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Volumn 8, Issue 12, 2013, Pages 1801-1810

New therapeutic potentials of Milk thistle (Silybum marianum)

Author keywords

Milk thistle; Protective; Silibinin; Silymarin; Therapeutic

Indexed keywords

ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING); CARBOPLATIN; CISPLATIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; DOPAMINE; DOXORUBICIN; FLAVONOLIGNAN; HEME OXYGENASE 1; MALONALDEHYDE; METRONIDAZOLE; MEVINOLIN; NICOTINIC RECEPTOR; PACLITAXEL; PLACEBO; PROLACTIN; PYRAZINAMIDE; REACTIVE OXYGEN METABOLITE; SEROTONIN; SILIBININ; SILIBININ PHOSPHATIDYLCHOLINE COMPLEX; SILYBUM MARIANUM EXTRACT; SILYMARIN; STRESS ACTIVATED PROTEIN KINASE; UNINDEXED DRUG; WARFARIN;

EID: 84890866108     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1300801236     Document Type: Article
Times cited : (72)

References (100)
  • 2
    • 34249884261 scopus 로고    scopus 로고
    • Milk thistle nomenclature: Why it matters in cancer research and pharmacokinetic studies
    • Kroll DJ, Shaw HS, Oberlies NH. (2007) Milk thistle nomenclature: Why it matters in cancer research and pharmacokinetic studies. Integrative Cancer Therapies, 6, 110-119.
    • (2007) Integrative Cancer Therapies , vol.6 , pp. 110-119
    • Kroll, D.J.1    Shaw, H.S.2    Oberlies, N.H.3
  • 5
    • 84879927679 scopus 로고    scopus 로고
    • Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride
    • Tzeng JI, Chen MF, Chung HH, Cheng JT. (2013) Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride. Phytotherapy Research, 27, 1023-1028.
    • (2013) Phytotherapy Research , vol.27 , pp. 1023-1028
    • Tzeng, J.I.1    Chen, M.F.2    Chung, H.H.3    Cheng, J.T.4
  • 6
    • 84882919360 scopus 로고    scopus 로고
    • Alterations in sulfur amino acid metabolism in mice treated with silymarin: A novel mechanism of its action involved in enhancement of the antioxidant defense in liver
    • Kwon do Y, Jung YS, Kim SJ, Kim YS, Choi DW, Kim YC. (2013) Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver. Planta Medica, 79, 997-1002.
    • (2013) Planta Medica , vol.79 , pp. 997-1002
    • Kwon Do, Y.1    Jung, Y.S.2    Kim, S.J.3    Kim, Y.S.4    Choi, D.W.5    Kim, Y.C.6
  • 7
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan SC, Girish C. (2006) Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. The Indian Journal of Medical Research, 124, 491-504.
    • (2006) The Indian Journal of Medical Research , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 11
    • 27444438669 scopus 로고    scopus 로고
    • Silymarin treatment of viral hepatitis: A systematic review
    • Mayer KE, Myers RP, Lee SS. (2005) Silymarin treatment of viral hepatitis: a systematic review. Journal of Viral Hepatitis, 12, 559-567.
    • (2005) Journal of Viral Hepatitis , vol.12 , pp. 559-567
    • Mayer, K.E.1    Myers, R.P.2    Lee, S.S.3
  • 13
    • 57949097025 scopus 로고    scopus 로고
    • Drug-drug interactions of silymarin on the perspective of pharmacokinetics
    • Wu JW, Lin LC, Tsai TH. (2009) Drug-drug interactions of silymarin on the perspective of pharmacokinetics. Journal of Ethnopharmacology, 121, 185-193.
