Reactive oxygen species in health and disease

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Alfadda, Assim A ^a,b   Sallam, Reem M ^a,b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CURCUMIN; DICLOFENAC; DITHIOTHREITOL; DOXYCYCLINE; GINSENOSIDE RB 1; MANGIFERIN; PLACEBO; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; RECOMBINANT ERYTHROPOIETIN; RESVERATROL; ROTTLERIN; TERT BUTYL HYDROPEROXIDE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BLOOD VESSEL DIAMETER; CELL METABOLISM; CHRONIC INFLAMMATION; COMORBIDITY; DIABETES MELLITUS; DISEASES; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENOMIC INSTABILITY; HEALTH; HUMAN; IMMUNE SYSTEM; INFECTION; INSULIN RESISTANCE; METABOLIC DISORDER; MITOCHONDRION; NEOPLASM; NONHUMAN; OBESITY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXYGEN SENSING; PATHOGENESIS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TOXICITY; TRANSCRIPTION REGULATION; ANIMAL; DRUG EFFECT; METABOLISM;

ANIMALS; ANTIOXIDANTS; DISEASE; HEALTH; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84866133072     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/936486     Document Type: Review

References (112)

1. Dröge W., Free radicals in the physiological control of cell function. Physiological Reviews 2002 82 1 47 95 2-s2.0-0036086130 (Pubitemid 34654215)
2. 2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. Circulation Research 2003 93 6 573 580 2-s2.0-0141608948 10.1161/01.RES.0000091261.19387.AE (Pubitemid 37163238)
3. DeNicola G. M., Karreth F. A., Humpton T. J., Gopinathan A., Wei C., Frese K., Mangal D., Yu K. H., Yeo C. J., Calhoun E. S., Scrimieri F., Winter J. M., Hruban R. H., Iacobuzio-Donahue C., Kern S. E., Blair I. A., Tuveson D. A., Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011 475 7354 106 109 2-s2.0-79960060305 10.1038/nature10189
4. Perera R. M., Bardeesy N., Cancer: when antioxidants are bad. Nature 2011 475 7354 43 44 2-s2.0-79960034499 10.1038/475043a
5. Go Y.-M., Park H., Koval M., Orr M., Reed M., Liang Y., Smith D., Pohl J., Jones D. P., A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free Radical Biology and Medicine 2010 48 2 275 283 2-s2.0-72649107557 10.1016/j.freeradbiomed.2009.10.050
6. Chen Y., Cai J., Jones D. P., Mitochondrial thioredoxin in regulation of oxidant-induced cell death. FEBS Letters 2006 580 28-29 6596 6602 2-s2.0-33751509841 10.1016/j.febslet.2006.11.007 (Pubitemid 44830129)
7. Chen Y., Cai J., Murphy T. J., Jones D. P., Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. Journal of Biological Chemistry 2002 277 36 33242 33248 2-s2.0-0037031939 10.1074/jbc.M202026200 (Pubitemid 34984844)
8. Zhang H., Luo Y., Zhang W., He Y., Dai S., Zhang R., Huang Y., Bernatchez P., Giordano F. J., Shadel G., Sessa W. C., Min W., Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. American Journal of Pathology 2007 170 3 1108 1120 2-s2.0-34247895799 10.2353/ajpath.2007.060960 (Pubitemid 47339377)
9. Guzy R. D., Schumacker P. T., Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Experimental Physiology 2006 91 5 807 819 2-s2.0-33747596652 10.1113/expphysiol.2006.033506 (Pubitemid 44266577)
10. Semenza G. L., Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life 2008 60 9 591 597 2-s2.0-56149089262 10.1002/iub.93
11. Merry T. L., McConell G. K., Do reactive oxygen species regulate skeletal muscle glucose uptake during contraction? Exercise and Sport Sciences Reviews 2012 40 2 102 105 10.1097/JES.0b013e318245837b
12. Sandström M. E., Zhang S.-J., Bruton J., Silva J. P., Reid M. B., Westerblad H., Katz A., Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. Journal of Physiology 2006 575 1 251 262 2-s2.0-33746810466 10.1113/jphysiol.2006.110601 (Pubitemid 44178142)
