메뉴 건너뛰기




Volumn 15, Issue 13, 2014, Pages 1177-1199

Pharmacological applications of antioxidants: Lights and shadows

Author keywords

Antioxidants; Mitochondrial dysfunction; Neurodegenerative diseases; NOX; Nrf2; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ANTIOXIDANT; APOCYNIN; CAFFEIC ACID PHENETYL ESTER; CELASTROL; CURCUMIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EBSELEN; ERDOSTEINE; FLAVONOID; FUDOSTEINE; GINKGO BILOBA EXTRACT; MELATONIN; NIMESULIDE; NITROXIDE DERIVATIVE; POLYPHENOL DERIVATIVE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RESVERATROL; SILYMARIN; SIRTUIN; SULFORAPHANE; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF1; TRIAZOLOPYRIMIDINE; TRITERPENOID; UBIDECARENONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZILEUTON;

EID: 84923996036     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450115666141024113925     Document Type: Article
Times cited : (96)

References (351)
  • 1
    • 77955917442 scopus 로고    scopus 로고
    • Oxidative stress in Alzheimer disease: A possibility for prevention
    • [1] Bonda DJ, Wang X, Perry G, et al. Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology 2010; 59: 290-4.
    • (2010) Neuropharmacology , vol.59 , pp. 290-294
    • Bonda, D.J.1    Wang, X.2    Perry, G.3
  • 2
    • 78049348191 scopus 로고    scopus 로고
    • Parkinson’s disease: Oxidative stress and therapeutic approaches
    • [2] Surendran S, Rajasankar S. Parkinson’s disease: oxidative stress and therapeutic approaches. Neurol Sci 2010; 31: 531-40.
    • (2010) Neurol Sci , vol.31 , pp. 531-540
    • Surendran, S.1    Rajasankar, S.2
  • 3
    • 33947675275 scopus 로고    scopus 로고
    • Oxidative damage in Huntington's disease pathogenesis
    • [3] Browne SE, Beal MF. Oxidative damage in Huntington's disease pathogenesis. Antioxid Redox Signal 2006; 8: 2061-73.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 2061-2073
    • Browne, S.E.1    Beal, M.F.2
  • 4
    • 2342417953 scopus 로고    scopus 로고
    • Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: Common links and potential therapeutic targets
    • [4] Mhatre M, Floyd RA, Hensley K. Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. J Alz Dis 2004; 6: 147-57.
    • (2004) J Alz Dis , vol.6 , pp. 147-157
    • Mhatre, M.1    Floyd, R.A.2    Hensley, K.3
  • 5
    • 1642264093 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy
    • [5] Gilgun-Sherki Y, Melamed E. The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J Neurol 2004; 251: 261-8.
    • (2004) J Neurol , vol.251 , pp. 261-268
    • Gilgun-Sherki, Y.1    Melamed, E.2
  • 6
    • 84870554511 scopus 로고    scopus 로고
    • Oxidative stress and cancer: An overview
    • [6] Sosa V, Moliné T, Somoza R, et al. Oxidative stress and cancer: an overview. Ageing Res Rev 2012; 12: 376-90.
    • (2012) Ageing Res Rev , vol.12 , pp. 376-390
    • Sosa, V.1    Moliné, T.2    Somoza, R.3
  • 7
    • 84867010053 scopus 로고    scopus 로고
    • Attenuation of oxidant damage in the postconditioned heart involves nonenzymatic response and partial catalytic protection
    • [7] Arreguin F, Garcia N, Hernandez-Resendiz S, et al. Attenuation of oxidant damage in the postconditioned heart involves nonenzymatic response and partial catalytic protection. Exp Physiol 2012; 97: 1119-30.
    • (2012) Exp Physiol , vol.97 , pp. 1119-1130
    • Arreguin, F.1    Garcia, N.2    Hernandez-Resendiz, S.3
  • 8
    • 77449152992 scopus 로고    scopus 로고
    • Oxidative stress and its role in the pathogenesis of ischaemic stroke
    • [8] Allen C, Bayraktutan U. Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int J Stroke 2009; 4: 461-70.
    • (2009) Int J Stroke , vol.4 , pp. 461-470
    • Allen, C.1    Bayraktutan, U.2
  • 10
    • 33745650110 scopus 로고    scopus 로고
    • Oxidative stress parameters in different systemic rheumatic diseases
    • [10] Firuzi O, Fuksa L, Spadaro C, et al. Oxidative stress parameters in different systemic rheumatic diseases. J Pharm Pharmacol 2006; 58: 951-7.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 951-957
    • Firuzi, O.1    Fuksa, L.2    Spadaro, C.3
  • 11
    • 42949146126 scopus 로고    scopus 로고
    • Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes and organ involvement in systemic sclerosis
    • [11] Riccieri V, Spadaro A, Fuksa L, et al. Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes and organ involvement in systemic sclerosis. Clin Rheumatol 2008; 27: 225-30.
    • (2008) Clin Rheumatol , vol.27 , pp. 225-230
    • Riccieri, V.1    Spadaro, A.2    Fuksa, L.3
  • 12
    • 44949242627 scopus 로고    scopus 로고
    • Protein oxidation markers in the serum and synovial fluid of psoriatic arthritis patients
    • [12] Firuzi O, Spadaro A, Spadaro C, et al. Protein oxidation markers in the serum and synovial fluid of psoriatic arthritis patients. J Clin Lab Anal 2008; 22: 210-5.
    • (2008) J Clin Lab Anal , vol.22 , pp. 210-215
    • Firuzi, O.1    Spadaro, A.2    Spadaro, C.3
  • 13
    • 80053004011 scopus 로고    scopus 로고
    • Chronic inflammatory disorders and their redox control: From molecular mechanisms to therapeutic opportunities
    • [13] Chiurchiù V, Maccarrone M. Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2011; 15: 2605-41.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2605-2641
    • Chiurchiù, V.1    Maccarrone, M.2
  • 14
    • 84860718879 scopus 로고    scopus 로고
    • Evaluating oxidative stress in human cardiovascular disease: Methodological aspects and considerations
    • [14] Lee R, Margaritis M, Channon K, Antoniades C. Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Curr Med Chem 2012; 19: 2504.
    • (2012) Curr Med Chem , vol.2012 , pp. 19
    • Lee, R.1    Margaritis, M.2    Channon, K.3    Antoniades, C.4
  • 16
    • 84862525472 scopus 로고    scopus 로고
    • Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies
    • [16] Montezano AC, Touyz RM. Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Ann Med 2012; 44: S2-S16.
    • (2012) Ann Med , vol.44 , pp. 2-16
    • Montezano, A.C.1    Touyz, R.M.2
  • 17
    • 84862840761 scopus 로고    scopus 로고
    • Pharmacologic strategies to target oxidative stress in heart failure
    • [17] Ahmed Z, Tang WW. Pharmacologic strategies to target oxidative stress in heart failure. Curr Heart Fail Rep 2012; 9: 14-22.
    • (2012) Curr Heart Fail Rep , vol.9 , pp. 14-22
    • Ahmed, Z.1    Tang, W.W.2
  • 18
    • 84907851875 scopus 로고    scopus 로고
    • Oxidative stress in diabetes
    • [18] Stadler K. Oxidative stress in diabetes. Adv Exp Med Biol 2012; 771: 272-87.
    • (2012) Adv Exp Med Biol , vol.771 , pp. 272-287
    • Stadler, K.1
  • 19
    • 84655176308 scopus 로고    scopus 로고
    • Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?
    • [19] Styskal J, Van Remmen H, Richardson A, Salmon AB. Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med 2012; 52: 46-58.
    • (2012) Free Radic Biol Med , vol.52 , pp. 46-58
    • Styskal, J.1    Van Remmen, H.2    Richardson, A.3    Salmon, A.B.4
  • 20
    • 84856480527 scopus 로고    scopus 로고
    • Alterations in oxidative stress biomarkers associated with mild hyperlipidemia and smoking
    • [20] Miri R, Saadati H, Ardi P, Firuzi O. Alterations in oxidative stress biomarkers associated with mild hyperlipidemia and smoking. Food Chem Toxicol 2012; 50: 920-6.
    • (2012) Food Chem Toxicol , vol.50 , pp. 920-926
    • Miri, R.1    Saadati, H.2    Ardi, P.3    Firuzi, O.4
  • 21
    • 84868594332 scopus 로고    scopus 로고
    • Plasma malondialdehyde levels and risk factors for the development of chronic complications in type 2 diabetic patients on insulin therapy
    • [21] Kaefer M, De Carvalho JA, Piva SJ, et al. Plasma malondialdehyde levels and risk factors for the development of chronic complications in type 2 diabetic patients on insulin therapy. Clin Lab 2012; 58: 973-8.
    • (2012) Clin Lab , vol.58 , pp. 973-978
    • Kaefer, M.1    De Carvalho, J.A.2    Piva, S.J.3
  • 22
    • 79957900741 scopus 로고    scopus 로고
    • Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
    • [22] Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol 2011; 254: 72-85.
    • (2011) Toxicol Appl Pharmacol , vol.254 , pp. 72-85
    • Yao, H.1    Rahman, I.2
  • 23
    • 77956257501 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis and treatment of asthma
    • [23] Dozor AJ. The role of oxidative stress in the pathogenesis and treatment of asthma. Ann NY Acad Sci 2010; 1203: 133-7.
    • (2010) Ann NY Acad Sci , vol.1203 , pp. 133-137
    • Dozor, A.J.1
  • 24
  • 25
    • 84862769027 scopus 로고    scopus 로고
    • New drug targets in depression: Inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
    • [25] Maes M, Fiar Z, Medina M, et al. New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology 2012; 20: 127-50.
    • (2012) Nflammopharmacology , vol.20 , pp. 27-50
    • Maes, M.1    Fiar, Z.2    Medina, M.3
  • 27
    • 78649908751 scopus 로고    scopus 로고
    • Oxidative stress in schizophrenia: An integrated approach
    • [27] Bitanihirwe BK, Woo T-UW. Oxidative stress in schizophrenia: an integrated approach. Neurosci Biobehav Rev 2011; 35: 878-93.
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 878-893
    • Bitanihirwe, B.K.1    Woo, T.-U.2
  • 28
    • 4244087065 scopus 로고
    • Reactive oxygen species in living systems: Source, biochemistry, and role in human disease
    • [28] Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 1991; 91: S14-S22.
    • (1991) Am J Med , vol.91 , pp. 14-22
    • Halliwell, B.1
  • 29
    • 58849158293 scopus 로고    scopus 로고
    • Reactive nitrogen species: Molecular mechanisms and potential significance in health and disease
    • [29] Martínez MC, Andriantsitohaina R. Reactive nitrogen species: molecular mechanisms and potential significance in health and disease. Antioxid Redox Signal 2009; 11: 669-702.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 669-702
    • Martínez, M.C.1    Riantsitohaina, R.2
  • 30
    • 84864800398 scopus 로고    scopus 로고
    • Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases
    • [30] Roe ND, Ren J. Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases. Vasc Pharmacol 2012; 57: 168-72.
    • (2012) Vasc Pharmacol , vol.57 , pp. 168-172
    • Roe, N.D.1    Ren, J.2
  • 31
    • 1542283780 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
    • [31] Alp NJ, Channon KM. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol 2004; 24: 413-20.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 413-420
    • Alp, N.J.1    Channon, K.M.2
  • 32
    • 79957890939 scopus 로고    scopus 로고
    • Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
    • [32] Drummond GR, Selemidis S, Griendling KK, Sobey CG. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov 2011; 10: 453-71.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 453-471
    • Drummond, G.R.1    Selemidis, S.2    Griendling, K.K.3    Sobey, C.G.4
  • 34
    • 84857438179 scopus 로고    scopus 로고
    • Tackling endothelial dysfunction by modulating NOS uncoupling: New insights into its pathogenesis and therapeutic possibilities
    • [34] Kietadisorn R, Juni RP, Moens AL. Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities. Am J Physiol Endocrinol Metab 2012; 302: E481-E495.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. 481-495
    • Kietadisorn, R.1    Juni, R.P.2    Moens, A.L.3
  • 35
    • 77953396132 scopus 로고    scopus 로고
    • Oral administration of Larginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase
    • [35] Tripathi P, Chandra M, Misra MK. Oral administration of Larginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase. Oxid Med Cell Longev 2009; 2: 231-7.
    • (2009) Oxid Med Cell Longev , vol.2 , pp. 231-237
    • Tripathi, P.1    Chandra, M.2    Misra, M.K.3
  • 36
    • 79551582218 scopus 로고    scopus 로고
    • Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart
    • [36] Okazaki T, Otani H, Shimazu T, et al. Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart. J Mol Cell Cardiol 2011; 50: 534-44.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 534-544
    • Okazaki, T.1    Otani, H.2    Shimazu, T.3
  • 37
    • 80052244346 scopus 로고    scopus 로고
    • Antioxidant therapy: Current status and future prospects
    • [37] Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: current status and future prospects. Curr Med Chem 2011; 18: 3871-88.
    • (2011) Curr Med Chem , vol.18 , pp. 3871-3888
    • Firuzi, O.1    Miri, R.2    Tavakkoli, M.3    Saso, L.4
  • 38
    • 43049159738 scopus 로고    scopus 로고
    • Antioxidants in cardiovascular health and disease: Key lessons from epidemiologic studies
    • [38] Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol 2008; 101: S75-S86.
    • (2008) Am J Cardiol , vol.101 , pp. 75-86
    • Willcox, B.J.1    Curb, J.D.2    Rodriguez, B.L.3
  • 39
    • 77950268110 scopus 로고    scopus 로고
    • The hormetic role of dietary antioxidants in free radical-related diseases
    • [39] Calabrese V, Cornelius C, Trovato-Salinaro A, et al. The hormetic role of dietary antioxidants in free radical-related diseases. Curr Pharm Design 2010; 16: 877-83.
    • (2010) Curr Pharm Design , vol.16 , pp. 877-883
    • Calabrese, V.1    Cornelius, C.2    Trovato-Salinaro, A.3
  • 40
    • 84873429169 scopus 로고    scopus 로고
    • Nutrition and neurodegeneration: Epidemiological evidence and challenges for future research
    • [40] Gillette Guyonnet S, Secher M, Vellas B. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research. Br J Clin Pharmacol 2013; 75: 738-55.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 738-755
    • Gillette Guyonnet, S.1    Secher, M.2    Vellas, B.3
  • 41
    • 84875953344 scopus 로고    scopus 로고
    • Dietary (Poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases
    • [41] Del Rio D, Rodriguez-Mateos A, Spencer JP, et al. Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 2013; 18: 1818-92.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1818-1892
    • Del Rio, D.1    Rodriguez-Mateos, A.2    Spencer, J.P.3
  • 42
    • 0029844446 scopus 로고    scopus 로고
    • Antioxidant activities of flavonoids as bioactive components of food
    • [42] Rice-Evans CA, Miller NJ. Antioxidant activities of flavonoids as bioactive components of food. Biochem Soc Trans 1996; 24: 790-95.
    • (1996) Biochem Soc Trans , vol.24 , pp. 790-795
    • Rice-Evans, C.A.1    Miller, N.J.2
  • 43
    • 75149193424 scopus 로고    scopus 로고
    • Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: Focus on reactivity, selectivity, and reaction mechanisms
    • [43] Aldini G, Vistoli G, Regazzoni L, et al. Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms. Antioxid Redox Sinal 2010; 12: 381-92.
    • (2010) Antioxid Redox Sinal , vol.12 , pp. 381-392
    • Aldini, G.1    Vistoli, G.2    Regazzoni, L.3
  • 44
    • 0025812485 scopus 로고
    • Free radical scavenging and inhibition of lipid peroxidation by betablockers and by agents that interfere with calcium metabolism. A physiologically-significant process
    • [44] Aruoma OI, Smith C, Cecchini R, Evans PJ, Halliwell B. Free radical scavenging and inhibition of lipid peroxidation by betablockers and by agents that interfere with calcium metabolism. A physiologically-significant process? Biochem Pharmacol 1991; 42: 735-43.
