메뉴 건너뛰기




Volumn 51, Issue 7, 2012, Pages 769-781

Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: A critical commentary

Author keywords

Aging; Antioxidants; Cancer; Free radicals

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BIOLOGICAL MARKER; CYANOCOBALAMIN; FOLIC ACID; MINERAL; MOLYBDENUM; NICOTINIC ACID; PLACEBO; PYRIDOXINE; RETINOL; RETINOL PALMITATE; RIBOFLAVIN; SELENIUM; VITAMIN; ZINC; ZINC OXIDE;

EID: 84870249796     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0389-2     Document Type: Review
Times cited : (52)

References (111)
  • 1
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298-300
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 2
    • 0023988217 scopus 로고
    • Oxidative damage to DNA: Relation to species metabolic rate and lifespan
    • Adelman R, Saul RL, Ames BN (1988) Oxidative damage to DNA: relation to species metabolic rate and lifespan. Proc Natl Acad Sci USA 85(8):2706-2708
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.8 , pp. 2706-2708
    • Adelman, R.1    Saul, R.L.2    Ames, B.N.3
  • 3
    • 0019422226 scopus 로고
    • Can dietary betacarotene materially reduce human cancer rates
    • Peto R, Doll R, Buckley JD, Sporn MB (1981) Can dietary betacarotene materially reduce human cancer rates? Nature 290(5803):201-208
    • (1981) Nature , vol.290 , Issue.5803 , pp. 201-208
    • Peto, R.1    Doll, R.2    Buckley, J.D.3    Sporn, M.B.4
  • 5
    • 0033917594 scopus 로고    scopus 로고
    • Diet and overall survival in a cohort of very elderly people
    • DOI 10.1097/00001648-200007000-00013
    • Fortes C, Forastiere F, Farchi S, Rapiti E, Pastori G, Perucci CA (2000) Diet and overall survival in a cohort of very elderly people. Epidemiology 4:440-445 (Pubitemid 30428938)
    • (2000) Epidemiology , vol.11 , Issue.4 , pp. 440-445
    • Fortes, C.1    Forastiere, F.2    Farchi, S.3    Rapiti, E.4    Pastori, G.5    Perucci, C.A.6
  • 6
    • 0003452109 scopus 로고    scopus 로고
    • American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research, Washington DC, USA
    • American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research (1997) Food, nutrition, and the prevention of cancer: a global perspective. Washington DC, USA
    • (1997) Food, Nutrition, and the Prevention of Cancer: A Global Perspective
  • 7
    • 35448966378 scopus 로고    scopus 로고
    • American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research, Washington DC, USA
    • American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research (2007) Food, nutrition, PHYSICAL ACTIVITY and the prevention of cancer: a global perspective, Washington DC, USA
    • (2007) Food, Nutrition, PHYSICAL ACTIVITY and the Prevention of Cancer: A Global Perspective
  • 11
    • 0032837556 scopus 로고    scopus 로고
    • Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer
    • Tsubono Y, Tsugane S, Gey KF (1999) Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer. Nutr Cancer 34(1):56-61 (Pubitemid 29382916)
    • (1999) Nutrition and Cancer , vol.34 , Issue.1 , pp. 56-61
    • Tsubono, Y.1    Tsugane, S.2    Gey, K.F.3
  • 12
    • 33750900766 scopus 로고    scopus 로고
    • Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
    • Wright ME, Lawson KA, Weinstein SJ, Pietinen P, Taylor PR, Virtamo J, Albanes D (2006) Higher baseline serum concentrations of vitamin E are associated with lower total and causespecific mortality in the a-Tocopherol, b-Carotene Cancer Prevention Study. Am J Clin Nutr 84(5):1200-1207 (Pubitemid 44730393)
