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Volumn 19, Issue 11, 2013, Pages 2011-2031

The clinical applications of curcumin: Current state and the future

Author keywords

Bioavailability; Cancer; Clinical application; Curcumin; Inflammation

Indexed keywords

ANTINEOPLASTIC AGENT; BIOPERINE; C3 COMPLEX; CAPECITABINE; CURCUMIN; DEMETHOXYCURCUMIN; DICLOFENAC; DIDEMETHOXYCURCUMIN; DOCETAXEL; ESTRADIOL VALERATE; FLUOROURACIL; FOLINIC ACID; GINKGO BILOBA EXTRACT; MESALAZINE; OXALIPLATIN; PHENYLBUTAZONE; PIPERINE; PLACEBO; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG;

EID: 84875388603     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161213805289255     Document Type: Article
Times cited : (121)

References (232)
  • 1
    • 27844474247 scopus 로고    scopus 로고
    • Drug discovery from medicinal plants
    • Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci 2005; 78: 431-41.
    • (2005) Life Sci , vol.78 , pp. 431-441
    • Balunas, M.J.1    Kinghorn, A.D.2
  • 2
    • 11344292132 scopus 로고    scopus 로고
    • The role of natural product chemistry in drug discovery
    • Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod 2004; 67: 2141-53.
    • (2004) J Nat Prod , vol.67 , pp. 2141-2153
    • Butler, M.S.1
  • 3
    • 29044445562 scopus 로고    scopus 로고
    • Medicinal plants: Traditions of yesterday and drugs of tomorrow
    • Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Asp Med 2006; 27: 1-93.
    • (2006) Mol Asp Med , vol.27 , pp. 1-93
    • Gurib-Fakim, A.1
  • 4
    • 34247109045 scopus 로고    scopus 로고
    • Natural Products as Sources of New Drugs over the Last 25 Years
    • Newman DJ, Cragg GM. Natural Products as Sources of New Drugs over the Last 25 Years. J Nat Prod 2007; 70: 461-77.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 5
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003; 66: 1022-37.
    • (2003) J Nat Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 6
    • 27944493214 scopus 로고    scopus 로고
    • Integrated approaches towards drug development from Ayurveda and other Indian system of medicines
    • Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol 2006; 103: 25-35.
    • (2006) J Ethnopharmacol , vol.103 , pp. 25-35
    • Mukherjee, P.K.1    Wahile, A.2
  • 7
    • 0026093041 scopus 로고
    • Pharmacology of Curcuma longa
    • Ammon H, Wahl MA. Pharmacology of Curcuma longa. Planta Med 1991; 57: 1-7.
    • (1991) Planta Med , vol.57 , pp. 1-7
    • Ammon, H.1    Wahl, M.A.2
  • 12
    • 9644303070 scopus 로고    scopus 로고
    • Antioxidant availability of turmeric in relation to its medicinal and culinary uses
    • Tilak JC, Banerjee M, Mohan H, Devasagayam T. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res 2004; 18: 798-804.
    • (2004) Phytother Res , vol.18 , pp. 798-804
    • Tilak, J.C.1    Banerjee, M.2    Mohan, H.3    Devasagayam, T.4
  • 14
    • 0028821016 scopus 로고
    • Hypertension and the pathogenesis of atherosclerosis-oxidative stress and the mediation of arterial inflammatory response-a new perspective
    • Alexander RW. Hypertension and the pathogenesis of atherosclerosis-oxidative stress and the mediation of arterial inflammatory response-a new perspective. Hypertension 1995; 25: 155-61.
    • (1995) Hypertension , vol.25 , pp. 155-161
    • Alexander, R.W.1
  • 15
    • 0029153361 scopus 로고
    • Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action
    • Keaney JF, Vita JA. Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis 1995; 38: 129-54.
    • (1995) Prog Cardiovasc Dis , vol.38 , pp. 129-154
    • Keaney, J.F.1    Vita, J.A.2
  • 17
    • 0028937961 scopus 로고
    • Gene-expression in acute myocardial stress-induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress
    • Das DK, Maulik N, Moraru, II. Gene-expression in acute myocardial stress-induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress. J Mol Cell Cardiol 1995; 27: 181-93.
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 181-193
    • Das, D.K.1    Maulik, N.2    Moraru, I.I.3
  • 19
    • 0035257624 scopus 로고    scopus 로고
    • Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease
    • Yoshizumi M, Tsuchiya K, Tamaki T. Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease. J Med Investig 2001; 48: 11-24.
    • (2001) J Med Investig , vol.48 , pp. 11-24
    • Yoshizumi, M.1    Tsuchiya, K.2    Tamaki, T.3
  • 20
    • 0345258505 scopus 로고    scopus 로고
    • Oxidative stress-induced signal transduction pathways in cardiac myocytes: Involvement of ROS in heart diseases
    • Takano H, Zou YZ, Hasegawa H, Akazawa H, Nagai T, Komuro I. Oxidative stress-induced signal transduction pathways in cardiac myocytes: Involvement of ROS in heart diseases. Antioxid Redox Signal 2003; 5: 789-94.
    • (2003) Antioxid Redox Signal , vol.5 , pp. 789-794
    • Takano, H.1    Zou, Y.Z.2    Hasegawa, H.3    Akazawa, H.4    Nagai, T.5    Komuro, I.6
  • 21
    • 0028134769 scopus 로고
    • Role of capsaicin, curcumin and dietary-N-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages
    • Joe B, Lokesh B. Role of capsaicin, curcumin and dietary-N-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1994; 1224: 255-63.
    • (1994) Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research , vol.1224 , pp. 255-263
    • Joe, B.1    Lokesh, B.2
  • 22
    • 0034655773 scopus 로고    scopus 로고
    • Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    • Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 2000; 28: 1303-12.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1303-1312
    • Motterlini, R.1    Foresti, R.2    Bassi, R.3    Green, C.J.4
  • 24
    • 34147165621 scopus 로고    scopus 로고
    • Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition
    • McNally SJ, Harrison EM, Ross JA, Garden OJ, Wigmore SJ. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int J Mol Med 2007; 19: 165-72.
    • (2007) Int J Mol Med , vol.19 , pp. 165-172
    • McNally, S.J.1    Harrison, E.M.2    Ross, J.A.3    Garden, O.J.4    Wigmore, S.J.5
  • 25
    • 79952601821 scopus 로고    scopus 로고
    • Interaction of a curcumin analogue dimethoxycurcumin with DNA
    • Kunwar A, Simon E, Singh U, et al. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des 2011; 77: 281-7.
    • (2011) Chem Biol Drug Des , vol.77 , pp. 281-287
    • Kunwar, A.1    Simon, E.2    Singh, U.3
  • 27
    • 0035002201 scopus 로고    scopus 로고
    • Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells
    • Moragoda L, Jaszewski R, Majumdar APN. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 2001; 21: 873-8.
    • (2001) Anticancer Res , vol.21 , pp. 873-878
    • Moragoda, L.1    Jaszewski, R.2    Majumdar, A.P.N.3
  • 28
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-X-L and IAP, the release of cytochrome c and inhibition of Akt
    • Woo JH, Kim YH, Choi YJ, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-X-L and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003; 24: 1199-208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3
  • 29
    • 0034836540 scopus 로고    scopus 로고
    • Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
    • Pan MH, Chang WL, Lin-Shiau SY, Ho CT, Lin JK. Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J Agric Food Chem 2001; 49: 1464-74.
    • (2001) J Agric Food Chem , vol.49 , pp. 1464-1474
    • Pan, M.H.1    Chang, W.L.2    Lin-Shiau, S.Y.3    Ho, C.T.4    Lin, J.K.5
  • 30
    • 54049145466 scopus 로고    scopus 로고
    • DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade-and mitochondrial-dependent pathway
    • Lin S-S, Huang H-P, Yang J-S, et al. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade-and mitochondrial-dependent pathway. Cancer Lett 2008; 272: 77-90.
    • (2008) Cancer Lett , vol.272 , pp. 77-90
    • Lin, S.-S.1    Huang, H.-P.2    Yang, J.-S.3
  • 31
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane)
    • Singh S, Aggarwal BB. Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). J Biol Chem 1995; 270: 24995-5000.
    • (1995) J Biol Chem , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 32
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B
    • Stephens L, Anderson K, Stokoe D, et al. Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B. Science 1998; 279: 710-4.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1    Anderson, K.2    Stokoe, D.3
  • 33
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt
    • Woo JH, Kim YH, Choi YJ, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003; 24: 1199-208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3
  • 34
    • 0031716184 scopus 로고    scopus 로고
    • Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells
    • Jee SH, Shen SC, Tseng CR, Chiu HC, Kuo ML. Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. J Investig Dermatol 1998; 111: 656-61.
    • (1998) J Investig Dermatol , vol.111 , pp. 656-661
    • Jee, S.H.1    Shen, S.C.2    Tseng, C.R.3    Chiu, H.C.4    Kuo, M.L.5
  • 35
    • 71749102389 scopus 로고    scopus 로고
    • Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers
    • Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM. Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. Biochem Pharmacol 2010; 79: 218-28.
    • (2010) Biochem Pharmacol , vol.79 , pp. 218-228
    • Tharakan, S.T.1    Inamoto, T.2    Sung, B.3    Aggarwal, B.B.4    Kamat, A.M.5
  • 36
    • 17844392101 scopus 로고    scopus 로고
    • Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL
    • Rashmi R, Kumar S, Karunagaran D. Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis 2005; 26: 713-23.