13. Merry T. L., Wadley G. D., Stathis C. G., Garnham A. P., Rattigan S., Hargreaves M., McConell G. K., N-Acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans. Journal of Physiology 2010 588 9 1623 1634 2-s2.0-77952929323 10.1113/jphysiol.2009.184333
14. Berzosa C., Cebrián I., Fuentes-Broto L., Gómez- Trullén E., Piedrafita E., Martínez-Ballarín E., López-Pingarrn L., Reiter R. J., García J. J., Acute exercise increases plasma total antioxidant status and antioxidant enzyme activities in untrained men. Journal of Biomedicine and Biotechnology 2011 2011 7 2-s2.0-79955015665 10.1155/2011/540458 540458
15. Hatao H., Oh-Ishi S., Itoh M., Leeuwenburgh C., Ohno H., Ookawara T., Kishi K., Yagyu H., Nakamura H., Matsuoka T., Effects of acute exercise on lung antioxidant enzymes in young and old rats. Mechanisms of Ageing and Development 2006 127 4 384 390 2-s2.0-33344479296 10.1016/j.mad.2005.12.008 (Pubitemid 43290542)
16. Rajendran R., Garva R., Krstic-Demonacos M., Demonacos C., Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. Journal of Biomedicine and Biotechnology 2011 2011 17 368276 10. 1155/2011/368276
17. Wu J., Bauer C. E., RegB/RegA, a global redox-responding two-component system. Advances in Experimental Medicine and Biology 2008 631 131 148 2-s2.0-55949136931 10.1007/978-0-387-78885-29
18. Biteau B., Labarre J., Toledano M. B., ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature 2003 425 6961 980 984 2-s2.0-0242416188 10.1038/nature02075 (Pubitemid 37376931)
19. Dröge W., Redox regulation in anabolic and catabolic processes. Current Opinion in Clinical Nutrition and Metabolic Care 2006 9 3 190 195 2-s2.0-33746228340 10.1097/01.mco.0000222098.98514.40 (Pubitemid 44097827)
20. Aitio M. L., N-acetylcysteinepasse-partout or much ado about nothing? British Journal of Clinical Pharmacology 2006 61 1 5 15 2-s2.0-33644905318 10.1111/j.1365-2125.2005.02523.x (Pubitemid 43381233)
21. Reliene R., Fischer E., Schiestl R. H., Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in Atm-deficient mice. Cancer Research 2004 64 15 5148 5153 2-s2.0-3442902484 10.1158/0008-5472.CAN-04- 0442 (Pubitemid 39006532)
22. Reliene R., Schiestl R. H., Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice. DNA Repair 2006 5 7 852 859 2-s2.0-33745263216 10.1016/j.dnarep.2006.05.003 (Pubitemid 43928890)
23. Sablina A. A., Budanov A. V., Ilyinskaya G. V., Agapova L. S., Kravchenko J. E., Chumakov P. M., The antioxidant function of the p53 tumor suppressor. Nature Medicine 2005 11 12 1306 1313 2-s2.0-28644447272 10.1038/nm1320 (Pubitemid 41752911)
24. Hayes J. D., McMahon M., NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends in Biochemical Sciences 2009 34 4 176 188 2-s2.0-63549121490 10.1016/j.tibs.2008.12.008
25. Hansson G. K., Libby P., The immune response in atherosclerosis: a double-edged sword. Nature Reviews Immunology 2006 6 7 508 519 2-s2.0-33745571976 10.1038/nri1882 (Pubitemid 43980523)
26. Doughan A. K., Harrison D. G., Dikalov S. I., Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circulation Research 2008 102 4 488 496 2-s2.0-41949104144 10.1161/CIRCRESAHA.107.162800 (Pubitemid 351651106)
27. Puddu P., Puddu G. M., Galletti L., Cravero E., Muscari A., Mitochondrial dysfunction as an initiating event in atherogenesis: a plausible hypothesis. Cardiology 2005 103 3 137 141 2-s2.0-21744434763 10.1159/000083440 (Pubitemid 41094860)
28. Wenzel P., Schuhmacher S., Kienhöfer J., Müller J., Hortmann M., Oelze M., Schulz E., Treiber N., Kawamoto T., Scharffetter-Kochanek K., Münzel T., Bürkle A., Bachschmid M. M., Daiber A., Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovascular Research 2008 80 2 280 289 2-s2.0-54149096363 10.1093/cvr/cvn182
