메뉴 건너뛰기




Volumn 8, Issue FEB, 2014, Pages

Rescue of tau-induced synaptic transmission pathology by paclitaxel

Author keywords

Aplysia; Homosynaptic depression; Mutant human tau; Paclitaxel; Tauopathy; Vesicle stores

Indexed keywords


EID: 84893647317     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00034     Document Type: Article
Times cited : (17)

References (94)
  • 1
    • 84855798135 scopus 로고    scopus 로고
    • Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction
    • doi: 10.1016/j.nbd.2011.10.022
    • Alldred, M. J., Duff, K. E., and Ginsberg, S. D. (2012). Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction. Neurobiol. Dis. 45, 751-762. doi: 10.1016/j.nbd.2011.10.022
    • (2012) Neurobiol. Dis , vol.45 , pp. 751-762
    • Alldred, M.J.1    Duff, K.E.2    Ginsberg, S.D.3
  • 2
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • doi: 10.1212/wnl.42.3.631
    • Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., and Hyman, B. T. (1992). Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42, 631-639. doi: 10.1212/wnl.42.3.631
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 3
    • 16844379161 scopus 로고    scopus 로고
    • Neuronal microtubules: When the MAP is the roadblock
    • doi: 10.1016/j.tcb.2005.02.001
    • Baas, P. W., and Qiang, L. (2005). Neuronal microtubules: when the MAP is the roadblock. Trends Cell Biol. 15, 183-187. doi: 10.1016/j.tcb.2005.02.001
    • (2005) Trends Cell Biol , vol.15 , pp. 183-187
    • Baas, P.W.1    Qiang, L.2
  • 4
    • 0024121582 scopus 로고
    • Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons
    • doi: 10.1073/pnas.85.7.2373
    • Bailey, C. H., and Chen, M. (1988). Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons. Proc. Natl. Acad. Sci. U S A 85, 2373-2377. doi: 10.1073/pnas.85.7.2373
    • (1988) Proc. Natl. Acad. Sci. U S A , vol.85 , pp. 2373-2377
    • Bailey, C.H.1    Chen, M.2
  • 5
    • 41349094144 scopus 로고    scopus 로고
    • Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia
    • doi: 10.1016/s0079-6123(07)00010-6
    • Bailey, C. H., and Kandel, E. R. (2008). Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia. Prog. Brain Res. 169, 179-198. doi: 10.1016/s0079-6123(07)00010-6
    • (2008) Prog. Brain Res , vol.169 , pp. 179-198
    • Bailey, C.H.1    Kandel, E.R.2
  • 6
    • 84868514765 scopus 로고    scopus 로고
    • Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies
    • doi: 10.1021/jm301079z
    • Ballatore, C., Brunden, K. R., Huryn, D. M., Trojanowski, J. Q., Lee, V. M., and Smith, A. B. 3rd, et al. (2012). Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. J. Med. Chem. 55, 8979-8996. doi: 10.1021/jm301079z
    • (2012) J. Med. Chem , vol.55 , pp. 8979-8996
    • Ballatore, C.1    Brunden, K.R.2    Huryn, D.M.3    Trojanowski, J.Q.4    Lee, V.M.5    Smith III, A.B.6
  • 7
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • doi: 10.1038/nrn2194
    • Ballatore, C., Lee, V. M., and Trojanowski, J. Q. (2007). Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci. 8, 663-672. doi: 10.1038/nrn2194
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 8
    • 78649498235 scopus 로고    scopus 로고
    • Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice
    • doi: 10.1371/journal.pone.0015477
    • Bittner, T., Fuhrmann, M., Burgold, S., Ochs, S. M., Hoffmann, N., Mitteregger, G., et al. (2010). Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One 5:e15477. doi: 10.1371/journal.pone.0015477
    • (2010) PLoS One , vol.5
    • Bittner, T.1    Fuhrmann, M.2    Burgold, S.3    Ochs, S.M.4    Hoffmann, N.5    Mitteregger, G.6
  • 9
    • 0025231966 scopus 로고
    • Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons
    • doi: 10.1073/pnas.87.5.2040
    • Braha, O., Dale, N., Hochner, B., Klein, M., Abrams, T. W., and Kandel, E. R. (1990). Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons. Proc. Natl. Acad. Sci. U S A 87, 2040-2044. doi: 10.1073/pnas.87.5.2040
    • (1990) Proc. Natl. Acad. Sci. U S A , vol.87 , pp. 2040-2044
    • Braha, O.1    Dale, N.2    Hochner, B.3    Klein, M.4    Abrams, T.W.5    Kandel, E.R.6
  • 10
    • 0028785525 scopus 로고
    • Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
    • doi: 10.1083/jcb.131.5.1327
    • Brandt, R., Leger, J., and Lee, G. (1995). Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J. Cell Biol. 131, 1327-1340. doi: 10.1083/jcb.131.5.1327
    • (1995) J. Cell Biol , vol.131 , pp. 1327-1340
    • Brandt, R.1    Leger, J.2    Lee, G.3
  • 11
    • 77952548786 scopus 로고    scopus 로고
    • Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors
    • doi: 10.1016/j.expneurol.2009.08.031
    • Brunden, K. R., Ballatore, C., Crowe, A., Smith, A. B. 3rd, Lee, V. M., and Trojanowski, J. Q. (2010a). Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Exp. Neurol. 223, 304-310. doi: 10.1016/j.expneurol.2009.08.031
    • (2010) Exp. Neurol , vol.223 , pp. 304-310
    • Brunden, K.R.1    Ballatore, C.2    Crowe, A.3    Smith III, A.B.4    Lee, V.M.5    Trojanowski, J.Q.6
  • 12
    • 84864395349 scopus 로고    scopus 로고
    • Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies
    • doi: 10.1042/bst20120010
    • Brunden, K. R., Ballatore, C., Lee, V. M., Smith, A. B. 3rd, and Trojanowski, J. Q. (2012). Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochem. Soc. Trans. 40, 661-666. doi: 10.1042/bst20120010