    • (1991) Biochem Pharmacol , vol.42 , pp. 735-743
    • Aruoma, O.I.1    Smith, C.2    Cecchini, R.3    Evans, P.J.4    Halliwell, B.5
  • 45
    • 78649645690 scopus 로고    scopus 로고
    • Free radical scavengers and spin traps-therapeutic implications for ischemic stroke
    • [45] Doeppner TR, Hermann DM. Free radical scavengers and spin traps-therapeutic implications for ischemic stroke. Best Pract Res Clin Anaesthesiol 2010; 24: 511-20.
    • (2010) Best Pract Res Clin Anaesthesiol , vol.24 , pp. 511-520
    • Doeppner, T.R.1    Hermann, D.M.2
  • 46
    • 0043167852 scopus 로고    scopus 로고
    • Hypochlorite scavenging activity of hydroxycinnamic acids evaluated by a rapid microplate method based on the measurement of chloramines
    • [46] Firuzi O, Giansanti L, Vento R, et al. Hypochlorite scavenging activity of hydroxycinnamic acids evaluated by a rapid microplate method based on the measurement of chloramines. J Pharm Pharmacol 2003; 55: 1021-7.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 1021-1027
    • Firuzi, O.1    Giansanti, L.2    Vento, R.3
  • 48
    • 33746549327 scopus 로고    scopus 로고
    • Neuroprotective effects of edaravone: A novel free radical scavenger in cerebrovascular injury
    • [48] Yoshida H, Yanai H, Namiki Y, et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev 2006; 12: 9-20.
    • (2006) CNS Drug Rev , vol.12 , pp. 9-20
    • Yoshida, H.1    Yanai, H.2    Namiki, Y.3
  • 49
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • [49] Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6: 593-7.
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 50
    • 84876849210 scopus 로고    scopus 로고
    • The antioxidant activity of coumarins and flavonoids
    • [50] Bubols GB, Vianna Dda R, Medina-Remon A, et al. The antioxidant activity of coumarins and flavonoids. Mini Rev Med Chem 2013; 13: 318-34.
    • (2013) Mini Rev Med Chem , vol.13 , pp. 318-334
    • Bubols, G.B.1    Vianna Dda, R.2    Medina-Remon, A.3
  • 51
    • 79953036116 scopus 로고    scopus 로고
    • In vitro analysis of iron chelating activity of flavonoids
    • [51] Mladenka P, Macakova K, Filipsky T, et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem 2011; 105: 693-701.
    • (2011) J Inorg Biochem , vol.105 , pp. 693-701
    • Mladenka, P.1    Macakova, K.2    Filipsky, T.3
  • 52
    • 84861508122 scopus 로고    scopus 로고
    • From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease
    • [52] Zheng H, Amit T, Bar-Am O, et al. From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease. J Alz Dis 2012; 30: 1-16.
    • (2012) J Alz Dis , vol.30 , pp. 1-16
    • Zheng, H.1    Amit, T.2    Bar-Am, O.3
  • 53
    • 84884776136 scopus 로고    scopus 로고
    • Renoprotective effect of the antioxidant curcumin: Recent findings
    • [53] Trujillo J, Chirino YI, Molina-Jijon E, et al. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol 2013; 1: 448-56.
    • (2013) Redox Biol , vol.1 , pp. 448-456
    • Trujillo, J.1    Chirino, Y.I.2    Molina-Jijon, E.3
  • 54
    • 84870429271 scopus 로고    scopus 로고
    • Terpene compounds in nature: A review of their potential antioxidant activity
    • [54] Gonzalez-Burgos E, Gomez-Serranillos MP. Terpene compounds in nature: a review of their potential antioxidant activity. Curr Med Chem 2012; 19: 5319-41.
    • (2012) Curr Med Chem , vol.19 , pp. 5319-5341
    • Gonzalez-Burgos, E.1    Gomez-Serranillos, M.P.2
  • 56
    • 84867761453 scopus 로고    scopus 로고
    • Beta-Carotene and other carotenoids in protection from sunlight
    • [56] Stahl W, Sies H. beta-Carotene and other carotenoids in protection from sunlight. Am J Clin Nutr 2012; 96: 1179-84.
    • (2012) Am J Clin Nutr , vol.96 , pp. 1179-1184
    • Stahl, W.1    Sies, H.2
  • 57
    • 84878183914 scopus 로고    scopus 로고
    • Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history
    • [57] Lu MF, Xiao ZT, Zhang HY. Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history. Biochem Biophys Res Commun 2013; 434: 701-4.
    • (2013) Biochem Biophys Res Commun , vol.434 , pp. 701-704
    • Lu, M.F.1    Xiao, Z.T.2    Zhang, H.Y.3
  • 58
    • 79955506452 scopus 로고    scopus 로고
    • The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established
    • [58] Hollman PC, Cassidy A, Comte B, et al. The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr 2011; 141: 989-1009.
    • (2011) J Nutr , vol.141 , pp. 989-1009
    • Hollman, P.C.1    Cassidy, A.2    Comte, B.3
  • 59
    • 77956170123 scopus 로고    scopus 로고
    • Polyphenols and health: Update and perspectives
    • [59] Sies H. Polyphenols and health: update and perspectives. Arch Biochem Biophys 2010; 501: 2-5.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 2-5
    • Sies, H.1
  • 60
    • 84863714863 scopus 로고    scopus 로고
    • Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects
    • [60] Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev 2012; 2012: 914273.
    • (2012) Oxid Med Cell Longev , pp. 2012
    • Vauzour, D.1
  • 61
    • 77955511388 scopus 로고    scopus 로고
    • Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity
    • [61] Mladnka P, Zatloukalová L, Filipsk T, Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med 2010; 49: 963-75.
    • (2010) Free Radic Biol Med , vol.49 , pp. 963-975
    • Mladnka, P.1    Zatloukalová, L.2    Filipsk, T.3    Hrdina, R.4
  • 62
    • 80055064858 scopus 로고    scopus 로고
    • Dietary polyphenols as antioxidants and anticancer agents: More questions than answers
    • [62] Hu M-L. Dietary polyphenols as antioxidants and anticancer agents: more questions than answers. Chang Gung Med J 2011; 34: 449-60.
    • (2011) Chang Gung Med J , vol.34 , pp. 449-460
    • Hu, M.-L.1
  • 63
    • 13844298231 scopus 로고    scopus 로고
    • Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: Direct or indirect effects? Antioxidant or not?
    • [63] Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr 2005; 81: 268S-76S.
    • (2005) Am J Clin Nutr , vol.81 , pp. 268-768
    • Halliwell, B.1    Rafter, J.2    Jenner, A.3
  • 64
    • 67650267213 scopus 로고    scopus 로고
    • Dietary flavonoids as antioxidants
    • [64] Terao J. Dietary flavonoids as antioxidants. Forum Nutr 2009; 61: 87-94.
    • (2009) Forum Nutr , vol.61 , pp. 87-94
    • Terao, J.1
  • 65
    • 53749096012 scopus 로고    scopus 로고
    • Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction
    • [65] Fraccarollo D, Widder JD, Galuppo P, et al. Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction. Circulation 2008; 118: 818-27.
    • (2008) Circulation , vol.118 , pp. 818-827
    • Fraccarollo, D.1    Widder, J.D.2    Galuppo, P.3
  • 66
    • 70349652240 scopus 로고    scopus 로고
    • The eNOS enhancer AVE 9488: A novel cardioprotectant against ischemia reperfusion injury
    • [66] Frantz S, Adamek A, Fraccarollo D, et al. The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury. Basic Res Cardiol 2009; 104: 773-79.
    • (2009) Basic Res Cardiol , vol.104 , pp. 773-779
    • Frantz, S.1    Adamek, A.2    Fraccarollo, D.3
  • 68
    • 79960090349 scopus 로고    scopus 로고
    • Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease
    • [68] Ghosh N, Ghosh R, Mandal SC. Antioxidant protection: a promising therapeutic intervention in neurodegenerative disease. Free Rad Res 2011; 45: 888-905.
    • (2011) Free Rad Res , vol.45 , pp. 888-905
    • Ghosh, N.1    Ghosh, R.2    Mandal, S.C.3
  • 69
    • 79955076193 scopus 로고    scopus 로고
    • Antioxidant therapies for acute spinal cord injury
    • [69] Hall ED. Antioxidant therapies for acute spinal cord injury. Neurotherapeutics 2011; 8: 152-67.
    • (2011) Neurotherapeutics , vol.8 , pp. 152-167
    • Hall, E.D.1
  • 70
    • 84864414278 scopus 로고    scopus 로고
    • Actions of “antioxidants” in the protection against atherosclerosis
    • [70] Lönn ME, Dennis JM, Stocker R. Actions of “antioxidants” in the protection against atherosclerosis. Free Radic Biol Med 2012; 53: 863-84.
    • (2012) Free Radic Biol Med , vol.53 , pp. 863-884
    • Lönn, M.E.1    Dennis, J.M.2    Stocker, R.3
  • 71
    • 33645885351 scopus 로고    scopus 로고
    • Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging
    • [71] Wu BJ, Kathir K, Witting PK, et al. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med 2006; 203: 1117-27.
    • (2006) J Exp Med , vol.203 , pp. 1117-1127
    • Wu, B.J.1    Kathir, K.2    Witting, P.K.3
  • 72
    • 79952585899 scopus 로고    scopus 로고
    • Haem oxygenase-1 and cardiovascular disease: Mechanisms and therapeutic potential
    • [72] Chan KH, Ng MK, Stocker R. Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential. Clin Sci (Lond) 2011; 120: 493-504.
    • (2011) Clin Sci (Lond) , vol.120 , pp. 493-504
    • Chan, K.H.1    Ng, M.K.2    Stocker, R.3
  • 73
    • 84857361069 scopus 로고    scopus 로고
    • Cardiovascular antioxidant therapy: A review of supplements, pharmacotherapies, and mechanisms
    • [73] Tinkel J, Hassanain H, Khouri SJ. Cardiovascular antioxidant therapy: a review of supplements, pharmacotherapies, and mechanisms. Cardiol Rev 2012; 20: 77-83.
    • (2012) Cardiol Rev , vol.20 , pp. 77-83
    • Tinkel, J.1    Hassanain, H.2    Khouri, S.J.3
  • 74
    • 84867777145 scopus 로고    scopus 로고
    • The Nrf2-ARE pathway: A valuable therapeutic target for the treatment of neurodegenerative diseases
    • [74] Joshi G, Johnson JA. The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat CNS Drug Discov 2012; 7: 218-29.
    • (2012) Recent Pat CNS Drug Discov , vol.7 , pp. 218-229
    • Joshi, G.1    Johnson, J.A.2
  • 75
    • 84875527422 scopus 로고    scopus 로고
    • Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury
    • [75] Cai L. Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury. Oxid Med Cell Longev 2013; 2013
    • (2013) Oxid Med Cell Longev , pp. 2013
    • Cai, L.1
  • 76
    • 84863825248 scopus 로고    scopus 로고
    • Small Molecule Modulators of Keap1Nrf2ARE Pathway as Potential Preventive and Therapeutic Agents
    • [76] Magesh S, Chen Y, Hu L. Small Molecule Modulators of Keap1Nrf2ARE Pathway as Potential Preventive and Therapeutic Agents. Med Res Rev 2012; 32: 687-726.
    • (2012) Med Res Rev , vol.32 , pp. 687-726
    • Magesh, S.1    Chen, Y.2    Hu, L.3
  • 77
    • 34548850603 scopus 로고    scopus 로고
    • Enhancing expression of Nrf2-driven genes protects the blood-brain barrier after brain injury
    • [77] Zhao J, Moore AN, Redell JB, Dash PK. Enhancing expression of Nrf2-driven genes protects the blood-brain barrier after brain injury. J Neurosci 2007; 27: 10240-8.
    • (2007) J Neurosci , vol.27 , pp. 10240-10248
    • Zhao, J.1    Moore, A.N.2    Redell, J.B.3    Dash, P.K.4
  • 78
    • 59349084488 scopus 로고    scopus 로고
    • Role of HDAC2 in the pathophysiology of COPD
    • [78] Barnes PJ. Role of HDAC2 in the pathophysiology of COPD. Ann Rev Physiol 2009; 71: 451-64.
    • (2009) Ann Rev Physiol , vol.71 , pp. 451-464
    • Barnes, P.J.1
  • 79
    • 84858155375 scopus 로고    scopus 로고
    • Pharmacological antioxidant strategies as therapeutic interventions for COPD
    • [79] Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochim Biophys Acta 2012; 1822: 714-28.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 714-728
    • Rahman, I.1
  • 80
    • 79960273488 scopus 로고    scopus 로고
    • NRF2 targeting: A promising therapeutic strategy in chronic obstructive pulmonary disease
    • [80] Boutten A, Goven D, Artaud-Macari E, Boczkowski J, Bonay M. NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease. Trends Mol Med 2011; 17: 363-71.
    • (2011) Trends Mol Med , vol.17 , pp. 363-371
    • Boutten, A.1    Goven, D.2    Artaud-Macari, E.3    Boczkowski, J.4    Bonay, M.5
  • 81
    • 84866163421 scopus 로고    scopus 로고
    • Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats
    • [81] Tapia E, Soto V, Ortiz-Vega KM, et al. Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats. Oxid Med Cell Longev 2012; 2012: 269039.
    • (2012) Oxid Med Cell Longev , vol.2012
    • Tapia, E.1    Soto, V.2    Ortiz-Vega, K.M.3
  • 82
    • 9644272830 scopus 로고    scopus 로고
    • Protection against electrophile and oxidative stress by induction of phase 2 genes: The quest for the elusive sensor that responds to inducers
    • [82] Holtzclaw WD, Dinkova-Kostova AT, Talalay P. Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. Adv Enz Reg 2004; 44: 335-67.
    • (2004) Adv Enz Reg , vol.44 , pp. 335-367
    • Holtzclaw, W.D.1    Dinkova-Kostova, A.T.2    Talalay, P.3
  • 83
    • 84874111758 scopus 로고    scopus 로고
    • The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation
    • [83] Bryan HK, Olayanju A, Goldring CE, Park BK. The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation. Biochem Pharmacol 2013; 85: 705-17.
    • (2013) Biochem Pharmacol , vol.85 , pp. 705-717
    • Bryan, H.K.1    Olayanju, A.2    Goldring, C.E.3    Park, B.K.4
  • 84
    • 84870902532 scopus 로고    scopus 로고
    • Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    • [84] Zhang M, An C, Gao Y, et al. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol 2013; 100: 30-47.
    • (2013) Prog Neurobiol , vol.100 , pp. 30-47
    • Zhang, M.1    An, C.2    Gao, Y.3
  • 85
    • 77951804865 scopus 로고    scopus 로고
    • Redox regulation of DNA repair: Implications for human health and cancer therapeutic development
    • [85] Luo M, He H, Kelley MR, Georgiadis MM. Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxid Redox Signal 2010; 12: 1247-69.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1247-1269
    • Luo, M.1    He, H.2    Kelley, M.R.3    Georgiadis, M.M.4
  • 86
    • 84872183989 scopus 로고    scopus 로고
    • Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases
    • [86] Barbagallo I, Galvano F, Frigiola A, et al. Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases. Antioxid Redox Signal 2013; 18: 507-21.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 507-521
    • Barbagallo, I.1    Galvano, F.2    Frigiola, A.3
  • 87
    • 84878156984 scopus 로고    scopus 로고
    • Monoclonal antibodies: Potential new therapeutic treatment against multiple myeloma
    • [87] Allegra A, Penna G, Alonci A, et al. Monoclonal antibodies: potential new therapeutic treatment against multiple myeloma. Eur J Haematol 2013; 90: 441-68.
    • (2013) Eur J Haematol , vol.90 , pp. 441-468
    • Allegra, A.1    Penna, G.2    Alonci, A.3
  • 88
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • [88] DeNicola GM, Karreth FA, Humpton TJ, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011; 475: 106-9.
    • (2011) Nature , vol.475 , pp. 106-109
    • Denicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3
  • 89
    • 79953889329 scopus 로고    scopus 로고
    • Nrf2 is overexpressed in pancreatic cancer: Implications for cell proliferation and therapy
    • [89] Lister A, Nedjadi T, Kitteringham NR, et al. Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer 2011; 10: 37-42.