    • (2009) Journal of Ethnopharmacology , vol.121 , pp. 185-193
    • Wu, J.W.1    Lin, L.C.2    Tsai, T.H.3
  • 14
    • 79959308273 scopus 로고    scopus 로고
    • Silymarin- A review on the pharmacodynamics and bioavailability enhancement approaches
    • Ghosh A, Ghosh T, Jain S. (2010) Silymarin- a review on the pharmacodynamics and bioavailability enhancement approaches. Journal of Pharmaceutical Science and Technology, 2, 348-355,
    • (2010) Journal of Pharmaceutical Science and Technology , vol.2 , pp. 348-355
    • Ghosh, A.1    Ghosh, T.2    Jain, S.3
  • 16
    • 84870460057 scopus 로고    scopus 로고
    • Absorption and metabolism of milk thistle flavanolignans in humans
    • Calani L, Brighenti F, Bruni R, Del Rio D. (2012) Absorption and metabolism of milk thistle flavanolignans in humans. Phytomedicine, 20, 40-46.
    • (2012) Phytomedicine , vol.20 , pp. 40-46
    • Calani, L.1    Brighenti, F.2    Bruni, R.3    Del Rio, D.4
  • 18
    • 77249169919 scopus 로고    scopus 로고
    • Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations
    • Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. (2010) Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. The Journal of Pharmacology and Experimental Therapeutics, 332, 1081-1087.
    • (2010) The Journal of Pharmacology and Experimental Therapeutics , vol.332 , pp. 1081-1087
    • Brantley, S.J.1    Oberlies, N.H.2    Kroll, D.J.3    Paine, M.F.4
  • 20
    • 79953252716 scopus 로고    scopus 로고
    • Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment
    • Tota S, Kamat PK, Shukla R, Nath C. (2011) Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment. Behavioural Brain Research, 221, 207-215.
    • (2011) Behavioural Brain Research , vol.221 , pp. 207-215
    • Tota, S.1    Kamat, P.K.2    Shukla, R.3    Nath, C.4
  • 23
    • 77954956439 scopus 로고    scopus 로고
    • Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-Parkinsonian rat: Involvement of estrogen receptors and oxidative stress
    • Baluchnejadmojarad T, Roghani M, Mafakheri M. (2010) Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-Parkinsonian rat: Involvement of estrogen receptors and oxidative stress. Neuroscience Letters, 480, 206-210.
    • (2010) Neuroscience Letters , vol.480 , pp. 206-210
    • Baluchnejadmojarad, T.1    Roghani, M.2    Mafakheri, M.3
  • 24
    • 35348879054 scopus 로고    scopus 로고
    • Silymarin and epithelial cancer chemoprevention: How close we are to bedside?
    • Kaur M, Agarwal R. (2007) Silymarin and epithelial cancer chemoprevention: how close we are to bedside? Toxicology and Applied Pharmacology, 224, 350-359.
    • (2007) Toxicology and Applied Pharmacology , vol.224 , pp. 350-359
    • Kaur, M.1    Agarwal, R.2
  • 25
    • 0032727651 scopus 로고    scopus 로고
    • Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: Comparison with silymarin
    • Bhatia N, Zhao J, Wolf DM, Agarwal R. (1999) Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Letters, 147, 77-84.
    • (1999) Cancer Letters , vol.147 , pp. 77-84
    • Bhatia, N.1    Zhao, J.2    Wolf, D.M.3    Agarwal, R.4
  • 26
    • 0032713528 scopus 로고    scopus 로고
    • Significant inhibition by the flavonoid antioxidant silymarin against 12-0-tetradecanoylphorbol 13-acetate caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1 alpha expression in SENCAR mouse epidermis: Implications in the prevention of stage I tumor promotion
    • Zho J, Sharma Y, Agarwal R. (1999) Significant inhibition by the flavonoid antioxidant silymarin against 12-0-tetradecanoylphorbol 13-acetate caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1 alpha expression in SENCAR mouse epidermis: Implications in the prevention of stage I tumor promotion. Molecular Carcinogenesis, 26, 321-333.