    • (2012) Biochem. Soc. Trans , vol.40 , pp. 661-666
    • Brunden, K.R.1    Ballatore, C.2    Lee, V.M.3    Smith III, A.B.4    Trojanowski, J.Q.5
  • 13
    • 70349638299 scopus 로고    scopus 로고
    • Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
    • doi: 10.1038/nrd2959
    • Brunden, K. R., Trojanowski, J. Q., and Lee, V. M. (2009). Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat. Rev. Drug Discov. 8, 783-793. doi: 10.1038/nrd2959
    • (2009) Nat. Rev. Drug Discov , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 14
    • 77958065504 scopus 로고    scopus 로고
    • Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
    • doi: 10.1523/jneurosci.3059-10.2010
    • Brunden, K. R., Zhang, B., Carroll, J., Yao, Y., Potuzak, J. S., Hogan, A. M., et al. (2010b). Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J. Neurosci. 30, 13861-13866. doi: 10.1523/jneurosci.3059-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 13861-13866
    • Brunden, K.R.1    Zhang, B.2    Carroll, J.3    Yao, Y.4    Potuzak, J.S.5    Hogan, A.M.6
  • 15
    • 80052716945 scopus 로고    scopus 로고
    • Synapsin regulation of vesicle organization and functional pools
    • doi: 10.1016/j.semcdb.2011.07.003
    • Bykhovskaia, M. (2011). Synapsin regulation of vesicle organization and functional pools. Semin. Cell Dev. Biol. 22, 387-392. doi: 10.1016/j.semcdb.2011.07.003
    • (2011) Semin. Cell Dev. Biol , vol.22 , pp. 387-392
    • Bykhovskaia, M.1
  • 16
    • 84862261275 scopus 로고    scopus 로고
    • Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice
    • doi: 10.1523/jneurosci.0936-12.2012
    • Chakroborty, S., Kim, J., Schneider, C., Jacobson, C., Molgo, J., and Stutzmann, G. E. (2012). Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. J. Neurosci. 32, 8341-8353. doi: 10.1523/jneurosci.0936-12.2012
    • (2012) J. Neurosci , vol.32 , pp. 8341-8353
    • Chakroborty, S.1    Kim, J.2    Schneider, C.3    Jacobson, C.4    Molgo, J.5    Stutzmann, G.E.6
  • 17
    • 32544447773 scopus 로고    scopus 로고
    • Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
    • doi: 10.1042/bst0340088
    • Chee, F., Mudher, A., Newman, T. A., Cuttle, M., Lovestone, S., and Shepherd, D. (2006). Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Biochem. Soc. Trans. 34, 88-90. doi: 10.1042/bst0340088
    • (2006) Biochem. Soc. Trans , vol.34 , pp. 88-90
    • Chee, F.1    Mudher, A.2    Newman, T.A.3    Cuttle, M.4    Lovestone, S.5    Shepherd, D.6
  • 18
    • 27744600579 scopus 로고    scopus 로고
    • Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
    • doi: 10.1016/j.nbd.2005.05.029
    • Chee, F. C., Mudher, A., Cuttle, M. F., Newman, T. A., Mackay, D., Lovestone, S., et al. (2005). Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiol. Dis. 20, 918-928. doi: 10.1016/j.nbd.2005.05.029
    • (2005) Neurobiol. Dis , vol.20 , pp. 918-928
    • Chee, F.C.1    Mudher, A.2    Cuttle, M.F.3    Newman, T.A.4    McKay, D.5    Lovestone, S.6
  • 19
    • 0345276572 scopus 로고    scopus 로고
    • Synaptic slaughter in Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2003.09.001
    • Coleman, P. D., and Yao, P. J. (2003). Synaptic slaughter in Alzheimer's disease. Neurobiol. Aging 24, 1023-1027. doi: 10.1016/j.neurobiolaging.2003.09.001
    • (2003) Neurobiol. Aging , vol.24 , pp. 1023-1027
    • Coleman, P.D.1    Yao, P.J.2
  • 20
    • 84878374182 scopus 로고    scopus 로고
    • Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy
    • doi: 10.1007/s00401-012-1038-9
    • Crimins, J. L., Rocher, A. B., and Luebke, J. I. (2012). Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy. Acta Neuropathol. 124, 777-795. doi: 10.1007/s00401-012-1038-9
    • (2012) Acta Neuropathol , vol.124 , pp. 777-795
    • Crimins, J.L.1    Rocher, A.B.2    Luebke, J.I.3
  • 21
    • 82355169037 scopus 로고    scopus 로고
    • Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy
    • doi: 10.1007/s00401-011-0877-0
    • Crimins, J. L., Rocher, A. B., Peters, A., Shultz, P., Lewis, J., and Luebke, J. I. (2011). Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy. Acta Neuropathol. 122, 551-564. doi: 10.1007/s00401-011-0877-0
    • (2011) Acta Neuropathol , vol.122 , pp. 551-564
    • Crimins, J.L.1    Rocher, A.B.2    Peters, A.3    Shultz, P.4    Lewis, J.5    Luebke, J.I.6
  • 22
    • 51349143580 scopus 로고    scopus 로고
    • Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin
    • doi: 10.1096/fj.08-109181
    • Cuchillo-Ibanez, I., Seereeram, A., Byers, H. L., Leung, K. Y., Ward, M. A., Anderton, B. H., et al. (2008). Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB J. 22, 3186-3195. doi: 10.1096/fj.08-109181
    • (2008) FASEB J , vol.22 , pp. 3186-3195
    • Cuchillo-Ibanez, I.1    Seereeram, A.2    Byers, H.L.3    Leung, K.Y.4    Ward, M.A.5    Anderton, B.H.6
  • 23
    • 0025139511 scopus 로고
    • Facilitatory and inhibitory transmitters modulate spontaneous transmitter release at cultured Aplysia sensorimotor synapses
    • Dale, N., and Kandel, E. R. (1990). Facilitatory and inhibitory transmitters modulate spontaneous transmitter release at cultured Aplysia sensorimotor synapses. J. Physiol. 421, 203-222.