    • (2011) Mol Cancer , vol.10 , pp. 37-42
    • Lister, A.1    Nedjadi, T.2    Kitteringham, N.R.3
  • 90
    • 84866133072 scopus 로고    scopus 로고
    • Reactive oxygen species in health and disease
    • [90] Alfadda AA, Sallam RM. Reactive oxygen species in health and disease. J Biomed Biotechnol 2012; 2012: 936486.
    • (2012) J Biomed Biotechnol , vol.2012
    • Alfadda, A.A.1    Sallam, R.M.2
  • 91
    • 84867034260 scopus 로고    scopus 로고
    • Role of nrf2 in oxidative stress and toxicity
    • [91] Ma Q. Role of nrf2 in oxidative stress and toxicity. Ann Rev Pharmacol Toxicol 2013; 53: 401-26.
    • (2013) Ann Rev Pharmacol Toxicol , vol.53 , pp. 401-426
    • Ma, Q.1
  • 92
    • 40449107193 scopus 로고    scopus 로고
    • Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    • [92] Ohta T, Iijima K, Miyamoto M, et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 2008; 68: 1303-9.
    • (2008) Cancer Res , vol.68 , pp. 1303-1309
    • Ohta, T.1    Iijima, K.2    Miyamoto, M.3
  • 93
    • 33750885385 scopus 로고    scopus 로고
    • Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
    • [93] Singh A, Misra V, Thimmulappa RK, et al. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLOS Med 2006; 3: e420-e425.
    • (2006) PLOS Med , vol.3 , pp. 420-425
    • Singh, A.1    Misra, V.2    Thimmulappa, R.K.3
  • 94
    • 84863769005 scopus 로고    scopus 로고
    • The keap1-nrf2 cell defense pathway-a promising therapeutic target?
    • [94] Copple IM. The keap1-nrf2 cell defense pathway-a promising therapeutic target? Adv Pharmacol 2012; 63: 43-8.
    • (2012) Adv Pharmacol , vol.63 , pp. 43-48
    • Copple, I.M.1
  • 95
    • 84895835925 scopus 로고    scopus 로고
    • Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration
    • [95] Kincaid B, Bossy-Wetzel E. Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci 2013; 5: 48-53.
    • (2013) Front Aging Neurosci , vol.5 , pp. 48-53
    • Kincaid, B.1    Bossy-Wetzel, E.2
  • 96
    • 84874709843 scopus 로고    scopus 로고
    • SIRT1 and SIRT2: Emerging targets in neurodegeneration
    • [96] Donmez G, Outeiro TF. SIRT1 and SIRT2: Emerging targets in neurodegeneration. EMBO Molecular Medicine 2013; 5: 344-52.
    • (2013) EMBO Molecular Medicine , vol.5 , pp. 344-352
    • Donmez, G.1    Outeiro, T.F.2
  • 97
    • 77958001297 scopus 로고    scopus 로고
    • Irtuins: Common targets in aging and in neurodegeneration
    • [97] de Oliveira RM, Pais TF, Outeiro TF. Irtuins: Common targets in aging and in neurodegeneration. Current Drug Targets 2010; 11: 1270-80.
    • (2010) Current Drug Targets , vol.11 , pp. 1270-1280
    • De Oliveira, R.M.1    Pais, T.F.2    Outeiro, T.F.3
  • 98
    • 84876012415 scopus 로고    scopus 로고
    • Redox-regulating sirtuins in aging, caloric restriction, and exercise
    • [98] Radak Z, Koltai E, Taylor AW, et al. Redox-regulating sirtuins in aging, caloric restriction, and exercise. Free Radic Biol Med 2013; 58: 87-97.
    • (2013) Free Radic Biol Med , vol.58 , pp. 87-97
    • Radak, Z.1    Koltai, E.2    Taylor, A.W.3
  • 100
    • 84866047359 scopus 로고    scopus 로고
    • Editorial on special topic: Sirtuins in metabolism, aging, and disease
    • APR
    • [100] Kazantsev AG, Outeiro TF. Editorial on special topic: Sirtuins in metabolism, aging, and disease. Frontiers Pharmacol 2012; 3 APR.
    • (2012) Frontiers Pharmacol , vol.3
    • Kazantsev, A.G.1    Outeiro, T.F.2
  • 101
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • [101] Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662-7.
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 102
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • [102] Someya S, Yu W, Hallows WC, et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010; 143: 802-12.
    • (2010) Cell , vol.143 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3
  • 103
    • 51449083112 scopus 로고    scopus 로고
    • SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
    • [103] Jacobs KM, Pennington JD, Bisht KS, et al. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci 2008; 4: 291-9.
    • (2008) Int J Biol Sci , vol.4 , pp. 291-299
    • Jacobs, K.M.1    Pennington, J.D.2    Bisht, K.S.3
  • 104
    • 84876045065 scopus 로고    scopus 로고
    • Resveratrol and related compounds as antioxidants with an allosteric mechanism of action in epigenetic drug targets
    • [104] Farghali H, Kutinova Canova N, Lekic N. Resveratrol and related compounds as antioxidants with an allosteric mechanism of action in epigenetic drug targets. Physiol Res 2013; 62: 1-13.
    • (2013) Physiol Res , vol.62 , pp. 1-13
    • Farghali, H.1    Kutinova Canova, N.2    Lekic, N.3
  • 105
    • 84867702707 scopus 로고    scopus 로고
    • Sirtuin activators and inhibitors
    • [105] Villalba JM, Alcain FJ. Sirtuin activators and inhibitors. Biofactors 2012; 38: 349-59.
    • (2012) Biofactors , vol.38 , pp. 349-359
    • Villalba, J.M.1    Alcain, F.J.2
  • 106
    • 33750455858 scopus 로고    scopus 로고
    • Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?
    • [106] Lotito SB, Frei B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 2006; 41: 1727-46.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1727-1746
    • Lotito, S.B.1    Frei, B.2
  • 107
    • 84878187312 scopus 로고    scopus 로고
    • Antioxidant relevance to human health
    • [107] Wahlqvist ML. Antioxidant relevance to human health. Asia Pac J Clin Nutr 2013; 22: 171-6.
    • (2013) Asia Pac J Clin Nutr , vol.22 , pp. 171-176
    • Wahlqvist, M.L.1
  • 108
    • 80054069941 scopus 로고    scopus 로고
    • Xanthine oxidase and uric acid in cardiovascular disease: Clinical impact and therapeutic options
    • editors, Elsevier
    • [108] Doehner W, Landmesser U, editors. Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options. Semin Nephrol; 2011: Elsevier.
    • (2011) Semin Nephrol
    • Doehner, W.1    Landmesser, U.2
  • 109
    • 77956176217 scopus 로고    scopus 로고
    • Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media
    • [109] Long LH, Hoi A, Halliwell B. Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media. Arch Biochem Biophys 2010; 501: 162-9.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 162-169
    • Long, L.H.1    Hoi, A.2    Halliwell, B.3
  • 111
    • 79958061878 scopus 로고    scopus 로고
    • The role of antioxidant versus prooxidant effects of green tea polyphenols in cancer prevention
    • [111] Forester SC, Lambert JD. The role of antioxidant versus prooxidant effects of green tea polyphenols in cancer prevention. Mol Nutr Food Res 2011; 55: 844-54.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 844-854
    • Forester, S.C.1    Lambert, J.D.2
  • 113
    • 84873344743 scopus 로고    scopus 로고
    • Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: Systematic review and meta-analysis of randomised controlled trials
    • [113] Myung SK, Ju W, Cho B, et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ 2013; 346: f10.
    • (2013) BMJ , vol.10 , pp. 346
    • Myung, S.K.1    Ju, W.2    Cho, B.3
  • 114
    • 84861927005 scopus 로고    scopus 로고
    • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    • [114] Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2012; 3: CD007176.
    • (2012) Cochrane Database Syst Rev , vol.3
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 115
    • 84870249796 scopus 로고    scopus 로고
    • Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: A critical commentary
    • [115] Dolara P, Bigagli E, Collins A. Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: a critical commentary. Eur J Nutr 2012; 51: 769-81.
    • (2012) Eur J Nutr , vol.51 , pp. 769-781
    • Dolara, P.1    Bigagli, E.2    Collins, A.3
  • 116
    • 0035004114 scopus 로고    scopus 로고
    • Flavonoid antioxidants
    • [116] Rice-Evans C. Flavonoid antioxidants. Curr Med Chem 2001; 8: 797-807.
    • (2001) Curr Med Chem , vol.8 , pp. 797-807
    • Rice-Evans, C.1
  • 118
    • 11844293406 scopus 로고    scopus 로고
    • Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry
    • [118] Firuzi O, Lacanna A, Petrucci R, Marrosu G, Saso L. Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry. Biochim Biophys Acta 2005; 1721: 174-84.
    • (2005) Biochim Biophys Acta , vol.1721 , pp. 174-184
    • Firuzi, O.1    Lacanna, A.2    Petrucci, R.3    Marrosu, G.4    Saso, L.5
  • 119
    • 36749081135 scopus 로고    scopus 로고
    • Resveratrol as an antioxidant and prooxidant agent: Mechanisms and clinical implications
    • [119] de la Lastra CA, Villegas I. Resveratrol as an antioxidant and prooxidant agent: mechanisms and clinical implications. Biochem Soc Trans 2007; 35: 1156-60.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1156-1160
    • De La Lastra, C.A.1    Villegas, I.2
  • 121
    • 79951579678 scopus 로고    scopus 로고
    • Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L-thyroxine-induced oxidative stress in rat renal cortex
    • [121] Jena S, Chainy GB. Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L-thyroxine-induced oxidative stress in rat renal cortex. Mol Biol Rep 2011; 38: 1047-54.
    • (2011) Mol Biol Rep , vol.38 , pp. 1047-1054
    • Jena, S.1    Chainy, G.B.2
  • 122
    • 55249116976 scopus 로고    scopus 로고
    • Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress
    • [122] Sahoo DK, Roy A, Chainy GB. Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chem Biol Interact 2008; 176: 121-8.
    • (2008) Chem Biol Interact , vol.176 , pp. 121-128
    • Sahoo, D.K.1    Roy, A.2    Chainy, G.B.3
  • 123
    • 36849091347 scopus 로고    scopus 로고
    • Antioxidant activity of 4methylcoumarins
    • [123] Pedersen JZ, Oliveira C, Incerpi S, et al. Antioxidant activity of 4methylcoumarins. J Pharm Pharmacol 2007; 59: 1721-8.
    • (2007) Pharm Pharmacol , vol.9 , pp. 721-728
    • Pedersen, J.Z.1    Oliveira, C.2    Incerpi, S.3
  • 124
    • 77955843923 scopus 로고    scopus 로고
    • Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems
    • [124] Morabito G, Trombetta D, Singh Brajendra K, et al. Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems. Biochimie 2010; 92: 1101-7.
    • (2010) Biochimie , vol.92 , pp. 1101-1107
    • Morabito, G.1    Trombetta, D.2    Singh Brajendra, K.3
  • 125
    • 77955845291 scopus 로고    scopus 로고
    • 4-Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation
    • [125] Natella F, Lorrain B, Prasad AK, et al. 4-Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation. Biochimie 2010; 92: 1147-52.
    • (2010) Biochimie , vol.92 , pp. 1147-1152
    • Natella, F.1    Lorrain, B.2    Prasad, A.K.3
  • 126
    • 77955843272 scopus 로고    scopus 로고
    • A spectroelectrochemical and chemical study on oxidation of 7, 8-dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium
    • [126] Petrucci R, Saso L, Kumar V, et al. A spectroelectrochemical and chemical study on oxidation of 7, 8-dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium. Biochimie 2010; 92: 1123-9.
    • (2010) Biochimie , vol.92 , pp. 1123-1129
    • Petrucci, R.1    Saso, L.2    Kumar, V.3
  • 128
    • 84857454548 scopus 로고    scopus 로고
    • Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress
    • [128] Garrido J, Gaspar A, Garrido EM, et al. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress. Biochimie 2012; 94: 961-7.
    • (2012) Biochimie , vol.94 , pp. 961-967
    • Garrido, J.1    Gaspar, A.2    Garrido, E.M.3
  • 129
    • 84888190788 scopus 로고    scopus 로고
    • Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure-Activity Relationships
    • [129] Razzaghi-Asl N, Garrido J, Khazraei H, Borges F, Firuzi O. Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure-Activity Relationships. Curr Med Chem 2013; 20: 4436-50.
    • (2013) Curr Med Chem , vol.20 , pp. 4436-4450
    • Razzaghi-Asl, N.1    Garrido, J.2    Khazraei, H.3    Borges, F.4    Firuzi, O.5
  • 130
    • 78149321255 scopus 로고    scopus 로고
    • Dietary phenolic acids and derivatives. Evaluation of the antioxidant activity of sinapic acid and its alkyl esters
    • [130] Gaspar A, Martins M, Silva P, et al. Dietary phenolic acids and derivatives. Evaluation of the antioxidant activity of sinapic acid and its alkyl esters. J Agric Food Chem 2010; 58: 11273-11280.
    • (2010) J Agric Food Chem , vol.58 , pp. 11273-11280
    • Gaspar, A.1    Martins, M.2    Silva, P.3
  • 131
    • 79953036116 scopus 로고    scopus 로고
    • In vitro analysis of iron chelating activity of flavonoids
    • [131] Mladnka P, Macáková K, Filipsk T, et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem 2011; 105: 693-701.
    • (2011) J Inorg Biochem , vol.105 , pp. 693-701
    • Mladnka, P.1    Macáková, K.2    Filipsk, T.3
  • 132
    • 77955843787 scopus 로고    scopus 로고
    • In vitro interactions of coumarins with iron
    • [132] Mladnka P, Macáková K, Zatloukalová L, et al. In vitro interactions of coumarins with iron. Biochimie 2010; 92: 1108-14.
    • (2010) Biochimie , vol.92 , pp. 1108-1114
    • Mladnka, P.1    Macáková, K.2    Zatloukalová, L.3
  • 133
    • 80054875266 scopus 로고    scopus 로고
    • Modulation of Nrf2/ARE pathway by food polyphenols: A nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
    • [133] Scapagnini G, Sonya V, Nader AG, et al. Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Mol Neurobiol 2011; 44: 192-201.
    • (2011) Mol Neurobiol , vol.44 , pp. 192-201
    • Scapagnini, G.1    Sonya, V.2    Nader, A.G.3
  • 134
    • 84876432735 scopus 로고    scopus 로고
    • Resveratrol protects spinal cord dorsal column from hypoxic injury by activating Nrf-2
    • [134] Kesherwani V, Atif F, Yousuf S, Agrawal SK. Resveratrol protects spinal cord dorsal column from hypoxic injury by activating Nrf-2. Neuroscience 2013; 241: 80-8.
    • (2013) Neuroscience , vol.241 , pp. 80-88
    • Kesherwani, V.1    Atif, F.2    Yousuf, S.3    Agrawal, S.K.4
  • 135
    • 84860540855 scopus 로고    scopus 로고
    • Resveratrol in medicinal chemistry: A critical review of its pharmacokinetics, drug-delivery, and membrane interactions
    • [135] Neves AR, Lucio M, Lima JL, Reis S. Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Curr Med Chem 2012; 19: 1663-81.
    • (2012) Curr Med Chem , vol.19 , pp. 1663-1681
    • Neves, A.R.1    Lucio, M.2    Lima, J.L.3    Reis, S.4
  • 136
    • 84875388603 scopus 로고    scopus 로고
    • The clinical applications of curcumin: Current state and the future
    • [136] Fan X, Zhang C, Liu D-b, Yan J, Liang H-p. The clinical applications of curcumin: current state and the future. Curr Pharm Design 2013; 19: 2011-31.
    • (2013) Curr Pharm Design , vol.19 , pp. 2011-2031
    • Fan, X.1    Zhang, C.2    D-B, L.3    Yan, J.4    Liang, H.-P.5
  • 137
    • 84877050134 scopus 로고    scopus 로고
    • Curcumin maintains cardiac and mitochondrial function in chronic kidney disease
    • [137] Correa F, Buelna-Chontal M, et al. Curcumin maintains cardiac and mitochondrial function in chronic kidney disease. Free Radic Biol Med 2013; 61C: 119-29.