    • (1999) Molecular Carcinogenesis , vol.26 , pp. 321-333
    • Zho, J.1    Sharma, Y.2    Agarwal, R.3
  • 27
    • 0033600782 scopus 로고    scopus 로고
    • Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin
    • Zi X, Agarwal R. (1999) Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin. Biochemical and Biophysical Research Communications, 263, 528-536.
    • (1999) Biochemical and Biophysical Research Communications , vol.263 , pp. 528-536
    • Zi, X.1    Agarwal, R.2
  • 28
    • 0036210452 scopus 로고    scopus 로고
    • Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis
    • Singh RP, Tyagi AK, Zhao J, Agarwal R. (2002) Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis, 23, 499-510.
    • (2002) Carcinogenesis , vol.23 , pp. 499-510
    • Singh, R.P.1    Tyagi, A.K.2    Zhao, J.3    Agarwal, R.4
  • 30
    • 0037485718 scopus 로고    scopus 로고
    • Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin
    • Katiyar-Santosh K. (2002) Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. International Journal of Oncology, 21, 1213-1222.
    • (2002) International Journal of Oncology , vol.21 , pp. 1213-1222
    • Katiyar-Santosh, K.1
  • 31
    • 0037231615 scopus 로고    scopus 로고
    • Cutaneous photodamage, oxidate stress, and topical antioxidant protection
    • Pinnell SR. (2003) Cutaneous photodamage, oxidate stress, and topical antioxidant protection. Journal of the American Academy of Dermatology, 48, 1-19.
    • (2003) Journal of the American Academy of Dermatology , vol.48 , pp. 1-19
    • Pinnell, S.R.1
  • 34
    • 27644439523 scopus 로고    scopus 로고
    • Mechanisms and preclinical efficacy of silibinin in preventing skin cancer
    • Singh RP, Agarwal R. (2005) Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. European Journal of Cancer, 41, 1969-1979.
    • (2005) European Journal of Cancer , vol.41 , pp. 1969-1979
    • Singh, R.P.1    Agarwal, R.2
  • 36
    • 77949873345 scopus 로고    scopus 로고
    • Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma
    • Brandon-Warner E, Sugg JA, Schrum LW, McKillop IH. (2010) Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma. Cancer Letters, 291, 120-129.
    • (2010) Cancer Letters , vol.291 , pp. 120-129
    • Brandon-Warner, E.1    Sugg, J.A.2    Schrum, L.W.3    McKillop, I.H.4
  • 37
    • 48749115799 scopus 로고    scopus 로고
    • Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation
    • Momeny M, Khorramizadeh MR, Ghaffari SH, Yousefi M, Yekaninejad MS, Esmaeili R, Jahanshiri Z, Nooridaloii MR. (2008) Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. European Journal of Pharmacology, 591, 13-20.
    • (2008) European Journal of Pharmacology , vol.591 , pp. 13-20
    • Momeny, M.1    Khorramizadeh, M.R.2    Ghaffari, S.H.3    Yousefi, M.4    Yekaninejad, M.S.5    Esmaeili, R.6    Jahanshiri, Z.7    Nooridaloii, M.R.8
  • 38
    • 0031921546 scopus 로고    scopus 로고
    • Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins
    • Zi X, Feyes DK, Agarwal R. (1998) Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins. Clinical Cancer Research: an official journal of the American Association for Cancer Research, 4, 1055-1064.
    • (1998) Clinical Cancer Research: An Official Journal of the American Association for Cancer Research , vol.4 , pp. 1055-1064
    • Zi, X.1    Feyes, D.K.2    Agarwal, R.3
  • 39
    • 83655203491 scopus 로고    scopus 로고
    • Influence of silibinin on differential expressions of total cytokine genes in human hepatocellular carcinoma cell lines
    • Lin ZY, Chuang WL. (2011) Influence of silibinin on differential expressions of total cytokine genes in human hepatocellular carcinoma cell lines. Biomedicine and Preventive Nutrition, 1, 91-94.