    • (1990) J. Physiol , vol.421 , pp. 203-222
    • Dale, N.1    Kandel, E.R.2
  • 24
    • 39749165656 scopus 로고    scopus 로고
    • Differential regulation of dynein and kinesin motor proteins by tau
    • doi: 10.1126/science.1152993
    • Dixit, R., Ross, J. L., Goldman, Y. E., and Holzbaur, E. L. (2008). Differential regulation of dynein and kinesin motor proteins by tau. Science 319, 1086-1089. doi: 10.1126/science.1152993
    • (2008) Science , vol.319 , pp. 1086-1089
    • Dixit, R.1    Ross, J.L.2    Goldman, Y.E.3    Holzbaur, E.L.4
  • 25
    • 35748954923 scopus 로고    scopus 로고
    • The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy
    • doi: 10.1074/jbc.m705282200
    • Eckermann, K., Mocanu, M. M., Khlistunova, I., Biernat, J., Nissen, A., Hofmann, A., et al. (2007). The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J. Biol. Chem. 282, 31755-31765. doi: 10.1074/jbc.m705282200
    • (2007) J. Biol. Chem , vol.282 , pp. 31755-31765
    • Eckermann, K.1    Mocanu, M.M.2    Khlistunova, I.3    Biernat, J.4    Nissen, A.5    Hofmann, A.6
  • 26
    • 37549071860 scopus 로고    scopus 로고
    • Synapsin regulates Basal synaptic strength, synaptic depression, and serotonin-induced facilitation of sensorimotor synapses in Aplysia
    • doi: 10.1152/jn.00604.2007
    • Fioravante, D., Liu, R. Y., Netek, A. K., Cleary, L. J., and Byrne, J. H. (2007). Synapsin regulates Basal synaptic strength, synaptic depression, and serotonin-induced facilitation of sensorimotor synapses in Aplysia. J. Neurophysiol. 98, 3568-3580. doi: 10.1152/jn.00604.2007
    • (2007) J. Neurophysiol , vol.98 , pp. 3568-3580
    • Fioravante, D.1    Liu, R.Y.2    Netek, A.K.3    Cleary, L.J.4    Byrne, J.H.5
  • 27
    • 77249133010 scopus 로고    scopus 로고
    • Prion-like mechanisms in neurodegenerative diseases
    • doi: 10.1038/nrn2786
    • Frost, B., and Diamond, M. I. (2010). Prion-like mechanisms in neurodegenerative diseases. Nat. Rev. Neurosci. 11, 155-159. doi: 10.1038/nrn2786
    • (2010) Nat. Rev. Neurosci , vol.11 , pp. 155-159
    • Frost, B.1    Diamond, M.I.2
  • 28
    • 0026800953 scopus 로고
    • Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons
    • doi: 10.1016/0896-6273(92)90185-g
    • Ghirardi, M., Braha, O., Hochner, B., Montarolo, P. G., Kandel, E. R., and Dale, N. (1992). Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons. Neuron 9, 479-489. doi: 10.1016/0896-6273(92)90185-g
    • (1992) Neuron , vol.9 , pp. 479-489
    • Ghirardi, M.1    Braha, O.2    Hochner, B.3    Montarolo, P.G.4    Kandel, E.R.5    Dale, N.6
  • 29
    • 0038708285 scopus 로고    scopus 로고
    • Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    • doi: 10.1212/01.wnl.0000063311.58879.01
    • Giannakopoulos, P., Herrmann, F. R., Bussiere, T., Bouras, C., Kovari, E., Perl, D. P., et al. (2003). Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 60, 1495-1500. doi: 10.1212/01.wnl.0000063311.58879.01
    • (2003) Neurology , vol.60 , pp. 1495-1500
    • Giannakopoulos, P.1    Herrmann, F.R.2    Bussiere, T.3    Bouras, C.4    Kovari, E.5    Perl, D.P.6
  • 30
    • 0021964247 scopus 로고
    • Simulation of synaptic depression, posttetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating gill-withdrawal reflex in Aplysia
    • Gingrich, K. J., and Byrne, J. H. (1985). Simulation of synaptic depression, posttetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating gill-withdrawal reflex in Aplysia. J. Neurophysiol. 53, 652-669.
    • (1985) J. Neurophysiol , vol.53 , pp. 652-669
    • Gingrich, K.J.1    Byrne, J.H.2
  • 31
    • 67349259007 scopus 로고    scopus 로고
    • Habituation in Aplysia: The Cheshire cat of neurobiology
    • doi: 10.1016/j.nlm.2009.03.005
    • Glanzman, D. L. (2009). Habituation in Aplysia: the Cheshire cat of neurobiology. Neurobiol. Learn. Mem. 92, 147-154. doi: 10.1016/j.nlm.2009.03.005
    • (2009) Neurobiol. Learn. Mem , vol.92 , pp. 147-154
    • Glanzman, D.L.1
  • 32
    • 11144258263 scopus 로고    scopus 로고
    • Mutations causing neurodegenerative tauopathies
    • doi: 10.1016/j.bbadis.2004.08.007
    • Goedert, M., and Jakes, R. (2005). Mutations causing neurodegenerative tauopathies. Biochim. Biophys. Acta 1739, 240-250. doi: 10.1016/j.bbadis.2004.08.007
    • (2005) Biochim. Biophys. Acta , vol.1739 , pp. 240-250
    • Goedert, M.1    Jakes, R.2
  • 33
    • 0035139540 scopus 로고    scopus 로고
    • Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy
    • doi: 10.1016/s0002-9440(10)63962-4
    • Hall, G. F., Lee, V. M., Lee, G., and Yao, J. (2001). Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy. Am. J. Pathol. 158, 235-246. doi: 10.1016/s0002-9440(10)63962-4
    • (2001) Am. J. Pathol , vol.158 , pp. 235-246
    • Hall, G.F.1    Lee, V.M.2    Lee, G.3    Yao, J.4
  • 34
    • 84883466237 scopus 로고    scopus 로고
    • Regulatable transgenic mouse models of Alzheimer disease: Onset, reversibility and spreading of Tau pathology
    • doi: 10.1111/febs.12250
    • Hochgrafe, K., Sydow, A., and Mandelkow, E. M. (2013). Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. FEBS J. 280, 4371-4381. doi: 10.1111/febs.12250
    • (2013) FEBS J , vol.280 , pp. 4371-4381
    • Hochgrafe, K.1    Sydow, A.2    Mandelkow, E.M.3
  • 35
    • 0023014025 scopus 로고
    • Additional component in the cellular mechanism of presynaptic facilitation contributes to behavioral dishabituation in Aplysia