29. Dai D. F., Johnson S. C., Villarin J. J., Chin M. T., Nieves-Cintrón M., Chen T., Marcinek D. J., Dorn G. W., Kang Y. J., Prolla T. A., Santana L. F., Rabinovitch P. S., Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and G α q overexpression-induced heart failure. Circulation Research 2011 108 7 837 846 2-s2.0-79954694973 10.1161/CIRCRESAHA.110.232306
30. McDermott-Roe C., Ye J., Ahmed R., Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature 2011 478 7367 114 118
31. Hotamisligil G. S., Inflammation and metabolic disorders. Nature 2006 444 7121 860 867 2-s2.0-33845866857 10.1038/nature05485 (Pubitemid 46024993)
32. Tu B. P., Weissman J. S., Oxidative protein folding in eukaryotes: mechanisms and consequences. Journal of Cell Biology 2004 164 3 341 346 2-s2.0-0842266604 10.1083/jcb.200311055 (Pubitemid 38174761)
33. Ron D., Walter P., Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews Molecular Cell Biology 2007 8 7 519 529 2-s2.0-34250899722 10.1038/nrm2199 (Pubitemid 46985379)
34. Schröder M., Kaufman R. J., The mammalian unfolded protein response. Annual Review of Biochemistry 2005 74 739 789 2-s2.0-22244446505 10.1146/annurev.biochem.73.011303.074134 (Pubitemid 40995523)
35. Haynes C. M., Ron D., The mitochondrial UPRprotecting organelle protein homeostasis. Journal of Cell Science 2010 123 22 3849 3855 2-s2.0-78649728763 10.1242/jcs.075119
36. Harding H. P., Zhang Y., Zeng H., Novoa I., Lu P. D., Calfon M., Sadri N., Yun C., Popko B., Paules R., Stojdl D. F., Bell J. C., Hettmann T., Leiden J. M., Ron D., An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell 2003 11 3 619 633 2-s2.0-0037353039 10.1016/S1097-2765(03)00105-9 (Pubitemid 36385118)
37. Cullinan S. B., Zhang D., Hannink M., Arvisais E., Kaufman R. J., Diehl J. A., Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Molecular and Cellular Biology 2003 23 20 7198 7209 2-s2.0-0141752795 10.1128/MCB.23.20.7198-7209.2003 (Pubitemid 37211002)
38. Cullinan S. B., Diehl J. A., PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. Journal of Biological Chemistry 2004 279 19 20108 20117 2-s2.0-2442542312 10.1074/jbc.M314219200 (Pubitemid 38623455)
39. Mathers J., Fraser J. A., McMahon M., Saunders R. D. C., Hayes J. D., McLellan L. I., Antioxidant and cytoprotective responses to redox stress. Biochemical Society Symposium 2004 71 157 176 2-s2.0-16244385292 (Pubitemid 41185484)
40. Zhang D. D., Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metabolism Reviews 2006 38 4 769 789 2-s2.0-33845442925 10.1080/03602530600971974 (Pubitemid 44903268)
41. Patti M. E., Corvera S., The role of mitochondria in the pathogenesis of type 2 diabetes. Endocrine Reviews 2010 31 3 364 395 2-s2.0-77954859197 10.1210/er.2009-0027
42. Virbasius J. V., Scarpulla R. C., Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proceedings of the National Academy of Sciences of the United States of America 1994 91 4 1309 1313 2-s2.0-0028011017 (Pubitemid 24059000)
43. Echtay K. S., Roussel D., St-Plerre J., Jekabsons M. B., Cadenas S., Stuart J. A., Harper J. A., Roebuck S. J., Morrison A., Pickering S., Clapham J. C., Brand M. D., Superoxide activates mitochondrial uncoupling proteins. Nature 2002 415 6867 96 99 2-s2.0-18244379331 10.1038/415096a (Pubitemid 34062457)
44. Andrews Z. B., Liu Z. W., Walllingford N., Erion D. M., Borok E., Friedman J. M., Tschöp M. H., Shanabrough M., Cline G., Shulman G. I., Coppola A., Gao X. B., Horvath T. L., Diano S., UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008 454 7206 846 851 2-s2.0-49649122302 10.1038/nature07181
45. Jastroch M., Divakaruni A. S., Mookerjee S., Treberg J. R., Brand M. D., Mitochondrial proton and electron leaks. Essays in Biochemistry 2010 47 53 67 2-s2.0-79551610255