    • (2005) Carcinogenesis , vol.26 , pp. 713-723
    • Rashmi, R.1    Kumar, S.2    Karunagaran, D.3
  • 38
    • 33845945097 scopus 로고    scopus 로고
    • Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3
    • Su CC, Lin JG, Li Temao, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res 2006; 26: 4379-89.
    • (2006) Anticancer Res , vol.26 , pp. 4379-4489
    • Su, C.C.1    Lin, J.G.2    Li, T.3
  • 39
    • 0032479574 scopus 로고    scopus 로고
    • Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships
    • Simon A, Allais D, Duroux J, Basly J, Durand-Fontanier S, Delage C. Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships. Cancer Lett 1998; 129: 111-6.
    • (1998) Cancer Lett , vol.129 , pp. 111-116
    • Simon, A.1    Allais, D.2    Duroux, J.3    Basly, J.4    Durand-Fontanier, S.5    Delage, C.6
  • 40
    • 0037069939 scopus 로고    scopus 로고
    • Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation
    • Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M, Aggarwal BB. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 2002; 21: 8852-61.
    • (2002) Oncogene , vol.21 , pp. 8852-8861
    • Mukhopadhyay, A.1    Banerjee, S.2    Stafford, L.J.3    Xia, C.4    Liu, M.5    Aggarwal, B.B.6
  • 41
    • 47949091512 scopus 로고    scopus 로고
    • Statin and Stromal Cell-Derived Factor-1 Additively Promote Angiogenesis by Enhancement of Progenitor Cells Incorporation into New Vessels
    • Shao H, Tan Y, Eton D, et al. Statin and Stromal Cell-Derived Factor-1 Additively Promote Angiogenesis by Enhancement of Progenitor Cells Incorporation into New Vessels. Stem cells 2008; 26: 1376-84.
    • (2008) Stem Cells , vol.26 , pp. 1376-1384
    • Shao, H.1    Tan, Y.2    Eton, D.3
  • 42
    • 54949090388 scopus 로고    scopus 로고
    • Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stabillity, inhibits NO production, inducible NO synthase expression and NFkappa B activation in RAW264.7 macrophages activated with LPS
    • Pae H-O, Jeong S-O, Kim HS, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stabillity, inhibits NO production, inducible NO synthase expression and NFkappa B activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res 2008; 52: 1082-91.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 1082-1091
    • Pae, H.-O.1    Jeong, S.-O.2    Kim, H.S.3
  • 43
    • 0037044179 scopus 로고    scopus 로고
    • Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line
    • Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA, Melnick SJ. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett 2002; 184: 1-6.
    • (2002) Cancer Lett , vol.184 , pp. 1-6
    • Ramachandran, C.1    Fonseca, H.B.2    Jhabvala, P.3    Escalon, E.A.4    Melnick, S.J.5
  • 44
    • 33751384016 scopus 로고    scopus 로고
    • Curcumin inhibits telomerase activity in human cancer cell lines
    • Cui S-X, Qu X-J, Xie Y-Y, et al. Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med 2006; 18: 227-31.
    • (2006) Int J Mol Med , vol.18 , pp. 227-231
    • Cui, S.-X.1    Qu, X.-J.2    Xie, Y.-Y.3
  • 45
    • 33947414787 scopus 로고    scopus 로고
    • Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity
    • Mukherjee S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Dey S, Roy M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol Cell Biochem 2007; 297: 31-9.
    • (2007) Mol Cell Biochem , vol.297 , pp. 31-39
    • Mukherjee, S.1    Ghosh, U.2    Bhattacharyya, N.P.3    Bhattacharya, R.K.4    Dey, S.5    Roy, M.6
  • 46
    • 70349905311 scopus 로고    scopus 로고
    • Curcumin induced cell death and inhibition of telomerase activity in mouse lymphoma p388d1 cells
    • Mishra VK, Kumar A. Curcumin induced cell death and inhibition of telomerase activity in mouse lymphoma p388d1 cells. Excli Journal 2009; 8: 20-9.
    • (2009) Excli Journal , vol.8 , pp. 20-29
    • Mishra, V.K.1    Kumar, A.2
  • 47
    • 77249158324 scopus 로고    scopus 로고
    • Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT
    • Lee JH, Chung IK. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett 2010; 290: 76-86.
    • (2010) Cancer Lett , vol.290 , pp. 76-86
    • Lee, J.H.1    Chung, I.K.2
  • 48
    • 0037028207 scopus 로고    scopus 로고
    • beta-Catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells
    • Jaiswal AS, Marlow BP, Gupta N, Narayan S. beta-Catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 2002; 21: 8414-27.
    • (2002) Oncogene , vol.21 , pp. 8414-8427
    • Jaiswal, A.S.1    Marlow, B.P.2    Gupta, N.3    Narayan, S.4
  • 49
    • 13844293171 scopus 로고    scopus 로고
    • Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting beta-cateninmediated transactivation and cell-cell adhesion pathways
    • Narayan S. Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting beta-cateninmediated transactivation and cell-cell adhesion pathways. J Mol Hist 2004; 35: 301-7.
    • (2004) J Mol Hist , vol.35 , pp. 301-307
    • Narayan, S.1
  • 50
    • 0037245268 scopus 로고    scopus 로고
    • Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin
    • Ray S, Chattopadhyay N, Mitra A, Siddiqi M, Chatterjee A. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin. J Environ Pathol Toxicol Oncol 2003; 22: 49-58.
    • (2003) J Environ Pathol Toxicol Oncol , vol.22 , pp. 49-58
    • Ray, S.1    Chattopadhyay, N.2    Mitra, A.3    Siddiqi, M.4    Chatterjee, A.5
  • 51
    • 84879789194 scopus 로고    scopus 로고
    • Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression
    • Tu C-T, Han B, Liu H-C, Zhang S-C. Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression. Mol Cell Biochem 2011; 358: 53-60.
    • (2011) Mol Cell Biochem , vol.358 , pp. 53-60
    • Tu, C.-T.1    Han, B.2    Liu, H.-C.3    Zhang, S.-C.4
  • 52
    • 84875396106 scopus 로고    scopus 로고
    • Curcumin Selectively Inhibits VCAM-1 Expression in Human Intestinal Microvascular Endothelial Cells (HIMEC)
    • Binion DG, Heidemann J, Li MS, Nelson VM, Rafiee P. Curcumin Selectively Inhibits VCAM-1 Expression in Human Intestinal Microvascular Endothelial Cells (HIMEC). Gastroenterology 2009; 136: A264-A.
    • (2009) Gastroenterology , vol.136
    • Binion, D.G.1    Heidemann, J.2    Li, M.S.3    Nelson, V.M.4    Rafiee, P.5
  • 53
    • 0032520716 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation
    • Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB. Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation. Biochem Pharmacol 1998; 55: 775-83.
    • (1998) Biochem Pharmacol , vol.55 , pp. 775-783
    • Kumar, A.1    Dhawan, S.2    Hardegen, N.J.3    Aggarwal, B.B.4
  • 54
    • 65849405779 scopus 로고    scopus 로고
    • Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro
    • Zhang L, Gu Z-L, Qin Z-H, Liang Z-Q. Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro. Acta Pharmacol Sin 2008; 29: 800-7.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 800-807
    • Zhang, L.1    Gu, Z.-L.2    Qin, Z.-H.3    Liang, Z.-Q.4
  • 55
    • 61549118204 scopus 로고    scopus 로고
    • Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion
    • Kim HI, Huang H, Cheepala S, Huang S, Chung J. Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. Cancer Prev Res (Phila) 2008; 1: 385-91.
    • (2008) Cancer Prev Res (Phila) , vol.1 , pp. 385-391
    • Kim, H.I.1    Huang, H.2    Cheepala, S.3    Huang, S.4    Chung, J.5
  • 56
    • 54749152839 scopus 로고    scopus 로고
    • Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1
    • Chen HW, Lee JY, Huang JY, et al. Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 2008; 68: 7428-38.
    • (2008) Cancer Res , vol.68 , pp. 7428-7438
    • Chen, H.W.1    Lee, J.Y.2    Huang, J.Y.3
  • 57
    • 84862972274 scopus 로고    scopus 로고
    • Curcumin down-regulates visfatin expression and inhibits breast cancer cell invasion
    • Kim SR, Park HJ, Bae YH, et al. Curcumin down-regulates visfatin expression and inhibits breast cancer cell invasion. Endocrinology 2012; 153: 554-63.
    • (2012) Endocrinology , vol.153 , pp. 554-563
    • Kim, S.R.1    Park, H.J.2    Bae, Y.H.3
  • 58
    • 3342920596 scopus 로고    scopus 로고
    • Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells
    • Holy J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells. Cell Motil Cytoskeleton 2004; 58: 253-68.
    • (2004) Cell Motil Cytoskeleton , vol.58 , pp. 253-268
    • Holy, J.1
  • 59
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 60
    • 38149110345 scopus 로고    scopus 로고
    • A few to flip the angiogenic switch
    • New York, NY
    • Rafii S, Lyden D. Cancer. A few to flip the angiogenic switch. Science (New York, NY) 2008; 319: 163.