    • (2006) American Journal of Clinical Nutrition , vol.84 , Issue.5 , pp. 1200-1207
    • Wright, M.E.1    Lawson, K.A.2    Weinstein, S.J.3    Pietinen, P.4    Taylor, P.R.5    Virtamo, J.6    Albanes, D.7
  • 14
    • 65949087685 scopus 로고    scopus 로고
    • Associations between alpha-tocopherol, beta-carotene, and retinol and prostate cancer survival
    • Watters JL, Gail MH, Weinstein SJ, Virtamo J, Albanes D (2009) Associations between alpha-tocopherol, beta-carotene, and retinol and prostate cancer survival. Cancer Res 69(9): 3833-3841
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 3833-3841
    • Watters, J.L.1    Gail, M.H.2    Weinstein, S.J.3    Virtamo, J.4    Albanes, D.5
  • 15
    • 27744591426 scopus 로고    scopus 로고
    • Plasma carotene and α-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: The Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA)
    • Buijsse B, Feskens EJ, Schlettwein-Gsell D, Ferry M, Kok FJ, Kromhout D, de Groot LC (2005) Plasma carotene and alphatocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA). Am J Clin Nutr 82(4):879-886 (Pubitemid 43779704)
    • (2005) American Journal of Clinical Nutrition , vol.82 , Issue.4 , pp. 879-886
    • Buijsse, B.1    Feskens, E.J.M.2    Schlettwein-Gsell, D.3    Ferry, M.4    Kok, F.J.5    Kromhout, D.6    De Groot, L.C.P.G.M.7
  • 18
    • 79953766429 scopus 로고    scopus 로고
    • Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: The Third National Health and Nutrition Examination Survey
    • Shardell MD, Alley DE, Hicks GE, El-Kamary SS, Miller RR, Semba RD, Ferrucci L (2011) Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination Survey. Nutr Res 31(3):178-189
    • (2011) Nutr Res , vol.31 , Issue.3 , pp. 178-189
    • Shardell, M.D.1    Alley, D.E.2    Hicks, G.E.3    El-Kamary, S.S.4    Miller, R.R.5    Semba, R.D.6    Ferrucci, L.7
  • 19
    • 4444347122 scopus 로고    scopus 로고
    • Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study
    • DOI 10.1038/sj.ejcn.1601945
    • Brevik A, Andersen LF, Karlsen A, Trygg KU, Blomhoff R, Drevon CA (2004) Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study. Eur J Clin Nutr 58(8):1166-1173 (Pubitemid 39172391)
    • (2004) European Journal of Clinical Nutrition , vol.58 , Issue.8 , pp. 1166-1173
    • Brevik, A.1    Andersen, L.F.2    Karlsen, A.3    Trygg, K.U.4    Blomhoff, R.5    Drevon, C.A.6
  • 21
  • 22
    • 0028895586 scopus 로고
    • A comparison of lymphocyte micronuclei and plasma micronutrients in vegetarians and nonvegetarians
    • Fenech M, Rinaldi J (1995) A comparison of lymphocyte micronuclei and plasma micronutrients in vegetarians and nonvegetarians. Carcinogenesis 16:223-230
    • (1995) Carcinogenesis , vol.16 , pp. 223-230
    • Fenech, M.1    Rinaldi, J.2
  • 24
    • 84859890126 scopus 로고    scopus 로고
    • Correlation between oxidative stress and antioxidant defence in South Indian urban vegetarians and non-vegetarians
    • Somannavar MS, Kodliwadmath MV (2012) Correlation between oxidative stress and antioxidant defence in South Indian urban vegetarians and non-vegetarians. Eur Rev Med Pharmacol Sci 16(3):351-354
    • (2012) Eur Rev Med Pharmacol Sci , vol.16 , Issue.3 , pp. 351-354
    • Somannavar, M.S.1    Kodliwadmath, M.V.2
  • 25
    • 0032405860 scopus 로고    scopus 로고
    • Serum carotenoids and oxidative DNA damage in human lymphocytes
    • DOI 10.1093/carcin/19.12.2159
    • Collins AR, Olmedilla B, Southon S, Granado F, Duthie SJ (1998) Serum carotenoids and oxidative DNA damage in human lymphocytes. Carcinogenesis 19(12):2159-2162 (Pubitemid 29010256)