46. Chan C. B., De Leo D., Joseph J. W., McQuaid T. S., Ha X. F., Xu F., Tsushima R. G., Pennefather P. S., Salapatek A. M. F., Wheeler M. B., Increased uncoupling protein-2 levels in β -cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 2001 50 6 1302 1310 2-s2.0-0034990987 (Pubitemid 32500162)
47. Zhang C. Y., Baffy G., Perret P., Krauss S., Peroni O., Grujic D., Hagen T., Vidal-Puig A. J., Boss O., Kim Y. B., Zheng X. X., Wheeler M. B., Shulman G. I., Chan C. B., Lowell B. B., Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes. Cell 2001 105 6 745 755 2-s2.0-0035875087 10.1016/S0092- 8674(01)00378-6 (Pubitemid 32635104)
48. Shaw J. M., Nunnari J., Mitochondrial dynamics and division in budding yeast. Trends in Cell Biology 2002 12 4 178 184 2-s2.0-0036536714 10.1016/S0962-8924(01)02246-2 (Pubitemid 34442240)
49. Bach D., Pich S., Soriano F. X., Vega N., Baumgartner B., Oriola J., Daugaard J. R., Lloberas J., Camps M., Zierath J. R., Rabasa-Lhoret R., Wallberg-Henriksson H., Laville M., Palacín M., Vidal H., Rivera F., Brand M., Zorzano A., Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: a novel regulatory mechanism altered in obesity. Journal of Biological Chemistry 2003 278 19 17190 17197 2-s2.0-0037593949 10.1074/jbc.M212754200 (Pubitemid 36799599)
50. Robertson A. P., Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. Journal of Biological Chemistry 2004 279 41 42351 42354 2-s2.0-5644248079 10.1074/jbc.R400019200 (Pubitemid 39372114)
51. Brookheart R. T., Michel C. I., Listenberger L. L., Ory D. S., Schaffer J. E., The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. Journal of Biological Chemistry 2009 284 12 7446 7454 2-s2.0-65549103396 10.1074/jbc.M806209200
52. Han C. Y., Kargi A. Y., Omer M., Chan C. K., Wabitsch M., O'Brien K. D., Wight T. N., Chait A., Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes 2010 59 2 386 396 2-s2.0-77449092780 10.2337/db09-0925
53. Shi H., Kokoeva M. V., Inouye K., Tzameli I., Yin H., Flier J. S., TLR4 links innate immunity and fatty acid-induced insulin resistance. Journal of Clinical Investigation 2006 116 11 3015 3025 2-s2.0-33750584214 10.1172/JCI28898 (Pubitemid 44684486)
54. Subramanian S., Han C. Y., Chiba T., McMillen T. S., Wang S. A., Haw A., Kirk E. A., O'Brien K. D., Chait A., Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 4 685 691 2-s2.0-42249089547 10.1161/ATVBAHA.107.157685 (Pubitemid 351651333)
55. Saraswathi V., Gao L., Morrow J. D., Chait A., Niswender K. D., Hasty A. H., Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. Journal of Nutrition 2007 137 7 1776 1782 2-s2.0-34447126323 (Pubitemid 47037706)
56. Houstis N., Rosen E. D., Lander E. S., Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006 440 7086 944 948 2-s2.0-33645860825 10.1038/nature04634
57. Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M., Increased adipose tissue expression of tumor necrosis factor- α in human obesity and insulin resistance. Journal of Clinical Investigation 1995 95 5 2409 2415 2-s2.0-0028931724
58. Wang M., The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome. Nutrition & Metabolism 2005 2 1 3
59. Kirwan J. P., Hauguel-De Mouzon S., Lepercq J., Challier J. C., Huston-Presley L., Friedman J. E., Kalhan S. C., Catalano P. M., TNF- α is a predictor of insulin resistance in human pregnancy. Diabetes 2002 51 7 2207 2213 2-s2.0-0036307159 (Pubitemid 34729026)
60. Stoner H. B., Little R. A., Frayn K. N., The effect of sepsis on the oxidation of carbohydrate and fat. British Journal of Surgery 1983 70 1 32 35 2-s2.0-0020663631 (Pubitemid 13176026)
61. Rudich A., Tlrosh A., Potashnik R., Hemi R., Kanety H., Bashan N., Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 1998 47 10 1562 1569 2-s2.0-0031683542 10.2337/diabetes.47.10.1562 (Pubitemid 28445343)
