Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

Journal of Biological Chemistry

Volumn 280, Issue 5, 2005, Pages 3628-3635

  Pickhardt, Marcus ^a   Gazova, Zuzana ^a   Von Bergen, Martin ^a   Khlistunova, Inna ^a   Wang, Yipeng ^a   Hascher, Antje ^a   Mandelkow, Eva Maria ^a   Biernat, Jacek ^a   Mandelkow, Eckhard ^a  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BODY FLUIDS; CELLS; CYTOLOGY; DISEASES; ELECTRON MICROSCOPY; FLUORESCENCE; MUTAGENESIS; NEUROLOGY; PROTEINS; TOXICITY;

ALZHEIMER'S DISEASE; ANTHRAQUINONES; CYTOPLASM; PAIRED HELICAL FILAMENTS (PHF);

DRUG PRODUCTS;

ANTHRAQUINONE; DAUNORUBICIN; DOXORUBICIN; EMODIN; PHF 005; PHF 016; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; IC 50; MICROTUBULE; NEUROBLASTOMA CELL; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; RAT;

ALZHEIMER DISEASE; ANIMALS; ANTHRAQUINONES; CELL LINE, TUMOR; GENE EXPRESSION; MICE; MICROSCOPY, ELECTRON; NEUROBLASTOMA; NEUROFIBRILLARY TANGLES; TAU PROTEINS;

ANIMALIA;

EID: 13544251748     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410984200     Document Type: Article

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