    • (1998) Carcinogenesis , vol.19 , Issue.12 , pp. 2159-2162
    • Collins, A.R.1    Olmedilla, B.2    Southon, S.3    Granado, F.4    Duthie, S.J.5
  • 28
    • 0028007092 scopus 로고    scopus 로고
    • DNA oxidative damage and life expectancy in houseflies
    • Agarwal S, Sohal RS (2004) DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci USA 91(25): 12332-12335
    • (2004) Proc Natl Acad Sci USA , vol.91 , Issue.25 , pp. 12332-12335
    • Agarwal, S.1    Sohal, R.S.2
  • 29
    • 31344439942 scopus 로고    scopus 로고
    • 10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice
    • DOI 10.1016/j.freeradbiomed.2005.08.037, PII S089158490500496X
    • Sohal RS, Kamzalov S, Sumien N, Ferguson M, Rebrin I, Heinrich KR, Forster MJ (2006) Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and lifespan of mice. Free Radic Biol Med 40(3):480-487 (Pubitemid 43139683)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.3 , pp. 480-487
    • Sohal, R.S.1    Kamzalov, S.2    Sumien, N.3    Ferguson, M.4    Rebrin, I.5    Heinrich, K.R.6    Forster, M.J.7
  • 31
    • 0029051426 scopus 로고
    • Oxidative DNA damage and senescence of human diploid fibroblast cells
    • Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 92(10):4337-4341
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.10 , pp. 4337-4341
    • Chen, Q.1    Fischer, A.2    Reagan, J.D.3    Yan, L.J.4    Ames, B.N.5
  • 33
    • 75149126964 scopus 로고    scopus 로고
    • Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
    • Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H (2009) Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci 64(12):1212-1220
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , Issue.12 , pp. 1212-1220
    • Zhang, Y.1    Ikeno, Y.2    Qi, W.3    Chaudhuri, A.4    Li, Y.5    Bokov, A.6    Thorpe, S.R.7    Baynes, J.W.8    Epstein, C.9    Richardson, A.10    Van Remmen, H.11
  • 34
    • 77955503270 scopus 로고    scopus 로고
    • Decreased energy metabolism extends lifespan in Caenorhabditis elegans without reducing oxidative damage
    • Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, Hekimi S (2010) Decreased energy metabolism extends lifespan in Caenorhabditis elegans without reducing oxidative damage. Genetics 185(2):559-571
    • (2010) Genetics , vol.185 , Issue.2 , pp. 559-571
    • Van Raamsdonk, J.M.1    Meng, Y.2    Camp, D.3    Yang, W.4    Jia, X.5    Bénard, C.6    Hekimi, S.7
  • 35
    • 84860390185 scopus 로고    scopus 로고
    • Increased lifespan from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage
    • Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, Gems D (2011) Increased lifespan from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med 51(8):1575-1582
    • (2011) Free Radic Biol Med , vol.51 , Issue.8 , pp. 1575-1582
    • Cabreiro, F.1    Ackerman, D.2    Doonan, R.3    Araiz, C.4    Back, P.5    Papp, D.6    Braeckman, B.P.7    Gems, D.8
  • 38
    • 0021745195 scopus 로고
    • Dietary vitamin C improves the survival of mice
    • Massie HR, Aiello VR, Doherty TJ (1984) Dietary vitamin C improves the survival of mice. Gerontology 30(6):371-375 (Pubitemid 15176249)
    • (1984) Gerontology , vol.30 , Issue.6 , pp. 371-375
    • Massie, H.R.1    Aiello, V.R.2    Doherty, T.J.3
  • 39
    • 0023009839 scopus 로고
    • Effect of dietary β-carotene on the survival of young and old mice
    • Massie HR, Ferreira JR Jr, DeWolfe LK (1986) Effect of dietary beta-carotene on the survival of young and old mice. Gerontology 32(4):189-195 (Pubitemid 17168364)