62. Lin Y., Berg A. H., Iyengar P., Lam T. K. T., Giacca A., Combs T. P., Rajala M. W., Du X., Rollman B., Li W., Hawkins M., Barzilai N., Rhodes C. J., Fantus I. G., Brownlee M., Scherer P. E., The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. Journal of Biological Chemistry 2005 280 6 4617 4626 2-s2.0-20044363264 10.1074/jbc.M411863200 (Pubitemid 40288630)
63. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I., Increased oxidative stress in obesity and its impact on metabolic syndrome. Journal of Clinical Investigation 2004 114 12 1752 1761 2-s2.0-15244342531 10.1172/JCI200421625 (Pubitemid 40385531)
64. Urakawa H., Katsuki A., Sumida Y., Gabazza E. C., Murashima S., Morioka K., Maruyama N., Kitagawa N., Tanaka T., Hori Y., Nakatani K., Yano Y., Adachi Y., Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men. Journal of Clinical Endocrinology and Metabolism 2003 88 10 4673 4676 2-s2.0-10744222995 10.1210/jc.2003-030202 (Pubitemid 37357510)
65. Hand C. K., Rouleau G. A., Familial amyotrophic lateral sclerosis. Muscle and Nerve 2002 25 2 135 159 2-s2.0-0036163923 10.1002/mus.10001 (Pubitemid 34117061)
66. Kaneto H., Katakami N., Matsuhisa M., Matsuoka T. A., Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators of Inflammation 2010 2010 11 2-s2.0-77952480033 10.1155/2010/453892 453892
67. Summers S. A., Nelson D. H., A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome. Diabetes 2005 54 3 591 602 2-s2.0-14644445144 10.2337/diabetes.54.3. 591 (Pubitemid 40322059)
68. Di Paola M., Cocco T., Lorusso M., Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 2000 39 22 6660 6668 2-s2.0-0034612304 10.1021/bi9924415 (Pubitemid 30353998)
69. Summers S. A., Garza L. A., Zhou H., Birnbaum M. J., Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Molecular and Cellular Biology 1998 18 9 5457 5464 2-s2.0-0031841949 (Pubitemid 28388128)
70. Maechler P., Wollheim C. B., Mitochondrial function in normal and diabetic β -cells. Nature 2001 414 6865 807 812 2-s2.0-0035856942 10.1038/414807a (Pubitemid 34000784)
71. Rorsman P., The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 1997 40 5 487 495 2-s2.0-0030894850 10.1007/s001250050706 (Pubitemid 27186783)
72. Malaisse W. J., Hutton J. C., Kawazu S., The stimulus-secretion coupling of glucose-induced insulin release; XXXV. The links between metabolic and cationic events. Diabetologia 1979 16 5 331 341 2-s2.0-0018741768 (Pubitemid 9200511)
73. Soejima A., Inoue K., Takai D., Kaneko M., Ishihara H., Oka Y., Hayashi J. I., Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6. Journal of Biological Chemistry 1996 271 42 26194 26199 2-s2.0-0029966749 10.1074/jbc.271.42.26194 (Pubitemid 26347466)
74. Kennedy E. D., Maechler P., Wollheim C. B., Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes 1998 47 3 374 380 2-s2.0-0031892856 10.2337/diabetes.47.3.374 (Pubitemid 28104198)
75. Tsuruzoe K., Araki E., Furukawa N., Shirotani T., Matsumoto K., Kaneko K., Motoshima H., Yoshizato K., Shirakami A., Kishikawa H., Miyazaki J. I., Shichiri M., Creation and characterization of a mitochondrial DNA-depleted pancreatic β -cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas. Diabetes 1998 47 4 621 631 2-s2.0-17444440352 10.2337/diabetes.47.4.621 (Pubitemid 28160454)
76. Silva J. P., Köhler M., Graff C., Oldfors A., Magnuson M. A., Berggren P. O., Larsson N. G., Impaired insulin secretion and β -cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nature Genetics 2000 26 3 336 340 2-s2.0-0033762782 10.1038/81649
77. Wallace D. C., Mitochondrial diseases in man and mouse. Science 1999 283 5407 1482 1488 2-s2.0-0033525773 10.1126/science.283.5407.1482 (Pubitemid 29133350)
