Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Nature

Volumn 475, Issue 7354, 2011, Pages 106-110

  Denicola, Gina M ^a,b   Karreth, Florian A ^a,c   Humpton, Timothy J ^a   Gopinathan, Aarthi ^a,b   Wei, Cong ^d   Frese, Kristopher ^a   Mangal, Dipti ^d   Yu, Kenneth H ^d   Yeo, Charles J ^e   Calhoun, Eric S ^f   Scrimieri, Francesca ^g   Winter, Jordan M ^g   Hruban, Ralph H ^g   Iacobuzio Donahue, Christine ^g   Kern, Scott E ^g   Blair, Ian A ^d   Tuveson, David A ^a  

^a CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f ALMA COLLEGE   (United States)

^g DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT; CANCER; GENE EXPRESSION; MUTATION; TOXICITY; TUMOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DETOXIFICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; MOUSE; NEOPLASM; NONHUMAN; ONCOGENE; ONCOGENE K RAS; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TUMOR CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYTOSKELETAL PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENES, MYC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-E2-RELATED FACTOR 2; NIH 3T3 CELLS; ONCOGENES; OXIDATION-REDUCTION; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); REACTIVE OXYGEN SPECIES;

MURINAE; MUS;

EID: 79960060305     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10189     Document Type: Article

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