    • (2011) Biomedicine and Preventive Nutrition , vol.1 , pp. 91-94
    • Lin, Z.Y.1    Chuang, W.L.2
  • 40
    • 33846326821 scopus 로고    scopus 로고
    • Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells
    • Lee SO, Jeong YJ, Im HG, Kim CH, Chang YC, Lee IS. (2007) Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biochemical and Biophysical Research Communications, 354, 165-171.
    • (2007) Biochemical and Biophysical Research Communications , vol.354 , pp. 165-171
    • Lee, S.O.1    Jeong, Y.J.2    Im, H.G.3    Kim, C.H.4    Chang, Y.C.5    Lee, I.S.6
  • 41
    • 67349099566 scopus 로고    scopus 로고
    • Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells
    • Kim S, Choi JH, Lim HI, Lee SK, Kim WW, Kim JS, Kim JH, Choe JH, Yang JH, Nam SJ, Lee JE. (2009) Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. Phytomedicine, 16, 573-580.
    • (2009) Phytomedicine , vol.16 , pp. 573-580
    • Kim, S.1    Choi, J.H.2    Lim, H.I.3    Lee, S.K.4    Kim, W.W.5    Kim, J.S.6    Kim, J.H.7    Choe, J.H.8    Yang, J.H.9    Nam, S.J.10    Lee, J.E.11
  • 42
    • 84884125502 scopus 로고    scopus 로고
    • Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS
    • Xu P, Yin Q, Shen J, Chen L, Yu H, Zhang Z, Li Y. (2013) Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS. International Journal of Pharmaceutics, 454, 21-30.
    • (2013) International Journal of Pharmaceutics , vol.454 , pp. 21-30
    • Xu, P.1    Yin, Q.2    Shen, J.3    Chen, L.4    Yu, H.5    Zhang, Z.6    Li, Y.7
  • 43
    • 84865634647 scopus 로고    scopus 로고
    • Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells
    • Lu W, Lin C, King TD, Chen H, Reynolds RC, Li Y. (2012) Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cellular Signalling, 24, 2291-2296.
    • (2012) Cellular Signalling , vol.24 , pp. 2291-2296
    • Lu, W.1    Lin, C.2    King, T.D.3    Chen, H.4    Reynolds, R.C.5    Li, Y.6
  • 47
    • 59549107896 scopus 로고    scopus 로고
    • Silibinin inhibits hypoxia-inducible factor-1á and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: Implications for anticancer therapy
    • García-Maceira P, Mateo J. (2009) Silibinin inhibits hypoxia-inducible factor-1á and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy. Oncogene, 28, 313-324.
    • (2009) Oncogene , vol.28 , pp. 313-324
    • García-Maceira, P.1    Mateo, J.2
  • 48
    • 4544287556 scopus 로고    scopus 로고
    • Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages
    • Tyagi A, Agarwal C, Harrison G, Glode LM, Agarwal R. (2004) Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis, 25, 1711-1720.
    • (2004) Carcinogenesis , vol.25 , pp. 1711-1720
    • Tyagi, A.1    Agarwal, C.2    Harrison, G.3    Glode, L.M.4    Agarwal, R.5
  • 49
    • 0036165375 scopus 로고    scopus 로고
    • Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    • Vinh PQ, Sugie S, Tanaka T, Hara A, Yamada Y, Katayama M, Deguchi T, Mori H. (2002) Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. Japanese Journal of Cancer Research: Gann, 93, 42-49.
    • (2002) Japanese Journal of Cancer Research: Gann , vol.93 , pp. 42-49
    • Vinh, P.Q.1    Sugie, S.2    Tanaka, T.3    Hara, A.4    Yamada, Y.5    Katayama, M.6    Deguchi, T.7    Mori, H.8
  • 52
    • 84883465250 scopus 로고    scopus 로고
    • Silibinin reverses drug resistance in human small-cell lung carcinoma cells
    • Sadava D, Kane SE. (2013) Silibinin reverses drug resistance in human small-cell lung carcinoma cells. Cancer Letters, 339, 102-106.