    • (1986) Gerontology , vol.32 , Issue.4 , pp. 189-195
    • Massie, H.R.1    Ferreira Jr., J.R.2    DeWolfe, L.K.3
  • 40
    • 0024273208 scopus 로고
    • Vitamin E supplementation and intense selection increase clonal life span in Paramecium tetraurelia
    • DOI 10.1016/0531-5565(88)90062-9
    • Thomas J, Nyberg D (1988) Vitamin E supplementation and intense selection increase clonal lifespan in Paramecium tetraurelia. Exp Gerontol 23(6):501-512 (Pubitemid 19000324)
    • (1988) Experimental Gerontology , vol.23 , Issue.6 , pp. 501-512
    • Thomas, J.1    Nyberg, D.2
  • 41
    • 0028122475 scopus 로고
    • Effect of BHA on longevity, antioxygenic enzymes and peroxides in Callosobruchus maculatus
    • DOI 10.1016/0531-5565(94)90041-8
    • Mahajan S, Garg SK, Lobana TS (1994) Effect of BHA on longevity, antioxygenic enzymes and peroxides in Callosobruchus maculatus. Exp Gerontol 29(5):585-591 (Pubitemid 24294550)
    • (1994) Experimental Gerontology , vol.29 , Issue.5 , pp. 585-591
    • Mahajan, S.1
  • 42
    • 0029058728 scopus 로고
    • The spin-trap N-tertalpha- phenyl-butylnitrone prolongs the lifespan of the senescence accelerated mouse
    • Edamatsu R, Mori A, Packer L (1995) The spin-trap N-tertalpha- phenyl-butylnitrone prolongs the lifespan of the senescence accelerated mouse. Biochem Biophys Res Commun 211(3):847-849
    • (1995) Biochem Biophys Res Commun , vol.211 , Issue.3 , pp. 847-849
    • Edamatsu, R.1    Mori, A.2    Packer, L.3
  • 43
    • 0030983324 scopus 로고    scopus 로고
    • Effect of "beta CATECHIN" on the life span of senescence accelerated mice (SAM-P8 strain)
    • Kumari MV, Yoneda T, Hiramatsu M (1997) Effect of "beta CATECHIN" on the life span of senescence accelerated mice (SAM-P8 strain). Biochem Mol Biol Int 41(5):1005-1011
    • (1997) Biochem Mol Biol Int , vol.41 , Issue.5 , pp. 1005-1011
    • Kumari, M.V.1    Yoneda, T.2    Hiramatsu, M.3
  • 44
    • 0032536389 scopus 로고    scopus 로고
    • Longevity of exercising male rats: Effect of an antioxidant supplemented diet
    • DOI 10.1016/S0047-6374(97)00140-1, PII S0047637497001401
    • Holloszy JO (1998) Longevity of exercising male rats: effect of an antioxidant supplemented diet. Mech Aging Dev 100(3): 211-219 (Pubitemid 28146702)
    • (1998) Mechanisms of Ageing and Development , vol.100 , Issue.3 , pp. 211-219
    • Holloszy, J.O.1
  • 45
    • 0033257950 scopus 로고    scopus 로고
    • Effects of lu-duo-wei capsule on prolonging lifespan of housefly and Drosophila melanogaster
    • Cui X, Dai XG, Li WB, Zhang BL, Fang YZ (1999) Effects of lu-duo-wei capsule on prolonging lifespan of housefly and Drosophila melanogaster. Am J Chin Med 27(3-4):407-413
    • (1999) Am J Chin Med , vol.27 , Issue.3-4 , pp. 407-413
    • Cui, X.1    Dai, X.G.2    Li, W.B.3    Zhang, B.L.4    Fang, Y.Z.5
  • 47
    • 11244327638 scopus 로고    scopus 로고
    • Establishing the background level of base oxidation in human lymphocyte DNA: Results of an inter-laboratory validation study
    • ESCODD
    • ESCODD, Gedik CM, Collins A (2004) Establishing the background level of base oxidation in human lymphocyte DNA: results of an inter-laboratory validation study. FASEB J. www.fasebj.org/cgi/doi/10.1096/fj.04-1767fje
    • (2004) FASEB J
    • Gedik, C.M.1    Collins, A.2
  • 48
    • 3042686779 scopus 로고    scopus 로고
    • Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair
    • DOI 10.1016/j.mrfmmm.2004.02.018, PII S0027510704001435
