Computer-aided design (CAD) of Mn(II) complexes: Superoxide dismutase mimetics with catalytic activity exceeding the native enzyme

Inorganic Chemistry

Volumn 40, Issue 8, 2001, Pages 1779-1789

  Aston, K ^c   Rath, N ^b   Naik, A ^a   Slomczynska, U ^a   Schall, O F ^a   Riley, D P ^a  

^a MetaPhore Pharmaceuticals   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; HYDROGEN PEROXIDE; IMINE; MACROCYCLIC COMPOUND; MANGANESE DERIVATIVE; MITOCHONDRIAL ENZYME; OXYGEN; PYRIDINE DERIVATIVE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; CALCULATION; CATALYSIS; CATALYST; CHEMICAL STRUCTURE; COMPUTER AIDED DESIGN; DIASTEREOISOMER; PH; POLYMERIZATION; PREDICTION; REDUCTION; STEREOCHEMISTRY;

CATALYSIS; COMPUTER-AIDED DESIGN; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HYDROGEN-ION CONCENTRATION; KINETICS; MANGANESE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM; SUPEROXIDE DISMUTASE;

EID: 0035831587     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic000958v     Document Type: Article

References (30)

1. Rational design of synthetic enzymes and their potential utility as human pharmaceuticals: Development of Mn(II)-based superoxide dismutase mimics