    • (2013) Free Radic Biol Med , vol.61 , pp. 119-129
    • Correa, F.1    Buelna-Chontal, M.2
  • 138
    • 84870421027 scopus 로고    scopus 로고
    • Multiple antidepressant potential modes of action of curcumin: A review of its antiinflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects
    • [138] Lopresti AL, Hood SD, Drummond PD. Multiple antidepressant potential modes of action of curcumin: a review of its antiinflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J Psychopharmacol 2012; 26: 1512-24.
    • (2012) J Psychopharmacol , vol.26 , pp. 1512-1524
    • Lopresti, A.L.1    Hood, S.D.2    Drummond, P.D.3
  • 139
    • 84867823334 scopus 로고    scopus 로고
    • Chemical and technological delivery systems for idebenone: A review of literature production
    • [139] Carbone C, Pignatello R, Musumeci T, Puglisi G. Chemical and technological delivery systems for idebenone: a review of literature production. Expert Opin Drug Del 2012; 9: 1377-92.
    • (2012) Expert Opin Drug Del , vol.9 , pp. 1377-1392
    • Carbone, C.1    Pignatello, R.2    Musumeci, T.3    Puglisi, G.4
  • 140
    • 0027092959 scopus 로고
    • Idebenone in senile dementia of Alzheimer type: A multicentre study
    • [140] Senin U, Parnetti L, Barbagallo-Sangiorgi G, et al. Idebenone in senile dementia of Alzheimer type: a multicentre study. Arch Gerontol Geriatr 1992; 15: 249-60.
    • (1992) Arch Gerontol Geriatr , vol.15 , pp. 249-260
    • Senin, U.1    Parnetti, L.2    Barbagallo-Sangiorgi, G.3
  • 141
    • 0028068622 scopus 로고
    • Idebenone, a new drug in the treatment of cognitive impairment in patients with dementia of the Alzheimer type
    • [141] Bergamasco B, Scarzella L, La Commare P. Idebenone, a new drug in the treatment of cognitive impairment in patients with dementia of the Alzheimer type. Funct Neurol 1994; 9: 161-7.
    • (1994) Funct Neurol , vol.9 , pp. 161-167
    • Bergamasco, B.1    Scarzella, L.2    La Commare, P.3
  • 142
    • 84858148877 scopus 로고    scopus 로고
    • Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease
    • [142] Mecocci P, Polidori MC. Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease. Biochim Biophys Acta 2012; 1822: 631-8.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 631-638
    • Mecocci, P.1    Polidori, M.C.2
  • 143
    • 0037400919 scopus 로고    scopus 로고
    • Melatonin: A novel protective agent against oxidative injury of the ischemic/reperfused heart
    • [143] Reiter RJ, Tan D-X. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc Res 2003; 58: 10-9.
    • (2003) Cardiovasc Res , vol.58 , pp. 10-19
    • Reiter, R.J.1    Tan, D.-X.2
  • 144
    • 84876850102 scopus 로고    scopus 로고
    • The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    • [144] Reiter RJ, Tan DX, Rosales-Corral S, Manchester LC. The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives. Mini Rev Med Chem 2013; 13: 373-84.
    • (2013) Mini Rev Med Chem , vol.13 , pp. 373-384
    • Reiter, R.J.1    Tan, D.X.2    Rosales-Corral, S.3    Manchester, L.C.4
  • 146
    • 84864886698 scopus 로고    scopus 로고
    • Antioxidant therapies: A potential role in perinatal medicine
    • [146] Miller S, Wallace E, Walker D. Antioxidant therapies: a potential role in perinatal medicine. Neuroendocrinology 2012; 96: 13-23.
    • (2012) Neuroendocrinology , vol.96 , pp. 13-23
    • Miller, S.1    Wallace, E.2    Walker, D.3
  • 147
    • 84858151224 scopus 로고    scopus 로고
    • Antioxidant therapies in traumatic brain and spinal cord injury
    • [147] Bains M, Hall ED. Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta 2012; 1822: 675-684.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 675-684
    • Bains, M.1    Hall, E.D.2
  • 148
    • 79959342434 scopus 로고    scopus 로고
    • Drug-mediated ototoxicity and tinnitus: Alleviation with melatonin
    • [148] Reiter R, Tan D, Korkmaz A, Fuentes-Broto L. Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. J Physiol Pharmacol 2011; 62: 151-6.
    • (2011) J Physiol Pharmacol , vol.62 , pp. 151-156
    • Reiter, R.1    Tan, D.2    Korkmaz, A.3    Fuentes-Broto, L.4
  • 149
    • 84867896898 scopus 로고    scopus 로고
    • Cisplatin and aminoglycoside antibiotics: Hearing loss and its prevention
    • [149] Schacht J, Talaska AE, Rybak LP. Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention. Anat Rec 2012; 295: 1837-50.
    • (2012) Anat Rec , vol.295 , pp. 1837-1850
    • Schacht, J.1    Talaska, A.E.2    Rybak, L.P.3
  • 150
    • 54249105259 scopus 로고    scopus 로고
    • Acetaminophen-induced nephrotoxicity: Pathophysiology, clinical manifestations, and management
    • [150] Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol 2008; 4: 2-6.
    • (2008) J Med Toxicol , vol.4 , pp. 2-6
    • Mazer, M.1    Perrone, J.2
  • 152
    • 84877828545 scopus 로고    scopus 로고
    • The chemistry and biological activities of N-acetylcysteine
    • [152] Samuni Y, Goldstein S, Dean OM, Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 2013; 1830: 4117-29.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 4117-4129
    • Samuni, Y.1    Goldstein, S.2    Dean, O.M.3    Berk, M.4
  • 153
    • 36549029828 scopus 로고    scopus 로고
    • N-acetylcysteine and neurodegenerative diseases: Basic and clinical pharmacology
    • [153] Arakawa M. N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology. Cerebellum 2007; 6: 308-14.
    • (2007) Cerebellum , vol.6 , pp. 308-314
    • Arakawa, M.1
  • 154
    • 79953111745 scopus 로고    scopus 로고
    • N-acetylcysteine in psychiatry: Current therapeutic evidence and potential mechanisms of action
    • [154] Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. JPN 2011; 36: 78-84.
    • (2011) JPN , vol.36 , pp. 78-84
    • Dean, O.1    Giorlando, F.2    Berk, M.3
  • 156
    • 0028361231 scopus 로고
    • Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue
    • [156] Bridgeman M, Marsden M, Selby C, Morrison D, MacNee W. Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue. Thorax 1994; 49: 670-5.
    • (1994) Thorax , vol.49 , pp. 670-675
    • Bridgeman, M.1    Marsden, M.2    Selby, C.3    Morrison, D.4    Macnee, W.5
  • 157
    • 84862286914 scopus 로고    scopus 로고
    • Antioxidant pharmacological therapies for COPD
    • [157] Rahman I, MacNee W. Antioxidant pharmacological therapies for COPD. Curr Opin Pharmacol 2012; 12: 256-65.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 256-265
    • Rahman, I.1    Macnee, W.2
  • 158
    • 84866545236 scopus 로고    scopus 로고
    • NAcetylcysteine Use for Amelioration of AminoglycosideInduced Ototoxicity in Dialysis Patients
    • Wiley Online Library
    • [158] Feldman L, Sherman RA, Weissgarten J, editors. NAcetylcysteine Use for Amelioration of AminoglycosideInduced Ototoxicity in Dialysis Patients. Semin Dialysis; 2012: Wiley Online Library.
    • (2012) Semin Dialysis
    • Feldman, L.1    Sherman, R.A.2    Weissgarten, J.3
  • 159
    • 84863993868 scopus 로고    scopus 로고
    • Platinum-induced ototoxicity in children: A consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale
    • [159] Brock PR, Knight KR, Freyer DR, et al. Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale. J Clin Oncol 2012; 30: 2408-17.
    • (2012) J Clin Oncol , vol.30 , pp. 2408-2417
    • Brock, P.R.1    Knight, K.R.2    Freyer, D.R.3
  • 160
    • 75749085711 scopus 로고    scopus 로고
    • The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: A meta-analysis of individual patient data
    • [160] Cazzola M, Floriani I, Page C. The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data. Pulm Pharmacol Ther 2010; 23: 135-44.
    • (2010) Pulm Pharmacol Ther , vol.23 , pp. 135-144
    • Cazzola, M.1    Floriani, I.2    Page, C.3
  • 161
    • 20844451178 scopus 로고    scopus 로고
    • The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: The EQUALIFE Study
    • [161] Moretti M, Bottrighi P, Dallari R, et al. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study. Drugs Exp Clin Res 2004; 30: 143-52.
    • (2004) Drugs Exp Clin Res , vol.30 , pp. 143-152
    • Moretti, M.1    Bottrighi, P.2    Dallari, R.3
  • 162
    • 65549110824 scopus 로고    scopus 로고
    • Erdosteine: Its relevance in COPD treatment
    • [162] Moretti M. Erdosteine: its relevance in COPD treatment. Expert Opin Drug Metab Toxicol 2009; 5: 11.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 11
    • Moretti, M.1
  • 163
    • 66649127216 scopus 로고    scopus 로고
    • Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine
    • [163] Osoata GO, Hanazawa T, Brindicci C, et al. Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest 2009; 135: 1513-20.
    • (2009) Chest , vol.135 , pp. 1513-1520
    • Osoata, G.O.1    Hanazawa, T.2    Brindicci, C.3
  • 164
    • 84858161403 scopus 로고    scopus 로고
    • Elevation of glutathione as a therapeutic strategy in Alzheimer disease
    • [164] Pocernich CB, Butterfield DA. Elevation of glutathione as a therapeutic strategy in Alzheimer disease. Biochim Biophys Acta 2012; 1822: 625-30.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 625-630
    • Pocernich, C.B.1    Butterfield, D.A.2
  • 165
    • 0037097270 scopus 로고    scopus 로고
    • Elevation of brain glutathione by glutamylcysteine ethyl ester protects against peroxynitrite induced oxidative stress
    • [165] Drake J, Kanski J, Varadarajan S, Tsoras M, Butterfield DA. Elevation of brain glutathione by glutamylcysteine ethyl ester protects against peroxynitrite induced oxidative stress. J Neurosci Res 2002; 68: 776-84.
    • (2002) J Neurosci Res , vol.68 , pp. 776-784
    • Drake, J.1    Kanski, J.2    Varadarajan, S.3    Tsoras, M.4    Butterfield, D.A.5
  • 166
    • 0344980763 scopus 로고    scopus 로고
    • Elevation of mitochondrial glutathione by glutamylcysteine ethyl ester protects mitochondria against peroxynitrite induced oxidative stress
    • [166] Drake J, Sultana R, Aksenova M, Calabrese V, Butterfield DA. Elevation of mitochondrial glutathione by glutamylcysteine ethyl ester protects mitochondria against peroxynitrite induced oxidative stress. J Neurosci Res 2003; 74: 917-27.
    • (2003) J Neurosci Res , vol.74 , pp. 917-927
    • Drake, J.1    Sultana, R.2    Aksenova, M.3    Calabrese, V.4    Butterfield, D.A.5
  • 167
    • 84872146192 scopus 로고    scopus 로고
    • Direct and indirect antioxidant properties of alpha-lipoic acid and therapeutic potential
    • [167] Rochette L, Ghibu S, Richard C, et al. Direct and indirect antioxidant properties of alpha-lipoic acid and therapeutic potential. Mol Nutr Food Res 2013; 57: 114-25.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 114-125
    • Rochette, L.1    Ghibu, S.2    Richard, C.3
  • 168
    • 26244450392 scopus 로고    scopus 로고
    • -lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    • [168] Ogborne RM, Rushworth SA, O’Connell MA. -lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arterioscler Thromb Vasc Biol 2005; 25: 2100-05.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2100-2105
    • Ogborne, R.M.1    Rushworth, S.A.2    O’Connell, M.A.3
  • 169
    • 0035399871 scopus 로고    scopus 로고
    • Beneficial effects of -lipoic acid and ascorbic acid on endothelium-dependent, nitric oxidemediated vasodilation in diabetic patients: Relation to parameters of oxidative stress
    • [169] Heitzer T, Finckh B, Albers S, et al. Beneficial effects of -lipoic acid and ascorbic acid on endothelium-dependent, nitric oxidemediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med 2001; 31: 53-61.
    • (2001) Free Radic Biol Med , vol.31 , pp. 53-61
    • Heitzer, T.1    Finckh, B.2    Albers, S.3
  • 170
    • 12844260091 scopus 로고    scopus 로고
    • Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) Study
    • [170] Sola S, Mir MQ, Cheema FA, et al. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) Study. Circulation 2005; 111: 343-8.
    • (2005) Circulation , vol.111 , pp. 343-348
    • Sola, S.1    Mir, M.Q.2    Cheema, F.A.3
  • 173
    • 77953648503 scopus 로고    scopus 로고
    • A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy?
    • [173] Lapchak PA. A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? Expert Opin Pharmacother 2010; 11: 1753-63.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 1753-1763
    • Lapchak, P.A.1
  • 174
    • 46849106962 scopus 로고    scopus 로고
    • The novel antioxidant edaravone: From bench to bedside
    • [174] Watanabe T, Tahara M, Todo S. The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther 2008; 26: 101-14.
    • (2008) Cardiovasc Ther , vol.26 , pp. 101-114
    • Watanabe, T.1    Tahara, M.2    Todo, S.3
  • 175
    • 27644520933 scopus 로고    scopus 로고
    • Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy
    • [175] Noor JI, Ikeda T, Mishima K, et al. Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy. Stroke 2005; 36: 2468-74.
    • (2005) Stroke , vol.36 , pp. 2468-2474
    • Noor, J.I.1    Ikeda, T.2    Mishima, K.3
  • 176
    • 84862560739 scopus 로고    scopus 로고
    • Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics
    • [176] Villamena FA, Das A, Nash KM. Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Fut Med Chem 2012; 4: 1171-207.
    • (2012) Fut Med Chem , vol.4 , pp. 1171-1207
    • Villamena, F.A.1    Das, A.2    Nash, K.M.3
  • 178
    • 46249131138 scopus 로고    scopus 로고
    • NXY-059 for the Treatment of Acute Stroke Pooled Analysis of the SAINT I and II Trials
    • [178] Diener H-C, Lees KR, Lyden P, et al. NXY-059 for the Treatment of Acute Stroke Pooled Analysis of the SAINT I and II Trials. Stroke 2008; 39: 1751-8.
    • (2008) Stroke , vol.39 , pp. 1751-1758
    • Diener, H.-C.1    Lees, K.R.2    Lyden, P.3
  • 179
    • 84884903879 scopus 로고    scopus 로고
    • Nitrone-based therapeutics for neurodegenerative diseases: Their use alone or in combination with lanthionines
    • [179] Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA. Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med 2013; 62: 145-56.
    • (2013) Free Radic Biol Med , vol.62 , pp. 145-156
    • Floyd, R.A.1    Castro Faria Neto, H.C.2    Zimmerman, G.A.3    Hensley, K.4    Towner, R.A.5
  • 180
    • 33846625176 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke
    • [180] Sena E, Wheble P, Sandercock P, Macleod M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke 2007; 38: 388-94.
    • (2007) Stroke , vol.38 , pp. 388-394
    • Sena, E.1    Wheble, P.2    Sandercock, P.3    Macleod, M.4
  • 181
    • 79952485476 scopus 로고    scopus 로고
    • Effects of lazaroids on intestinal ischemia and reperfusion injury in experimental models
    • [181] Flessas II, Papalois AE, Toutouzas K, Zagouri F, Zografos GC. Effects of lazaroids on intestinal ischemia and reperfusion injury in experimental models. J Surg Res 2011; 166: 265-74.
    • (2011) J Surg Res , vol.166 , pp. 265-274
    • Flessas, I.I.1    Papalois, A.E.2    Toutouzas, K.3    Zagouri, F.4    Zografos, G.C.5
  • 183
    • 84868219299 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Drug therapy from the bench to the bedside
    • Thieme Medical Publishers
    • [183] Gibson SB, Bromberg MB, editors. Amyotrophic lateral sclerosis: drug therapy from the bench to the bedside. Semin Neurol; 2012: Thieme Medical Publishers.
