III, Mumby MC, Bloom GS: Molecular interactions among protein phosphatase 2A, tau, and microtubules: implications for the regulation of tau phosphorylation and the development of tauopathies. J Biol Chem 274:25490-25498, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 25490-25498
-
-
Sontag, E.1
Nunbhakdi-Craig, V.2
Lee, G.3
Brandt, R.4
Kamibayashi, C.5
Kuret, J.6
White III, C.L.7
Mumby, M.C.8
Bloom, G.S.9
-
27
-
-
0034680902
-
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rate forebrain
-
Bennecib M, Gong C, Grundke-Iqbal I, Iqbal K: Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rate forebrain. FEBS Lett 485:87-93, 2000
-
(2000)
FEBS Lett
, vol.485
, pp. 87-93
-
-
Bennecib, M.1
Gong, C.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
28
-
-
0027214404
-
Phosphoprotein phosphatase activities in Alzheimer disease brain
-
Gong CX, Singh T, Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K: Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 61:921-927, 1993
-
(1993)
J Neurochem
, vol.61
, pp. 921-927
-
-
Gong, C.X.1
Singh, T.2
Wang, J.Z.3
Zaidi, T.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
29
-
-
0027945346
-
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
-
Matsuo E, Shin R, Billingsley M, Van deVoorde A, O'Connor M, Trojanowski JQ, Lee VM: Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 4:989-1002, 1994
-
(1994)
Neuron
, vol.4
, pp. 989-1002
-
-
Matsuo, E.1
Shin, R.2
Billingsley, M.3
Van Devoorde, A.4
O'Connor, M.5
Trojanowski, J.Q.6
Lee, V.M.7
-
30
-
-
0035075793
-
PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus
-
Vogelsberg-Ragaglia V, Schuck T, Trojanowski J, Lee V: PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Exp Neurol 168:402-412, 2001
-
(2001)
Exp Neurol
, vol.168
, pp. 402-412
-
-
Vogelsberg-Ragaglia, V.1
Schuck, T.2
Trojanowski, J.3
Lee, V.4
-
31
-
-
1842510667
-
Altered expression levels of the protein phosphatase 2A ABαC enzyme are associated with Alzheimer disease pathology
-
Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S, White CL III: Altered expression levels of the protein phosphatase 2A ABαC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 63:287-301, 2004
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 287-301
-
-
Sontag, E.1
Luangpirom, A.2
Hladik, C.3
Mudrak, I.4
Ogris, E.5
Speciale, S.6
White III, C.L.7
-
32
-
-
5644293035
-
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
-
Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL III: Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 63:1080-1091, 2004
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 1080-1091
-
-
Sontag, E.1
Hladik, C.2
Montgomery, L.3
Luangpirom, A.4
Mudrak, I.5
Ogris, E.6
White III, C.L.7
-
33
-
-
0029113874
-
Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain
-
Gong CX, Shaikh S, Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K: Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J Neurochem 65:732-738, 1995
-
(1995)
J Neurochem
, vol.65
, pp. 732-738
-
-
Gong, C.X.1
Shaikh, S.2
Wang, J.Z.3
Zaidi, T.4
Grundke-Iqbal, I.5
Iqbal, K.6
|