Oxidative stress and cancer: An overview

Ageing Research Reviews

Volumn 12, Issue 1, 2013, Pages 376-390

  Sosa, Venus ^a   Moliné, Teresa ^a   Somoza, Rosa ^a   Paciucci, Rosanna ^a   Kondoh, Hiroshi ^b   LLeonart, Matilde E ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Cancer; Cancer stem cells; Glycolysis; Oxidative stress; Therapy

Indexed keywords

2 [(2,3 BIS(NITROOXY)PROPYL)DISULFANYL]BENZOATE; 3 BROMOPIRUVATE; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BENZOIC ACID DERIVATIVE; BETULIC ACID; BEZIELLE; BZL 101; CURCUMIN; DEOXYGLUCOSE; DITHIOPHENE; DOCETAXEL; DOXORUBICIN; FENRETINIDE; FLUOROURACIL; FUCOIDIN; GT 094; HERBACEOUS AGENT; INTERLEUKIN 24; LONIDAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; NSC 656240; OXALIPLATIN; PACLITAXEL; PHOSPHOTRANSFERASE INHIBITOR; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIOPHENE DERIVATIVE; TOCOPHEROL; TOLFENAMIC ACID; TRITERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

3' UNTRANSLATED REGION; ANGIOGENESIS; ANTIOXIDANT ACTIVITY; BIOENERGY; BREAST CANCER; CANCER CELL; CANCER GENETICS; CANCER STEM CELL; CANCER THERAPY; CELL DAMAGE; CELL ENERGY; CELL HYPOXIA; CELL PROLIFERATION; CLINICAL TRIAL (TOPIC); COLON CANCER; DNA DAMAGE; ENVIRONMENTAL FACTOR; EPITHELIAL MESENCHYMAL TRANSITION; EUKARYOTIC CELL; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; IONIZING RADIATION; KIDNEY CARCINOMA; LEUKEMIA; LIVER CELL CARCINOMA; LUNG CANCER; METASTASIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MULTIMODALITY CANCER THERAPY; NEOPLASM; NONHUMAN; ONCOGENE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PROSTATE CANCER; PROSTATE CARCINOMA; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; ENERGY METABOLISM; ENVIRONMENT; EPITHELIAL-MESENCHYMAL TRANSITION; GENES, TUMOR SUPPRESSOR; GLYCOLYSIS; HUMANS; MICRORNAS; NEOPLASM METASTASIS; NEOPLASMS; ONCOGENES; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; STEM CELLS;

EUKARYOTA;

EID: 84870554511     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2012.10.004     Document Type: Review

References (173)

1. Afzal S., Jensen S.A., Sorensen J.B., Henriksen T., Weimann A., Poulsen H.E. Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin. Cancer Chemotherapy and Pharmacology 2012, 69:301-307.
2. Al-Hajj M., Wicha M.S., Benito-Hernandez A., Morrison S.J., Clarke M.F. Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:3983-3988.
3. Alano C.C., Garnier P., Ying W., Higashi Y., Kauppinen T.M., Swanson R.A. NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. Journal of Neuroscience 2010, 30:2967-2978.
4. Alexandre J., Hu Y., Lu W., Pelicano H., Huang P. Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species. Cancer Research 2007, 67:3512-3517.
5. Allred D.C., Anderson S.J., Paik S., Wickerham D.L., Nagtegaal I.D., Swain S.M., Mamounas E.P., Julian T.B., Geyer C.E., Costantino J.P., Land S.R., Wolmark N. Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24. Journal of Clinical Oncology 2012, 30:1268-1273.
6. Almeida M., Han L., Martin-Millan M., O'Brien C.A., Manolagas S.C. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. Journal of Biological Chemistry 2007, 282:27298-27305.
7. Anastasiou D., Poulogiannis G., Asara J.M., Boxer M.B., Jiang J.K., Shen M., Bellinger G., Sasaki A.T., Locasale J.W., Auld D.S., Thomas C.J., Vander Heiden M.G., Cantley L.C. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011, 334:1278-1283.
8. Appierto V., Tiberio P., Villani M.G., Cavadini E., Formelli F. PLAB induction in fenretinide-induced apoptosis of ovarian cancer cells occurs via a ROS-dependent mechanism involving ER stress and JNK activation. Carcinogenesis 2009, 30:824-831.