    • (2012) Semin Neurol
    • Gibson, S.B.1    Bromberg, M.B.2
  • 184
    • 79958152853 scopus 로고    scopus 로고
    • Superoxide dismutase in redox biology: The roles of superoxide and hydrogen peroxide
    • [184] Buettner GR. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem 2011; 11: 341.
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 341
    • Buettner, G.R.1
  • 185
    • 0032823769 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
    • [185] Halliwell B. Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Rad Res 1999; 31: 261-72.
    • (1999) Free Rad Res , vol.31 , pp. 261-272
    • Halliwell, B.1
  • 186
    • 0037124547 scopus 로고    scopus 로고
    • Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation
    • [186] Veronese FM, Caliceti P, Schiavon O, Sergi M. Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation. Adv Drug Deliv Rev 2002; 54: 587-606.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 587-606
    • Veronese, F.M.1    Caliceti, P.2    Schiavon, O.3    Sergi, M.4
  • 187
    • 77954735594 scopus 로고    scopus 로고
    • Superoxide dismutase mimics: Chemistry, pharmacology, and therapeutic potential
    • [187] Batini-Haberle I, Rebouças JS, Spasojevi I. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal 2010; 13: 877-918.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 877-918
    • Batini-Haberle, I.1    Rebouças, J.S.2    Spasojevi, I.3
  • 188
    • 0035831587 scopus 로고    scopus 로고
    • Computer-aided design (CAD) of Mn(II) complexes: Superoxide dismutase mimetics with catalytic activity exceeding the native enzyme
    • [188] Aston K, Rath N, Naik A, et al. Computer-aided design (CAD) of Mn(II) complexes: superoxide dismutase mimetics with catalytic activity exceeding the native enzyme. Inorg Chem 2001; 40: 1779-89.
    • (2001) Inorg Chem , vol.40 , pp. 1779-1789
    • Aston, K.1    Rath, N.2    Naik, A.3
  • 189
    • 77954113727 scopus 로고    scopus 로고
    • Potential therapeutic benefits of strategies directed to mitochondria
    • [189] Camara AK, Lesnefsky EJ, Stowe DF. Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal 2010; 13: 279-347.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 279-347
    • Camara, A.K.1    Lesnefsky, E.J.2    Stowe, D.F.3
  • 190
    • 71549136876 scopus 로고    scopus 로고
    • Redox control of asthma: Molecular mechanisms and therapeutic opportunities
    • [190] Comhair SA, Erzurum SC. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2010; 12: 93-124.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 93-124
    • Comhair, S.A.1    Erzurum, S.C.2
  • 191
    • 79955959849 scopus 로고    scopus 로고
    • Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction
    • [191] de Haan J, Cooper M. Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction. Front Biosci 2011; 3: 709.
    • (2011) Front Biosci , vol.3 , pp. 709
    • De Haan, J.1    Cooper, M.2
  • 192
    • 33644631485 scopus 로고    scopus 로고
    • Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol
    • [192] Pacher P, Nivorozhkin A, Szabó C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 2006; 58: 87-114.
    • (2006) Pharmacol Rev , vol.58 , pp. 87-114
    • Pacher, P.1    Nivorozhkin, A.2    Szabó, C.3
  • 193
    • 81555220895 scopus 로고    scopus 로고
    • ROS and RNS signaling in heart disorders: Could antioxidant treatment be successful?
    • [193] Afanas' ev I. ROS and RNS signaling in heart disorders: could antioxidant treatment be successful? Oxid Med Cell Longev 2011; 2011.
    • (2011) Oxid Med Cell Longev , pp. 2011
    • Afanas' Ev, I.1
  • 194
    • 0023360005 scopus 로고
    • Free radical-mediated reperfusion injury: A selective review
    • [194] Bulkley G. Free radical-mediated reperfusion injury: a selective review. Br J Cancer 1987; 8: 66.
    • (1987) Br J Cancer , vol.8 , pp. 66
    • Bulkley, G.1
  • 195
    • 0030002692 scopus 로고    scopus 로고
    • Role of xanthine oxidase and its inhibitor in hypoxia: Reoxygenation injury
    • [195] Saugstad OD. Role of xanthine oxidase and its inhibitor in hypoxia: reoxygenation injury. Pediatrics 1996; 98: 103-7.
    • (1996) Pediatrics , vol.98 , pp. 103-107
    • Saugstad, O.D.1
  • 196
    • 44949262935 scopus 로고    scopus 로고
    • Mammalian xanthine oxidoreductase-mechanism of transition from xanthine dehydrogenase to xanthine oxidase
    • [196] Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T. Mammalian xanthine oxidoreductase-mechanism of transition from xanthine dehydrogenase to xanthine oxidase. FEBS J 2008; 275: 3278-89.
    • (2008) FEBS J , vol.275 , pp. 3278-3289
    • Nishino, T.1    Okamoto, K.2    Eger, B.T.3    Pai, E.F.4    Nishino, T.5
  • 197
    • 0021740648 scopus 로고
    • Effect of allopurinol treatment in premature infants with idiopathic respiratory distress syndrome
    • [197] Boda D, Nemeth I, Hencz P, Denes K. Effect of allopurinol treatment in premature infants with idiopathic respiratory distress syndrome. Dev Pharmacol Ther 1984; 7: 357-63.
    • (1984) Dev Pharmacol Ther , vol.7 , pp. 357-363
    • Boda, D.1    Nemeth, I.2    Hencz, P.3    Denes, K.4
  • 198
    • 0031930898 scopus 로고    scopus 로고
    • Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity
    • [198] Van Bel F, Shadid M, Moison RM, et al. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics 1998; 101: 185-93.
    • (1998) Pediatrics , vol.101 , pp. 185-193
    • Van Bel, F.1    Shadid, M.2    Moison, R.M.3
  • 199
    • 33947331502 scopus 로고    scopus 로고
    • Effect of allopurinol supplementation on nitric oxide levels in asphyxiated newborns
    • [199] Gunes T, Ozturk MA, Koklu E, Kose K, Gunes I. Effect of allopurinol supplementation on nitric oxide levels in asphyxiated newborns. Pediatr Neurol 2007; 36: 17-24.
    • (2007) Pediatr Neurol , vol.36 , pp. 17-24
    • Gunes, T.1    Ozturk, M.A.2    Koklu, E.3    Kose, K.4    Gunes, I.5
  • 200
    • 84864330120 scopus 로고    scopus 로고
    • NADPH oxidases as therapeutic targets in ischemic stroke
    • [200] Kahles T, Brandes RP. NADPH oxidases as therapeutic targets in ischemic stroke. Cell Mol Life Sci 2012; 69: 2345-63.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2345-2363
    • Kahles, T.1    Brandes, R.P.2
  • 201
    • 84859853336 scopus 로고    scopus 로고
    • NADPH oxidases as regulators of tumor angiogenesis: Current and emerging concepts
    • [201] Coso S, Harrison I, Harrison CB, et al. NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxid Redox Signal 2012; 16: 1229-47.
    • (2012) Antioxid Redox Signal , vol.16 , pp. 1229-1247
    • Coso, S.1    Harrison, I.2    Harrison, C.B.3
  • 202
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidase-dependent signaling in endothelial cells: Role in physiology and pathophysiology
    • [202] Frey RS, Ushio-Fukai M, Malik AB. NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal 2009; 11: 791-810.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 203
    • 84864360749 scopus 로고    scopus 로고
    • Targeting NOX enzymes in the central nervous system: Therapeutic opportunities
    • [203] Sorce S, Krause K-H, Jaquet V. Targeting NOX enzymes in the central nervous system: therapeutic opportunities. Cell Mol Life Sci 2012; 69: 2387-407.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2387-2407
    • Sorce, S.1    Krause, K.-H.2    Jaquet, V.3
  • 204
    • 84875181886 scopus 로고    scopus 로고
    • Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress
    • [204] Radermacher KA, Wingler K, Langhauser F, et al. Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. Antioxid Redox Signal 2013; 18: 1418-27.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1418-1427
    • Radermacher, K.A.1    Wingler, K.2    Langhauser, F.3
  • 205
    • 84855440127 scopus 로고    scopus 로고
    • NADPH oxidasedependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach
    • [205] Octavia Y, Brunner-La Rocca HP, Moens AL. NADPH oxidasedependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach. Free Radic Biol Med 2012; 52: 291-7.
    • (2012) Free Radic Biol Med , vol.52 , pp. 291-297
    • Octavia, Y.1    Brunner-La Rocca, H.P.2    Moens, A.L.3
  • 207
    • 38549138327 scopus 로고    scopus 로고
    • Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    • [207] Heumüller S, Wind S, Barbosa-Sicard E, et al. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008; 51: 211-7.
    • (2008) Hypertension , vol.51 , pp. 211-217
    • Heumüller, S.1    Wind, S.2    Barbosa-Sicard, E.3
  • 208
    • 84866068439 scopus 로고    scopus 로고
    • Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies
    • [208] Sedeek M, Montezano AC, Hebert RL, et al. Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies. J Cardiovasc Pharmacol Transl Res 2012; 5: 509-18.
    • (2012) J Cardiovasc Pharmacol Transl Res , vol.5 , pp. 509-518
    • Sedeek, M.1    Montezano, A.C.2    Hebert, R.L.3
  • 209
    • 77956813371 scopus 로고    scopus 로고
    • Comparative pharmacology of chemically distinct NADPH oxidase inhibitors
    • [209] Wind S, Beuerlein K, Eucker T, et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol 2010; 161: 885-98.
    • (2010) Br J Pharmacol , vol.161 , pp. 885-898
    • Wind, S.1    Beuerlein, K.2    Eucker, T.3
  • 210
    • 12844281747 scopus 로고    scopus 로고
    • A peroxisome proliferatoractivated receptor- agonist reduces infarct size in transient but not in permanent ischemia
    • [210] Shimazu T, Inoue I, Araki N, et al. A peroxisome proliferatoractivated receptor- agonist reduces infarct size in transient but not in permanent ischemia. Stroke 2005; 36: 353-9.
    • (2005) Stroke , vol.36 , pp. 353-359
    • Shimazu, T.1    Inoue, I.2    Araki, N.3
  • 211
    • 8144228247 scopus 로고    scopus 로고
    • The preventive antioxidant action of thiazolidinediones: A new therapeutic prospect in diabetes and insulin resistance
    • [211] Da Ros R, Assaloni R, Ceriello A. The preventive antioxidant action of thiazolidinediones: a new therapeutic prospect in diabetes and insulin resistance. Diabetic Med 2004; 21: 1249-52.
    • (2004) Diabetic Med , vol.21 , pp. 1249-1252
    • Da Ros, R.1    Assaloni, R.2    Ceriello, A.3
  • 212
    • 75149139411 scopus 로고    scopus 로고
    • Antioxidant therapy in human endocrine disorders
    • [212] Golbidi S, Laher I. Antioxidant therapy in human endocrine disorders. Med Sci Monit 2010; 16: RA9.
    • (2010) Med Sci Monit , vol.16
    • Golbidi, S.1    Laher, I.2
  • 213
    • 77957350902 scopus 로고    scopus 로고
    • PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B
    • [213] Lu X, Murphy TC, Nanes MS, Hart CM. PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol 2010; 299: L559-66.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299 , pp. 559-666
    • Lu, X.1    Murphy, T.C.2    Nanes, M.S.3    Hart, C.M.4
  • 214
    • 38549101139 scopus 로고    scopus 로고
    • Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan
    • [214] Nakamura T, Yamamoto E, Kataoka K, et al. Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan. Hypertension 2008; 51: 296-301.
    • (2008) Hypertension , vol.51 , pp. 296-301
    • Nakamura, T.1    Yamamoto, E.2    Kataoka, K.3
  • 215
    • 77955727857 scopus 로고    scopus 로고
    • Celastrol: A new therapeutic potential of traditional Chinese medicine
    • [215] Morita T. Celastrol: a new therapeutic potential of traditional Chinese medicine. Am J Hypertens 2010; 23: 821-7.
    • (2010) Am J Hypertens , vol.23 , pp. 821-827
    • Morita, T.1
  • 216
    • 26244435620 scopus 로고    scopus 로고
    • Herbal medicines for liver diseases
    • [216] Dhiman RK, Chawla YK. Herbal medicines for liver diseases. Dig Dis Sci 2005; 50: 1807-12.
    • (2005) Dig Dis Sci , vol.50 , pp. 1807-1812
    • Dhiman, R.K.1    Chawla, Y.K.2
  • 217
    • 33748472277 scopus 로고    scopus 로고
    • Health benefits of herbs and spices: The past, the present, the future
    • [217] Tapsell LC, Hemphill I, Cobiac L, et al. Health benefits of herbs and spices: the past, the present, the future. Medic J Austr 2006; 185: S4-24.
    • (2006) Medic J Austr , vol.185 , pp. 4-24
    • Tapsell, L.C.1    Hemphill, I.2    Cobiac, L.3
  • 218
    • 67651213131 scopus 로고    scopus 로고
    • A systematic review of the potential herbal sources of future drugs effective in oxidantrelated diseases
    • [218] Hasani-Ranjbar S, Larijani B, Abdollahi M. A systematic review of the potential herbal sources of future drugs effective in oxidantrelated diseases. Inflam Allergy Drug Targets 2009; 8: 2-10.
    • (2009) Inflam Allergy Drug Targets , vol.8 , pp. 2-10
    • Hasani-Ranjbar, S.1    Larijani, B.2    Abdollahi, M.3
  • 219
    • 82855175265 scopus 로고    scopus 로고
    • Scholey A. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence
    • [219] Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol 2011; 21: 841-60.
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 841-860
    • Sarris, J.1    Panossian, A.2    Schweitzer, I.3    Stough, C.4
  • 220
    • 34249884261 scopus 로고    scopus 로고
    • Milk thistle nomenclature: Why it matters in cancer research and pharmacokinetic studies
    • [220] Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther 2007; 6: 110-19.
    • (2007) Integr Cancer Ther , vol.6 , pp. 110-119
    • Kroll, D.J.1    Shaw, H.S.2    Oberlies, N.H.3
  • 221
    • 77950540443 scopus 로고    scopus 로고
    • Identification of hepatoprotective flavonolignans from silymarin
    • [221] Polyak SJ, Morishima C, Lohmann V, et al. Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci USA 2010; 107: 5995-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5995-5999
    • Polyak, S.J.1    Morishima, C.2    Lohmann, V.3
  • 222
    • 78650028517 scopus 로고    scopus 로고
    • Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial
    • [222] Freedman ND, Curto TM, Morishima C, et al. Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial. Aliment Pharmacol Ther 2011; 33: 127-37.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 127-137
    • Freedman, N.D.1    Curto, T.M.2    Morishima, C.3
  • 223
    • 55249084176 scopus 로고    scopus 로고
    • Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
    • [223] Ferenci P, Scherzer TM, Kerschner H, et al. Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy. Gastroenterology 2008; 135: 1561-7.
    • (2008) Gastroenterology , vol.135 , pp. 1561-1567
    • Ferenci, P.1    Scherzer, T.M.2    Kerschner, H.3
  • 224
    • 40549139768 scopus 로고    scopus 로고
    • An updated systematic review with meta-analysis for the clinical evidence of silymarin
    • [224] Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed 2008; 15: 9-20.
    • (2008) Forsch Komplementmed , vol.15 , pp. 9-20
    • Saller, R.1    Brignoli, R.2    Melzer, J.3    Meier, R.4
  • 225
    • 0037109597 scopus 로고    scopus 로고
    • Milk thistle for the treatment of liver disease: A systematic review and meta-analysis
    • [225] Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am J Med 2002; 113: 506-15.
    • (2002) Am J Med , vol.113 , pp. 506-515
    • Jacobs, B.P.1    Dennehy, C.2    Ramirez, G.3    Sapp, J.4    Lawrence, V.A.5
  • 226
    • 82255185729 scopus 로고    scopus 로고
    • Effect of ginkgo biloba extract 50 on immunity and antioxidant enzyme activities in ischemia reperfusion rats
    • [226] Lu S, Guo X, Zhao P. Effect of ginkgo biloba extract 50 on immunity and antioxidant enzyme activities in ischemia reperfusion rats. Molecules 2011; 16: 9194-206.