    • Møller P, Loft S (2004) Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair. Mutat Res 551:79-89 (Pubitemid 38833498)
    • (2004) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.551 , Issue.1-2 , pp. 79-89
    • Moller, P.1    Loft, S.2
  • 49
    • 0029998738 scopus 로고    scopus 로고
    • Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes
    • Duthie SJ, Ma A, Ross MA, Collins AR (1996) Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 56(6):1291-1295 (Pubitemid 26080971)
    • (1996) Cancer Research , vol.56 , Issue.6 , pp. 1291-1295
    • Duthie, S.J.1    Ma, A.2    Ross, M.A.3    Collins, A.R.4
  • 50
    • 3042520332 scopus 로고    scopus 로고
    • Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers
    • DOI 10.1007/s00394-004-0470-6
    • Møller P, Viscovich M, Lykkesfeld J, Loft S, Jensen A, Poulsen HE (2004) Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. Eur J Nutr 43:267-274 (Pubitemid 39371620)
    • (2004) European Journal of Nutrition , vol.43 , Issue.5 , pp. 267-274
    • Moller, P.1    Viscovich, M.2    Lykkesfeldt, J.3    Loft, S.4    Jensen, A.5    Poulsen, H.E.6
  • 51
    • 0037354821 scopus 로고    scopus 로고
    • Nutritional modulation of DNA repair in a human intervention study
    • DOI 10.1093/carcin/24.3.511
    • Collins AR, Harrington V, Drew J, Melvin R (2003) Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis 24:511-515 (Pubitemid 36432648)
    • (2003) Carcinogenesis , vol.24 , Issue.3 , pp. 511-515
    • Collins, A.R.1    Harrington, V.2    Drew, J.3    Melvin, R.4
  • 53
    • 79955953728 scopus 로고    scopus 로고
    • Supplementation of a western diet with golden kiwifruits (Actinidia chinensis var'.Hort 16A':) effects on biomarkers of oxidation damage and antioxidant protection
    • Brevik A, Gaivão I, Medin T, Jørgenesen A, Piasek A, Eliasson J, Karlsen A, Blomhoff R, Veggan T, Duttaroy AK, Collins AR (2011) Supplementation of a western diet with golden kiwifruits (Actinidia chinensis var'.Hort 16A':) effects on biomarkers of oxidation damage and antioxidant protection. Nutr J 18(10):54
    • (2011) Nutr J , vol.18 , Issue.10 , pp. 54
    • Brevik, A.1    Gaivão, I.2    Medin, T.3    Jørgenesen, A.4    Piasek, A.5    Eliasson, J.6    Karlsen, A.7    Blomhoff, R.8    Veggan, T.9    Duttaroy, A.K.10    Collins, A.R.11
  • 54
  • 56
    • 0033941891 scopus 로고    scopus 로고
    • The effects of vitamin C and vitamin E on oxidative DNA damage: Results from a randomized controlled trial
    • Huang HY, Helzlsouer KJ, Appel LJ (2000) The effects of vitamin C and vitamin E on oxidative DNA damage: results from a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 7:647-652 (Pubitemid 30482693)
    • (2000) Cancer Epidemiology Biomarkers and Prevention , vol.9 , Issue.7 , pp. 647-652
    • Huang, H.-Y.1    Helzlsouer, K.J.2    Appel, L.J.3
  • 61
    • 0032913315 scopus 로고    scopus 로고
    • Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA
    • DOI 10.2337/diabetes.48.1.176
    • Lean MEJ, Noroozi M, Kelly I, Burns J, Talwar D, Sattar N, Crozier A (1999) Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 48:176-181 (Pubitemid 29019370)
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 176-181
    • Lean, M.E.J.1    Noroozi, M.2    Kelly, I.3    Burns, J.4    Talwar, D.5    Sattar, N.6    Crozier, A.7
  • 63
    • 81055134838 scopus 로고    scopus 로고
    • Increasing the vegetable intake dose is associated with a rise in plasma carotenoids without modifying oxidative stress or inflammation in overweight or obese postmenopausal women