9. Arnold R.S., Shi J., Murad E., Whalen A.M., Sun C.Q., Polavarapu R., Parthasarathy S., Petros J.A., Lambeth J.D. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:5550-5555.
10. Bae I., Fan S., Meng Q., Rih J.K., Kim H.J., Kang H.J., Xu J., Goldberg I.D., Jaiswal A.K., Rosen E.M. BRCA1 induces antioxidant gene expression and resistance to oxidative stress. Cancer Research 2004, 64:7893-7909.
11. Banning A., Deubel S., Kluth D., Zhou Z., Brigelius-Flohe R. The GI-GPx gene is a target for Nrf2. Molecular and Cellular Biology 2005, 25:4914-4923.
12. Bannister J. Free Radicals in Biology and Medicine 2007, 10:250-266. B.H.P.O.
13. Bar-Even A., Flamholz A., Noor E., Milo R. Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nature Chemical Biology 2012, 8:509-517.
14. Barzilai A., Rotman G., Shiloh Y. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amsterdam) 2002, 1:3-25.
15. Beckner M.E., Gobbel G.T., Abounader R., Burovic F., Agostino N.R., Laterra J., Pollack I.F. Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Laboratory Investigation 2005, 85:1457-1470.
16. Bell E.L., Emerling B.M., Ricoult S.J., Guarente L. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Oncogene 2011, 30:2986-2996.
17. Benezra M., Chevallier N., Morrison D.J., MacLachlan T.K., El-Deiry W.S., Licht J.D. BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. Journal of Biological Chemistry 2003, 278:26333-26341.
18. Benhar M., Engelberg D., Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Reports 2002, 3:420-425.
19. Bensinger S.J., Christofk H.R. New aspects of the Warburg effect in cancer cell biology. Seminars in Cell & Developmental Biology 2012, 23:352-361.
20. Berg J.M., Tymoczko J.L., Stryer L. Biochemistry 2002, W H Freeman, New York. 5th edition.
21. Block K.I., Koch A.C., Mead M.N., Tothy P.K., Newman R.A., Gyllenhaal C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. International Journal of Cancer 2008, 123:1227-1239.
22. Borrelli A., Schiattarella A., Mancini R., Morelli F., Capasso C., De L.V., Gori E., Mancini A. The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro. International Journal of Cancer 2011, 128:453-459.
23. Bos J.L. ras oncogenes in human cancer: a review. Cancer Research 1989, 49:4682-4689.
24. Burns D.M., Richter J.D. CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation. Genes & Development 2008, 22:3449-3460.
25. Bustamante E., Pedersen P.L. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proceedings of the National Academy of Sciences of the United States of America 1977, 74:3735-3739.
26. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
27. Cavalieri E., Chakravarti D., Guttenplan J., Hart E., Ingle J., Jankowiak R., Muti P., Rogan E., Russo J., Santen R., Sutter T. Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention. Biochimica et Biophysica Acta 2006, 1766:63-78.
28. Cha Y.Y., Lee E.O., Lee H.J., Park Y.D., Ko S.G., Kim D.H., Kim H.M., Kang I.C., Kim S.H. Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway. Clinica Chimica Acta 2004, 348:41-48.
29. Chen C., Wei Y., Hummel M., Hoffmann T.K., Gross M., Kaufmann A.M., Albers A.E. Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PLoS One 2011, 6:e16466.
30. Chen V., Staub R.E., Fong S., Tagliaferri M., Cohen I., Shtivelman E. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. PLoS One 2012, 7:e30300.
31. Cheng G., Zielonka J., Dranka B.P., McAllister D., Mackinnon A.C., Joseph J., Kalyanaraman B. Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. Cancer Research 2012, 72:2634-2644.
32. Chintharlapalli S., Papineni S., Lei P., Pathi S., Safe S. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. BMC Cancer 2011, 11:371.
33. Chiu H.W., Chen Y.A., Ho S.Y., Wang Y.J. Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells. PLoS One 2012, 7:e31579.
34. Church S.L., Grant J.W., Ridnour L.A., Oberley L.W., Swanson P.E., Meltzer P.S., Trent J.M. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proceedings of the National Academy of Sciences of the United States of America 1993, 90:3113-3117.
35. Colen C.B., Seraji-Bozorgzad N., Marples B., Galloway M.P., Sloan A.E., Mathupala S.P. Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery 2006, 59:1313-1323.