    • (2011) Molecules , vol.16 , pp. 9194-9206
    • Lu, S.1    Guo, X.2    Zhao, P.3
  • 227
    • 84878688864 scopus 로고    scopus 로고
    • Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicininduced cardiac injury in rats
    • [227] Boghdady NAE. Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicininduced cardiac injury in rats. Cell Biochemistry and Function 2013; 31: 344-51.
    • (2013) Cell Biochemistry and Function , vol.31 , pp. 344-351
    • Boghdady, N.1
  • 228
    • 0141749421 scopus 로고    scopus 로고
    • Neuroprotective effects of Ginkgo biloba extract
    • [228] Ahlemeyer B, Krieglstein J. Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci 2003; 60: 1779-92.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1779-1792
    • Ahlemeyer, B.1    Krieglstein, J.2
  • 229
    • 0036343060 scopus 로고    scopus 로고
    • The CNS effects of Ginkgo biloba extracts and ginkgolide B
    • [229] Maclennan KM, Darlington CL, Smith PF. The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog Neurobiol 2002; 67: 235-57.
    • (2002) Prog Neurobiol , vol.67 , pp. 235-257
    • Maclennan, K.M.1    Darlington, C.L.2    Smith, P.F.3
  • 230
    • 84879317704 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of ginkgo biloba in neuropsychiatric disorders: From ancient tradition to modern-day medicine
    • [230] Brondino N, De Silvestri A, Re S, et al. A systematic review and meta-analysis of ginkgo biloba in neuropsychiatric disorders: From ancient tradition to modern-day medicine. Evid Based Complement Alternat Med 2013; 2013.
    • (2013) Evid Based Complement Alternat Med , pp. 2013
    • Brondino, N.1    De Silvestri, A.2    Re, S.3
  • 231
    • 79959266946 scopus 로고    scopus 로고
    • Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: A randomized, double-blind, placebo-controlled trial
    • [231] Zhang WF, Tan YL, Zhang XY, et al. Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: A randomized, double-blind, placebo-controlled trial. J Clin Psychol 2011; 72: 615-621.
    • (2011) J Clin Psychol , vol.72 , pp. 615-621
    • Zhang, W.F.1    Tan, Y.L.2    Zhang, X.Y.3
  • 232
    • 38349102172 scopus 로고    scopus 로고
    • Multifaceted therapeutic benefits of Ginkgo biloba L.: Chemistry, efficacy, safety, and uses
    • [232] Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: Chemistry, efficacy, safety, and uses. J Food Sci 2008; 73: R14-19.
    • (2008) J Food Sci , vol.73 , pp. 14-19
    • Mahadevan, S.1    Park, Y.2
  • 233
    • 20744439442 scopus 로고    scopus 로고
    • Protective role of Melissa officinalis L. Extract on liver of hyperlipidemic rats: A morphological and biochemical study
    • [233] Bolkent S, Yanardag R, Karabulut-Bulan O, Yesilyaprak B. Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: a morphological and biochemical study. J Ethnopharmacol 2005; 99: 391-8.
    • (2005) J Ethnopharmacol , vol.99 , pp. 391-398
    • Bolkent, S.1    Yanardag, R.2    Karabulut-Bulan, O.3    Yesilyaprak, B.4
  • 234
    • 2342547102 scopus 로고    scopus 로고
    • Melissa officinalis L. Essential oil: Antitumoral and antioxidant activities
    • [234] de Sousa AC, Alviano DS, Blank AF, et al. Melissa officinalis L. essential oil: antitumoral and antioxidant activities. J Pharm Pharmacol 2004; 56: 677-81.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 677-681
    • De Sousa, A.C.1    Alviano, D.S.2    Blank, A.F.3
  • 235
    • 79251469964 scopus 로고    scopus 로고
    • Investigation of antioxidant capacity of Melissa officinalis L. Essential oils
    • [235] Meftahizade H, Sargsyan E, Moradkhani H. Investigation of antioxidant capacity of Melissa officinalis L. essential oils. J Med Plant Res 2013; 4: 1391-5.
    • (2013) J Med Plant Res , vol.4 , pp. 1391-1395
    • Meftahizade, H.1    Sargsyan, E.2    Moradkhani, H.3
  • 236
    • 0038141740 scopus 로고    scopus 로고
    • Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: A double blind, randomised, placebo controlled trial
    • [236] Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: A double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiat 2003; 74: 863-6.
    • (2003) J Neurol Neurosurg Psychiat , vol.74 , pp. 863-866
    • Akhondzadeh, S.1    Noroozian, M.2    Mohammadi, M.3
  • 237
    • 3242769024 scopus 로고    scopus 로고
    • Attenuation of laboratoryinduced stress in humans after acute administration of Melissa officinalis (Lemon balm)
    • [237] Kennedy DO, Little W, Scholey AB. Attenuation of laboratoryinduced stress in humans after acute administration of Melissa officinalis (lemon balm). Psychosom Med 2004; 66: 607-13.
    • (2004) Psychosom Med , vol.66 , pp. 607-613
    • Kennedy, D.O.1    Little, W.2    Scholey, A.B.3
  • 238
    • 79951572465 scopus 로고    scopus 로고
    • A double-blind placebocontrolled randomized trial of melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease
    • [238] Burns A, Perry E, Holmes C, et al. A double-blind placebocontrolled randomized trial of melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease. Dement Geriatr Cog Disord 2011; 31: 158-64.
    • (2011) Dement Geriatr Cog Disord , vol.31 , pp. 158-164
    • Burns, A.1    Perry, E.2    Holmes, C.3
  • 239
    • 84863913716 scopus 로고    scopus 로고
    • Effects of melissa officinalis l. On oxidative status and biochemical parameters in occupationally exposed workers to aluminum: A before after clinical trial
    • [239] Fazli D, Malekirad AA, Pilevarian AA, et al. Effects of melissa officinalis l. on oxidative status and biochemical parameters in occupationally exposed workers to aluminum: A before after clinical trial. Int J Pharmacol 2012; 8: 455-8.
    • (2012) Int J Pharmacol , vol.8 , pp. 455-458
    • Fazli, D.1    Malekirad, A.A.2    Pilevarian, A.A.3
  • 240
    • 79953327118 scopus 로고    scopus 로고
    • Effects of Melissa officinalis L. On oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation
    • [240] Zeraatpishe A, Oryan S, Bagheri MH, et al. Effects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation. Toxicol Indust Health 2011; 27: 205-212.
    • (2011) Toxicol Indust Health , vol.27 , pp. 205-212
    • Zeraatpishe, A.1    Oryan, S.2    Bagheri, M.H.3
  • 241
    • 33746511987 scopus 로고    scopus 로고
    • Lemon balm (Melissa officinalis L.): An evidence-based systematic review by the Natural Standard Research Collaboration
    • [241] Ulbricht C, Brendler T, Gruenwald J, et al. Lemon balm (Melissa officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother 2005; 5: 71-114.
    • (2005) J Herb Pharmacother , vol.5 , pp. 71-114
    • Ulbricht, C.1    Brendler, T.2    Gruenwald, J.3
  • 243
    • 79956315187 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: Evidence for benefits beyond LDL-cholesterol lowering
    • [243] Marzilli M. Pleiotropic effects of statins: evidence for benefits beyond LDL-cholesterol lowering. Am J Cardiovasc Drugs 2010; 10 Suppl 1: 3-9.
    • Am J Cardiovasc Drugs 2010; 10 Suppl , vol.1 , pp. 3-9
    • Marzilli, M.1
  • 244
    • 80052968360 scopus 로고    scopus 로고
    • Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: Beneficial effects of therapy with the AT1 receptor blocker telmisartan
    • [244] Knorr M, Hausding M, Kroller-Schuhmacher S, et al. Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan. Arterioscler Thromb Vasc Biol 2011; 31: 2223-31.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2223-2231
    • Knorr, M.1    Hausding, M.2    Kroller-Schuhmacher, S.3
  • 245
    • 29344445466 scopus 로고    scopus 로고
    • Endothelial antioxidant actions of dihydropyridines and angiotensin converting enzyme inhibitors
    • [245] Rosenkranz AC, Lob H, Breitenbach T, Berkels R, Roesen R. Endothelial antioxidant actions of dihydropyridines and angiotensin converting enzyme inhibitors. Eur J Pharmacol 2006; 529: 55-62.
    • (2006) Eur J Pharmacol , vol.529 , pp. 55-62
    • Rosenkranz, A.C.1    Lob, H.2    Breitenbach, T.3    Berkels, R.4    Roesen, R.5
  • 246
    • 77956395196 scopus 로고    scopus 로고
    • Oxidative stress and vascular function: Implications for pharmacologic treatments
    • [246] Weseler AR, Bast A. Oxidative stress and vascular function: implications for pharmacologic treatments. Curr Hypertens Rep 2010; 12: 154-61.
    • (2010) Curr Hypertens Rep , vol.12 , pp. 154-161
    • Weseler, A.R.1    Bast, A.2
  • 247
    • 33847073821 scopus 로고    scopus 로고
    • Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice
    • [247] Oak J-H, Cai H. Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes 2007; 56: 118-26.
    • (2007) Diabetes , vol.56 , pp. 118-126
    • Oak, J.-H.1    Cai, H.2
  • 249
    • 0035949650 scopus 로고    scopus 로고
    • Are ACE inhibitors a “magic bullet” against oxidative stress?
    • [249] Münzel T, Keaney JF. Are ACE inhibitors a “magic bullet” against oxidative stress? Circulation 2001; 104: 1571-74.
    • (2001) Circulation , vol.104 , pp. 1571-1574
    • Münzel, T.1    Keaney, J.F.2
  • 250
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • [250] Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998; 97: 1129-35.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 251
    • 0028939363 scopus 로고
    • The effect of cholesterol-lowering and antioxidant therapy on endotheliumdependent coronary vasomotion
    • [251] Anderson TJ, Meredith IT, Yeung AC, et al. The effect of cholesterol-lowering and antioxidant therapy on endotheliumdependent coronary vasomotion. New Eng J Med 1995; 332: 488-93.
    • (1995) New Eng J Med , vol.332 , pp. 488-493
    • Erson, T.J.1    Meredith, I.T.2    Yeung, A.C.3
  • 252
    • 0036845042 scopus 로고    scopus 로고
    • Dosedependent regulation of NAD (P) H oxidase expression by angiotensin II in human endothelial cells protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease
    • [252] Rueckschloss U, Quinn MT, Holtz J, Morawietz H. Dosedependent regulation of NAD (P) H oxidase expression by angiotensin II in human endothelial cells protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2002; 22: 1845-51.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1845-1851
    • Rueckschloss, U.1    Quinn, M.T.2    Holtz, J.3    Morawietz, H.4
  • 253
    • 37349010303 scopus 로고    scopus 로고
    • Adverse balance of nitric oxide/peroxynitrite in the dysfunctional endothelium can be reversed by statins
    • [253] Heeba G, Hassan MK, Khalifa M, Malinski T. Adverse balance of nitric oxide/peroxynitrite in the dysfunctional endothelium can be reversed by statins. J Cardiovasc Pharmacol 2007; 50: 391-8.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 391-398
    • Heeba, G.1    Hassan, M.K.2    Khalifa, M.3    Malinski, T.4
  • 254
    • 84055182538 scopus 로고    scopus 로고
    • Myocardial Redox State Predicts In-Hospital Clinical Outcome After Cardiac SurgeryEffects of Short-Term Pre-Operative Statin Treatment
    • [254] Antoniades C, Demosthenous M, Reilly S, et al. Myocardial Redox State Predicts In-Hospital Clinical Outcome After Cardiac SurgeryEffects of Short-Term Pre-Operative Statin Treatment. J Am Coll Med 2012; 59: 60-70.
    • (2012) J am Coll Med , vol.59 , pp. 60-70
    • Antoniades, C.1    Demosthenous, M.2    Reilly, S.3
  • 255
    • 33947111435 scopus 로고    scopus 로고
    • Antioxidant activity of carvedilol in cardiovascular disease
    • [255] Dandona P, Ghanim H, Brooks DP. Antioxidant activity of carvedilol in cardiovascular disease. J Hypertens 2007; 25: 731-41.
    • (2007) J Hypertens , vol.25 , pp. 731-741
    • Dandona, P.1    Ghanim, H.2    Brooks, D.P.3
  • 256
    • 84888130953 scopus 로고    scopus 로고
    • Nebivolol, a multifaceted antioxidant and cardioprotectant in hypertensive heart disease
    • [256] Khan MU, Zhao W, Zhao T, et al. Nebivolol, a multifaceted antioxidant and cardioprotectant in hypertensive heart disease. J Cardiovasc Pharmacol 2013; 62: 445-51.
    • (2013) J Cardiovasc Pharmacol , vol.62 , pp. 445-451
    • Khan, M.U.1    Zhao, W.2    Zhao, T.3
  • 257
    • 33745253810 scopus 로고    scopus 로고
    • Antioxidant effects and the therapeutic mode of action of calcium channel blockers in hypertension and atherosclerosis
    • [257] Godfraind T. Antioxidant effects and the therapeutic mode of action of calcium channel blockers in hypertension and atherosclerosis. Philos Trans R Soc Lond B Biol Sci 2005; 360: 2259-72.
    • (2005) Philos Trans R Soc Lond B Biol Sci , vol.360 , pp. 2259-2272
    • Godfraind, T.1
  • 258
    • 84655168081 scopus 로고    scopus 로고
    • Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: Potential therapeutic strategies
    • [258] Tousoulis D, Papageorgiou N, Briasoulis A, et al. Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: potential therapeutic strategies. Heart Fail Rev 2012; 17: 65-79.
    • (2012) Heart Fail Rev , vol.17 , pp. 65-79
    • Tousoulis, D.1    Papageorgiou, N.2    Briasoulis, A.3
  • 259
    • 26844441980 scopus 로고    scopus 로고
    • Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM)
    • [259] Daosukho C, Ittarat W, Lin S-m, et al. Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM). J Mol Cell Cardiol 2005; 39: 792-803.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 792-803
    • Daosukho, C.1    Ittarat, W.2    S-M, L.3
  • 260
    • 37549050190 scopus 로고    scopus 로고
    • Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase
    • [260] Wakade C, Khan MM, De Sevilla LM, et al. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology 2008; 149: 367-79.
    • (2008) Endocrinology , vol.149 , pp. 367-379
    • Wakade, C.1    Khan, M.M.2    De Sevilla, L.M.3
  • 261
    • 84879711933 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of the neuroprotective agent edaravone for noncardioembolic cerebral infarction
    • [261] Shinohara Y, Inoue S. Cost-effectiveness analysis of the neuroprotective agent edaravone for noncardioembolic cerebral infarction. J Stroke Cerebrovasc Dis 2013; 22: 668-74.
    • (2013) J Stroke Cerebrovasc Dis , vol.22 , pp. 668-674
    • Shinohara, Y.1    Inoue, S.2
  • 262
    • 80052424569 scopus 로고    scopus 로고
    • Quantifying the effectiveness and costefficiency of food supplementation with antioxidants for male infertility
    • [262] Comhaire F, Decleer W. Quantifying the effectiveness and costefficiency of food supplementation with antioxidants for male infertility. Reprod Biomed Online 2011; 23: 361-2.
    • (2011) Reprod Biomed Online , vol.23 , pp. 361-362
    • Comhaire, F.1    Decleer, W.2
  • 263
    • 84870496528 scopus 로고    scopus 로고
    • Pioglitazone and vitamin E for nonalcoholic steatohepatitis: A cost utility analysis
    • [263] Mahady SE, Wong G, Craig JC, George J. Pioglitazone and vitamin E for nonalcoholic steatohepatitis: a cost utility analysis. Hepatology 2012; 56: 2172-9.
    • (2012) Hepatology , vol.56 , pp. 2172-2179
    • Mahady, S.E.1    Wong, G.2    Craig, J.C.3    George, J.4
  • 264
    • 84857208875 scopus 로고    scopus 로고
    • A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka
    • [264] Senarathna SM, Sri Ranganathan S, Buckley N, Fernandopulle R. A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka. BMC Clin Pharmacol 2012; 12: 6.