78. Antonetti D. A., Reynet C., Kahn C. R., Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus. Journal of Clinical Investigation 1995 95 3 1383 1388 2-s2.0-0028967724
79. Lee H. K., Song J. H., Shin C. S., Park D. J., Park K. S., Lee K. U., Koh C. S., Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Research and Clinical Practice 1998 42 3 161 167 2-s2.0-0032429843 10.1016/S0168-8227(98) 00110-7 (Pubitemid 29009776)
80. Maechler P., Jornot L., Wollheim C. B., Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. Journal of Biological Chemistry 1999 274 39 27905 27913 2-s2.0-0033600762 10.1074/jbc.274.39.27905 (Pubitemid 29458046)
81. Tiedge M., Lortz S., Drinkgern J., Lenzen S., Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997 46 11 1733 1742 2-s2.0-0030689041 (Pubitemid 27456404)
82. Acharya J. D., Ghaskadbi S. S., Islets and their antioxidant defense. Islets 2010 2 4 225 235 2-s2.0-77957037030 10.4161/isl.2.4.12219
83. Zhu X.-F., Zou H.-D., PEDF in diabetic retinopathy: a protective effect of oxidative stress. Journal of Biomedicine and Biotechnology 2012 2012 8 580687 10. 1155/2012/580687
84. Chen J. X., Stinnett A., Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity. Laboratory Investigation 2008 88 12 1316 1328 2-s2.0-56649086772 10.1038/labinvest.2008.92
85. Chapman I. M., Obesity in old age. Frontiers of Hormone Research 2008 36 97 106
86. Horvath T. L., Andrews Z. B., Diano S., Fuel utilization by hypothalamic neurons: roles for ROS. Trends in Endocrinology and Metabolism 2009 20 2 78 87 2-s2.0-63749097442 10.1016/j.tem.2008.10.003
87. Sorbara M. T., Girardin S. E., Mitochondrial ROS fuel the inflammasome. Cell Research 2011 21 4 558 560 2-s2.0-79954421862 10.1038/cr.2011.20
88. Tschopp J., Mitochondria: sovereign of inflammation? European Journal of Immunology 2011 41 5 1196 1202 2-s2.0-79955161193 10.1002/eji.201141436
89. Escames G., Lopez L. C., Garcia J. A., Garcia-Corzo L., Ortiz F., Acuna-Castroviejo D., Mitochondrial DNA and inflammatory diseases. Human Genetics 2012 131 2 161 173 10.1007/s00439-011-1057-y
90. Salminen A., Kaarniranta K., Kauppinen A., Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging 2012 4 3 166 175
91. Salminen A., Ojala J., Kaarniranta K., Kauppinen A., Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cellular and Molecular Life Sciences, 2012. In press 10. 1007/s00018-012-0962-0
92. Zhou R., Yazdi A. S., Menu P., Tschopp J., A role for mitochondria in NLRP3 inflammasome activation. Nature 2011 469 7329 221 225 2-s2.0-78651393239 10.1038/nature09663
93. Dostert C., Pétrilli V., Van Bruggen R., Steele C., Mossman B. T., Tschopp J., Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008 320 5876 674 677 2-s2.0-43249125839 10.1126/science.1156995 (Pubitemid 351928351)
94. Haase L. W., Bactericidal action of hydrogen peroxide, peroxides, and oxidizing compounds. Die Pharmazie 1950 5 9 436 437 2-s2.0-77049294964
95. Feng H., Xiang H., Zhang J., Genome-wide transcriptional profiling of the response of staphylococcus aureus to cryptotanshinone. Journal of Biomedicine and Biotechnology 2009 2009 8 617509 10. 1155/2009/617509
96. Schwarz K. B., Oxidative stress during viral infection: a review. Free Radical Biology and Medicine 1996 21 5 641 649 2-s2.0-0029782304 10.1016/0891-5849(96)00131-1 (Pubitemid 26331094)
97. Mandas A., Iorio E. L., Congiu M. G., Oxidative imbalance in HIV-1 infected patients treated with antiretroviral therapy. Journal of Biomedicine and Biotechnology 2009 7 749575 10. 1155/2009/749575, 2009
98. Shin D.-H., Martinez S. S., Parsons M., Jayaweera D. T., Campa A., Baum M. K., Relationship of oxidative stress with HIV disease progression in HIV/HCV co-infected and HIV Mono-infected adults in Miami international journal of bioscience. Biochemistry and Bioinformatics 2012 2 3 217 222