    • (2013) Cancer Letters , vol.339 , pp. 102-106
    • Sadava, D.1    Kane, S.E.2
  • 54
    • 51049109239 scopus 로고    scopus 로고
    • Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible NO synthase in human lung carcinoma A549 cells
    • Chittezhath M, Deep G, Singh RP, Agarwal C, Agarwal R. (2008) Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible NO synthase in human lung carcinoma A549 cells. Molecular Cancer Therapeutics, 7, 1817-1826.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 1817-1826
    • Chittezhath, M.1    Deep, G.2    Singh, R.P.3    Agarwal, C.4    Agarwal, R.5
  • 56
    • 20144372639 scopus 로고    scopus 로고
    • Milk thistle and prostate cancer: Differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells
    • Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ. (2005) Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. Cancer Research, 65, 4448-4457.
    • (2005) Cancer Research , vol.65 , pp. 4448-4457
    • Davis-Searles, P.R.1    Nakanishi, Y.2    Kim, N.C.3    Graf, T.N.4    Oberlies, N.H.5    Wani, M.C.6    Wall, M.E.7    Agarwal, R.8    Kroll, D.J.9
  • 57
    • 5144224381 scopus 로고    scopus 로고
    • A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer
    • Singh RP, Agarwal R. (2004) A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutation Research, 555, 21-32.
    • (2004) Mutation Research , vol.555 , pp. 21-32
    • Singh, R.P.1    Agarwal, R.2
  • 58
    • 41949087545 scopus 로고    scopus 로고
    • Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels
    • Verschoyle RD, Greaves P, Patel K, Marsden DA, Brown K, Steward WP, Gescher AJ. (2008) Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels. European Journal of Cancer, 44, 898-906.
    • (2008) European Journal of Cancer , vol.44 , pp. 898-906
    • Verschoyle, R.D.1    Greaves, P.2    Patel, K.3    Marsden, D.A.4    Brown, K.5    Steward, W.P.6    Gescher, A.J.7
  • 60
    • 84884525706 scopus 로고    scopus 로고
    • Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer
    • Su CH, Chen LJ, Liao JF, Cheng JT. (2013) Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. Journal of Medicinal Food, 16, 778-784.
    • (2013) Journal of Medicinal Food , vol.16 , pp. 778-784
    • Su, C.H.1    Chen, L.J.2    Liao, J.F.3    Cheng, J.T.4
  • 63
    • 0037057520 scopus 로고    scopus 로고
    • Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats
    • Kohno H, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, Mori H. (2002) Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. International Journal of Cancer, 101, 461-468.
    • (2002) International Journal of Cancer , vol.101 , pp. 461-468
    • Kohno, H.1    Tanaka, T.2    Kawabata, K.3    Hirose, Y.4    Sugie, S.5    Tsuda, H.6    Mori, H.7
  • 64
    • 84855560688 scopus 로고    scopus 로고
    • Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats
    • Sangeetha N, Viswanathan P, Balasubramanian T, Nalini N. (2012) Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats. European Journal of Pharmacology, 674, 430-438.
    • (2012) European Journal of Pharmacology , vol.674 , pp. 430-438
    • Sangeetha, N.1    Viswanathan, P.2    Balasubramanian, T.3    Nalini, N.4
  • 65
    • 40949106128 scopus 로고    scopus 로고
    • Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis
    • Singh RP, Gu M, Agarwal R. (2008) Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Research, 68, 2043-2050.
    • (2008) Cancer Research , vol.68 , pp. 2043-2050
    • Singh, R.P.1    Gu, M.2    Agarwal, R.3
  • 66
    • 84879793868 scopus 로고    scopus 로고
    • In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells
    • pii: S0304-3835(12)00539-3. doi: 10.1016/j.canlet.2012.09.004
    • Nambiar D, Prajapati V, Agarwal R, Singh RP. (2012) In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells. Cancer Letters, pii: S0304-3835(12)00539-3. doi: 10.1016/j.canlet.2012.09.004.