    • doi: 10.1073/pnas.83.22.8794
    • Hochner, B., Klein, M., Schacher, S., and Kandel, E. R. (1986). Additional component in the cellular mechanism of presynaptic facilitation contributes to behavioral dishabituation in Aplysia. Proc. Natl. Acad. Sci. U S A 83, 8794-8798. doi: 10.1073/pnas.83.22.8794
    • (1986) Proc. Natl. Acad. Sci. U S A , vol.83 , pp. 8794-8798
    • Hochner, B.1    Klein, M.2    Schacher, S.3    Kandel, E.R.4
  • 36
    • 30544452263 scopus 로고    scopus 로고
    • The axonal transport of mitochondria
    • doi: 10.1242/jcs.02745
    • Hollenbeck, P. J., and Saxton, W. M. (2005). The axonal transport of mitochondria. J. Cell Sci. 118, 5411-5419. doi: 10.1242/jcs.02745
    • (2005) J. Cell Sci , vol.118 , pp. 5411-5419
    • Hollenbeck, P.J.1    Saxton, W.M.2
  • 37
    • 78650251838 scopus 로고    scopus 로고
    • Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
    • doi: 10.1016/j.neuron.2010.11.030
    • Hoover, B. R., Reed, M. N., Su, J., Penrod, R. D., Kotilinek, L. A., Grant, M. K., et al. (2010). Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron 68, 1067-1081. doi: 10.1016/j.neuron.2010.11.030
    • (2010) Neuron , vol.68 , pp. 1067-1081
    • Hoover, B.R.1    Reed, M.N.2    Su, J.3    Penrod, R.D.4    Kotilinek, L.A.5    Grant, M.K.6
  • 38
    • 78751644048 scopus 로고    scopus 로고
    • Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease
    • doi: 10.1038/nrn2967
    • Ittner, L. M., and Gotz, J. (2011). Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat. Rev. Neurosci. 12, 65-72. doi: 10.1038/nrn2967
    • (2011) Nat. Rev. Neurosci , vol.12 , pp. 65-72
    • Ittner, L.M.1    Gotz, J.2
  • 39
    • 77955322042 scopus 로고    scopus 로고
    • Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
    • doi: 10.1016/j.cell.2010.06.036
    • Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., Van Eersel, J., et al. (2010). Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142, 387-397. doi: 10.1016/j.cell.2010.06.036
    • (2010) Cell , vol.142 , pp. 387-397
    • Ittner, L.M.1    Ke, Y.D.2    Delerue, F.3    Bi, M.4    Gladbach, A.5    van Eersel, J.6
  • 40
    • 79251490998 scopus 로고    scopus 로고
    • Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis
    • doi: 10.1101/lm.1949711
    • Jin, I., Kandel, E. R., and Hawkins, R. D. (2011). Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis. Learn. Mem. 18, 96-102. doi: 10.1101/lm.1949711
    • (2011) Learn. Mem , vol.18 , pp. 96-102
    • Jin, I.1    Kandel, E.R.2    Hawkins, R.D.3
  • 41
    • 37449001322 scopus 로고    scopus 로고
    • How do microtubule-targeted drugs work? An overview
    • doi: 10.2174/156800907783220417
    • Jordan, M. A., and Kamath, K. (2007). How do microtubule-targeted drugs work? An overview. Curr. Cancer Drug Targets 7, 730-742. doi: 10.2174/156800907783220417
    • (2007) Curr. Cancer Drug Targets , vol.7 , pp. 730-742
    • Jordan, M.A.1    Kamath, K.2
  • 42
    • 0035744704 scopus 로고    scopus 로고
    • The molecular biology of memory storage: A dialog between genes and synapses
    • doi: 10.1023/A:1014775008533
    • Kandel, E. R. (2001). The molecular biology of memory storage: a dialog between genes and synapses. Biosci. Rep. 21, 565-611. doi: 10.1023/A:1014775008533
    • (2001) Biosci. Rep , vol.21 , pp. 565-611
    • Kandel, E.R.1
  • 43
    • 23744505053 scopus 로고    scopus 로고
    • Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia
    • doi: 10.1101/lm.92105
    • Khoutorsky, A., and Spira, M. E. (2005). Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia. Learn. Mem. 12, 414-422. doi: 10.1101/lm.92105
    • (2005) Learn. Mem , vol.12 , pp. 414-422
    • Khoutorsky, A.1    Spira, M.E.2
  • 44
    • 84874201513 scopus 로고    scopus 로고
    • Synaptic alterations in the rTg4510 mouse model of tauopathy
    • doi: 10.1002/cne.23234
    • Kopeikina, K. J., Polydoro, M., Tai, H. C., Yaeger, E., Carlson, G. A., Pitstick, R., et al. (2013). Synaptic alterations in the rTg4510 mouse model of tauopathy. J. Comp. Neurol. 521, 1334-1353. doi: 10.1002/cne.23234
    • (2013) J. Comp. Neurol , vol.521 , pp. 1334-1353
    • Kopeikina, K.J.1    Polydoro, M.2    Tai, H.C.3    Yaeger, E.4    Carlson, G.A.5    Pitstick, R.6
  • 45
    • 0042889049 scopus 로고    scopus 로고
    • Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
    • doi: 10.1073/pnas.1533448100
    • Kraemer, B. C., Zhang, B., Leverenz, J. B., Thomas, J. H., Trojanowski, J. Q., and Schellenberg, G. D. (2003). Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc. Natl. Acad. Sci. U S A 100, 9980-9985. doi: 10.1073/pnas.1533448100
    • (2003) Proc. Natl. Acad. Sci. U S A , vol.100 , pp. 9980-9985
    • Kraemer, B.C.1    Zhang, B.2    Leverenz, J.B.3    Thomas, J.H.4    Trojanowski, J.Q.5    Schellenberg, G.D.6
  • 46
    • 83055160858 scopus 로고    scopus 로고
    • Early improved and late defective cognition is reflected by dendritic spines in Tau. P301L mice
    • doi: 10.1523/jneurosci.4859-11.2011
    • Kremer, A., Maurin, H., Demedts, D., Devijver, H., Borghgraef, P., and Van Leuven, F. (2011). Early improved and late defective cognition is reflected by dendritic spines in Tau. P301L mice. J. Neurosci. 31, 18036-18047. doi: 10.1523/jneurosci.4859-11.2011
    • (2011) J. Neurosci , vol.31 , pp. 18036-18047
    • Kremer, A.1    Maurin, H.2    Demedts, D.3    Devijver, H.4    Borghgraef, P.5    van Leuven, F.6
  • 47
    • 0027992814 scopus 로고