    • (2008) Science , vol.319 , pp. 163
    • Rafii, S.1    Lyden, D.C.2
  • 61
    • 39849102836 scopus 로고    scopus 로고
    • HIF1 alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, Lu KV, Petritsch C, et al. HIF1 alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008; 13: 206-20.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3
  • 62
    • 0034531766 scopus 로고    scopus 로고
    • HIF-1: Using two hands to flip the angiogenic switch
    • Semenza GL. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev 2000; 19: 59-65.
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 59-65
    • Semenza, G.L.1
  • 63
    • 34250170761 scopus 로고    scopus 로고
    • Curcumin inhibits hypoxiainduced angiogenesis via down-regulation of HIF-1
    • BAE MK, KIM SH, JEONG JW, et al. Curcumin inhibits hypoxiainduced angiogenesis via down-regulation of HIF-1. Oncol Rep 2006; 15: 1557-62.
    • (2006) Oncol Rep , vol.15 , pp. 1557-1562
    • Bae, M.K.1    Kim, S.H.2    Jeong, J.W.3
  • 64
    • 0034791260 scopus 로고    scopus 로고
    • Role of AP-1 and HIF-1 transcription factors in TGF-β activation of VEGF expression
    • Shih SC, Claffey KP. Role of AP-1 and HIF-1 transcription factors in TGF-β activation of VEGF expression. Growth Factors 2001; 19: 19-34.
    • (2001) Growth Factors , vol.19 , pp. 19-34
    • Shih, S.C.1    Claffey, K.P.2
  • 65
    • 33847066381 scopus 로고    scopus 로고
    • The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    • Bachmeier BE, Nerlich AG, Iancu CM, et al. The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice. Cell Physiol Biochem 2007; 19: 137-52.
    • (2007) Cell Physiol Biochem , vol.19 , pp. 137-152
    • Bachmeier, B.E.1    Nerlich, A.G.2    Iancu, C.M.3
  • 66
    • 84875393748 scopus 로고    scopus 로고
    • Anti-angiogenic effect of resveratrol and curcumin through the inhibition of microvessel density, vegf and its receptor VEGFR-2 (flk-1) in ehrlich ascites carcinoma-bearing mice
    • El-Azab F, Hishe H, Moustafa Y, El-Awady E. Anti-angiogenic effect of resveratrol and curcumin through the inhibition of microvessel density, vegf and its receptor VEGFR-2 (flk-1) in ehrlich ascites carcinoma-bearing mice. Haematologica-the Hematology Journal 2010; 95: 352.
    • (2010) Haematologica-the Hematology Journal , vol.95 , pp. 352
    • El-Azab, F.1    Hishe, H.2    Moustafa, Y.3    El-Awady, E.4
  • 67
    • 4143118999 scopus 로고    scopus 로고
    • Antimicrobial activity of wool fabric treated with curcumin
    • Han SY, Yang Y. Antimicrobial activity of wool fabric treated with curcumin. Dyes and Pigments 2005; 64: 157-61.
    • (2005) Dyes and Pigments , vol.64 , pp. 157-161
    • Han, S.Y.1    Yang, Y.2
  • 68
    • 65649112148 scopus 로고    scopus 로고
    • Study of antimicrobial activity of aloevera, chitosan, and curcumin on cotton, wool, and rabbit hair
    • Ammayappan L, Moses JJ. Study of antimicrobial activity of aloevera, chitosan, and curcumin on cotton, wool, and rabbit hair. Fibers and Polymers 2009; 10: 161-6.
    • (2009) Fibers and Polymers , vol.10 , pp. 161-166
    • Ammayappan, L.1    Moses, J.J.2
  • 70
  • 72
    • 13444301277 scopus 로고    scopus 로고
    • Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties
    • Mishra S, Narain U, Mishra R, Misra K. Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties. Bioorg Med Chem 2005; 13: 1477-86.
    • (2005) Bioorg Med Chem , vol.13 , pp. 1477-1486
    • Mishra, S.1    Narain, U.2    Mishra, R.3    Misra, K.4
  • 75
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions
    • Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions. Anticancer Res. 2001; 21: 2895-900.
    • (2001) Anticancer Res , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3
  • 76
    • 0034772953 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer
    • Sharma RA, McLelland HR, Hill KA, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 2001; 7: 1894-900.
    • (2001) Clin Cancer Res , vol.7 , pp. 1894-1900
    • Sharma, R.A.1    McLelland, H.R.2    Hill, K.A.3
  • 78
    • 84867891335 scopus 로고    scopus 로고
    • A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis
    • Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res 2012.
    • (2012) Phytother Res
    • Chandran, B.1    Goel, A.2
  • 80
    • 4644332608 scopus 로고    scopus 로고
    • Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
    • Garcea G, Jones D, Singh R, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer 2004; 90: 1011-5.
    • (2004) Br J Cancer , vol.90 , pp. 1011-1015
    • Garcea, G.1    Jones, D.2    Singh, R.3
  • 81
    • 12844277237 scopus 로고    scopus 로고
    • Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences
    • Garcea G, Berry DP, Jones DJL, et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomark Prev 2005; 14: 120-5.
    • (2005) Cancer Epidemiol Biomark Prev , vol.14 , pp. 120-125
    • Garcea, G.1    Berry, D.P.2    Jones, D.J.L.3
  • 82
    • 53349161258 scopus 로고    scopus 로고
    • Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects
    • Vareed SK, Kakarala M, Ruffin MT, et al. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomark Prev 2008; 17: 1411-7.
    • (2008) Cancer Epidemiol Biomark Prev , vol.17 , pp. 1411-1417
    • Vareed, S.K.1    Kakarala, M.2    Ruffin, M.T.3
  • 83
    • 0033062493 scopus 로고    scopus 로고
    • Efficacy of curcumin in the management of chronic anterior uveitis
    • Lal B, Kapoor A, Asthana O, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res 1999; 13: 318-22.
    • (1999) Phytother Res , vol.13 , pp. 318-322
    • Lal, B.1    Kapoor, A.2    Asthana, O.3
  • 84
    • 78650689102 scopus 로고    scopus 로고
    • Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. Long-term follow-up
    • Allegri P, Mastromarino A, Neri P. Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol 2010; 4: 1201-6.
    • (2010) Clin Ophthalmol , vol.4 , pp. 1201-1206
    • Allegri, P.1    Mastromarino, A.2    Neri, P.3
  • 85
    • 0033817448 scopus 로고    scopus 로고
    • Role of curcumin in idiopathic inflammatory orbital pseudotumours
    • Lal B, Kapoor A, Agrawal P, Asthana O, Srimal R. Role of curcumin in idiopathic inflammatory orbital pseudotumours. Phytother Res 2000; 14: 443-7.
    • (2000) Phytother Res , vol.14 , pp. 443-447
    • Lal, B.1    Kapoor, A.2    Agrawal, P.3    Asthana, O.4    Srimal, R.5
  • 86
    • 0035552235 scopus 로고    scopus 로고
    • Dyspepsia, irritable bowel syndrome, and constipation: Review and what's new
    • Camilleri M. Dyspepsia, irritable bowel syndrome, and constipation: review and what's new. Rev Gastroenterol Disord 2001; 1: 2-17.
    • (2001) Rev Gastroenterol Disord , vol.1 , pp. 2-17
    • Camilleri, M.1
  • 87
    • 13144307050 scopus 로고    scopus 로고
    • Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: A pilot study
    • Bundy R, Walker AF, Middleton RW, Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complem Med 2004; 10: 1015-8.
    • (2004) J Altern Complem Med , vol.10 , pp. 1015-1018
    • Bundy, R.1    Walker, A.F.2    Middleton, R.W.3    Booth, J.4
  • 89
    • 68449085126 scopus 로고    scopus 로고
    • Curcumin has bright prospects for the treatment of inflammatory bowel disease
    • Hanai H, Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des 2009; 15: 2087-94.
    • (2009) Curr Pharm Des , vol.15 , pp. 2087-2094
    • Hanai, H.1    Sugimoto, K.2
  • 90
    • 80052168264 scopus 로고    scopus 로고
    • Curcumin for inflammatory bowel disease: A review of human studies
    • Taylor RA, Leonard MC. Curcumin for inflammatory bowel disease: a review of human studies. Altern Med Rev 2011; 16: 152-6.
    • (2011) Altern Med Rev , vol.16 , pp. 152-156
    • Taylor, R.A.1    Leonard, M.C.2
  • 91
    • 27144456477 scopus 로고    scopus 로고
    • Curcumin therapy in inflammatory bowel disease: A pilot study
    • Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005; 50: 2191-3.
    • (2005) Dig Dis Sci , vol.50 , pp. 2191-2193
    • Holt, P.R.1    Katz, S.2    Kirshoff, R.3
  • 92
    • 33845292957 scopus 로고    scopus 로고
    • Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial
    • Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2006; 4: 1502-6.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1502-1506
    • Hanai, H.1    Iida, T.2    Takeuchi, K.3
  • 93
    • 30744474181 scopus 로고    scopus 로고
    • A pilot study of the antioxidant effect of curcumin in tropical pancreatitis
    • Durgaprasad S, Pai CG, Alvres JF, Namitha S. A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian J Med Res 2005; 122: 315-8.
    • (2005) Indian J Med Res , vol.122 , pp. 315-318
    • Durgaprasad, S.1    Pai, C.G.2    Alvres, J.F.3    Namitha, S.4
  • 94
    • 34248334669 scopus 로고    scopus 로고
    • Natural products as a gold mine for arthritis treatment
    • Khanna D, Sethi G, Ahn KS, et al. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol 2007; 7: 344-51.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 344-351
    • Khanna, D.1    Sethi, G.2    Ahn, K.S.3
  • 95
    • 79952201693 scopus 로고    scopus 로고
    • Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis
    • Belcaro G, Cesarone M, Dugall M, et al. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010; 52: 55-62.