36. de Groof A.J., te Lindert M.M., van Dommelen M.M., Wu M., Willemse M., Smift A.L., Winer M., Oerlemans F., Pluk H., Fransen J.A., Increased Wieringa B. OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype. Molecular Cancer 2009, 8:54.
37. Dhar S.K., Tangpong J., Chaiswing L., Oberley T.D., St Clair D.K. Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Cancer Research 2011, 71:6684-6695.
38. Diebold I., Petry A., Djordjevic T., Belaiba R.S., Fineman J., Black S., Schreiber C., Fratz S., Hess J., Kietzmann T., Gorlach A. Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxidants & Redox Signaling 2010, 13:399-412.
39. Diehn M., Cho R.W., Lobo N.A., Kalisky T., Dorie M.J., Kulp A.N., Qian D., Lam J.S., Ailles L.E., Wong M., Joshua B., Kaplan M.J., Wapnir I., Dirbas F.M., Somlo G., Garberoglio C., Paz B., Shen J., Lau S.K., Quake S.R., Brown J.M., Weissman I.L., Clarke M.F. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009, 458:780-783.
40. Esufali S., Charames G.S., Pethe V.V., Buongiorno P., Bapat B. Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. Cancer Research 2007, 67:2469-2479.
41. Favaro E., Ramachandran A., McCormick R., Gee H., Blancher C., Crosby M., Devlin C., Blick C., Buffa F., Li J.L., Vojnovic B., Pires das N.R., Glazer P., Iborra F., Ivan M., Ragoussis J., Harris A.L. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One 2010, 5:e10345.
42. Fei J., Hong A., Dobbins T.A., Jones D., Lee C.S., Loo C., Al-Ghamdi M., Harnett G.B., Clark J., O'Brien C.J., Rose B. Prognostic significance of vascular endothelial growth factor in squamous cell carcinomas of the tonsil in relation to human papillomavirus status and epidermal growth factor receptor. Annals of Surgical Oncology 2009, 16:2908-2917.
43. Fogal V., Richardson A.D., Karmali P.P., Scheffler I.E., Smith J.W., Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Molecular and Cellular Biology 2010, 30:1303-1318.
44. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine 1995, 1:27-31.
45. Funes J.M., Quintero M., Henderson S., Martinez D., Qureshi U., Westwood C., Clements M.O., Bourboulia D., Pedley R.B., Moncada S., Boshoff C. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:6223-6228.
46. Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., Dang C.V. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
47. Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis. Nature Reviews Cancer 2004, 4:891-899.
48. Geschwind J.F., Ko Y.H., Torbenson M.S., Magee C., Pedersen P.L. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Research 2002, 62:3909-3913.
49. Govindarajan B., Sligh J.E., Vincent B.J., Li M., Canter J.A., Nickoloff B.J., Rodenburg R.J., Smeitink J.A., Oberley L., Zhang Y., Slingerland J., Arnold R.S., Lambeth J.D., Cohen C., Hilenski L., Griendling K., Martinez-Diez M., Cuezva J.M., Arbiser J.L. Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. Journal of Clinical Investigation 2007, 117:719-729.
50. Graham K.A., Kulawiec M., Owens K.M., Li X., Desouki M.M., Chandra D., Singh K.K. NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer Biology and Therapy 2010, 10:223-231.
51. Guijarro M.V., Leal J.F., Blanco-Aparicio C., Alonso S., Fominaya J., Lleonart M., Castellvi J., Cajal S., Carnero A. MAP17 enhances the malignant behavior of tumor cells through ROS increase. Carcinogenesis 2007, 28:2096-2104.
52. Guppy M., Leedman P., Zu X., Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochemical Journal 2002, 364:309-315.
53. Halliwell B., Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. American Journal of Clinical Nutrition 1993, 57:715S-724S.
54. Haorah J., Ramirez S.H., Schall K., Smith D., Pandya R., Persidsky Y. Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. Journal of Neurochemistry 2007, 101:566-576.
55. Haraguchi N., Ishii H., Mimori K., Tanaka F., Ohkuma M., Kim H.M., Akita H., Takiuchi D., Hatano H., Nagano H., Barnard G.F., Doki Y., Mori M. CD13 is a therapeutic target in human liver cancer stem cells. Journal of Clinical Investigation 2010, 120:3326-3339.