    • Microtubule stabilizing drugs for the treatment of Alzheimer's disease
    • doi: 10.1016/0197-4580(94)90179-1
    • Lee, V. M., Daughenbaugh, R., and Trojanowski, J. Q. (1994). Microtubule stabilizing drugs for the treatment of Alzheimer's disease. Neurobiol. Aging 15(Suppl. 2), S87-S89. doi: 10.1016/0197-4580(94)90179-1
    • (1994) Neurobiol. Aging , vol.15 , Issue.SUPPL. 2
    • Lee, V.M.1    Daughenbaugh, R.2    Trojanowski, J.Q.3
  • 48
    • 0001034893 scopus 로고
    • Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse
    • doi: 10.1073/pnas.82.9.3035
    • Llinas, R., Mcguinness, T. L., Leonard, C. S., Sugimori, M., and Greengard, P. (1985). Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proc. Natl. Acad. Sci. U S A 82, 3035-3039. doi: 10.1073/pnas.82.9.3035
    • (1985) Proc. Natl. Acad. Sci. U S A , vol.82 , pp. 3035-3039
    • Llinas, R.1    McGuinness, T.L.2    Leonard, C.S.3    Sugimori, M.4    Greengard, P.5
  • 49
    • 0345276565 scopus 로고    scopus 로고
    • Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
    • doi: 10.1016/j.neurobiolaging.2003.04.007
    • Mandelkow, E. M., Stamer, K., Vogel, R., Thies, E., and Mandelkow, E. (2003). Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol. Aging 24, 1079-1085. doi: 10.1016/j.neurobiolaging.2003.04.007
    • (2003) Neurobiol. Aging , vol.24 , pp. 1079-1085
    • Mandelkow, E.M.1    Stamer, K.2    Vogel, R.3    Thies, E.4    Mandelkow, E.5
  • 50
    • 0035864366 scopus 로고    scopus 로고
    • Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed aplysia sensorimotor synapses
    • Manseau, F., Fan, X., Hueftlein, T., Sossin, W., and Castellucci, V. F. (2001). Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed aplysia sensorimotor synapses. J. Neurosci. 21, 1247-1256.
    • (2001) J. Neurosci , vol.21 , pp. 1247-1256
    • Manseau, F.1    Fan, X.2    Hueftlein, T.3    Sossin, W.4    Castellucci, V.F.5
  • 52
    • 13244295499 scopus 로고    scopus 로고
    • β-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
    • doi: 10.1124/jpet.104.074450
    • Michaelis, M. L., Ansar, S., Chen, Y., Reiff, E. R., Seyb, K. I., Himes, R. H., et al. (2005). β-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents. J. Pharmacol. Exp. Ther. 312, 659-668. doi: 10.1124/jpet.104.074450
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 659-668
    • Michaelis, M.L.1    Ansar, S.2    Chen, Y.3    Reiff, E.R.4    Seyb, K.I.5    Himes, R.H.6
  • 53
    • 0036931159 scopus 로고    scopus 로고
    • Tau neurofibrillary pathology and microtubule stability
    • doi: 10.1385/jmn:19:3:289
    • Michaelis, M. L., Dobrowsky, R. T., and Li, G. (2002). Tau neurofibrillary pathology and microtubule stability. J. Mol. Neurosci. 19, 289-293. doi: 10.1385/jmn:19:3:289
    • (2002) J. Mol. Neurosci , vol.19 , pp. 289-293
    • Michaelis, M.L.1    Dobrowsky, R.T.2    Li, G.3
  • 54
    • 0031906761 scopus 로고    scopus 로고
    • Protection against beta-amyloid toxicity in primary neurons by paclitaxel (Taxol)
    • doi: 10.1046/j.1471-4159.1998.70041623.x
    • Michaelis, M. L., Ranciat, N., Chen, Y., Bechtel, M., Ragan, R., Hepperle, M., et al. (1998). Protection against beta-amyloid toxicity in primary neurons by paclitaxel (Taxol). J. Neurochem. 70, 1623-1627. doi: 10.1046/j.1471-4159.1998.70041623.x
    • (1998) J. Neurochem , vol.70 , pp. 1623-1627
    • Michaelis, M.L.1    Ranciat, N.2    Chen, Y.3    Bechtel, M.4    Ragan, R.5    Hepperle, M.6
  • 55
    • 38549129613 scopus 로고    scopus 로고
    • The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss and coassembly with endogenous Tau in inducible mouse models of tauopathy
    • doi: 10.1523/jneurosci.2824-07.2008
    • Mocanu, M. M., Nissen, A., Eckermann, K., Khlistunova, I., Biernat, J., Drexler, D., et al. (2008). The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss and coassembly with endogenous Tau in inducible mouse models of tauopathy. J. Neurosci. 28, 737-748. doi: 10.1523/jneurosci.2824-07.2008
    • (2008) J. Neurosci , vol.28 , pp. 737-748
    • Mocanu, M.M.1    Nissen, A.2    Eckermann, K.3    Khlistunova, I.4    Biernat, J.5    Drexler, D.6
  • 56
    • 84857063878 scopus 로고    scopus 로고
    • Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA
    • doi: 10.3389/fnsyn.2011.00003
    • Moreno, H., Choi, S., Yu, E., Brusco, J., Avila, J., Moreira, J. E., et al. (2011). Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA. Front. Synaptic Neurosci. 3:3. doi: 10.3389/fnsyn.2011.00003
    • (2011) Front. Synaptic Neurosci , vol.3 , pp. 3
    • Moreno, H.1    Choi, S.2    Yu, E.3    Brusco, J.4    Avila, J.5    Moreira, J.E.6
  • 57
    • 70350455072 scopus 로고    scopus 로고
    • Axonal transport defects in neurodegenerative diseases
    • doi: 10.1523/JNEUROSCI.3463-09.2009
    • Morfini, G. A., Burns, M., Binder, L. I., Kanaan, N. M., Lapointe, N., Bosco, D. A., et al. (2009). Axonal transport defects in neurodegenerative diseases. J. Neurosci. 29, 12776-12786. doi: 10.1523/JNEUROSCI.3463-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 12776-12786
    • Morfini, G.A.1    Burns, M.2    Binder, L.I.3    Kanaan, N.M.4    Lapointe, N.5    Bosco, D.A.6
  • 58
    • 48249103491 scopus 로고    scopus 로고
    • Neurodegenerative lysosomal disorders: A continuum from development to late age
    • Nixon, R. A., Yang, D. S., and Lee, J. H. (2008). Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy 4, 590-599.