    • (2012) Cancer Letters
    • Nambiar, D.1    Prajapati, V.2    Agarwal, R.3    Singh, R.P.4
  • 67
    • 0035877237 scopus 로고    scopus 로고
    • Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: Involvement of protein kinase C
    • Kang SN, Lee MH, Kim KM, Cho D, Kim TS. (2001) Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C. Biochemical Pharmacology, 61, 1487-1495.
    • (2001) Biochemical Pharmacology , vol.61 , pp. 1487-1495
    • Kang, S.N.1    Lee, M.H.2    Kim, K.M.3    Cho, D.4    Kim, T.S.5
  • 68
    • 33748748204 scopus 로고    scopus 로고
    • Silymarin causes caspases activation and apoptosis in K562 leukemia cells through inactivation of Akt pathway
    • Zhong X, Zhu Y, Lu Q, Zhang J, Ge Z, Zheng S. (2006) Silymarin causes caspases activation and apoptosis in K562 leukemia cells through inactivation of Akt pathway. Toxicology, 227, 211-216.
    • (2006) Toxicology , vol.227 , pp. 211-216
    • Zhong, X.1    Zhu, Y.2    Lu, Q.3    Zhang, J.4    Ge, Z.5    Zheng, S.6
  • 69
    • 82455184370 scopus 로고    scopus 로고
    • A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells
    • Zhang J, Luan Q, Liu Y, Lee DY, Wang Z. (2011) A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Natural Product Communications, 6, 1653-1656.
    • (2011) Natural Product Communications , vol.6 , pp. 1653-1656
    • Zhang, J.1    Luan, Q.2    Liu, Y.3    Lee, D.Y.4    Wang, Z.5
  • 71
    • 0037111357 scopus 로고    scopus 로고
    • Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy
    • Dietzmann J, Thiel U, Ansorge S, Neumann KH, Tager M. (2002) Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy. Free Radical Biology and Medicine, 33, 1347-1354.
    • (2002) Free Radical Biology and Medicine , vol.33 , pp. 1347-1354
    • Dietzmann, J.1    Thiel, U.2    Ansorge, S.3    Neumann, K.H.4    Tager, M.5
  • 73
    • 33846345425 scopus 로고    scopus 로고
    • Protective effect of silymarin on oxidative stress in rat brain
    • Nencini C, Giorgi G, Micheli L. (2007) Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine, 14, 129-135.
    • (2007) Phytomedicine , vol.14 , pp. 129-135
    • Nencini, C.1    Giorgi, G.2    Micheli, L.3
  • 74
    • 84867737488 scopus 로고    scopus 로고
    • Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-êB expression
    • Wang C, Wang Z, Zhang X, Zhang X, Dong L, Xing Y, Li Y, Liu Z, Chen L, Qiao H, Wang L, Zhu C. (2012) Protection by silibinin against experimental ischemic stroke: up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-êB expression. Neuroscience Letters, 529, 45-50.
    • (2012) Neuroscience Letters , vol.529 , pp. 45-50
    • Wang, C.1    Wang, Z.2    Zhang, X.3    Zhang, X.4    Dong, L.5    Xing, Y.6    Li, Y.7    Liu, Z.8    Chen, L.9    Qiao, H.10    Wang, L.11    Zhu, C.12
  • 79
    • 78649876040 scopus 로고    scopus 로고
    • Anti-hyperlipidemic and anti-atherosclerotic activities of silymarins from cultivated and wild plants of Silybum marianum L. With different contents of flavonolignans
    • Radjabian T, Huseini HF. (2010) Anti-hyperlipidemic and anti-atherosclerotic activities of silymarins from cultivated and wild plants of Silybum marianum L. with different contents of flavonolignans. Iranian Journal of Pharmacology and Therapeutics, 9, 63-67.