    • (2010) Panminerva Med , vol.52 , pp. 55-62
    • Belcaro, G.1    Cesarone, M.2    Dugall, M.3
  • 96
    • 35148838593 scopus 로고    scopus 로고
    • Curcumin induces apoptosis and inhibits prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis
    • Park C, Moon DO, Choi IW, et al. Curcumin induces apoptosis and inhibits prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med 2007; 20: 365-72.
    • (2007) Int J Mol Med , vol.20 , pp. 365-372
    • Park, C.1    Moon, D.O.2    Choi, I.W.3
  • 97
    • 0018887037 scopus 로고
    • Preliminary study on antirheumatic activity of curcumin (diferuloyl methane)
    • Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 1980; 71: 632-4.
    • (1980) Indian J Med Res , vol.71 , pp. 632-634
    • Deodhar, S.D.1    Sethi, R.2    Srimal, R.C.3
  • 98
    • 0033748814 scopus 로고    scopus 로고
    • Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters
    • Heng M, Song M, Harker J, Heng M. Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. Br J Dermatol 2000; 143: 937-49.
    • (2000) Br J Dermatol , vol.143 , pp. 937-949
    • Heng, M.1    Song, M.2    Harker, J.3    Heng, M.4
  • 99
    • 40649085271 scopus 로고    scopus 로고
    • Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial
    • Kurd SK, Smith N, VanVoorhees A, et al. Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial. J Am Acad Dermatol 2008; 58: 625-31.
    • (2008) J Am Acad Dermatol , vol.58 , pp. 625-631
    • Kurd, S.K.1    Smith, N.2    Vanvoorhees, A.3
  • 100
    • 0016700683 scopus 로고
    • Endocrinology in cancer of the breast. Status and prospects
    • Brennan M. Endocrinology in cancer of the breast. Status and prospects. Am J Clin Pathol 1975; 64: 797.
    • (1975) Am J Clin Pathol , vol.64 , pp. 797
    • Brennan, M.1
  • 101
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211-8.
    • (2005) Cancer Cell , vol.7 , pp. 211-218
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 102
    • 79951601296 scopus 로고    scopus 로고
    • Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin
    • He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investig 2011; 29: 208-13.
    • (2011) Cancer Investig , vol.29 , pp. 208-213
    • He, Z.Y.1    Shi, C.B.2    Wen, H.3    Li, F.L.4    Wang, B.L.5    Wang, J.6
  • 103
    • 80455155235 scopus 로고    scopus 로고
    • Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NFkappaB and AP-1 pathway in vitro
    • Liu S, Wang Z, Hu Z, et al. Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NFkappaB and AP-1 pathway in vitro. J Huazhong Univ Sci Technolog Med Sci 2011; 31: 530-4.
    • (2011) J Huazhong Univ Sci Technolog Med Sci , vol.31 , pp. 530-534
    • Liu, S.1    Wang, Z.2    Hu, Z.3
  • 104
    • 80053194778 scopus 로고    scopus 로고
    • Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A
    • Liu HS, Ke CS, Cheng HC, Huang CYF, Su CL. Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Mol Pharmacol 2011; 80: 638-46.
    • (2011) Mol Pharmacol , vol.80 , pp. 638-646
    • Liu, H.S.1    Ke, C.S.2    Cheng, H.C.3    Huang, C.Y.F.4    Su, C.L.5
  • 105
    • 78651272490 scopus 로고    scopus 로고
    • Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells
    • Singh M, Singh N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol Cell Biochem 2011; 347: 1-11.
    • (2011) Mol Cell Biochem , vol.347 , pp. 1-11
    • Singh, M.1    Singh, N.2
  • 106
    • 77955077389 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade-and mitochondria-dependent pathways
    • Wu SH, Hang LW, Yang JS, et al. Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade-and mitochondria-dependent pathways. Anticancer Res 2010; 30: 2125-33.
    • (2010) Anticancer Res , vol.30 , pp. 2125-2133
    • Wu, S.H.1    Hang, L.W.2    Yang, J.S.3
  • 107
    • 42549165647 scopus 로고    scopus 로고
    • Guidelines for the clinical management of familial adenomatous polyposis (FAP)
    • Vasen HFA, Moeslein G, Alonso A, et al. Guidelines for the clinical management of familial adenomatous polyposis (FAP). Gut 2008; 57: 704-13.
    • (2008) Gut , vol.57 , pp. 704-713
    • Vasen, H.F.A.1    Moeslein, G.2    Alonso, A.3
  • 108
    • 33746353391 scopus 로고    scopus 로고
    • Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis
    • Cruz-Correa M, Shoskes DA, Sanchez P, et al. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 2006; 4: 1035-8.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1035-1038
    • Cruz-Correa, M.1    Shoskes, D.A.2    Sanchez, P.3
  • 109
    • 70349466801 scopus 로고    scopus 로고
    • The potential role of curcumin in patients with monoclonal gammopathy of undefined significance-its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker
    • Golombick T, Diamond TH, Badmaev V, Manoharan A, Ramakrishna R. The potential role of curcumin in patients with monoclonal gammopathy of undefined significance-its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker. Clin Cancer Res 2009; 15: 5917-22.
    • (2009) Clin Cancer Res , vol.15 , pp. 5917-5922
    • Golombick, T.1    Diamond, T.H.2    Badmaev, V.3    Manoharan, A.4    Ramakrishna, R.5
  • 110
    • 79955804832 scopus 로고    scopus 로고
    • Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
    • Carroll RE, Benya RV, Turgeon DK, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res 2011; 4: 354-64.
    • (2011) Cancer Prev Res , vol.4 , pp. 354-364
    • Carroll, R.E.1    Benya, R.V.2    Turgeon, D.K.3
  • 111
    • 67349087690 scopus 로고    scopus 로고
    • Liver metastases after colonic carcinoma-palliative chemotherapy plus curcumin
    • Braumann C, Guenther N, Loeffler LM, Dubiel W. Liver metastases after colonic carcinoma-palliative chemotherapy plus curcumin. Int J Colorectal Dis 2009; 24: 859-60.
    • (2009) Int J Colorectal Dis , vol.24 , pp. 859-860
    • Braumann, C.1    Guenther, N.2    Loeffler, L.M.3    Dubiel, W.4
  • 112
    • 48949086300 scopus 로고    scopus 로고
    • Phase II study of curcumin and gemcitabine in patients with advanced pancreatic cancer
    • Epelbaum R, Vizel B, Bar-Sela G. Phase II study of curcumin and gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2008; 26: 15619.
    • (2008) J Clin Oncol , vol.26 , pp. 15619
    • Epelbaum, R.1    Vizel, B.2    Bar-Sela, G.3
  • 113
    • 79959612772 scopus 로고    scopus 로고
    • A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer
    • Kanai M, Yoshimura K, Asada M, et al. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol 2011; 68: 157-64.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 157-164
    • Kanai, M.1    Yoshimura, K.2    Asada, M.3
  • 114
    • 51649118928 scopus 로고    scopus 로고
    • Phase II trial of curcumin in patients with advanced pancreatic cancer
    • Dhillon N, Aggarwal BB, Newman RA, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008; 14: 4491-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 4491-4499
    • Dhillon, N.1    Aggarwal, B.B.2    Newman, R.A.3
  • 115
    • 77954160638 scopus 로고    scopus 로고
    • Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer
    • Bayet-Robert M, Kwiatkowski F, Leheurteur M, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther 2010; 9: 8-14.
    • (2010) Cancer Biol Ther , vol.9 , pp. 8-14
    • Bayet-Robert, M.1    Kwiatkowski, F.2    Leheurteur, M.3
  • 119
    • 0030761094 scopus 로고    scopus 로고
    • The presenilins and Alzheimer's disease
    • Hutton M, Hardy J. The presenilins and Alzheimer's disease. Hum Mol Genet 1997; 6: 1639-46.
    • (1997) Hum Mol Genet , vol.6 , pp. 1639-1646
    • Hutton, M.1    Hardy, J.2
  • 120
    • 0032745193 scopus 로고    scopus 로고
    • Worldwide prevalence and incidence of dementia
    • Fratiglioni L, De Ronchi D, Aguero TH. Worldwide prevalence and incidence of dementia. Drugs Aging 1999; 15: 365-75.
    • (1999) Drugs Aging , vol.15 , pp. 365-375
    • Fratiglioni, L.1    de Ronchi, D.2    Aguero, T.H.3
  • 121
    • 42249112650 scopus 로고    scopus 로고
    • The effect of curcumin (turmeric) on Alzheimer's disease: An overview
    • Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann Indian Acad Neur 2008; 11: 13-9.
    • (2008) Ann Indian Acad Neur , vol.11 , pp. 13-19
    • Mishra, S.1    Palanivelu, K.2
  • 122
    • 84856803616 scopus 로고    scopus 로고
    • Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in alzheimer's brain
    • Mutsuga M, Chambers JK, Uchida K, et al. Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in alzheimer's brain. J Vet Med Sci 2011; 74: 51-7.
