The hormetic role of dietary antioxidants in free radical-related diseases

Current Pharmaceutical Design

Volumn 16, Issue 7, 2010, Pages 877-883

  Calabrese, V ^a   Cornelius, C ^a   Trovato Salinaro, A ^a   Cambria, M T ^a   Locascio, M S ^a   Di Rienzo, L ^b   Condorelli, D F ^a   Mancuso, C ^c   De Lorenzo, A ^b   Calabrese, E J ^d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Antioxidants; Free radicals; Hormesis; Vitagenes

Indexed keywords

ANTIOXIDANT; CURCUMIN; FERULIC ACID; FREE RADICAL; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; INDOMETACIN; POLYPHENOL; REACTIVE OXYGEN METABOLITE; RESVERATROL; SILDENAFIL;

CALORIC INTAKE; CELL STRESS; DIET SUPPLEMENTATION; DIETARY INTAKE; ENERGY CONSUMPTION; FRUIT; GASTRITIS; HUMAN; IMPOTENCE; OXIDATIVE STRESS; PEPTIC ULCER; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; STOMACH INJURY; TEA; UPREGULATION; VEGETABLE;

AGING; ANTIOXIDANTS; DIET; FREE RADICALS; HUMANS; OXIDATIVE STRESS;

EID: 77950268110     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210790883615     Document Type: Review

References (114)