    • (2008) Autophagy , vol.4 , pp. 590-599
    • Nixon, R.A.1    Yang, D.S.2    Lee, J.H.3
  • 59
    • 67649580185 scopus 로고    scopus 로고
    • Motor-dependent microtubule disassembly driven by tubulin tyrosination
    • doi: 10.1083/jcb.200902142
    • Peris, L., Wagenbach, M., Lafanechere, L., Brocard, J., Moore, A. T., Kozielski, F., et al. (2009). Motor-dependent microtubule disassembly driven by tubulin tyrosination. J. Cell Biol. 185, 1159-1166. doi: 10.1083/jcb.200902142
    • (2009) J. Cell Biol , vol.185 , pp. 1159-1166
    • Peris, L.1    Wagenbach, M.2    Lafanechere, L.3    Brocard, J.4    Moore, A.T.5    Kozielski, F.6
  • 60
    • 69449093036 scopus 로고    scopus 로고
    • Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    • doi: 10.1523/JNEUROSCI.1065-09.2009
    • Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E., and Davies, P. (2009). Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J. Neurosci. 29, 10741-10749. doi: 10.1523/JNEUROSCI.1065-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3    Castillo, P.E.4    Davies, P.5
  • 61
    • 84884285081 scopus 로고    scopus 로고
    • Synaptic changes in Alzheimer's disease and its models
    • doi: 10.1016/j.neuroscience.2012.05.050
    • Pozueta, J., Lefort, R., and Shelanski, M. L. (2013). Synaptic changes in Alzheimer's disease and its models. Neuroscience 251, 51-65. doi: 10.1016/j.neuroscience.2012.05.050
    • (2013) Neuroscience , vol.251 , pp. 51-65
    • Pozueta, J.1    Lefort, R.2    Shelanski, M.L.3
  • 62
    • 84884289093 scopus 로고    scopus 로고
    • Axonal transport and mitochondrial dysfunction in Alzheimer's disease
    • doi: 10.1159/000342020
    • Riemer, J., and Kins, S. (2013). Axonal transport and mitochondrial dysfunction in Alzheimer's disease. Neurodegener. Dis. 12, 111-124. doi: 10.1159/000342020
    • (2013) Neurodegener. Dis , vol.12 , pp. 111-124
    • Riemer, J.1    Kins, S.2
  • 63
    • 0242559052 scopus 로고    scopus 로고
    • Learning in Aplysia: Looking at synaptic plasticity from both sides
    • doi: 10.1016/j.tins.2003.09.014
    • Roberts, A. C., and Glanzman, D. L. (2003). Learning in Aplysia: looking at synaptic plasticity from both sides. Trends Neurosci. 26, 662-670. doi: 10.1016/j.tins.2003.09.014
    • (2003) Trends Neurosci , vol.26 , pp. 662-670
    • Roberts, A.C.1    Glanzman, D.L.2
  • 64
    • 77952554382 scopus 로고    scopus 로고
    • Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
    • doi: 10.1016/j.expneurol.2009.07.029
    • Rocher, A. B., Crimins, J. L., Amatrudo, J. M., Kinson, M. S., Todd-Brown, M. A., Lewis, J., et al. (2010). Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp. Neurol. 223, 385-393. doi: 10.1016/j.expneurol.2009.07.029
    • (2010) Exp. Neurol , vol.223 , pp. 385-393
    • Rocher, A.B.1    Crimins, J.L.2    Amatrudo, J.M.3    Kinson, M.S.4    Todd-Brown, M.A.5    Lewis, J.6
  • 65
    • 0030175394 scopus 로고    scopus 로고
    • Definition of the readily releasable pool of vesicles at hippocampal synapses
    • doi: 10.1016/s0896-6273(00)80146-4
    • Rosenmund, C., and Stevens, C. F. (1996). Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16, 1197-1207. doi: 10.1016/s0896-6273(00)80146-4
    • (1996) Neuron , vol.16 , pp. 1197-1207
    • Rosenmund, C.1    Stevens, C.F.2
  • 66
    • 0037566352 scopus 로고    scopus 로고
    • Effective expression of the green fluorescent fusion proteins in cultured Aplysia neurons
    • doi: 10.1016/s0165-0270(03)00072-4
    • Sahly, I., Erez, H., Khoutorsky, A., Shapira, E., and Spira, M. E. (2003). Effective expression of the green fluorescent fusion proteins in cultured Aplysia neurons. J. Neurosci. Methods 126, 111-117. doi: 10.1016/s0165-0270(03)00072-4
    • (2003) J. Neurosci. Methods , vol.126 , pp. 111-117
    • Sahly, I.1    Erez, H.2    Khoutorsky, A.3    Shapira, E.4    Spira, M.E.5
  • 67
    • 84881556239 scopus 로고    scopus 로고
    • Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2013.05.003
    • Saul, A., Sprenger, F., Bayer, T. A., and Wirths, O. (2013). Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease. Neurobiol. Aging 34, 2564-2573. doi: 10.1016/j.neurobiolaging.2013.05.003
    • (2013) Neurobiol. Aging , vol.34 , pp. 2564-2573
    • Saul, A.1    Sprenger, F.2    Bayer, T.A.3    Wirths, O.4
  • 68
    • 0021043993 scopus 로고
    • Neurite regeneration by Aplysia neurons in dissociated cell culture: Modulation by Aplysia hemolymph and the presence of the initial axonal segment
    • Schacher, S., and Proshansky, E. (1983). Neurite regeneration by Aplysia neurons in dissociated cell culture: modulation by Aplysia hemolymph and the presence of the initial axonal segment. J. Neurosci. 3, 2403-2413.