    • (2011) J Vet Med Sci , vol.74 , pp. 51-57
    • Mutsuga, M.1    Chambers, J.K.2    Uchida, K.3
  • 123
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride O, Saffiotti U, Gajdusek D. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 1987; 235: 877-80.
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.3    Saffiotti, U.4    Gajdusek, D.5
  • 124
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (Lond) 1987; 325: 733-6.
    • (1987) Nature (Lond) , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3
  • 125
    • 0028945660 scopus 로고
    • Evidence that A beta 42 is the real culprit in Alzheimer's disease
    • Younkin SG. Evidence that A beta 42 is the real culprit in Alzheimer's disease. Ann Neurol 1995; 37: 287-8.
    • (1995) Ann Neurol , vol.37 , pp. 287-288
    • Younkin, S.G.1
  • 126
    • 0033600274 scopus 로고    scopus 로고
    • Tanslating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ. Tanslating cell biology into therapeutic advances in Alzheimer's disease. Nature (Lond) 1999; 399: 23-31.
    • (1999) Nature (Lond) , vol.399 , pp. 23-31
    • Selkoe, D.J.1
  • 127
    • 0033621739 scopus 로고    scopus 로고
    • Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
    • Iwata N, Tsubuki S, Takaki Y, et al. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med 2000; 6: 143-50.
    • (2000) Nat Med , vol.6 , pp. 143-150
    • Iwata, N.1    Tsubuki, S.2    Takaki, Y.3
  • 128
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci 2003; 6: 345-51.
    • (2003) Nat Neurosci , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 129
    • 0032523168 scopus 로고    scopus 로고
    • Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age-and stress-induced impairments in long-term potentiation
    • Murray CA, Lynch MA. Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age-and stress-induced impairments in long-term potentiation. J Neurosci 1998; 18: 2974-81.
    • (1998) J Neurosci , vol.18 , pp. 2974-2981
    • Murray, C.A.1    Lynch, M.A.2
  • 130
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001; 21: 8370-7.
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 131
    • 0035686083 scopus 로고    scopus 로고
    • Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
    • Frautschy SA, Hu W, Kim P, et al. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 2001; 22: 993-1005.
    • (2001) Neurobiol Aging , vol.22 , pp. 993-1005
    • Frautschy, S.A.1    Hu, W.2    Kim, P.3
  • 132
    • 1442314722 scopus 로고    scopus 로고
    • Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease
    • Sung S, Yao Y, Uryu K, et al. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease. FASEB J 2004; 18: 323-5.
    • (2004) FASEB J , vol.18 , pp. 323-325
    • Sung, S.1    Yao, Y.2    Uryu, K.3
  • 133
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    • Fassbender K, Simons M, Bergmann C, et al. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 2001; 98: 5856-61.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5856-5861
    • Fassbender, K.1    Simons, M.2    Bergmann, C.3
  • 134
    • 0035160066 scopus 로고    scopus 로고
    • A Cholesterol-Lowering Drug Reduces [beta]-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease
    • Refolo LM, Pappolla MA, LaFrancois J, et al. A Cholesterol-Lowering Drug Reduces [beta]-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease. Neurobiol Dis 2001; 8: 890-9.
    • (2001) Neurobiol Dis , vol.8 , pp. 890-899
    • Refolo, L.M.1    Pappolla, M.A.2    Lafrancois, J.3
  • 135
    • 0037151057 scopus 로고    scopus 로고
    • Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    • Hsu HY, Wen MH. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem 2002; 277: 22131-9.
    • (2002) J Biol Chem , vol.277 , pp. 22131-22139
    • Hsu, H.Y.1    Wen, M.H.2
  • 136
    • 12144282992 scopus 로고    scopus 로고
    • Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides
    • Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem 2004; 9: 954-60.
    • (2004) J Biol Inorg Chem , vol.9 , pp. 954-960
    • Huang, X.1    Atwood, C.S.2    Moir, R.D.3    Hartshorn, M.A.4    Tanzi, R.E.5    Bush, A.I.6
  • 137
    • 77956410717 scopus 로고    scopus 로고
    • Oral curcumin for the treatment of mild-to-moderate Alzheimer's disease: Tolerability and clinical and biomarker efficacy results of a placebo-controlled 24-week study
    • USA, July 26-31
    • Ringman JM CG, Tend E, et al. Oral curcumin for the treatment of mild-to-moderate Alzheimer's disease: Tolerability and clinical and biomarker efficacy results of a placebo-controlled 24-week study. Proceedings of the Abstract of International Conference on Alzheimer's Disease Chicago, USA, July 26-31, 2008: T774.
    • (2008) Proceedings of the Abstract of International Conference On Alzheimer's Disease Chicago
    • Ringman, J.M.C.G.1    Tend, E.2
  • 138
    • 38349131641 scopus 로고    scopus 로고
    • Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease
    • Baum L, Lam CWK, Cheung SKK, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol 2008; 28: 110-3.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 110-113
    • Baum, L.1    Lam, C.W.K.2    Cheung, S.K.K.3
  • 139
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal MF. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 1992; 31: 119-30.
    • (1992) Ann Neurol , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 142
    • 0035003439 scopus 로고    scopus 로고
    • Chemistry and biochemistry of oxidative stress in neurodegenerative disease
    • Sayre LM, Smith MA, Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 2001; 8: 721-38.
    • (2001) Curr Med Chem , vol.8 , pp. 721-738
    • Sayre, L.M.1    Smith, M.A.2    Perry, G.3
  • 143
    • 0035949786 scopus 로고    scopus 로고
    • Incidence of Alzheimer's disease in a rural community in India
    • Chandra V, Pandav R, Dodge H, et al. Incidence of Alzheimer's disease in a rural community in India. Neurology 2001; 57: 985-9.
    • (2001) Neurology , vol.57 , pp. 985-989
    • Chandra, V.1    Pandav, R.2    Dodge, H.3
  • 144
  • 145
    • 33846464996 scopus 로고    scopus 로고
    • Mitochondrial complex I inhibition in Parkinson's disease: How can curcumin protect mitochondria?
    • Mythri RB, Jagatha B, Pradhan N, Andersen J, Bharath MMS. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxid Redox Signal 2007; 9: 399-408.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 399-408
    • Mythri, R.B.1    Jagatha, B.2    Pradhan, N.3    Andersen, J.4    Bharath, M.M.S.5
  • 146
    • 0037053338 scopus 로고    scopus 로고
    • Specific modification of mitochondrial protein thiols in response to oxidative stress
    • Lin TK, Hughes G, Muratovska A, et al. Specific modification of mitochondrial protein thiols in response to oxidative stress. J Biol Chem 2002; 277: 17048-56.
    • (2002) J Biol Chem , vol.277 , pp. 17048-17056
    • Lin, T.K.1    Hughes, G.2    Muratovska, A.3
  • 147
    • 0034714346 scopus 로고    scopus 로고
    • Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity
    • Jha N, Jurma O, Lalli G, et al. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. J Biol Chem 2000; 275: 26096-101.
    • (2000) J Biol Chem , vol.275 , pp. 26096-26101
    • Jha, N.1    Jurma, O.2    Lalli, G.3
  • 148
    • 33646948530 scopus 로고    scopus 로고
    • Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
    • Keeney PM, Xie J, Capaldi RA, Bennett Jr JP. Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci 2006; 26: 5256-64.
    • (2006) J Neurosci , vol.26 , pp. 5256-5264
    • Keeney, P.M.1    Xie, J.2    Capaldi, R.A.3    Bennett, J.P.4
  • 149
    • 0141510019 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial complex I due to peroxynitrite
    • Murray J, Taylor SW, Zhang B, Ghosh SS, Capaldi RA. Oxidative damage to mitochondrial complex I due to peroxynitrite. J Biol Chem 2003; 278: 37223-30.
    • (2003) J Biol Chem , vol.278 , pp. 37223-37230
    • Murray, J.1    Taylor, S.W.2    Zhang, B.3    Ghosh, S.S.4    Capaldi, R.A.5
  • 150
    • 0032525741 scopus 로고    scopus 로고
    • In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties
    • Chan MMY, Huang HI, Fenton MR, Fong D. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol 1998; 55: 1955-62.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1955-1962
    • Chan, M.M.Y.1    Huang, H.I.2    Fenton, M.R.3    Fong, D.4
  • 152
    • 36249019785 scopus 로고    scopus 로고
    • Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: A dynamic model
    • Vali S, Mythri R, Jagatha B, et al. Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model. Neuroscience 2007; 149: 917-30.
    • (2007) Neuroscience , vol.149 , pp. 917-930
    • Vali, S.1    Mythri, R.2    Jagatha, B.3
  • 153
    • 39149124146 scopus 로고    scopus 로고
    • Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies
    • Jagatha B, Mythri RB, Vali S, Bharath M. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic Biol Med 2008; 44: 907-17.
    • (2008) Free Radic Biol Med , vol.44 , pp. 907-917
    • Jagatha, B.1    Mythri, R.B.2    Vali, S.3    Bharath, M.4
  • 154
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 2003; 43: 545-84.
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 155
    • 0034602442 scopus 로고    scopus 로고
    • Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
    • Giasson BI, Duda JE, Murray IV, et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 2000; 290: 985-9.
    • (2000) Science , vol.290 , pp. 985-989
    • Giasson, B.I.1    Duda, J.E.2    Murray, I.V.3
  • 156
    • 0037205095 scopus 로고    scopus 로고
    • Tyrosine 125 of [alpha]-synuclein plays a critical role for dimerization following nitrative stress
    • Takahashi T, Yamashita H, Nakamura T, Nagano Y, Nakamura S. Tyrosine 125 of [alpha]-synuclein plays a critical role for dimerization following nitrative stress. Brain Res 2002; 938: 73-80.