1. Halliwell B. Biochemistry of oxidative stress. Biochem Soc Trans 2007; 35:1147-1150
2. Youdim KA, Spencer JP, Schroeter H, Rice-Evans C. Dietary flavonoids as potential neuroprotectants. Biol Chem 2002; 383: 503-519
3. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66.
4. Gopalakrishnan A, Kong TA. Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells. Food Chem Toxicol 2008; 46: 1257-1270
5. Calabrese V, Bates TE, Mancuso C, Cornelius C, Ventimiglia B, Cambria MT, et al. Curcumin and the cellular stress response in free radical-related diseases. Mol Nutr Food Res 2008; 52: 1062-1073
6. Calabrese V, Calafato S, Puleo E, Cornelius C, Sapienza M, Morganti P, et al. Redox regulation of cellular stress response by ferulic acid ethyl ester in human dermal fibroblasts: role of vitagenes. Clin Dermatol 2008; 26: 358-363
7. Di Renzo L, Bertoli A, Bigioni M, Del Gobbo V, Premrov MG, Calabrese V, et al. Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome. Curr Pharm Des 2008; 14: 2699-2706
8. Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP, Gescher AJ. Dietary polyphenolic phytochemicals-promising cancer chemopreventive agents in humans? a review of their clinical properties. Int J Cancer 2007; 120: 451-458
9. van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA. Brassica vegetables and cancer prevention. epidemiology and mechanisms. Adv Exp Med Biol 1999; 472: 159-168
10. London SJ, Yuan J-M, Chung F-L, Gao Y-T, Coetzee GA, Ross RK, et al. Isothiocyanates, glutathione Stransferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 2000; 356: 724-729
11. Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC. A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol Biomarkers Prev 2003; 12: 1403-1409
12. Sporn MB. Carcinogenesis and cancer: different perspectives on the same disease. Cancer Res 1991; 51: 6215-6218
13. Liu H, Dinkova-Kostova AT, Talalay P. Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. Proc Natl Acad Sci USA 2008; 105: 15926-15931
14. Bastianetto S, Quirion R. Natural extracts as possible protective agents of brain aging. Neurobiol Aging 2002; 23: 891-897
15. Yang CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 2001; 21: 381-406.
16. Calabrese V, Guagliano E, Sapienza M, Panebianco M, Calafato S, Puleo E, et al. Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. Neurochem Res 2007; 32: 757-773
17. Siekmeier R, Steffen C, März W. Role of oxidants and antioxidants in atherosclerosis: results of in vitro and in vivo investigations. J Cardiovasc Pharmacol Ther 2007; 12: 265-282
18. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of Ikappa B kinase. Nature 2000; 403: 103-108
19. Hayes DJ, Kelleher MO, Eggleston IM. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr 2008; 47: 73-88.
20. Calabrese EJ, Baldwin LA. Chemical hormesis: its historical foundations as a biological hypothesis. Toxicol Pathol 1999; 27: 195-216.
21. Calabrese EJ, Baldwin LA. Hormesis: the dose-response revolution. Annu Rev Pharmacol Toxicol 2003; 43: 175-197
22. Calabrese EJ. Hormesis and medicine. Br J Clin Pharmacol 2008; 66: 594-617.
23. Mattson MP, Son TG, Camandola S. Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose Response 2007; 5: 174-186
24. Mattson MP. Dietary factors, hormesis and health. Ageing Res Rev 2008; 7: 43-48
25. Calabrese EJ. Stress biology and hormesis: the Yerkes-Dodson law in psychology - a special case of the hormesis dose response. Crit Rev Toxicol 2008; 38: 453-462
26. Calabrese EJ. Alzheimer's disease drugs: an application of the hormetic dose-response model. Crit Rev Toxicol 2008; 38: 419-451
27. Leonardi ET, Mytilineou C. Cell culture models of neuronal degeneration and neuroprotection. Implications for Parkinson's disease. Adv Exp Med Biol 1998; 446: 203-222
28. Sayre LM, Smith MA, Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 2001; 8: 721-738
29. Lovell MA, Markesbery WR. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res 2007; 35: 7497-7504
30. Polidori MC, Griffiths HR, Mariani E, Mecocci P. Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids 2007; 32: 553-559
31. Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic Biol Med 2002; 32: 1264-1275
32. Kregel KC, Zhang HJ. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 2007; 292: R18-36.
33. Sultana R, Perluigi M, Butterfield DA. Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics. Antioxid Redox Signal 2006; 8: 2021-2037
34. Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MB. Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. Mol Nutr Food Res 2006; 50: 229-234
35. Mandel S, Weinreb O, Reznichenko L, Kalfon L, Amit T. Green tea catechins as brain-permeable, non toxic iron chelators to "iron out iron" from the brain. J Neural Transm Suppl 2006; 71: 249-257
36. Rattan SIS. Hormesis in aging. Ageing Res Rev 2008; 7: 63-78.
37. Calabrese EJ. Astrocytes: adaptive responses to low doses of neurotoxins. Crit Rev Toxicol 2008; 38: 463-471
38. Calabrese EJ. Pharmacological enhancement of neuronal survival. Crit Rev Toxicol 2008; 38: 349-389
39. Calabrese EJ. Neuroscience and hormesis: overview and general findings. Crit Rev Toxicol 2008; 38: 249-252
