Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway

Current Drug Safety

Volumn 7, Issue 2, 2012, Pages 106-119

  Bosnjak, Zeljko J ^a   Yan, Yasheng ^a   Canfield, Scott ^a   Muravyeva, Maria Y ^a   Kikuchi, Chika ^a   Wells, Clive W ^a   Corbett, John A ^a   Bai, Xiaowen ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Differentiation; Embryonic stem cells; Ketamine; Neurons; Neurotoxicity

Indexed keywords

CASPASE 3; CYTOCHROME C; KETAMINE; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; REACTIVE OXYGEN METABOLITE; SCAVENGER; SYNAPSIN I; TRANSCRIPTION FACTOR SOX2; TROLOX C;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME RELEASE; ENZYME SYNTHESIS; GOLGI COMPLEX; HUMAN; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 84864798841     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488612802715663     Document Type: Article

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