56. Hayashi S., Hajiro-Nakanishi K., Makino Y., Eguchi H., Yodoi J., Tanaka H. Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator. Nucleic Acids Research 1997, 25:4035-4040.
57. Hervouet E., Cizkova A., Demont J., Vojtiskova A., Pecina P., Franssen-van Hal N.L., Keijer J., Simonnet H., Ivanek R., Kmoch S., Godinot C., Houstek J. HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 2008, 29:1528-1537.
58. Hu X., Macdonald D.M., Huettner P.C., Feng Z., El Naqa I.M., Schwarz J.K., Mutch D.G., Grigsby P.W., Powell S.N., Wang X. A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecologic Oncology 2009, 114:457-464.
59. Hybertson B.M., Gao B., Bose S.K., McCord J.M. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Molecular Aspects of Medicine 2011, 32:234-246.
60. Indran I.R., Hande M.P., Pervaiz S. Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase. Molecular Aspects of Medicine 2010, 31:21-28.
61. Ishimoto T., Nagano O., Yae T., Tamada M., Motohara T., Oshima H., Oshima M., Ikeda T., Asaba R., Yagi H., Masuko T., Shimizu T., Ishikawa T., Kai K., Takahashi E., Imamura Y., Baba Y., Ohmura M., Suematsu M., Baba H., Saya H. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011, 19:387-400.
62. Iyer N.V., Kotch L.E., Agani F., Leung S.W., Laughner E., Wenger R.H., Gassmann M., Gearhart J.D., Lawler A.M., Yu A.Y., Semenza G.L. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes & Development 1998, 12:149-162.
63. Jacobs J.J., Kieboom K., Marino S., DePinho R.A., van L.M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999, 397:164-168.
64. Jeong W.J., Yoon J., Park J.C., Lee S.H., Lee S.H., Kaduwal S., Kim H., Yoon J.B., Choi K.Y. Ras stabilization through aberrant activation of Wnt/beta-catenin signaling promotes intestinal tumorigenesis. Science Signaling 2012, 5:ra30.
65. Jin J.O., Song M.G., Kim Y.N., Park J.I., Kwak J.Y. The mechanism of fucoidan-induced apoptosis in leukemic cells: involvement of ERK1/2, JNK, glutathione, and nitric oxide. Molecular Carcinogenesis 2010, 49:771-782.
66. Jose C., Bellance N., Rossignol R. Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma. Biochimica et Biophysica Acta 2011, 1807:552-561.
67. Kang K.W., Lee S.J., Park J.W., Kim S.G. Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Molecular Pharmacology 2002, 62:1001-1010.
68. Kayamori K., Sakamoto K., Nakashima T., Takayanagi H., Morita K., Omura K., Nguyen S.T., Miki Y., Iimura T., Himeno A., Akashi T., Yamada-Okabe H., Ogata E., Yamaguchi A. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. American Journal of Pathology 2010, 176:968-980.
69. Khor T.O., Huang M.T., Kwon K.H., Chan J.Y., Reddy B.S., Kong A.N. Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Research 2006, 66:11580-11584.
70. Kim H.M., Haraguchi N., Ishii H., Ohkuma M., Okano M., Mimori K., Eguchi H., Yamamoto H., Nagano H., Sekimoto M., Doki Y., Mori M. Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon. Annals of Surgical Oncology 2012, 19:S539-S548.
71. Kim H.S., Patel K., Muldoon-Jacobs K., Bisht K.S., Aykin-Burns N., Pennington J.D., van der Meer R., Nguyen P., Savage J., Owens K.M., Vassilopoulos A., Ozden O., Park S.H., Singh K.K., Abdulkadir S.A., Spitz D.R., Deng C.X., Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010, 17:41-52.
72. Kim Y.R., Oh J.E., Kim M.S., Kang M.R., Park S.W., Han J.Y., Eom H.S., Yoo N.J., Lee S.H. Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. Journal of Pathology 2010, 220:446-451.
73. Kim J.W., Dang C.V. Cancer's molecular sweet tooth and the Warburg effect. Cancer Research 2006, 66:8927-8930.
74. Ko Y.H., Pedersen P.L., Geschwind J.F. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Letters 2001, 173:83-91.
75. Kohle C., Bock K.W. Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochemical Pharmacology 2007, 73:1853-1862.
76. Kondoh H., Lleonart M.E., Gil J., Wang J., Degan P., Peters G., Martinez D., Carnero A., Beach D. Glycolytic enzymes can modulate cellular life span. Cancer Research 2005, 65:177-185.