    • (2002) Brain Res , vol.938 , pp. 73-80
    • Takahashi, T.1    Yamashita, H.2    Nakamura, T.3    Nagano, Y.4    Nakamura, S.5
  • 157
    • 33644945380 scopus 로고    scopus 로고
    • Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for α-synuclein fibrils in vitro
    • Ono K, Yamada M. Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for α-synuclein fibrils in vitro. J Neurochem 2006; 97: 105-15.
    • (2006) J Neurochem , vol.97 , pp. 105-115
    • Ono, K.1    Yamada, M.2
  • 158
    • 84858595914 scopus 로고    scopus 로고
    • Curcumin prevents aggregation in α -synuclein by increasing the reconfiguration rate
    • Ahmad B, Lapidus LJ. Curcumin prevents aggregation in α -synuclein by increasing the reconfiguration rate. J Biol Chem 2012; 287: 1-14.
    • (2012) J Biol Chem , vol.287 , pp. 1-14
    • Ahmad, B.1    Lapidus, L.J.2
  • 159
    • 33645737200 scopus 로고    scopus 로고
    • Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: A statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: Co-sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline
    • Sacco RL AR, Albers G, Alberts MJ, Benavente O, Furie K, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Circulation 2006; 113: e409-49.
    • (2006) Circulation , vol.113
    • Sacco, R.L.A.R.1    Albers, G.2    Alberts, M.J.3    Benavente, O.4    Furie, K.5
  • 160
    • 31144462116 scopus 로고    scopus 로고
    • Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice
    • Olszanecki R, Jawien J, Gajda M, et al. Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice. J Physiol Pharmacol 2005; 56: 627-35.
    • (2005) J Physiol Pharmacol , vol.56 , pp. 627-635
    • Olszanecki, R.1    Jawien, J.2    Gajda, M.3
  • 161
    • 38349011007 scopus 로고    scopus 로고
    • Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials
    • Strimpakos AS, Sharma RA. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 2008; 10: 511-45.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 511-545
    • Strimpakos, A.S.1    Sharma, R.A.2
  • 162
    • 0026078494 scopus 로고
    • Doxorubicin-induced cardiac toxicity
    • Doroshow JH. Doxorubicin-induced cardiac toxicity. N Engl J Med 1991; 324: 843-5.
    • (1991) N Engl J Med , vol.324 , pp. 843-845
    • Doroshow, J.H.1
  • 163
    • 62049085133 scopus 로고    scopus 로고
    • The protective role of curcumin in cardiovascular diseases
    • Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009; 133: 145-51.
    • (2009) Int J Cardiol , vol.133 , pp. 145-151
    • Wongcharoen, W.1    Phrommintikul, A.2
  • 164
    • 0031801988 scopus 로고    scopus 로고
    • Curcumin attenuation of acute adriamycin myocardial toxicity in rats
    • Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998; 124: 425-7.
    • (1998) Br J Pharmacol , vol.124 , pp. 425-427
    • Venkatesan, N.1
  • 165
    • 33644837326 scopus 로고    scopus 로고
    • Control of cardiac growth by histone acetylation/deacetylation
    • Backs J, Olson EN. Control of cardiac growth by histone acetylation/deacetylation. Circ Res 2006; 98: 15-24.
    • (2006) Circ Res , vol.98 , pp. 15-24
    • Backs, J.1    Olson, E.N.2
  • 166
    • 33746457753 scopus 로고    scopus 로고
    • Enhanced histone acetylation and transcription: A dynamic perspective
    • Clayton AL, Hazzalin CA, Mahadevan LC. Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell 2006; 23: 289-96.
    • (2006) Mol Cell , vol.23 , pp. 289-296
    • Clayton, A.L.1    Hazzalin, C.A.2    Mahadevan, L.C.3
  • 167
    • 0034916613 scopus 로고    scopus 로고
    • p300/CBP proteins: HATs for transcriptional bridges and scaffolds
    • Chan HM, La Thangue NB. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci 2001; 114: 2363-73.
    • (2001) J Cell Sci , vol.114 , pp. 2363-2373
    • Chan, H.M.1    la Thangue, N.B.2
  • 168
    • 33746127271 scopus 로고    scopus 로고
    • Curcumin is an inhibitor of p300 histone acetylatransferase
    • Marcu MG, Jung YJ, Lee S, et al. Curcumin is an inhibitor of p300 histone acetylatransferase. Med Chem 2006; 2: 169-74.
    • (2006) Med Chem , vol.2 , pp. 169-174
    • Marcu, M.G.1    Jung, Y.J.2    Lee, S.3
  • 169
    • 40549117477 scopus 로고    scopus 로고
    • Curcumin prevents and reverses murine cardiac hypertrophy
    • Li HL, Liu C, de Couto G, et al. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Investig 2008; 118: 879.
    • (2008) J Clin Investig , vol.118 , pp. 879
    • Li, H.L.1    Liu, C.2    de Couto, G.3
  • 170
    • 40549135974 scopus 로고    scopus 로고
    • The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
    • Morimoto T, Sunagawa Y, Kawamura T, et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Investig 2008; 118: 868-78.
    • (2008) J Clin Investig , vol.118 , pp. 868-878
    • Morimoto, T.1    Sunagawa, Y.2    Kawamura, T.3
  • 171
    • 17144382445 scopus 로고    scopus 로고
    • Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion
    • Yeh CH, Chen TP, Wu YC, Lin YM, Jing Lin P. Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg Res 2005; 125: 109-16.
    • (2005) J Surg Res , vol.125 , pp. 109-116
    • Yeh, C.H.1    Chen, T.P.2    Wu, Y.C.3    Lin, Y.M.4    Jing, L.P.5
  • 172
    • 0034647026 scopus 로고    scopus 로고
    • An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen
    • Ramirez BA, Soler A, Carrión-Gutiérrez MA, et al. An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen. Mech Ageing Dev 2000; 114: 207-10.
    • (2000) Mech Ageing Dev , vol.114 , pp. 207-210
    • Ramirez, B.A.1    Soler, A.2    Carrión-Gutiérrez, M.A.3
  • 173
    • 67651206071 scopus 로고    scopus 로고
    • The effect of curcumin on lipid level in patients with acute coronary syndrome
    • Alwi I, Santoso T, Suyono S, et al. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 2008; 40: 201-10.
    • (2008) Acta Med Indones , vol.40 , pp. 201-210
    • Alwi, I.1    Santoso, T.2    Suyono, S.3
  • 174
    • 0037015288 scopus 로고    scopus 로고
    • Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation
    • Ceriello A, Taboga C, Tonutti L, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation. Circulation 2002; 106: 1211-8.
    • (2002) Circulation , vol.106 , pp. 1211-1218
    • Ceriello, A.1    Taboga, C.2    Tonutti, L.3
  • 175
    • 33747344675 scopus 로고    scopus 로고
    • Differential effects of curcumin on vasoactive factors in the diabetic rat heart
    • Farhangkhoee H, Khan ZA, Chen S, Chakrabarti S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr Metab (Lond) 2006; 3: 27.
    • (2006) Nutr Metab (Lond) , vol.3 , pp. 27
    • Farhangkhoee, H.1    Khan, Z.A.2    Chen, S.3    Chakrabarti, S.4
  • 176
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357: 593-615.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 177
    • 46349109182 scopus 로고    scopus 로고
    • Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: A randomized, parallel-group, placebo-controlled, 8-week study
    • Usharani P, Mateen A, Naidu M, Raju Y, Chandra N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs in R&D 2008; 9: 243-50.
    • (2008) Drugs In R&D , vol.9 , pp. 243-250
    • Usharani, P.1    Mateen, A.2    Naidu, M.3    Raju, Y.4    Chandra, N.5
  • 178
    • 84859470499 scopus 로고    scopus 로고
    • Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study
    • Appendino G, Belcaro G, Cornelli U, et al. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med 2011; 53: 43-9.
    • (2011) Panminerva Med , vol.53 , pp. 43-49
    • Appendino, G.1    Belcaro, G.2    Cornelli, U.3
  • 179
    • 0037378445 scopus 로고    scopus 로고
    • The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The RENAAL study
    • Keane WF, Brenner BM, De Zeeuw D, et al. The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study. Kidney Int 2003; 63: 1499-507.
    • (2003) Kidney Int , vol.63 , pp. 1499-1507
    • Keane, W.F.1    Brenner, B.M.2    de Zeeuw, D.3
  • 180
    • 0036667558 scopus 로고    scopus 로고
    • Renal damage mediated by oxidative stress: A hypothesis of protective effects of red wine
    • Rodrigo R, Rivera G. Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine. Free Radic Biol Med 2002; 33: 409-22.
    • (2002) Free Radic Biol Med , vol.33 , pp. 409-422
    • Rodrigo, R.1    Rivera, G.2
  • 181
  • 182
    • 80054052195 scopus 로고    scopus 로고
    • Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-beta and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study
    • Khajehdehi P, Pakfetrat M, Javidnia K, et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-beta and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol 2011; 45: 365-70.