40. Cook R, Calabrese EJ. The importance of hormesis to public health. Environ Health Perspect 2006; 114: 1631-1635
41. Calabrese EJ. Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis. Ageing Res Rev 2008; 7: 8-20.
42. Mancuso C, Bates TE, Butterfield DA, Calafato S, Cornelius C, De Lorenzo A, et al. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci 2007; 12: 1107-1123
43. Mancuso C, Perluigi M, Cini C, De Marco C, Giuffrida Stella AM, Calabrese V. Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay. J Neurosci Res 2006; 84: 1385-1391
44. Calabrese V, Colombrita C, Sultana R, Scapagnini G, Calvani M, Butterfield DA, et al. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function. Antioxid Redox Signal 2006; 8: 404-416
45. Shibahara S. The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism. Tohoku J Exp Med 2003; 200: 167-186
46. Calabrese V, Maines MD. Antiaging medicine: antioxidants and aging. Antioxid Redox Signal 2006; 8, 362-364
47. Lee SS, Gao W, Mazzola S, Thomas MN, Csizmadia E, Otterbein LE, et al. Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells. FASEB J 2007; 21: 3450-3457
48. Hegazi RA, Rao KN, Mayle A, Sepulveda AR, Otterbein LE, Plevy SE. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 2005; 202: 1703-1713
49. Ott MC, Scott JR, Bihari A, Badhwar A, Otterbein LE, Gray DK, et al. Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion. FASEB J 2005; 19: 106-108
50. Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM. Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat Rev Neurosci 2007; 8: 766-775
51. Hundahl CA, Kelsen J, Dewilde S, Hay-Schmidt A. Neuroglobin in the rat brain (II): co-localisation with neurotransmitters. Neuroendocrinology 2008; 88:183-198
52. Kim CK, Rivier CL. Nitric oxide and carbon monoxide have a stimulatory role in the hypothalamic-pituitary-adrenal response to physico-emotional stressors in rats. Endocrinology 2000; 141: 2244-2253
53. Kostoglou-Athanassiou I, Costa A, Navarra P, Nappi G, Forsling ML, Grossman AB. Endotoxin stimulates an endogenous pathway regulating corticotropin-releasing hormone and vasopressin release involving the generation of nitric oxide and carbon monoxide. J Neuroimmunol 1998; 86:104-109
54. Mandel S, Youdim MB. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radic Biol Med 2004; 37: 304-317
55. Pan T, Jankovic J, Le W. Potential therapeutic properties of green tea polyphenols in Parkinson's disease. Drugs Aging 2003; 20: 711-721
56. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr 2005; 81: 215S-7S.
57. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 2001; 30: 433-446
58. Pan MH, Lin-Shiau SY, Ho CT, Lin JH, Lin JK. Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem Pharmacol 2000; 59: 357-367
59. Luchsinger JA, Noble JM, Scarmeas N. Diet and Alzheimer's disease. Curr Neurol Neurosci Rep 2007; 7: 366-372
60. Luchsinger JA, Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol 2004; 3: 579-587
61. Ritz MF, Ratajczak P, Curin Y, Cam E, Mendelowitsch A, Pinet F, et al. Chronic treatment with red wine polyphenol compounds mediates neuroprotection in a rat model of ischemic cerebral stroke. J Nutr 2008; 138: 519-525
62. Vauzour D, Vafeiadou K, Corona G, Pollard SE, Tzounis X, Spencer JP. Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. J Agric Food Chem 2007; 55: 2854-2860
63. Ates O, Cayli S, Altinoz E, Gurses I, Yucel N, Sener M, et al. Neuroprotection by resveratrol against traumatic brain injury in rats. Mol Cell Biochem 2007; 294: 137-144
64. Zhang H, Schools GP, Lei T, Wang W, Kimelberg HK, Zhou M. Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp Neurol 2008; 212: 44-52.
65. Kiziltepe U, Turan NN, Han U, Ulus AT, Akar F. Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury. J Vasc Surg 2004; 40: 138-145
66. Calabrese V, Calvani M, Butterfield DA. Acetyl-L-carnitineinduced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J Neurosci Res 2006; 84, 398-408.
67. Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006; 72: 1439-1452
68. Krenz M, Cohen MV, Downey JM. The protective and antiprotective effects of ethanol in a myocardial infarct model. Ann N Y Acad Sci 2002; 957: 103-114
69. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5: 493-506.
70. Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004; 74: 935-968
71. Cao Z, Li Y. Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur J Pharmacol 2004; 489: 39-48.
72. Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH, et al. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis 2006; 11: 943-953
73. Divya CS, Pillai MR. Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NF-kB and AP-1 translocation, and modulation of apoptosis. Mol Carcinog 2006; 45: 320-332
74. Pérez-Arriaga L, Mendoza-Magaña ML, Cortés- Zárate R, Corona- Rivera A, Bobadilla-Morales L, Troyo-Sanromán R, et al. Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop 2006; 98: 152-161
75. Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine 2000; 7: 303-308
76. Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol 2008; 75: 787-809.
77. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001; 21: 8370-8377
78. Dinkova-Kostova AT, Talalay P. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis 1999; 20: 911-914
79. Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol 2001; 39: 541-547
80. Basu NK, Ciotti M, Hwang MS, Kole L, Mitra PS, Cho JW, et al. Differential and special properties of the major human UGT1- encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem 2004; 279: 1429-1441
81. Oetari S, Sudibyo M, Commandeur JN, Samhoedi R, Vermeulen NP. Effects of curcumin on cytochrome P450 and glutathione Stransferase activities in rat liver. Biochem Pharmacol 1996; 51: 39-45.
82. Kalfon L, Youdim MB, Mandel SA. Green tea polyphenol (-) - epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of bad: implications for neuroprotection. J Neurochem 2007; 100: 992-1002.
83. Weinreb O, Amit T, Youdim MB. A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin- 3-gallate. Free Radic Biol Med 2007; 43: 546-556
84. Kanski J, Aksenova M, Stoyanova A, Butterfield DA. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J Nutr Biochem 2002; 13: 273-281
85. Kikuzaki H, Hisamoto M, Hirose K, Akiyama K, Taniguchi H. Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem 2002; 50: 2161-2168
86. Yan JJ, Cho JY, Kim HS, Kim KL, Jung JS, Huh SO, et al. Protection against beta-amyloid peptide toxicity in vivo with longterm administration of ferulic acid. Br J Pharmacol 2001; 133: 89-96.
87. Clifford MN, Wu W, Kirkpatrick J, Kuhnert N. Profiling the chlorogenic acids and other caffeic acid derivatives of herbal chrysanthemum by LC-MSn. J Agric Food Chem 2007; 55: 929-936
88. Scapagnini G, Butterfield DA, Colombrita C, Sultana R, Pascale A, Calabrese V. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal 2004; 6: 811-818
89. Sultana R, Ravagna A, Mohmmad-Abdul H, Calabrese V, Butterfield DA. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem 2005; 92: 749-758
90. Perluigi M, Joshi G, Sultana R, Calabrese V, De Marco C, Coccia R, et al. In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress. J Neurosci Res 2006; 84: 418-426
91. Joshi G, Perluigi M, Sultana R, Agrippino R, Calabrese V, Butterfield DA. In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2- amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. Neurochem Int 2006; 48: 318-327
92. Butterfield DA, Perluigi M, Sultana R. Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics. Eur J Pharmacol 2006; 545: 39-50.
93. Butterfield DA, Sultana R. Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. J Alzheimers Dis 2007; 12: 61-72.
94. Sultana R, Newman SF, Abdul HM, Cai J, Pierce WM, Klein JB, et al. Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study. J Neurosci Res 2006; 84: 409-417
95. Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm 2007; 330: 155-163
96. Anselmi C, Centini M, Maggiore M, Gaggelli N, Andreassi M, Buonocore A, et al. Non-covalent inclusion of ferulic acid with alpha-cyclodextrin improves photo-stability and delivery: NMR and modeling studies. J Pharm Biomed Anal 2008; 46: 645-652
97. Souto EB, Anselmi C, Centini M, Müller RH. Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN). Int J Pharm 2005; 295: 261-268
98. Zhou S, Yung Chan S, Cher Goh B, Chan E, Duan W, Huang M, et al. Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet 2005; 44: 279-304.
99. The Medical Letter 2008; 7: 25.
100. Jackson G, Montorsi P, Cheitlin MD. Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective. Urology 2006; 68: 47-60.
101. Stein RA. Managing concomitant cardiac disease and erectile dysfunction. Rev Urol 2002; 4: S39-47.
102. O'Brien WM. Pharmacology of nonsteroidal anti-inflammatory drugs. Practical review for clinicians. Am J Med 1983;75: 32-39
103. Carmichael J, Shankel SW. Effects of nonsteroidal antiinflammatory drugs on prostaglandins and renal function. Am J Med 1985; 78: 992-1000.
104. Freeman WD, Aguilar MI. Management of warfarin-related intracerebral hemorrhage. Expert Rev Neurother 2008; 8: 271-290
105. August DA, Landau J, Caputo D, Hong J, Lee MJ, Yang CS. Ingestion of green tea rapidly decreases prostaglandin E2 levels in rectal mucosa in humans. Cancer Epidemiol Biomarkers Prev 1999; 8: 709-713
106. Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, et al. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem Res 2008; 33: 2444-2471
107. Halliwell B. Dietary polyphenols: good, bad, or indifferent for your health? Cardiovasc Res 2007; 73: 341-347
108. Halliwell B. Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 2008; 476: 107-112
109. Jedrychowski W, Maugeri U. An apple a day may hold colorectal cancer at bay: recent evidence from a case-control study. Rev Environ Health 2009; 24: 59-74.
110. Karppi J, Kurl S, Nurmi T, Rissanen TH, Pukkala E, Nyyssönen K. Serum lycopene and the risk of cancer: the kuopio ischaemic heart disease risk factor (KIHD) study. Ann Epidemiol 2009; 19: 512-518
111. Soerensen M, Christensen K, Stevnsner T, Christiansen L. The Mnsuperoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. Mech Ageing Dev 2009; 130: 308-314
112. McCord JM. Superoxide dismutase, lipid peroxidation, and bellshaped dose response curves. Dose Response 2008; 6: 223-238
113. Saremi A, Arora R. Vitamin E and cardiovascular disease. Am J Ther 2009 May 15.
114. Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol 2008; 101: 75-86.