77. Kondoh H., Lleonart M.E., Bernard D., Gil J. Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization. Histology and Histopathology 2007, 22:85-90.
78. Kondoh H., Lleonart M.E., Nakashima Y., Yokode M., Tanaka M., Bernard D., Gil J., Beach D. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxidants & Redox Signaling 2007, 9:293-299.
79. Kotsinas A., Aggarwal V., Tan E.J., Levy B., Gorgoulis V.G. PIG3: A novel link between oxidative stress and DNA damage response in cancer. Cancer Letters 2012, 327:97-102.
80. Kovacic P., Jacintho J.D. Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Current Medicinal Chemistry 2001, 8:773-796.
81. Krek A., Grun D., Poy M.N., Wolf R., Rosenberg L., Epstein E.J., MacMenamin P., da P.I., Gunsalus K.C., Stoffel M., Rajewsky N. Combinatorial microRNA target predictions. Nature Genetics 2005, 37:495-500.
82. Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Caceres-Cortes J., Minden M., Paterson B., Caligiuri M.A., Dick J.E. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367:645-648.
83. Lebedeva I.V., Su Z.Z., Sarkar D., Gopalkrishnan R.V., Waxman S., Yacoub A., Dent P., Fisher P.B. Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis. Oncogene 2005, 24:585-596.
84. Lee J.J., Kim B.C., Park M.J., Lee Y.S., Kim Y.N., Lee B.L., Lee J.S. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell Death and Differentiation 2011, 18:666-677.
85. Lee K., Esselman W.J. Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. Free Radical Biology and Medicine 2002, 33:1121-1132.
86. Levine R.L. Carbonyl modified proteins in cellular regulation, aging, and disease. Free Radical Biology and Medicine 2002, 32:790-796.
87. Li Y., He K., Huang Y., Zheng D., Gao C., Cui L., Jin Y.H. Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells. Molecular Carcinogenesis 2010, 49:630-640.
88. Liao D., Johnson R.S. Hypoxia: a key regulator of angiogenesis in cancer. Cancer and Metastasis Reviews 2007, 26:281-290.
89. Lim S.D., Sun C., Lambeth J.D., Marshall F., Amin M., Chung L., Petros J.A., Increased Arnold R.S. Nox1 and hydrogen peroxide in prostate cancer. Prostate 2005, 62:200-207.
90. Liu F., Wang J., Chang A.K., Liu B., Yang L., Li Q., Wang P., Zou X. Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells. Phytomedicine 2012, 19:797-803.
91. Liu J., Gu X., Robbins D., Li G., Shi R., McCord J.M., Zhao Y. Protandim a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model. PLoS One 2009, 4:e5284.
92. Luo Y., Zou P., Zou J., Wang J., Zhou D., Liu L. Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKalpha dependent manner. Experimental Gerontology 2011, 46:860-867.
93. Maciag A., Sithanandam G., Anderson L.M. Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells. Carcinogenesis 2004, 25:2231-2237.
94. Malumbres M., Barbacid M. RAS oncogenes: the first 30 years. Nature Reviews Cancer 2003, 3:459-465.
95. Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., Brooks M., Reinhard F., Zhang C.C., Shipitsin M., Campbell L.L., Polyak K., Brisken C., Yang J., Weinberg R.A. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
96. Marconett C.N., Morgenstern T.J., San Roman A.K., Sundar S.N., Singhal A.K., Firestone G.L. BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biology & Therapy 2010, 10:397-405.
97. Mateescu B., Batista L., Cardon M., Gruosso T., de F.Y., Mariani O., Nicolas A., Meyniel J.P., Cottu P., Sastre-Garau X., Mechta-Grigoriou F. miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nature Medicine 2011, 17:1627-1635.
98. Mathe E., Nguyen G.H., Funamizu N., He P., Moake M., Croce C.M., Hussain S.P. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. International Journal of Cancer 2012, 131:760-765.
99. Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., Hurley P.J., Bunz F., Hwang P.M. p53 regulates mitochondrial respiration. Science 2006, 312:1650-1653.
100. Matsui A., Ikeda T., Enomoto K., Hosoda K., Nakashima H., Omae K., Watanabe M., Hibi T., Kitajima M. Increased formation of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Letters 2000, 151:87-95.