    • (1983) J. Neurosci , vol.3 , pp. 2403-2413
    • Schacher, S.1    Proshansky, E.2
  • 69
    • 33746899756 scopus 로고    scopus 로고
    • The synaptic vesicle: Cycle of exocytosis and endocytosis
    • doi: 10.1016/j.conb.2006.05.006
    • Schweizer, F. E., and Ryan, T. A. (2006). The synaptic vesicle: cycle of exocytosis and endocytosis. Curr. Opin. Neurobiol. 16, 298-304. doi: 10.1016/j.conb.2006.05.006
    • (2006) Curr. Opin. Neurobiol , vol.16 , pp. 298-304
    • Schweizer, F.E.1    Ryan, T.A.2
  • 70
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • doi: 10.1126/science.1074069
    • Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791. doi: 10.1126/science.1074069
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 71
    • 77957265942 scopus 로고    scopus 로고
    • Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons
    • doi: 10.1007/s00401-010-0689-7
    • Shemesh, O. A., and Spira, M. E. (2010a). Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons. Acta Neuropathol. 120, 209-222. doi: 10.1007/s00401-010-0689-7
    • (2010) Acta Neuropathol , vol.120 , pp. 209-222
    • Shemesh, O.A.1    Spira, M.E.2
  • 72
    • 77449107515 scopus 로고    scopus 로고
    • Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: Implications for the pathogenesis of paclitaxel-induced polyneuropathy
    • doi: 10.1007/s00401-009-0586-0
    • Shemesh, O. A., and Spira, M. E. (2010b). Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathy. Acta Neuropathol. 119, 235-248. doi: 10.1007/s00401-009-0586-0
    • (2010) Acta Neuropathol , vol.119 , pp. 235-248
    • Shemesh, O.A.1    Spira, M.E.2
  • 73
    • 79955952344 scopus 로고    scopus 로고
    • Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel
    • doi: 10.1016/j.nbd.2011.03.008
    • Shemesh, O. A., and Spira, M. E. (2011). Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel. Neurobiol. Dis. 43, 163-175. doi: 10.1016/j.nbd.2011.03.008
    • (2011) Neurobiol. Dis , vol.43 , pp. 163-175
    • Shemesh, O.A.1    Spira, M.E.2
  • 74
    • 40449093880 scopus 로고    scopus 로고
    • Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching
    • doi: 10.1111/j.1600-0854.2007.00695.x
    • Shemesh, O. A., Erez, H., Ginzburg, I., and Spira, M. E. (2008). Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Traffic 9, 458-471. doi: 10.1111/j.1600-0854.2007.00695.x
    • (2008) Traffic , vol.9 , pp. 458-471
    • Shemesh, O.A.1    Erez, H.2    Ginzburg, I.3    Spira, M.E.4
  • 75
    • 84855601539 scopus 로고    scopus 로고
    • Spines, plasticity, and cognition in Alzheimer's model mice
    • doi: 10.1155/2012/319836
    • Spires-Jones, T., and Knafo, S. (2012). Spines, plasticity, and cognition in Alzheimer's model mice. Neural Plast. 2012:319836. doi: 10.1155/2012/319836
    • (2012) Neural Plast , vol.2012 , pp. 319836
    • Spires-Jones, T.1    Knafo, S.2
  • 76
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles, neurofilaments and APP vesicles in neurons and enhances oxidative stress
    • doi: 10.1083/jcb.200108057
    • Stamer, K., Vogel, R., Thies, E., Mandelkow, E., and Mandelkow, E. M. (2002). Tau blocks traffic of organelles, neurofilaments and APP vesicles in neurons and enhances oxidative stress. J. Cell Biol. 156, 1051-1063. doi: 10.1083/jcb.200108057
    • (2002) J. Cell Biol , vol.156 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 77
    • 20044385920 scopus 로고    scopus 로고
    • Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
    • doi: 10.1126/science.1105681
    • Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., et al. (2005). Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288. doi: 10.1126/science.1105681
    • (2005) Science , vol.307 , pp. 1282-1288
    • Stokin, G.B.1    Lillo, C.2    Falzone, T.L.3    Brusch, R.G.4    Rockenstein, E.5    Mount, S.L.6
  • 78
    • 70349319844 scopus 로고    scopus 로고
    • Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
    • doi: 10.1111/j.1471-4159.2009.06316.x
    • Stoothoff, W., Jones, P. B., Spires-Jones, T. L., Joyner, D., Chhabra, E., Bercury, K., et al. (2009). Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J. Neurochem. 111, 417-427. doi: 10.1111/j.1471-4159.2009.06316.x
    • (2009) J. Neurochem , vol.111 , pp. 417-427
    • Stoothoff, W.1    Jones, P.B.2    Spires-Jones, T.L.3    Joyner, D.4    Chhabra, E.5    Bercury, K.6
  • 79
    • 2942556680 scopus 로고    scopus 로고
    • The synaptic vesicle cycle
    • doi: 10.1146/annurev.neuro.26.041002.131412
    • Sudhof, T. C. (2004). The synaptic vesicle cycle. Annu. Rev. Neurosci. 27, 509-547. doi: 10.1146/annurev.neuro.26.041002.131412
    • (2004) Annu. Rev. Neurosci , vol.27 , pp. 509-547
    • Sudhof, T.C.1
  • 80
    • 77953046399 scopus 로고    scopus 로고
    • Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts
    • doi: 10.1523/jneurosci.0048-10.2010
    • Sudo, H., and Baas, P. W. (2010). Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. J. Neurosci. 30, 7215-7226. doi: 10.1523/jneurosci.0048-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 7215-7226
    • Sudo, H.1    Baas, P.W.2
  • 81
    • 80855138109 scopus 로고    scopus 로고
    • Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model
    • doi: 10.1007/s12031-011-9604-5
    • Sydow, A., Van Der Jeugd, A., Zheng, F., Ahmed, T., Balschun, D., Petrova, O., et al. (2011a). Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model. J. Mol. Neurosci. 45, 432-437. doi: 10.1007/s12031-011-9604-5
    • (2011) J. Mol. Neurosci , vol.45 , pp. 432-437
    • Sydow, A.1    Van Der Jeugd, A.2    Zheng, F.3    Ahmed, T.4    Balschun, D.5    Petrova, O.6
  • 82
    • 79951818085 scopus 로고    scopus 로고
    • Tau-induced defects in synaptic plasticity, learning and memory are reversible in transgenic mice after switching off the toxic Tau mutant
    • doi: 10.1523/jneurosci.5245-10.2011