    • (2011) Scand J Urol Nephrol , vol.45 , pp. 365-370
    • Khajehdehi, P.1    Pakfetrat, M.2    Javidnia, K.3
  • 184
    • 70349902499 scopus 로고    scopus 로고
    • Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of liposome-encapsulated curcumin
    • Takahashi M, Uechi S, Takara K, Asikin Y, Wada K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric Food Chem 2009; 57: 9141-6.
    • (2009) J Agric Food Chem , vol.57 , pp. 9141-9146
    • Takahashi, M.1    Uechi, S.2    Takara, K.3    Asikin, Y.4    Wada, K.5
  • 185
    • 84875384223 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis
    • Kurzrock R, Li L. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. J Clin Oncol (Meeting Abstracts) 2005: 4091.
    • (2005) J Clin Oncol (Meeting Abstracts) , pp. 4091
    • Kurzrock, R.1    Li, L.2
  • 186
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998; 64: 353-6.
    • (1998) Planta Med , vol.64 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.6
  • 187
    • 24644508916 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin
    • Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin. Cancer 2005; 104: 1322-31.
    • (2005) Cancer , vol.104 , pp. 1322-1331
    • Li, L.1    Braiteh, F.S.2    Kurzrock, R.3
  • 188
    • 34248193849 scopus 로고    scopus 로고
    • Liposomal curcumin with and without oxaliplatin: Effects on cell growth, apoptosis, and angiogenesis in colorectal cancer
    • Li L, Ahmed B, Mehta K, Kurzrock R. Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer. Mol Cancer Ther 2007; 6: 1276.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1276
    • Li, L.1    Ahmed, B.2    Mehta, K.3    Kurzrock, R.4
  • 189
    • 58149165086 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor κB by an AKT-independent pathway
    • Wang D, Veena MS, Stevenson K, et al. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor κB by an AKT-independent pathway. Clin Cancer Res 2008; 14: 6228-36.
    • (2008) Clin Cancer Res , vol.14 , pp. 6228-6236
    • Wang, D.1    Veena, M.S.2    Stevenson, K.3
  • 190
    • 32444435388 scopus 로고    scopus 로고
    • Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin
    • Liu A, Lou H, Zhao L, Fan P. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed Anal 2006; 40: 720-7.
    • (2006) J Pharm Biomed Anal , vol.40 , pp. 720-727
    • Liu, A.1    Lou, H.2    Zhao, L.3    Fan, P.4
  • 191
    • 33846234714 scopus 로고    scopus 로고
    • Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats
    • Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm 2007; 330: 155-63.
    • (2007) Int J Pharm , vol.330 , pp. 155-163
    • Maiti, K.1    Mukherjee, K.2    Gantait, A.3    Saha, B.P.4    Mukherjee, P.K.5
  • 192
    • 78650689102 scopus 로고    scopus 로고
    • Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. Long-term follow-up
    • Auckland, NZ
    • Allegri P, Mastromarino A, Neri P. Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clinical Ophthalmology (Auckland, NZ) 2010; 4: 1201.
    • (2010) Clinical Ophthalmology , vol.4 , pp. 1201
    • Allegri, P.1    Mastromarino, A.2    Neri, P.3
  • 193
    • 79952201693 scopus 로고    scopus 로고
    • Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis
    • Belcaro G, Cesarone M, Dugall M, et al. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010; 52: 55.
    • (2010) Panminerva Med , vol.52 , pp. 55
    • Belcaro, G.1    Cesarone, M.2    Dugall, M.3
  • 194
    • 79952253826 scopus 로고    scopus 로고
    • Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients
    • Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 2010; 15: 337-44.
    • (2010) Altern Med Rev , vol.15 , pp. 337-344
    • Belcaro, G.1    Cesarone, M.R.2    Dugall, M.3
  • 195
    • 79955411920 scopus 로고    scopus 로고
    • Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation
    • Cuomo J, Appendino G, Dern AS, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod 2011; 74: 664-9.
    • (2011) J Nat Prod , vol.74 , pp. 664-669
    • Cuomo, J.1    Appendino, G.2    Dern, A.S.3
  • 196
    • 84856725493 scopus 로고    scopus 로고
    • Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
    • Kanai M, Imaizumi A, Otsuka Y, et al. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol 2012; 69: 65-70.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 65-70
    • Kanai, M.1    Imaizumi, A.2    Otsuka, Y.3
  • 197
    • 84861101552 scopus 로고    scopus 로고
    • Improved Bioavailability of Poorly Water-Soluble Drug Curcumin in Cellulose Acetate Solid Dispersion
    • Wan S, Sun Y, Qi X, Tan F. Improved Bioavailability of Poorly Water-Soluble Drug Curcumin in Cellulose Acetate Solid Dispersion. AAPS PharmSciTech 2011; 13: 159-66.
    • (2011) AAPS PharmSciTech , vol.13 , pp. 159-166
    • Wan, S.1    Sun, Y.2    Qi, X.3    Tan, F.4
  • 198
    • 80051519201 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of curcumin via a solid lipid-based selfemulsifying drug delivery system using a spray-drying technique
    • Yan YD, Kim JA, Kwak MK, Yoo BK, Yong CS, Choi HG. Enhanced oral bioavailability of curcumin via a solid lipid-based selfemulsifying drug delivery system using a spray-drying technique. Biol Pharm Bull 2011; 34: 1179-86.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1179-1186
    • Yan, Y.D.1    Kim, J.A.2    Kwak, M.K.3    Yoo, B.K.4    Yong, C.S.5    Choi, H.G.6
  • 199
    • 80052594404 scopus 로고    scopus 로고
    • PLGA-nanoparticles Improves the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms
    • Xie X, Tao Q, Zou Y, et al. PLGA-nanoparticles Improves the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms. J Agric Food Chem 2011; 59: 9280-9.
    • (2011) J Agric Food Chem , vol.59 , pp. 9280-9289
    • Xie, X.1    Tao, Q.2    Zou, Y.3
  • 200
    • 78650024236 scopus 로고    scopus 로고
    • Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability
    • Wu X, Xu J, Huang X, Wen C. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 2011; 37: 15-23.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 15-23
    • Wu, X.1    Xu, J.2    Huang, X.3    Wen, C.4
  • 201
    • 79952143791 scopus 로고    scopus 로고
    • Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin
    • Kakkar V, Singh S, Singla D, Kaur IP. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol Nutr Food Res 2011; 55: 495-503.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 495-503
    • Kakkar, V.1    Singh, S.2    Singla, D.3    Kaur, I.P.4
  • 202
    • 47049093012 scopus 로고    scopus 로고
    • Micelles of poly (ethylene oxide)-b-poly (ε-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin
    • Ma Z, Haddadi A, Molavi O, Lavasanifar A, Lai R, Samuel J. Micelles of poly (ethylene oxide)-b-poly (ε-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed Mater Res 2008; 86: 300-10.
    • (2008) J Biomed Mater Res , vol.86 , pp. 300-310
    • Ma, Z.1    Haddadi, A.2    Molavi, O.3    Lavasanifar, A.4    Lai, R.5    Samuel, J.6
  • 203
    • 77951218485 scopus 로고    scopus 로고
    • Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: A novel controlled delivery vehicle for cancer therapy
    • Mohanty C, Acharya S, Mohanty AK, Dilnawaz F, Sahoo SK. Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy. Nanomedicine 2010; 5: 433-49.
    • (2010) Nanomedicine , vol.5 , pp. 433-449
    • Mohanty, C.1    Acharya, S.2    Mohanty, A.K.3    Dilnawaz, F.4    Sahoo, S.K.5
  • 204
    • 78650179595 scopus 로고    scopus 로고
    • Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo
    • Song Z, Feng R, Sun M, et al. Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo. J Colloid Interface Sci 2011; 354: 116-23.
    • (2011) J Colloid Interface Sci , vol.354 , pp. 116-123
    • Song, Z.1    Feng, R.2    Sun, M.3
  • 205
    • 79955667342 scopus 로고    scopus 로고
    • Innovative preparation of curcumin for improved oral bioavailability
    • Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 2011; 34: 660-5.
    • (2011) Biol Pharm Bull , vol.34 , pp. 660-665
    • Sasaki, H.1    Sunagawa, Y.2    Takahashi, K.3
  • 206
    • 33749265462 scopus 로고    scopus 로고
    • Curcumin and dehydrozingerone derivatives: Synthesis, radiolabeling, and evaluation for β-amyloid plaque imaging
    • Ryu EK, Choe YS, Lee KH, Choi Y, Kim BT. Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for β-amyloid plaque imaging. J Med Chem 2006; 49: 6111-9.
    • (2006) J Med Chem , vol.49 , pp. 6111-6119
    • Ryu, E.K.1    Choe, Y.S.2    Lee, K.H.3    Choi, Y.4    Kim, B.T.5
  • 207
    • 33746353391 scopus 로고    scopus 로고
    • Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis
    • Cruz-Correa M, Shoskes DA, Sanchez P, et al. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 2006; 4: 1035-8.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1035-1038
    • Cruz-Correa, M.1    Shoskes, D.A.2    Sanchez, P.3
  • 208
    • 2642585744 scopus 로고    scopus 로고
    • Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function
    • Balasubramanian S, Eckert RL. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. Sci STKE 2004; 279: 24007-14.