    • (2012) BMC Clin Pharmacol , vol.12 , pp. 6
    • Senarathna, S.M.1    Sri Ranganathan, S.2    Buckley, N.3    Fernandopulle, R.4
  • 265
    • 84877805850 scopus 로고    scopus 로고
    • Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals
    • [265] Cicero AF, Borghi C. Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals. Curr Hypertens Rep 2013; 15: 260-7.
    • (2013) Curr Hypertens Rep , vol.15 , pp. 260-267
    • Cicero, A.F.1    Borghi, C.2
  • 266
    • 34547700397 scopus 로고    scopus 로고
    • Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: Can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy?
    • [266] Ankola DD, Viswanad B, Bhardwaj V, Ramarao P, Kumar MN. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? Eur J Pharm Biopharm 2007; 67: 361-9.
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 361-369
    • Ankola, D.D.1    Viswanad, B.2    Bhardwaj, V.3    Ramarao, P.4    Kumar, M.N.5
  • 267
    • 77649210149 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer: Systematic review and economic evaluation
    • [267] Cooper K, Squires H, Carroll C, et al. Chemoprevention of colorectal cancer: systematic review and economic evaluation. Health Technol Assess 2010; 14: 1-206.
    • (2010) Health Technol Assess , vol.14 , pp. 1-206
    • Cooper, K.1    Squires, H.2    Carroll, C.3
  • 269
    • 27644475899 scopus 로고    scopus 로고
    • Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function
    • [269] Nicolson GL. Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function. Pathol Oncol Res 2005; 11: 139-44.
    • (2005) Pathol Oncol Res , vol.11 , pp. 139-144
    • Nicolson, G.L.1
  • 270
    • 84880155718 scopus 로고    scopus 로고
    • Chinese herbal medicine for gout: A systematic review of randomized clinical trials
    • [270] Li XX, Han M, Wang YY, Liu JP. Chinese herbal medicine for gout: a systematic review of randomized clinical trials. Clin Rheumatol 2013; 32: 943-59.
    • (2013) Clin Rheumatol , vol.32 , pp. 943-959
    • Li, X.X.1    Han, M.2    Wang, Y.Y.3    Liu, J.P.4
  • 271
    • 84861927005 scopus 로고    scopus 로고
    • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    • [271] Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008: Cd007176.
    • Cochrane Database Syst Rev , vol.2008
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 272
    • 19944427642 scopus 로고    scopus 로고
    • Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality
    • [272] Miller ER, III, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142: 37-46.
    • (2005) Ann Intern Med , vol.142 , pp. 37-46
    • Miller, E.R.1    Pastor-Barriuso, R.2    Dalal, D.3
  • 273
    • 65649121093 scopus 로고    scopus 로고
    • The questionable association of vitamin E supplementation and mortality--inconsistent results of different meta-analytic approaches
    • [273] Gerss J, Kopcke W. The questionable association of vitamin E supplementation and mortality--inconsistent results of different meta-analytic approaches. Cell Mol Biol (Noisy-le-grand) 2009; 55 Suppl: 1111-1120.
    • (2009) Cell Mol Biol (Noisy-Le-Grand) , vol.55 , pp. 1111-1120
    • Gerss, J.1    Kopcke, W.2
  • 274
    • 11144356468 scopus 로고    scopus 로고
    • Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease
    • [274] Shekelle PG, Morton SC, Jungvig LK, et al. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med 2004; 19: 380-9.
    • (2004) J Gen Intern Med , vol.19 , pp. 380-389
    • Shekelle, P.G.1    Morton, S.C.2    Jungvig, L.K.3
  • 275
    • 44449173037 scopus 로고    scopus 로고
    • Statin treatment as a confounding factor in human trials with vitamin
    • [275] Violi F, Cangemi R. Statin treatment as a confounding factor in human trials with vitamin E. J Nutr 2008; 138: 1179-81.
    • (2008) E. J Nutr , vol.138 , pp. 1179-1181
    • Violi, F.1    Cangemi, R.2
  • 276
    • 77952486784 scopus 로고    scopus 로고
    • Beta-carotene and lung cancer in smokers: Review of hypotheses and status of research
    • [276] Goralczyk R. Beta-carotene and lung cancer in smokers: review of hypotheses and status of research. Nutr Cancer 2009; 61: 767-74.
    • (2009) Nutr Cancer , vol.61 , pp. 767-774
    • Goralczyk, R.1
  • 277
    • 28544439691 scopus 로고    scopus 로고
    • Carotenoid actions and their relation to health and disease
    • [277] Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005; 26: 459-516.
    • (2005) Mol Aspects Med , vol.26 , pp. 459-516
    • Krinsky, N.I.1    Johnson, E.J.2
  • 278
    • 27944481354 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intrauterine growth retardation in mice
    • [278] Xu DX, Chen YH, Wang H, et al. Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intrauterine growth retardation in mice. Toxicol Sci 2005; 88: 525-33.
    • (2005) Toxicol Sci , vol.88 , pp. 525-533
    • Xu, D.X.1    Chen, Y.H.2    Wang, H.3
  • 279
    • 84888151936 scopus 로고    scopus 로고
    • Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice
    • [279] Zhao M, Chen YH, Chen X, et al. Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Toxicol Lett 2014; 224: 201-8.
    • (2014) Toxicol Lett , vol.224 , pp. 201-208
    • Zhao, M.1    Chen, Y.H.2    Chen, X.3
  • 280
    • 84896459851 scopus 로고    scopus 로고
    • Astrocytes protect against diazinon-and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione
    • [280] Pizzurro DM, Dao K, Costa LG. Astrocytes protect against diazinon-and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione. Toxicology 2014; 319: 59-68.
    • (2014) Toxicology , vol.319 , pp. 59-68
    • Pizzurro, D.M.1    Dao, K.2    Costa, L.G.3
  • 281
    • 84901786704 scopus 로고    scopus 로고
    • Fetotoxicity of 2,4-dichlorophenoxyacetic acid in rats and the protective role of vitamin e
    • [281] Mazhar FM, Moawad KM, El-Dakdoky MH, Amer AS. Fetotoxicity of 2,4-dichlorophenoxyacetic acid in rats and the protective role of vitamin e. Toxicol Indust Health 2014; 30: 480-8.
    • (2014) Toxicol Indust Health , vol.30 , pp. 480-488
    • Mazhar, F.M.1    Moawad, K.M.2    El-Dakdoky, M.H.3    Amer, A.S.4
  • 282
    • 84860918303 scopus 로고    scopus 로고
    • The Prenatal Toxic Effect of Methylmercury on the Development of the Appendicular Skeleton of Rat Fetuses and the Protective Role of Vitamin
    • [282] Abd El-Aziz GS, El-Fark MMO, Saleh HAM. The Prenatal Toxic Effect of Methylmercury on the Development of the Appendicular Skeleton of Rat Fetuses and the Protective Role of Vitamin E. Anat Rec 2012; 295: 939-49.
    • (2012) E. Anat Rec , vol.295 , pp. 939-949
    • Abd El-Aziz, G.S.1    El-Fark, M.2    Saleh, H.3
  • 283
    • 84879159921 scopus 로고    scopus 로고
    • Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox
    • [283] Cordova FM, Aguiar AS, Peres TV, et al. Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox. Arch Toxicol 2013; 87: 1231-44.
    • (2013) Arch Toxicol , vol.87 , pp. 1231-1244
    • Cordova, F.M.1    Aguiar, A.S.2    Peres, T.V.3
  • 284
    • 0344069780 scopus 로고    scopus 로고
    • Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats
    • [284] Jahnke G, Marr M, Myers C, et al. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci 1999; 50: 271-9.
    • (1999) Toxicol Sci , vol.50 , pp. 271-279
    • Jahnke, G.1    Marr, M.2    Myers, C.3
  • 285
    • 33747078117 scopus 로고    scopus 로고
    • Toxicology and safety of antioxidant of bamboo leaves. Part 2: Developmental toxicity test in rats with antioxidant of bamboo leaves
    • [285] Lu B, Wu X, Shi J, Dong Y, Zhang Y. Toxicology and safety of antioxidant of bamboo leaves. Part 2: Developmental toxicity test in rats with antioxidant of bamboo leaves. Food Chem Toxicol 2006; 44: 1739-43.
    • (2006) Food Chem Toxicol , vol.44 , pp. 1739-1743
    • Lu, B.1    Wu, X.2    Shi, J.3    Dong, Y.4    Zhang, Y.5
  • 286
    • 77955088481 scopus 로고    scopus 로고
    • Resveratrol as a therapeutic agent for neurodegenerative diseases
    • [286] Sun AY, Wang Q, Simonyi A, Sun GY. Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol 2010; 41: 375-83.
    • (2010) Mol Neurobiol , vol.41 , pp. 375-383
    • Sun, A.Y.1    Wang, Q.2    Simonyi, A.3    Sun, G.Y.4
  • 287
    • 77952674793 scopus 로고    scopus 로고
    • Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation
    • [287] Zhang F, Liu J, Shi JS. Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation. Eur J Pharmacol 2010; 636: 1-7.
    • (2010) Eur J Pharmacol , vol.636 , pp. 1-7
    • Zhang, F.1    Liu, J.2    Shi, J.S.3
  • 289
    • 77649243226 scopus 로고    scopus 로고
    • Vitamin e neuroprotection for cisplatin neuropathy: A randomized, placebo-controlled trial
    • [289] Pace A, Giannarelli D, Galiè E, et al. Vitamin e neuroprotection for cisplatin neuropathy: A randomized, placebo-controlled trial. Neurology 2010; 74: 762-6.
    • (2010) Neurology , vol.74 , pp. 762-766
    • Pace, A.1    Giannarelli, D.2    Galiè, E.3
  • 290
    • 84864798841 scopus 로고    scopus 로고
    • Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway
    • [290] Bosnjak ZJ, Yan Y, Canfield S, et al. Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Safety 2012; 7: 106-19.
    • (2012) Curr Drug Safety , vol.7 , pp. 106-119
    • Bosnjak, Z.J.1    Yan, Y.2    Canfield, S.3
  • 291
    • 84866275612 scopus 로고    scopus 로고
    • Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference
    • [291] Sies H, Hollman PC, Grune T, et al. Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference. Adv Nutr 2012; 3: 217-21.
    • (2012) Adv Nutr , vol.3 , pp. 217-221
    • Sies, H.1    Hollman, P.C.2    Grune, T.3
  • 292
    • 77957021509 scopus 로고    scopus 로고
    • Targeting tissue oxidative damage by means of cell signaling modulators: The antioxidant concept revisited
    • [292] Leonarduzzi G, Sottero B, Poli G. Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited. Pharmacol Ther 2010; 128: 336-74.
    • (2010) Pharmacol Ther , vol.128 , pp. 336-374
    • Leonarduzzi, G.1    Sottero, B.2    Poli, G.3
  • 293
    • 77249122561 scopus 로고    scopus 로고
    • Design and development of nanovehicle-based delivery systems for preventive or therapeutic supplementation with flavonoids
    • [293] Leonarduzzi G, Testa G, Sottero B, Gamba P, Poli G. Design and development of nanovehicle-based delivery systems for preventive or therapeutic supplementation with flavonoids. Curr Med Chem 2010; 17: 74-95.
    • (2010) Curr Med Chem , vol.17 , pp. 74-95
    • Leonarduzzi, G.1    Testa, G.2    Sottero, B.3    Gamba, P.4    Poli, G.5
  • 294
    • 80051487233 scopus 로고    scopus 로고
    • Advanced drug delivery systems of curcumin for cancer chemoprevention
    • [294] Bansal SS, Goel M, Aqil F, Vadhanam MV, Gupta RC. Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res 2011; 4: 1158-71.
    • (2011) Cancer Prev Res , vol.4 , pp. 1158-1171
    • Bansal, S.S.1    Goel, M.2    Aqil, F.3    Vadhanam, M.V.4    Gupta, R.C.5
  • 295
    • 84857098192 scopus 로고    scopus 로고
    • Challenges associated with curcumin therapy in Alzheimer disease
    • [295] Belkacemi A, Doggui S, Dao L, Ramassamy C. Challenges associated with curcumin therapy in Alzheimer disease. Expert Rev Mol Med 2011; 13: e34.
    • (2011) Expert Rev Mol Med , vol.34 , pp. 13
    • Belkacemi, A.1    Doggui, S.2    Dao, L.3    Ramassamy, C.4
  • 296
    • 84858709095 scopus 로고    scopus 로고
    • Administration of resveratrol: What formulation solutions to bioavailability limitations?
    • [296] Amri A, Chaumeil J, Sfar S, Charrueau C. Administration of resveratrol: what formulation solutions to bioavailability limitations? J Control Release 2012; 158: 182-93.
    • (2012) J Control Release , vol.158 , pp. 182-193
    • Amri, A.1    Chaumeil, J.2    Sfar, S.3    Charrueau, C.4
  • 297
    • 0023924814 scopus 로고
    • Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance
    • [297] Beckman JS, Minor R, White C, et al. Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem 1988; 263: 6884-92.
    • (1988) J Biol Chem , vol.263 , pp. 6884-6892
    • Beckman, J.S.1    Minor, R.2    White, C.3
  • 299
    • 68149160611 scopus 로고    scopus 로고
    • Nanoparticle-mediated delivery of superoxide dismutase to the brain: An effective strategy to reduce ischemia-reperfusion injury
    • [299] Reddy MK, Labhasetwar V. Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury. FASEB J 2009; 23: 1384-95.
    • (2009) FASEB J , vol.23 , pp. 1384-1395
    • Reddy, M.K.1    Labhasetwar, V.2
  • 300
    • 69749119817 scopus 로고    scopus 로고
    • Detection of hydrogen peroxide with chemiluminescent micelles
    • [300] Lee D, Erigala VR, Dasari M, et al. Detection of hydrogen peroxide with chemiluminescent micelles. Int J Nanomed 2008; 3: 471-6.
    • (2008) Int J Nanomed , vol.3 , pp. 471-476
    • Lee, D.1    Erigala, V.R.2    Dasari, M.3
  • 301
    • 79951576388 scopus 로고    scopus 로고
    • Reduction of oxidative stress by phydroxybenzyl alcohol-containing biodegradable polyoxalate nanoparticulate antioxidant
    • [301] Kim S, Park H, Song Y, et al. Reduction of oxidative stress by phydroxybenzyl alcohol-containing biodegradable polyoxalate nanoparticulate antioxidant. Biomaterials 2011; 32: 3021-9.
    • (2011) Biomaterials , vol.32 , pp. 3021-3029
    • Kim, S.1    Park, H.2    Song, Y.3
  • 302
    • 77952291181 scopus 로고    scopus 로고
    • The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase
    • [302] Rosenbaugh EG, Roat JW, Gao L, et al. The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase. Biomaterials 2010; 31: 5218-26.
    • (2010) Biomaterials , vol.31 , pp. 5218-5226
    • Rosenbaugh, E.G.1    Roat, J.W.2    Gao, L.3
  • 303
    • 33646773612 scopus 로고    scopus 로고
    • Endothelial targeting of highaffinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1
    • [303] Muro S, Dziubla T, Qiu W, et al. Endothelial targeting of highaffinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1. J Pharmacol Exp Ther 2006; 317: 1161-9.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1161-1169
    • Muro, S.1    Dziubla, T.2    Qiu, W.3
  • 304
    • 84870849440 scopus 로고    scopus 로고
    • Inhibition and induction of glutathione Stransferases by flavonoids: Possible pharmacological and toxicological consequences
    • [304] Bousova I, Skalova L. Inhibition and induction of glutathione Stransferases by flavonoids: possible pharmacological and toxicological consequences. Drug Metab Rev 2012; 44: 267-86.
    • (2012) Drug Metab Rev , vol.44 , pp. 267-286
    • Bousova, I.1    Skalova, L.2
  • 305
    • 84865013476 scopus 로고    scopus 로고
    • Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione Stransferase
    • [305] Bousova I, Hajek J, Drsata J, Skalova L. Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione Stransferase. Xenobiotica 2012; 42: 872-9.