    • Sydow, A., Van Der Jeugd, A., Zheng, F., Ahmed, T., Balschun, D., Petrova, O., et al. (2011b). Tau-induced defects in synaptic plasticity, learning and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J. Neurosci. 31, 2511-2525. doi: 10.1523/jneurosci.5245-10.2011
    • (2011) J. Neurosci , vol.31 , pp. 2511-2525
    • Sydow, A.1    Van Der Jeugd, A.2    Zheng, F.3    Ahmed, T.4    Balschun, D.5    Petrova, O.6
  • 83
    • 84866478442 scopus 로고    scopus 로고
    • The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system
    • doi: 10.1016/j.ajpath.2012.06.033
    • Tai, H. C., Serrano-Pozo, A., Hashimoto, T., Frosch, M. P., Spires-Jones, T. L., and Hyman, B. T. (2012). The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am. J. Pathol. 181, 1426-1435. doi: 10.1016/j.ajpath.2012.06.033
    • (2012) Am. J. Pathol , vol.181 , pp. 1426-1435
    • Tai, H.C.1    Serrano-Pozo, A.2    Hashimoto, T.3    Frosch, M.P.4    Spires-Jones, T.L.5    Hyman, B.T.6
  • 84
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • doi: 10.1002/ana.410300410
    • Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., Deteresa, R., Hill, R., et al. (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30, 572-580. doi: 10.1002/ana.410300410
    • (1991) Ann. Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6
  • 85
    • 33947307791 scopus 로고    scopus 로고
    • Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1
    • doi: 10.1523/jneurosci.4674-06.2007
    • Thies, E., and Mandelkow, E. M. (2007). Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J. Neurosci. 27, 2896-2907. doi: 10.1523/jneurosci.4674-06.2007
    • (2007) J. Neurosci , vol.27 , pp. 2896-2907
    • Thies, E.1    Mandelkow, E.M.2
  • 86
    • 0035958642 scopus 로고    scopus 로고
    • Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
    • doi: 10.1126/science.1062382
    • Wittmann, C. W., Wszolek, M. F., Shulman, J. M., Salvaterra, P. M., Lewis, J., Hutton, M., et al. (2001). Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293, 711-714. doi: 10.1126/science.1062382
    • (2001) Science , vol.293 , pp. 711-714
    • Wittmann, C.W.1    Wszolek, M.F.2    Shulman, J.M.3    Salvaterra, P.M.4    Lewis, J.5    Hutton, M.6
  • 87
    • 84872714502 scopus 로고    scopus 로고
    • Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
    • doi: 10.1074/jbc.m112.394528
    • Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., et al. (2013). Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J. Biol. Chem. 288, 1856-1870. doi: 10.1074/jbc.m112.394528
    • (2013) J. Biol. Chem , vol.288 , pp. 1856-1870
    • Wu, J.W.1    Herman, M.2    Liu, L.3    Simoes, S.4    Acker, C.M.5    Figueroa, H.6
  • 88
    • 33846538660 scopus 로고    scopus 로고
    • Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    • doi: 10.1016/j.neuron.2007.01.010
    • Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S. M., Iwata, N., Saido, T. C., et al. (2007). Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351. doi: 10.1016/j.neuron.2007.01.010
    • (2007) Neuron , vol.53 , pp. 337-351
    • Yoshiyama, Y.1    Higuchi, M.2    Zhang, B.3    Huang, S.M.4    Iwata, N.5    Saido, T.C.6
  • 89
    • 84858204150 scopus 로고    scopus 로고
    • Synapses and dendritic spines as pathogenic targets in Alzheimer's disease
    • doi: 10.1155/2012/247150
    • Yu, W., and Lu, B. (2012). Synapses and dendritic spines as pathogenic targets in Alzheimer's disease. Neural Plast. 2012:247150. doi: 10.1155/2012/247150
    • (2012) Neural Plast , vol.2012 , pp. 247150
    • Yu, W.1    Lu, B.2
  • 90
    • 84857676337 scopus 로고    scopus 로고
    • A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Abeta on synapses and dendritic spines
    • doi: 10.1093/hmg/ddr576
    • Yu, W., Polepalli, J., Wagh, D., Rajadas, J., Malenka, R., and Lu, B. (2012). A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Abeta on synapses and dendritic spines. Hum. Mol. Genet. 21, 1384-1390. doi: 10.1093/hmg/ddr576
    • (2012) Hum. Mol. Genet , vol.21 , pp. 1384-1390
    • Yu, W.1    Polepalli, J.2    Wagh, D.3    Rajadas, J.4    Malenka, R.5    Lu, B.6
  • 91
    • 77956587739 scopus 로고    scopus 로고
    • Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
    • doi: 10.1523/JNEUROSCI.2357-10.2010
    • Zempel, H., Thies, E., Mandelkow, E., and Mandelkow, E. M. (2010). Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J. Neurosci. 30, 11938-11950. doi: 10.1523/JNEUROSCI.2357-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 11938-11950
    • Zempel, H.1    Thies, E.2    Mandelkow, E.3    Mandelkow, E.M.4
  • 92
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • doi: 10.1523/jneurosci.4922-11.2012
    • Zhang, B., Carroll, J., Trojanowski, J. Q., Yao, Y., Iba, M., Potuzak, J. S., et al. (2012). The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J. Neurosci. 32, 3601-3611. doi: 10.1523/jneurosci.4922-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 3601-3611
    • Zhang, B.1    Carroll, J.2    Trojanowski, J.Q.3    Yao, Y.4    Iba, M.5    Potuzak, J.S.6
  • 93
    • 0037115035 scopus 로고    scopus 로고
    • Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture
    • Zhao, Y., and Klein, M. (2002). Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture. J. Neurosci. 22, 10671-10679.
    • (2002) J. Neurosci , vol.22 , pp. 10671-10679
    • Zhao, Y.1    Klein, M.2
  • 94
    • 1542720541 scopus 로고    scopus 로고
    • Changes in the readily releasable pool of transmitter and in efficacy of release induced by high-frequency firing at Aplysia sensorimotor synapses in culture
    • doi: 10.1152/jn.01019.2003
    • Zhao, Y., and Klein, M. (2004). Changes in the readily releasable pool of transmitter and in efficacy of release induced by high-frequency firing at Aplysia sensorimotor synapses in culture. J. Neurophysiol. 91, 1500-1509. doi: 10.1152/jn.01019.2003
    • (2004) J. Neurophysiol , vol.91 , pp. 1500-1509
    • Zhao, Y.1    Klein, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.