    • Crane TE, Kubota C, West JL, Kroggel MA, Wertheim BC, Thomson CA (2011) Increasing the vegetable intake dose is associated with a rise in plasma carotenoids without modifying oxidative stress or inflammation in overweight or obese postmenopausal women. J Nutr 141(10):1827-1833
    • (2011) J Nutr , vol.141 , Issue.10 , pp. 1827-1833
    • Crane, T.E.1    Kubota, C.2    West, J.L.3    Kroggel, M.A.4    Wertheim, B.C.5    Thomson, C.A.6
  • 64
    • 0024341197 scopus 로고
    • Chemoprevention of experimental carcinogenesis in animals
    • DOI 10.1016/0091-7435(89)90031-5
    • Moon RC, Mehta RG (1989) Chemoprevention of experimental carcinogenesis in animals. Prev Med 18(5):576-591 (Pubitemid 20009353)
    • (1989) Preventive Medicine , vol.18 , Issue.5 , pp. 576-591
    • Moon, R.C.1    Mehta, R.G.2
  • 66
    • 0034492496 scopus 로고    scopus 로고
    • Role of diet modification in cancer prevention
    • Abdulla M, Gruber P (2000) Role of diet modification in cancer prevention. BioFactors 12(1-4):45-51 (Pubitemid 32107384)
    • (2000) BioFactors , vol.12 , Issue.1-4 , pp. 45-51
    • Abdulla, M.1    Gruber, P.2
  • 68
    • 0030916162 scopus 로고    scopus 로고
    • Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction
    • DOI 10.1016/S0140-6736(97)01234-8
    • Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR, Heinonen OP (1997) Randomised trial of alphatocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349(9067):1715-1720 (Pubitemid 27252669)
    • (1997) Lancet , vol.349 , Issue.9067 , pp. 1715-1720
    • Rapola, J.M.1    Virtamo, J.2    Ripatti, S.3    Huttunen, J.K.4    Albanes, D.5    Taylor, P.R.6    Heinonen, O.P.7
  • 70
    • 3042621001 scopus 로고    scopus 로고
    • Effect of α-tocopherol and β-carotene supplementation on coronary heart disease during the 6-year post-trial follow-up in the ATBC study
    • DOI 10.1016/j.ehj.2004.05.007, PII S0195668X04003124
    • Törnwall ME, Virtamo J, Korhonen PA, Virtanen MJ, Taylor PR, Albanes D, Huttunen JK (2004) Effect of alpha-tocopherol and beta-carotene supplementation on coronary heart disease during the 6-year post-trial follow-up in the ATBC study. Eur Heart J 25(13):1171-1178 (Pubitemid 38834075)
    • (2004) European Heart Journal , vol.25 , Issue.13 , pp. 1171-1178
    • Tornwall, M.E.1    Virtamo, J.2    Korhonen, P.A.3    Virtanen, M.J.4    Taylor, P.R.5    Albanes, D.6    Huttunen, J.K.7
  • 71
    • 10644263516 scopus 로고    scopus 로고
    • The Beta-Carotene and Retinol Efficacy Trial: Incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping β-carotene and retinol supplements
    • DOI 10.1093/jnci/djh320
    • Goodman GE, Thornquist MD, Balmes J, Cullen MR, Meyskens FL Jr, Omenn GS, Valanis B, Williams JH Jr (2004) The betacarotene and retinol efficacy trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst 96(23):1743-1750 (Pubitemid 39654568)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.23 , pp. 1743-1750
    • Goodman, G.E.1    Thornquist, M.D.2    Balmes, J.3    Cullen, M.R.4    Meykens Jr., F.L.5    Omenn, G.S.6    Valanis, B.7    Williams Jr., J.H.8
  • 73
    • 0029925181 scopus 로고    scopus 로고
    • Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
    • DOI 10.1016/S0140-6736(96)90866-1
    • Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ (1996) Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347(9004):781-786 (Pubitemid 26091640)
    • (1996) Lancet , vol.347 , Issue.9004 , pp. 781-786
    • Stephens, N.G.1    Parsons, A.2    Schofield, P.M.3    Kelly, F.4    Cheeseman, K.5    Mitchinson, M.J.6    Brown, M.J.7
  • 74