    • (2012) Xenobiotica , vol.42 , pp. 872-879
    • Bousova, I.1    Hajek, J.2    Drsata, J.3    Skalova, L.4
  • 306
    • 84889263950 scopus 로고    scopus 로고
    • Interaction of Anthocyanins with Drug-metabolizing and Antioxidant Enzymes
    • [306] Bartikova H, Skalova L, Drsata J, Bousova I. Interaction of Anthocyanins with Drug-metabolizing and Antioxidant Enzymes. Curr Med Chem 2013; 20: 4665-79.
    • (2013) Curr Med Chem , vol.20 , pp. 4665-4679
    • Bartikova, H.1    Skalova, L.2    Drsata, J.3    Bousova, I.4
  • 307
    • 84882877558 scopus 로고    scopus 로고
    • Antioxidant therapy: Still in search of the 'magic bullet'
    • [307] Benfeito S, Oliveira C, Soares P, et al. Antioxidant therapy: still in search of the 'magic bullet'. Mitochondrion 2013; 13: 427-35.
    • (2013) Mitochondrion , vol.13 , pp. 427-435
    • Benfeito, S.1    Oliveira, C.2    Soares, P.3
  • 308
    • 84892368437 scopus 로고    scopus 로고
    • Antioxidants as therapies: Can we improve on nature?
    • [308] Murphy MP. Antioxidants as therapies: can we improve on nature? Free Radic Biol Med 2013; 8: 20-3.
    • (2013) Free Radic Biol Med , vol.8 , pp. 20-23
    • Murphy, M.P.1
  • 309
    • 79957437638 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction: Therapeutic implications
    • [309] Gori T, Münzel T. Oxidative stress and endothelial dysfunction: Therapeutic implications. Ann Med 2011; 43: 259-72.
    • (2011) Ann Med , vol.43 , pp. 259-272
    • Gori, T.1    Münzel, T.2
  • 311
    • 84868191543 scopus 로고    scopus 로고
    • The role of targeted therapy and biomarkers in breast cancer treatment
    • [311] Stopeck AT, Brown-Glaberman U, Wong HY, et al. The role of targeted therapy and biomarkers in breast cancer treatment. Clin Exp Metastasis 2012; 29: 807-19.
    • (2012) Clin Exp Metastasis , vol.29 , pp. 807-819
    • Stopeck, A.T.1    Brown-Glaberman, U.2    Wong, H.Y.3
  • 312
    • 0037373302 scopus 로고    scopus 로고
    • Antioxidant nutrients and chronic disease: Use of biomarkers of exposure and oxidative stress status in epidemiologic research
    • [312] Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr 2003; 133: 933-40.
    • (2003) J Nutr , vol.133 , pp. 933-940
    • Mayne, S.T.1
  • 314
    • 84880283997 scopus 로고    scopus 로고
    • Alzheimer's disease and antioxidant therapy: How long how far?
    • [314] Teixeira J, Silva T, Andrade PB, Borges F. Alzheimer's disease and antioxidant therapy: how long how far? Curr Med Chem 2013; 20: 2939-52.
    • (2013) Curr Med Chem , vol.20 , pp. 2939-2952
    • Teixeira, J.1    Silva, T.2    Rade, P.B.3    Borges, F.4
  • 315
    • 33847071146 scopus 로고    scopus 로고
    • Targeting antioxidants to mitochondria by conjugation to lipophilic cations
    • [315] Murphy MP, Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 2007; 47: 629-56.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 629-656
    • Murphy, M.P.1    Smith, R.A.2
  • 316
    • 84875158695 scopus 로고    scopus 로고
    • Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2
    • [316] Kahles T, Brandes RP. Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal 2013; 18: 1400-17.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1400-1417
    • Kahles, T.1    Brandes, R.P.2
  • 317
    • 84879047011 scopus 로고    scopus 로고
    • Cellular metabolic and autophagic pathways: Traffic control by redox signaling
    • [317] Dodson M, Darley-Usmar V, Zhang J. Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med 2013; 63: 207-21.
    • (2013) Free Radic Biol Med , vol.63 , pp. 207-221
    • Dodson, M.1    Darley-Usmar, V.2    Zhang, J.3
  • 318
    • 63349087445 scopus 로고    scopus 로고
    • Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation
    • [318] Tahara EB, Navarete FD, Kowaltowski AJ. Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Free Radic Biol Med 2009; 46: 1283-97.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1283-1297
    • Tahara, E.B.1    Navarete, F.D.2    Kowaltowski, A.J.3
  • 319
    • 70349745567 scopus 로고    scopus 로고
    • Mitochondria--a neglected drug target
    • [319] Murphy MP. Mitochondria--a neglected drug target. Curr Opin Investig Drugs 2009; 10: 1022.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1022
    • Murphy, M.P.1
  • 320
    • 77949882290 scopus 로고    scopus 로고
    • Mitochondrial energetics and therapeutics
    • [320] Wallace DC, Fan W, Procaccio V. Mitochondrial energetics and therapeutics. Annu Rev Pathol 2010; 5: 297-303.
    • (2010) Annu Rev Pathol , vol.5 , pp. 297-303
    • Wallace, D.C.1    Fan, W.2    Procaccio, V.3
  • 322
    • 33847071146 scopus 로고    scopus 로고
    • Targeting antioxidants to mitochondria by conjugation to lipophilic cations
    • [322] Murphy MP, Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 2007; 47: 629-56.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 629-656
    • Murphy, M.P.1    Smith, R.A.2
  • 323
    • 79957764437 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants as therapies
    • [323] Smith R, Murphy MP. Mitochondria-targeted antioxidants as therapies. Discov Med 2011; 11: 106-14.
    • (2011) Discov Med , vol.11 , pp. 106-114
    • Smith, R.1    Murphy, M.P.2
  • 324
    • 67649757115 scopus 로고    scopus 로고
    • A mitochondria-targeted Snitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
    • [324] Prime TA, Blaikie FH, Evans C, et al. A mitochondria-targeted Snitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci USA 2009; 106: 10764-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10764-10769
    • Prime, T.A.1    Blaikie, F.H.2    Evans, C.3
  • 325
    • 84859067775 scopus 로고    scopus 로고
    • Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold
    • [325] Teixeira J, Soares P, Benfeito S, et al. Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold. Free Radic Res 2012; 46: 600-11.
    • (2012) Free Radic Res , vol.46 , pp. 600-611
    • Teixeira, J.1    Soares, P.2    Benfeito, S.3
  • 326
    • 33748201552 scopus 로고    scopus 로고
    • Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents
    • [326] Szeto HH. Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J 2006; 8: E521-31.
    • (2006) AAPS J , vol.8 , pp. 521-631
    • Szeto, H.H.1
  • 327
    • 84858281225 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics
    • [327] Reddy PH, Tripathi R, Troung Q, et al. Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics. Biochim Biophys Acta 2012; 1822: 639-49.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 639-649
    • Reddy, P.H.1    Tripathi, R.2    Troung, Q.3
  • 328
    • 77955090213 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics—a novel therapeutic target for Alzheimer's disease?
    • [328] Su B, Wang X, Bonda D, et al. Abnormal mitochondrial dynamics—a novel therapeutic target for Alzheimer's disease? Mol Neurobiol 2010; 41: 87-96.
    • (2010) Mol Neurobiol , vol.41 , pp. 87-96
    • Su, B.1    Wang, X.2    Bonda, D.3
  • 329
    • 71849088759 scopus 로고    scopus 로고
    • Mitochondria: A therapeutic target in neurodegeneration
    • [329] Moreira PI, Zhu X, Wang X, et al. Mitochondria: a therapeutic target in neurodegeneration. Biochim Biophys Acta 2010; 1802: 212-20.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 212-220
    • Moreira, P.I.1    Zhu, X.2    Wang, X.3
  • 330
    • 84878934179 scopus 로고    scopus 로고
    • In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives
    • [330] Severina II, Severin FF, Korshunova GA, et al. In search of novel highly active mitochondria-targeted antioxidants: thymoquinone and its cationic derivatives. FEBS lett 2013; 587: 2018-24.
    • (2013) FEBS Lett , vol.587 , pp. 2018-2024
    • Severina, I.I.1    Severin, F.F.2    Korshunova, G.A.3
  • 332
    • 42449145243 scopus 로고    scopus 로고
    • Antioxidant Gene Therapy for Cardiovascular Disease Current Status and Future Perspectives
    • [332] Levonen A-L, Vähäkangas E, Koponen JK, Ylä-Herttuala S. Antioxidant Gene Therapy for Cardiovascular Disease Current Status and Future Perspectives. Circulation 2008; 117: 2142-50.
    • (2008) Circulation , vol.117 , pp. 2142-2150
    • Levonen, A.-L.1    Vähäkangas, E.2    Koponen, J.K.3    Ylä-Herttuala, S.4
  • 333
    • 84896399040 scopus 로고    scopus 로고
    • Antioxidant gene therapy against neuronal cell death
    • [333] Navarro-Yepes J, Zavala-Flores L, Annadurai A, et al. Antioxidant gene therapy against neuronal cell death. Pharmacol Ther 2014; 142(2): 206-30.
    • (2014) Pharmacol Ther , vol.142 , Issue.2 , pp. 206-230
    • Navarro-Yepes, J.1    Zavala-Flores, L.2    Annadurai, A.3
  • 334
    • 84862777338 scopus 로고    scopus 로고
    • Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion
    • [334] Liu Y, Tang L, Chen B. Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion. Free Radic Biol Med 2012; 52: 909-15.
    • (2012) Free Radic Biol Med , vol.52 , pp. 909-915
    • Liu, Y.1    Tang, L.2    Chen, B.3
  • 335
    • 0032491202 scopus 로고    scopus 로고
    • Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbits
    • [335] Li Q, Bolli R, Qiu Y, et al. Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbits. Circulation 1998; 98: 1438-48.
    • (1998) Circulation , vol.98 , pp. 1438-1448
    • Li, Q.1    Bolli, R.2    Qiu, Y.3
  • 336
    • 0035836603 scopus 로고    scopus 로고
    • Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction
    • [336] Li Q, Bolli R, Qiu Y, et al. Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction. Circulation 2001; 103: 1893-8.
    • (2001) Circulation , vol.103 , pp. 1893-1898
    • Li, Q.1    Bolli, R.2    Qiu, Y.3
  • 337
    • 35348821858 scopus 로고    scopus 로고
    • Restoration of peroxisomal catalase import in a model of human cellular aging
    • [337] Koepke JI, Nakrieko KA, Wood CS, et al. Restoration of peroxisomal catalase import in a model of human cellular aging. Traffic 2007; 8: 1590-600.
    • (2007) Traffic , vol.8 , pp. 1590-1600
    • Koepke, J.I.1    Nakrieko, K.A.2    Wood, C.S.3
  • 338
    • 80052448901 scopus 로고    scopus 로고
    • Targeted intracellular catalase delivery protects neonatal rat myocytes from hypoxiareoxygenation and ischemia-reperfusion injury
    • [338] Undyala V, Terlecky SR, Vander Heide RS. Targeted intracellular catalase delivery protects neonatal rat myocytes from hypoxiareoxygenation and ischemia-reperfusion injury. Cardiovasc Pathol 2011; 20: 272-80.
    • (2011) Cardiovasc Pathol , vol.20 , pp. 272-280
    • Undyala, V.1    Terlecky, S.R.2    Vander Heide, R.S.3
  • 339
    • 68949197420 scopus 로고    scopus 로고
    • Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice
    • [339] Li D, Lai Y, Yue Y, et al. Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice. PLoS ONE 2009; 4.
    • (2009) Plos ONE , pp. 4
    • Li, D.1    Lai, Y.2    Yue, Y.3
  • 340
    • 72449195264 scopus 로고    scopus 로고
    • Identification of the amino acid sequence that targets peroxiredoxin 6 to lysosome-like structures of lung epithelial cells
    • [340] Sorokina EM, Feinstein SI, Milovanova TN, Fisher AB. Identification of the amino acid sequence that targets peroxiredoxin 6 to lysosome-like structures of lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009; 297: L871-80.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. 871-980
    • Sorokina, E.M.1    Feinstein, S.I.2    Milovanova, T.N.3    Fisher, A.B.4
  • 341
    • 40549119796 scopus 로고    scopus 로고
    • Protein transduction of an antioxidant enzyme: Subcellular localization of superoxide dismutase fusion protein in cells
    • [341] Dae WK, So YK, Sun HL, et al. Protein transduction of an antioxidant enzyme: Subcellular localization of superoxide dismutase fusion protein in cells. J Biocem Mol Biol 2008; 41: 170-5.
    • (2008) J Biocem Mol Biol , vol.41 , pp. 170-175
    • Dae, W.K.1    So, Y.K.2    Sun, H.L.3
  • 342
    • 46249108461 scopus 로고    scopus 로고
    • Regulation of ROS signal transduction by NADPH oxidase 4 localization
    • [342] Chen K, Kirber MT, Xiao H, Yang Y, Keaney Jr JF. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 2008; 181: 1129-39.
    • (2008) J Cell Biol , vol.181 , pp. 1129-1139
    • Chen, K.1    Kirber, M.T.2    Xiao, H.3    Yang, Y.4    Keaney, J.F.5
  • 343
    • 84870546924 scopus 로고    scopus 로고
    • How to boost antioxidants by lipophilization?
    • [343] Laguerre M, Bayrasy C, Lecomte J, et al. How to boost antioxidants by lipophilization? Biochimie 2013; 95: 20-6.
    • (2013) Biochimie , vol.95 , pp. 20-26
    • Laguerre, M.1    Bayrasy, C.2    Lecomte, J.3
  • 344
    • 84879794974 scopus 로고    scopus 로고
    • Boosting antioxidants by lipophilization: A strategy to increase cell uptake and target mitochondria
    • [344] Bayrasy C, Chabi B, Laguerre M, et al. Boosting antioxidants by lipophilization: A strategy to increase cell uptake and target mitochondria. Pharmaceut Res 2013; 30: 1979-89.
    • (2013) Pharmaceut Res , vol.30 , pp. 1979-1989
    • Bayrasy, C.1    Chabi, B.2    Laguerre, M.3
  • 345
    • 77954790495 scopus 로고    scopus 로고
    • New therapies for chronic obstructive pulmonary disease
    • [345] Barnes PJ. New therapies for chronic obstructive pulmonary disease. Med Princ Pract 2010; 19: 330-38.
    • (2010) Med Princ Pract , vol.19 , pp. 330-338
    • Barnes, P.J.1
  • 346
    • 0033768749 scopus 로고    scopus 로고
    • Actions of melatonin in the reduction of oxidative stress
    • [346] Reiter RJ, Tan D-x, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress. J Biomed Sci 2000; 7: 444-58.
    • (2000) J Biomed Sci , vol.7 , pp. 444-458
    • Reiter, R.J.1    D-X, T.2    Osuna, C.3    Gitto, E.4
  • 347
    • 84871887089 scopus 로고    scopus 로고
    • Recoupling the cardiac nitric oxide synthases: Tetrahydrobiopterin synthesis and recycling
    • [347] Alkaitis MS, Crabtree MJ. Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling. Curr Heart Fail Rep 2012; 9: 200-10.
    • (2012) Curr Heart Fail Rep , vol.9 , pp. 200-210
    • Alkaitis, M.S.1    Crabtree, M.J.2
  • 348
    • 84871952669 scopus 로고    scopus 로고
    • Neuroprotective treatment for perinatal asphyxia
    • [348] Solevag AL, Nakstad B. Neuroprotective treatment for perinatal asphyxia. Tidsskr Nor Laegeforen 2012; 132: 2396-9.
    • (2012) Tidsskr Nor Laegeforen , vol.132 , pp. 2396-2399
    • Solevag, A.L.1    Nakstad, B.2
  • 351
    • 4544264510 scopus 로고    scopus 로고
    • The relationship between antioxidant supplements and oxidative stress in renal transplant recipients: A review
    • [351] Blackhall ML, Coombes JS, Fassett R. The relationship between antioxidant supplements and oxidative stress in renal transplant recipients: A review. Asaio Journal 2004; 50: 451-7.
    • (2004) Asaio Journal , vol.50 , pp. 451-457
    • Blackhall, M.L.1    Coombes, J.S.2    Fassett, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.