    • (2010) Iranian Journal of Pharmacology and Therapeutics , vol.9 , pp. 63-67
    • Radjabian, T.1    Huseini, H.F.2
  • 80
    • 33845618025 scopus 로고    scopus 로고
    • The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: A randomized, double-blind, placebo-controlled, clinical trial
    • Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. (2006) The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytotherapy Research, 20, 1036-1039.
    • (2006) Phytotherapy Research , vol.20 , pp. 1036-1039
    • Huseini, H.F.1    Larijani, B.2    Heshmat, R.3    Fakhrzadeh, H.4    Radjabipour, B.5    Toliat, T.6    Raza, M.7
  • 81
    • 0036700586 scopus 로고    scopus 로고
    • Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent
    • Lirussi F, Beccarello A, Zanette G, De Monte A, Donadon V, Velussi M, Crepaldi G. (2002) Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent. Diabetes, Nutrition and Metabolism, 15, 222-231.
    • (2002) Diabetes, Nutrition and Metabolism , vol.15 , pp. 222-231
    • Lirussi, F.1    Beccarello, A.2    Zanette, G.3    De Monte, A.4    Donadon, V.5    Velussi, M.6    Crepaldi, G.7
  • 83
    • 0030907984 scopus 로고    scopus 로고
    • Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients
    • Velussi M, Cernigoi AM, De Monte A, Dapas F, Caffau C, Zilli M. (1997) Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. Journal of Hepatology, 26, 871-879.
    • (1997) Journal of Hepatology , vol.26 , pp. 871-879
    • Velussi, M.1    Cernigoi, A.M.2    De Monte, A.3    Dapas, F.4    Caffau, C.5    Zilli, M.6
  • 84
    • 84878262927 scopus 로고    scopus 로고
    • Anti-oxidant therapy in non-alcoholic fatty liver disease: The role of silymarin
    • Abenavoli L, Milic N, Capasso F. (2012) Anti-oxidant therapy in non-alcoholic fatty liver disease: the role of silymarin. Endocrine, 42, 754-755.
    • (2012) Endocrine , vol.42 , pp. 754-755
    • Abenavoli, L.1    Milic, N.2    Capasso, F.3
  • 86
    • 0141953283 scopus 로고    scopus 로고
    • Silymarin is a selective estrogen receptor β (ERβ) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats
    • Seidlová-Wuttke T, Becker V, Christoffel H, Jarry W, Wuttke D. (2003) Silymarin is a selective estrogen receptor β (ERβ) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats. Journal of Steroid Biochemistry & Molecular Biology, 86, 179-188.
    • (2003) Journal of Steroid Biochemistry & Molecular Biology , vol.86 , pp. 179-188
    • Seidlová-Wuttke, T.1    Becker, V.2    Christoffel, H.3    Jarry, W.4    Wuttke, D.5
  • 87
    • 73449128972 scopus 로고    scopus 로고
    • Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats
    • El-Shitany NA, Hegazy S, El-Desoky K. (2010) Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Phytomedicine, 17, 116-125.
    • (2010) Phytomedicine , vol.17 , pp. 116-125
    • El-Shitany, N.A.1    Hegazy, S.2    El-Desoky, K.3
  • 88
    • 84866733059 scopus 로고    scopus 로고
    • Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats
    • Ashkavand Z, Malekinejad H, Amniattalab A, Rezaei-Golmisheh A, Vishwanath BS. (2012) Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. Phytomedicine, 19, 1200-1205.
    • (2012) Phytomedicine , vol.19 , pp. 1200-1205
    • Ashkavand, Z.1    Malekinejad, H.2    Amniattalab, A.3    Rezaei-Golmisheh, A.4    Vishwanath, B.S.5
  • 89
    • 2942595972 scopus 로고    scopus 로고
    • Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: Protective effects of silymarin
    • Moreland N, La Grange L, Montoya R. (2002) Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin. BMC Complementary and Alternative Medicine, 2, 10.