    • 0001518392 scopus 로고    scopus 로고
    • Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin e after myocardial infarction: Results of the GISSI-Prevenzione trial
    • GISSI
    • GISSI (1999) Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354(9177):447-455
    • (1999) Lancet , vol.354 , Issue.9177 , pp. 447-455
  • 75
    • 0034688195 scopus 로고    scopus 로고
    • Vitamin E supplementation and cardiovascular events in high-risk patients
    • DOI 10.1056/NEJM200001203420302
    • Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P (2000) Vitamin E supplementation and cardiovascular events in highrisk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 342(3):154-160 (Pubitemid 30051646)
    • (2000) New England Journal of Medicine , vol.342 , Issue.3 , pp. 154-160
    • Yusuf, S.1
  • 79
    • 2342646106 scopus 로고    scopus 로고
    • Associations of Mortality with Ocular Disorders and an Intervention of High-Dose Antioxidants and Zinc in the Age-Related Eye Disease Study: AREDS Report No. 13
    • DOI 10.1001/archopht.122.5.716
    • Clemons TE, Kurinij N, Sperduto RD (2004) AREDS Research Group. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the age-related eye disease. Arch Ophthalmol 122(5):716-726 (Pubitemid 38607400)
    • (2004) Archives of Ophthalmology , vol.122 , Issue.5 , pp. 716-726
    • Clemons, T.E.1    Kurinij, N.2    Sperduto, R.D.3    Bressler, S.B.4
  • 80
    • 55549119313 scopus 로고    scopus 로고
    • Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: A randomized trial
    • Zhang SM, Cook NR, Albert CM, Gaziano JM, Buring JE, Manson JE (2008) Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA 300(17):2012-2021
    • (2008) JAMA , vol.300 , Issue.17 , pp. 2012-2021
    • Zhang, S.M.1    Cook, N.R.2    Albert, C.M.3    Gaziano, J.M.4    Buring, J.E.5    Manson, J.E.6
  • 83
    • 77956994609 scopus 로고    scopus 로고
    • Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: A post-intervention follow-up in the SU.VI.MAX study
    • Hercberg S, Kesse-Guyot E, Druesne-Pecollo N, Touvier M, Favier A, Latino-Martel P, Briançon S, Galan P (2010) Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: a post-intervention follow-up in the SU.VI.MAX study. Int J Cancer 127(8):1875-1881
    • (2010) Int J Cancer , vol.127 , Issue.8 , pp. 1875-1881
    • Hercberg, S.1    Kesse-Guyot, E.2    Druesne-Pecollo, N.3    Touvier, M.4    Favier, A.5    Latino-Martel, P.6    Briançon, S.7    Galan, P.8
  • 84
    • 0037031094 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360(9326):23-33
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 23-33
  • 88
    • 0038116394 scopus 로고    scopus 로고
    • Incidence of Cancer and Mortality Following α-Tocopherol and β-Carotene Supplementation: A Postintervention Follow-up
    • DOI 10.1001/jama.290.4.476
    • Virtamo J, Pietinen P, Huttunen JK, Korhonen P, Malila N, Virtanen MJ, Albanes D, Taylor PR, Albert P, ATBC Study Group (2003) Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA 290(4):476-485 (Pubitemid 37430501)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.4 , pp. 476-485
    • Virtamo, J.1
  • 92
    • 77953452943 scopus 로고    scopus 로고
    • Beta-carotene supplementation and cancer risk: A systematic review and metaanalysis of randomized controlled trials
    • Druesne-Pecollo N, Latino-Martel P, Norat T, Barrandon E, Bertrais S, Galan P, Hercberg S (2010) Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Int J Cancer 127(1):172-184
    • (2010) Int J Cancer , vol.127 , Issue.1 , pp. 172-184