    • (2004) Sci STKE , vol.279 , pp. 24007-24014
    • Balasubramanian, S.1    Eckert, R.L.2
  • 209
    • 0038043190 scopus 로고    scopus 로고
    • Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin
    • Fang JY, Hung CF, Chiu HC, Wang JJ, Chan TF. Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin. J Pharm Pharmacol 2003; 55: 593-601.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 593-601
    • Fang, J.Y.1    Hung, C.F.2    Chiu, H.C.3    Wang, J.J.4    Chan, T.F.5
  • 210
    • 0031589212 scopus 로고    scopus 로고
    • Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides
    • Verma SP, Salamone E, Goldin B. Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem Biophys Res Commun 1997; 233: 692-6.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 692-696
    • Verma, S.P.1    Salamone, E.2    Goldin, B.3
  • 211
    • 77955869442 scopus 로고    scopus 로고
    • Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry
    • Padhye S, Chavan D, Pandey S, Deshpande J, Swamy K, Sarkar F. Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry. Mini Rev Med Chem 2010; 10: 372-87.
    • (2010) Mini Rev Med Chem , vol.10 , pp. 372-387
    • Padhye, S.1    Chavan, D.2    Pandey, S.3    Deshpande, J.4    Swamy, K.5    Sarkar, F.6
  • 212
    • 84863024153 scopus 로고    scopus 로고
    • A novel mono-carbonyl analogue of curcumin induces apoptosis in ovarian carcinoma cells via endoplasmic reticulum stress and reactive oxygen species production
    • Zhang X, Zhang H, Zhu G, et al. A novel mono-carbonyl analogue of curcumin induces apoptosis in ovarian carcinoma cells via endoplasmic reticulum stress and reactive oxygen species production. Mol Med Rep 2011; 5: 739-44.
    • (2011) Mol Med Rep , vol.5 , pp. 739-744
    • Zhang, X.1    Zhang, H.2    Zhu, G.3
  • 213
    • 84863381930 scopus 로고    scopus 로고
    • The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition
    • Wang X, Zhang Y, Zhang X, Tian W, Feng W, Chen T. The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition. Int J Oncol 2011; 40: 1189-95.
    • (2011) Int J Oncol , vol.40 , pp. 1189-1195
    • Wang, X.1    Zhang, Y.2    Zhang, X.3    Tian, W.4    Feng, W.5    Chen, T.6
  • 214
    • 84855405573 scopus 로고    scopus 로고
    • Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression
    • Bao B, Ali S, Banerjee S, et al. Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression. Cancer Res 2012; 72: 335-45.
    • (2012) Cancer Res , vol.72 , pp. 335-345
    • Bao, B.1    Ali, S.2    Banerjee, S.3
  • 215
    • 84863776767 scopus 로고    scopus 로고
    • A Novel Synthetic Mono-Carbonyl Analogue of Curcumin, A13, Exhibits Anti-Inflammatory Effects In vivo by Inhibition of Inflammatory Mediators
    • Wang Y, Yu C, Pan Y, et al. A Novel Synthetic Mono-Carbonyl Analogue of Curcumin, A13, Exhibits Anti-Inflammatory Effects In vivo by Inhibition of Inflammatory Mediators. Inflammation 2011; 35: 594-604.
    • (2011) Inflammation , vol.35 , pp. 594-604
    • Wang, Y.1    Yu, C.2    Pan, Y.3
  • 216
    • 79958116796 scopus 로고    scopus 로고
    • A novel mono-carbonyl analogue of curcumin,(1E, 4E)-1, 5-bis (2, 3-dimethoxyphenyl) penta-1, 4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway
    • Wang Y, Xiao J, Zhou H, et al. A novel mono-carbonyl analogue of curcumin,(1E, 4E)-1, 5-bis (2, 3-dimethoxyphenyl) penta-1, 4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway. J Med Chem 2011; 54: 3768-78.
    • (2011) J Med Chem , vol.54 , pp. 3768-3778
    • Wang, Y.1    Xiao, J.2    Zhou, H.3
  • 217
    • 79960091795 scopus 로고    scopus 로고
    • Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin
    • Kunwar A, Barik A, Sandur SK, Indira Priyadarsini K. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res 2011; 45: 959-65.
    • (2011) Free Radic Res , vol.45 , pp. 959-965
    • Kunwar, A.1    Barik, A.2    Sandur, S.K.3    Indira, P.K.4
  • 218
    • 80051544986 scopus 로고    scopus 로고
    • Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes
    • Patwardhan RS, Checker R, Sharma D, Kohli V, Priyadarsini K, Sandur SK. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol 2011; 82: 642-57.
    • (2011) Biochem Pharmacol , vol.82 , pp. 642-657
    • Patwardhan, R.S.1    Checker, R.2    Sharma, D.3    Kohli, V.4    Priyadarsini, K.5    Sandur, S.K.6
  • 219
    • 70449367087 scopus 로고    scopus 로고
    • Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas
    • Hutzen B, Friedman L, Sobo M, et al. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int J Oncol 2009; 35: 867-72.
    • (2009) Int J Oncol , vol.35 , pp. 867-872
    • Hutzen, B.1    Friedman, L.2    Sobo, M.3
  • 220
    • 79959202798 scopus 로고    scopus 로고
    • PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells
    • Al-Hujaily EM, Mohamed AG, Al-Sharif I, et al. PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells. Breast Cancer Res Treat 2011; 128: 97-107.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 97-107
    • Al-Hujaily, E.M.1    Mohamed, A.G.2    Al-Sharif, I.3
  • 221
    • 77950800699 scopus 로고    scopus 로고
    • Synthesis and biological analysis of a new curcumin analogue for enhanced anti-tumor activity in HepG 2 cells
    • XIAO J, CHU Y, HU K, et al. Synthesis and biological analysis of a new curcumin analogue for enhanced anti-tumor activity in HepG 2 cells. Oncol Rep 2010; 23: 1435-41.
    • (2010) Oncol Rep , vol.23 , pp. 1435-1441
    • Xiao, J.1    Chu, Y.2    Hu, K.3
  • 222
    • 34447536575 scopus 로고    scopus 로고
    • Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity
    • Kalpana C, Sudheer A, Rajasekharan K, Menon V. Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med J 2007; 48: 124-30.
    • (2007) Singapore Med J , vol.48 , pp. 124-130
    • Kalpana, C.1    Sudheer, A.2    Rajasekharan, K.3    Menon, V.4
  • 224
    • 40949108125 scopus 로고    scopus 로고
    • Diphenyl difluoroketone: A curcumin derivative with potent in vivo anticancer activity
    • Subramaniam D, May R, Sureban SM, et al. Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer Res 2008; 68: 1962-9.
    • (2008) Cancer Res , vol.68 , pp. 1962-1969
    • Subramaniam, D.1    May, R.2    Sureban, S.M.3
  • 225
    • 42549169394 scopus 로고    scopus 로고
    • A broadly neuroprotective derivative of curcumin
    • Liu Y, Dargusch R, Maher P, Schubert D. A broadly neuroprotective derivative of curcumin. J Neurochem 2008; 105: 1336-45.
    • (2008) J Neurochem , vol.105 , pp. 1336-1345
    • Liu, Y.1    Dargusch, R.2    Maher, P.3    Schubert, D.4
  • 227
    • 0037902047 scopus 로고    scopus 로고
    • 4-hydroxy-3-methoxybenzoic acid methyl ester: A curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: Potential for prostate cancer management
    • Kumar AP, Garcia GE, Ghosh R, Rajnarayanan RV, Alworth WL, Slaga TJ. 4-hydroxy-3-methoxybenzoic acid methyl ester: A curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: Potential for prostate cancer management. Neoplasia 2003; 5: 255-66.
    • (2003) Neoplasia , pp. 255-266
    • Kumar, A.P.1    Garcia, G.E.2    Ghosh, R.3    Rajnarayanan, R.V.4    Alworth, W.L.5    Slaga, T.J.6
  • 228
    • 19044373252 scopus 로고    scopus 로고
    • Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation
    • Sup Shim J, Hoon Kim D, Jung HJ, et al. Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation. Bioorg Med Chem 2002; 10: 2439-44.
    • (2002) Bioorg Med Chem , vol.10 , pp. 2439-2444
    • Sup, S.J.1    Hoon, K.D.2    Jung, H.J.3
  • 229
    • 59449093810 scopus 로고    scopus 로고
    • Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability
    • Kurien BT, Scofield RH. Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res 2009; 15: 747.
    • (2009) Clin Cancer Res , vol.15 , pp. 747
    • Kurien, B.T.1    Scofield, R.H.2
  • 230
    • 77954275621 scopus 로고    scopus 로고
    • Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity
    • Bielak-Zmijewska A, Sikora-Polaczek M, Nieznanski K, et al. Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity. Cell Prolif 2010; 43: 354-64.
    • (2010) Cell Prolif , vol.43 , pp. 354-364
    • Bielak-Zmijewska, A.1    Sikora-Polaczek, M.2    Nieznanski, K.3
  • 231
    • 0036401602 scopus 로고    scopus 로고
    • Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes
    • Sakano K, Kawanishi S. Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes. Arch Biochem Biophys 2002; 405: 223-30.
    • (2002) Arch Biochem Biophys , vol.405 , pp. 223-230
    • Sakano, K.1    Kawanishi, S.2
  • 232
    • 77952928396 scopus 로고    scopus 로고
    • Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers
    • Chen Y, Liu WH, Chen BL, et al. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann Pharmacother 2010; 44: 1038-45.
    • (2010) Ann Pharmacother , vol.44 , pp. 1038-1045
    • Chen, Y.1    Liu, W.H.2    Chen, B.L.3


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