    • (2002) BMC Complementary and Alternative Medicine , vol.2 , pp. 10
    • Moreland, N.1    La Grange, L.2    Montoya, R.3
  • 91
    • 67650554807 scopus 로고    scopus 로고
    • Silymarin BIO-C ®, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats
    • Capasso R, Aviello G, Capasso F, Savino F, Izzo AA, Lembo F, Borrelli F. (2004) Silymarin BIO-C ®, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats. Phytomedicine, 16, 839-844.
    • (2004) Phytomedicine , vol.16 , pp. 839-844
    • Capasso, R.1    Aviello, G.2    Capasso, F.3    Savino, F.4    Izzo, A.A.5    Lembo, F.6    Borrelli, F.7
  • 93
    • 77953023898 scopus 로고    scopus 로고
    • Downregulation of nuclear factor kappa B (NF-kB) pathway by silibinin inhuman monocytes challenged with Paracoccidioides brasiliensis
    • Bannwart CF, Nakaira-Takahagi E, Golim MA, Medeiros LTL, Romão M, Weel IC, Peraçoli MT. (2010) Downregulation of nuclear factor kappa B (NF-kB) pathway by silibinin inhuman monocytes challenged with Paracoccidioides brasiliensis. Life Sciences, 86, 880-886.
    • (2010) Life Sciences , vol.86 , pp. 880-886
    • Bannwart, C.F.1    Nakaira-Takahagi, E.2    Golim, M.A.3    Medeiros, L.T.L.4    Romão, M.5    Weel, I.C.6    Peraçoli, M.T.7
  • 95
    • 0029879066 scopus 로고    scopus 로고
    • Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silybinin
    • Dehmlow C, Erhard J, De Groot H. (1996) Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silybinin. Hepatology, 23, 749-754.
    • (1996) Hepatology , vol.23 , pp. 749-754
    • Dehmlow, C.1    Erhard, J.2    De Groot, H.3
  • 96
    • 0029929692 scopus 로고    scopus 로고
    • Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells
    • Dehmlow C, Murawski N, de Groot H. (1996) Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sciences, 58, 1591-1600.
    • (1996) Life Sciences , vol.58 , pp. 1591-1600
    • Dehmlow, C.1    Murawski, N.2    De Groot, H.3
  • 97
    • 0344687228 scopus 로고    scopus 로고
    • Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1β and prostaglandin E2 synthesis by silymarin
    • Kang JS, Jeon YJ, Park SK, Yang KH, Kim HM. (2004) Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1β and prostaglandin E2 synthesis by silymarin. Biochemical Pharmacology, 67, 175-181.
    • (2004) Biochemical Pharmacology , vol.67 , pp. 175-181
    • Kang, J.S.1    Jeon, Y.J.2    Park, S.K.3    Yang, K.H.4    Kim, H.M.5
  • 98
    • 34548510607 scopus 로고    scopus 로고
    • Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury
    • Toklu HZ, Tunali-Akbay T, Erkanli G, Yüksel M, Ercan F, Sener G. (2007) Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns, 33, 908-916.
    • (2007) Burns , vol.33 , pp. 908-916
    • Toklu, H.Z.1    Tunali-Akbay, T.2    Erkanli, G.3    Yüksel, M.4    Ercan, F.5    Sener, G.6
  • 99
    • 14844331730 scopus 로고    scopus 로고
    • Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: Possible involvement of cAMP
    • Crocenzi FA, Basiglio CL, Pérez LM, Portesio MS, Pozzi EJ, Roma MG. (2005) Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: Possible involvement of cAMP. Biochemical Pharmacology, 69, 1113-1120.
    • (2005) Biochemical Pharmacology , vol.69 , pp. 1113-1120
    • Crocenzi, F.A.1    Basiglio, C.L.2    Pérez, L.M.3    Portesio, M.S.4    Pozzi, E.J.5    Roma, M.G.6


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