    • Druesne-Pecollo, N.1    Latino-Martel, P.2    Norat, T.3    Barrandon, E.4    Bertrais, S.5    Galan, P.6    Hercberg, S.7
  • 94
    • 84863154674 scopus 로고    scopus 로고
    • Effects of beta-carotene supplements on cancer prevention: Meta-analysis of randomized controlled trials
    • Jeon YJ, Myung SK, Lee EH, Kim Y, Chang YJ, Ju W, Cho HJ, Seo HG, Huh BY (2011) Effects of beta-carotene supplements on cancer prevention: meta-analysis of randomized controlled trials. Nutr CancerNov 63(8):1196-1207
    • (2011) Nutr CancerNov , vol.63 , Issue.8 , pp. 1196-1207
    • Jeon, Y.J.1    Myung, S.K.2    Lee, E.H.3    Kim, Y.4    Chang, Y.J.5    Ju, W.6    Cho, H.J.7    Seo, H.G.8    Huh, B.Y.9
  • 98
    • 80053054596 scopus 로고    scopus 로고
    • Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: A systematic review and meta-analysis
    • Papaioannou D, Cooper KL, Carroll C, Hind D, Squires H, Tappenden P, Logan RF (2011) Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: a systematic review and meta-analysis. Colorectal Dis 13(10):1085-1099
    • (2011) Colorectal Dis , vol.13 , Issue.10 , pp. 1085-1099
    • Papaioannou, D.1    Cooper, K.L.2    Carroll, C.3    Hind, D.4    Squires, H.5    Tappenden, P.6    Logan, R.F.7
  • 103
    • 55549119313 scopus 로고    scopus 로고
    • Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: A randomized trial
    • Zhang SM, Cook NR, Albert CM, Gaziano JM, Buring JE, Manson JE (2008) Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA 300(17):2012-2021
    • (2008) JAMA , vol.300 , Issue.17 , pp. 2012-2021
    • Zhang, S.M.1    Cook, N.R.2    Albert, C.M.3    Gaziano, J.M.4    Buring, J.E.5    Manson, J.E.6
  • 105
    • 84861927005 scopus 로고    scopus 로고
    • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    • issue , Wiley, New York
    • Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2010) Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. The Cochrane Collaboration, issue 1, Wiley, New York
    • (2010) The Cochrane Collaboration , Issue.1
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 108
    • 0010607277 scopus 로고
    • The effect of vitamin e and b-carotene on the incidence of lung cancer and other cancers in male smokers
    • The a-Tocopherol and b-Carotene Cancer Prevention Study Group
    • The a-Tocopherol and b-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and b-carotene on the incidence of lung cancer and other cancers in male smokers. New Engl J Med 330:1029-1035
    • (1994) New Engl J Med , vol.330 , pp. 1029-1035
  • 111
    • 84871335640 scopus 로고    scopus 로고
    • Direzione Generale Igiene e Sicurezza Degli Alimenti e della Nutrizione Commissione Unica per la Dietetica e la Nutrizione
    • Dipartimento Sanita' Pubblica Veterinaria, Sicurezza Alimentare E Organi Collegiali Per La Tutela Della Salute., Ministero Della Salute, Rome, Italy
    • Dipartimento Sanita' Pubblica Veterinaria, Sicurezza Alimentare E Organi Collegiali Per La Tutela Della Salute. Direzione Generale Igiene E Sicurezza Degli Alimenti E Della Nutrizione Commissione Unica Per La Dietetica E La Nutrizione. Uso Di Prodotti Naturali Come Tisane Ed Integratori Alimentari Da Parte Dei Gruppi Più Vulnerabili Della Popolazione Come Bambini E Donne In Gravidanza O Durante L'allattamento. Ministero Della Salute, Rome, Italy, 2012
    • (2012) Uso di Prodotti Naturali Come Tisane Ed Integratori Alimentari da Parte Dei Gruppi Più Vulnerabili della Popolazione Come Bambini e Donne in Gravidanza O Durante l'Allattamento


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.