99. Tsai J.-H., Chen H.-W., Chen Y.-W., Liu J.-Y., Lii C.-K., The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin e in conjunction with DTT. Journal of Biomedicine and Biotechnology 2010 2010 7 2-s2.0-77953485564 10.1155/2010/486267 486267
100. Maioli E., Greci L., Soucek K., Hyzdalova M., Pecorelli A., Fortino V., Valacchi G., Rottlerin inhibits ROS formation and prevents NFB activation in MCF-7 and HT-29 cells. Journal of Biomedicine and Biotechnology 2009 2009 7 2-s2.0-77749316168 10.1155/2009/742936 742936
101. Samuhasaneeto S., Thong-Ngam D., Kulaputana O., Suyasunanont D., Klaikeaw N., Curcumin decreased oxidative stress, inhibited NF- κ B activation, and improved liver pathology in ethanol-induced liver injury in rats. Journal of Biomedicine and Biotechnology 2009 2009 8 2-s2.0-68949132656 10.1155/2009/981963 981963
102. Shan Q., Lu J., Zheng Y., Li J., Zhou Z., Hu B., Zhang Z., Fan S., Mao Z., Wang Y. J., Ma D., Purple sweet potato color ameliorates cognition deficits and attenuates oxidative damage and inflammation in aging mouse brain induced by D-galactose. Journal of Biomedicine and Biotechnology 2009 2009 9 2-s2.0-71149093864 10.1155/2009/564737 564737
103. Xia R., Zhao B., Wu Y., Ginsenoside Rb1 preconditioning enhances eNOS expression and attenuates myocardial ischemia/reperfusion injury in diabetic rats. Journal of Biomedicine and Biotechnology 2011 2011 8 767930 10. 1155/2011/767930
104. Cecere F., Iuliano A., Albano F., Zappelli C., Castellano I., Grimaldi P., Masullo M., De Vendittis E., Ruocco M. R., Diclofenac-induced apoptosis in the neuroblastoma cell line SH-SY5Y: possible involvement of the mitochondrial superoxide dismutase. Journal of Biomedicine and Biotechnology 2010 2010 11 2-s2.0-77954556789 10.1155/2010/801726 801726
105. De Beuf A., Hou X.-H., D'Haese P. C., Verhulst A., Epoetin delta reduces oxidative stress in primary human renal tubular cells. Journal of Biomedicine and Biotechnology 2010 2010 9 2-s2.0-77952526531 10.1155/2010/395785 395785
106. Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H. P., Ron D., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000 287 5453 664 666 2-s2.0-0034723235 10.1126/science.287.5453.664 (Pubitemid 30070916)
107. Özcan U., Cao Q., Yilmaz E., Lee A. H., Iwakoshi N. N., Özdelen E., Tuncman G., Görgün C., Glimcher L. H., Hotamisligil G. S., Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004 306 5695 457 461 2-s2.0-5644231992 10.1126/science.1103160 (Pubitemid 39372439)
108. Wellen K. E., Hotamisligil G. S., Inflammation, stress, and diabetes. Journal of Clinical Investigation 2005 115 5 1111 1119 2-s2.0-18244370762 10.1172/JCI200525102 (Pubitemid 40629025)
109. Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z. W., Karin M., Shoelson S. E., Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikk β Science 2001 293 5535 1673 1677 2-s2.0-0035979775 10.1126/science.1061620 (Pubitemid 32807849)
110. Cai D., Yuan M., Frantz D. F., Melendez P. A., Hansen L., Lee J., Shoelson S. E., Local and systemic insulin resistance resulting from hepatic activation of IKK- β and NF- κ B. Nature Medicine 2005 11 2 183 190 2-s2.0-14644427890 10.1038/nm1166 (Pubitemid 40321354)
111. Arkan M. C., Hevener A. L., Greten F. R., Maeda S., Li Z. W., Long J. M., Wynshaw-Boris A., Poli G., Olefsky J., Karin M., IKK- β links inflammation to obesity-induced insulin resistance. Nature Medicine 2005 11 2 191 198 2-s2.0-20044387026 10.1038/nm1185 (Pubitemid 40321355)
112. Meijer C. A., Le Haen P. A. A., Van Dijk R. A., Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study. Clinical Science 2012 122 421 428 10.1042/CS20110234