101. Matsuzawa A., Ichijo H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochimica et Biophysica Acta 2008, 1780:1325-1336.
102. McCord A.M., Jamal M., Shankavaram U.T., Lang F.F., Camphausen K., Tofilon P.J. Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro. Molecular Cancer Research 2009, 7:489-497.
103. Mishima Y., Matsumoto-Mishima Y., Terui Y., Katsuyama M., Yamada M., Mori M., Ishizaka Y., Ikeda K., Watanabe J., Mizunuma N., Hayasawa H., Hatake K. Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells. Journal of the National Cancer Institute 2002, 94:1020-1028.
104. Miska E.A., Alvarez-Saavedra E., Townsend M., Yoshii A., Sestan N., Rakic P., Constantine-Paton M., Horvitz H.R. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology 2004, 5:R68.
105. Molofsky A.V., He S., Bydon M., Morrison S.J., Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes & Development 2005, 19:1432-1437.
106. Mulholland D.J., Kobayashi N., Ruscetti M., Zhi A., Tran L.M., Huang J., Gleave M., Wu H. Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Research 2012, 72:1878-1889.
107. Nathan C.F., Arrick B.A., Murray H.W., DeSantis N.M., Cohn Z.A. Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. Journal of Experimental Medicine 1981, 153:766-782.
108. Nathan C.F., Cohn Z.A. Antitumor effects of hydrogen peroxide in vivo. Journal of Experimental Medicine 1981, 154:1539-1553.
109. Nguyen T., Nioi P., Pickett C.B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. Journal of Biological Chemistry 2009, 284:13291-13295.
110. Ni W., Zhan Y., He H., Maynard E., Balschi J.A., Oettgen P. Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II. Circulation Research 2007, 101:985-994.
111. O'Brien C.A., Pollett A., Gallinger S., Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
112. Oh J.Y., Giles N., Landar A., Darley-Usmar V. Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. Biochemical Journal 2008, 411:297-306.
113. Omori E., Inagaki M., Mishina Y., Matsumoto K., Ninomiya-Tsuji J. Epithelial transforming growth factor beta-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:3365-3370.
114. Oudard S., Poirson F., Miccoli L., Bourgeois Y., Vassault A., Poisson M., Magdelenat H., Dutrillaux B., Poupon M.F. Mitochondria-bound hexokinase as target for therapy of malignant gliomas. International Journal of Cancer 1995, 62:216-222.
115. Park J.S., Sharma L.K., Li H., Xiang R., Holstein D., Wu J., Lechleiter J., Naylor S.L., Deng J.J., Lu J., Bai Y. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Human Molecular Genetics 2009, 18:1578-1589.
116. Pathi S.S., Jutooru I., Chadalapaka G., Sreevalsan S., Anand S., Thatcher G.R., Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research 2011, 9:195-202.
117. Perez A.T., Arun B., Tripathy D., Tagliaferri M.A., Shaw H.S., Kimmick G.G., Cohen I., Shtivelman E., Caygill K.A., Grady D., Schactman M., Shapiro C.L. A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Research and Treatment 2010, 120:111-118.
118. Piao L.S., Hur W., Kim T.K., Hong S.W., Kim S.W., Choi J.E., Sung P.S., Song M.J., Lee B.C., Hwang D., Yoon S.K. CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma. Cancer Letters 2012, 315:129-137.
119. Piccirillo S.G., Reynolds B.A., Zanetti N., Lamorte G., Binda E., Broggi G., Brem H., Olivi A., Dimeco F., Vescovi A.L. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006, 444:761-765.
120. Plecita-Hlavata L., Lessard M., Santorova J., Bewersdorf J., Jezek P. Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in INS-1E and HEP-G2 cells viewed by 4Pi microscopy. Biochimica et Biophysica Acta 2008, 1777:834-846.
121. Prince M.E., Sivanandan R., Kaczorowski A., Wolf G.T., Kaplan M.J., Dalerba P., Weissman I.L., Clarke M.F., Ailles L.E. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:973-978.
122. Pritchard K.I., Julian J.A., Holloway C.M., McCready D., Gulenchyn K.Y., George R., Hodgson N., Lovrics P., Perera F., Elavathil L., O'Malley F.P., Down N., Bodurtha A., Shelley W., Levine M.N. Prospective study of 2-[18F]fluorodeoxyglucose positron emission tomography in the assessment of regional nodal spread of disease in patients with breast cancer: an Ontario clinical oncology group study. Journal of Clinical Oncology 2012, 30:1274-1279.
123. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., Bissell M.J. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005, 436:123-127.
124. Rai P., Young J.J., Burton D.G., Giribaldi M.G., Onder T.T., Weinberg R.A. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene 2011, 30:1489-1496.
125. Raj L., Ide T., Gurkar A.U., Foley M., Schenone M., Li X., Tolliday N.J., Golub T.R., Carr S.A., Shamji A.F., Stern A.M., Mandinova A., Schreiber S.L., Lee S.W. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 2011, 475:231-234.
126. Ramanathan B., Jan K.Y., Chen C.H., Hour T.C., Yu H.J., Pu Y.S. Resistance to paclitaxel is proportional to cellular total antioxidant capacity. Cancer Research 2005, 65:8455-8460.
127. Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111.
128. Rhyu D.Y., Yang Y., Ha H., Lee G.T., Song J.S., Uh S.T., Lee H.B. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. Journal of Americam Society of Nephrology 2005, 16:667-675.
129. Ricci-Vitiani L., Lombardi D.G., Pilozzi E., Biffoni M., Todaro M., Peschle C., De M.R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445:111-115.
130. Rosen E.M., Fan S., Pestell R.G., Goldberg I.D. BRCA1 gene in breast cancer. Journal of Cellular Physiology 2003, 196:19-41.
131. Rossignol R., Gilkerson R., Aggeler R., Yamagata K., Remington S.J., Capaldi R.A. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Research 2004, 64:985-993.
132. Rothe F., Ignatiadis M., Chaboteaux C., Haibe-Kains B., Kheddoumi N., Majjaj S., Badran B., Fayyad-Kazan H., Desmedt C., Harris A.L., Piccart M., Sotiriou C. Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. PLoS One 2011, 6:e20980.
133. Rouleau M., Patel A., Hendzel M.J., Kaufmann S.H., Poirier G.G. PARP inhibition: PARP1 and beyond. Nature Reviews Cancer 2010, 10:293-301.
134. Sanchez-Arago M., Chamorro M., Cuezva J.M. Selection of cancer cells with repressed mitochondria triggers colon cancer progression. Carcinogenesis 2010, 31:567-576.
135. Seo Y., Kinsella T.J. Essential role of DNA base excision repair on survival in an acidic tumor microenvironment. Cancer Research 2009, 69:7285-7293.
136. Shao C., Folkard M., Held K.D., Prise K.M. Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation. BMC Cancer 2008, 8:184.
137. Shi Y.H., Wang Y.X., Bingle L., Gong L.H., Heng W.J., Li Y., Fang W.G. In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways. Journal of Pathology 2005, 205:530-536.
138. Simic M.G., Bergtold D.S., Karam L.R. Generation of oxy radicals in biosystems. Mutation Research 1989, 214:3-12.
139. Simone N.L., Soule B.P., Ly D., Saleh A.D., Savage J.E., Degraff W., Cook J., Harris C.C., Gius D., Mitchell J.B. Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One 2009, 4:e6377.
140. Singh A., Misra V., Thimmulappa R.K., Lee H., Ames S., Hoque M.O., Herman J.G., Baylin S.B., Sidransky D., Gabrielson E., Brock M.V., Biswal S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Medicine 2006, 3:e420.
141. Skinner H.D., Zheng J.Z., Fang J., Agani F., Jiang B.H. Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling. Journal of Biological Chemistry 2004, 279:45643-45651.
142. Smolkova K., Bellance N., Scandurra F., Genot E., Gnaiger E., Plecita-Hlavata L., Jezek P., Rossignol R. Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. Journal of Bioenergetics and Biomembranes 2010, 42:55-67.
143. Soeda A., Park M., Lee D., Mintz A., Androutsellis-Theotokis A., McKay R.D., Engh J., Iwama T., Kunisada T., Kassam A.B., Pollack I.F., Park D.M. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene 2009, 28:3949-3959.
144. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273:59-63.
145. Sotgia F., Del G.F., Casimiro M.C., Bonuccelli G., Mercier I., Whitaker-Menezes D., Daumer K.M., Zhou J., Wang C., Katiyar S., Xu H., Bosco E., Quong A.A., Aronow B., Witkiewicz A.K., Minetti C., Frank P.G., Jimenez S.A., Knudsen E.S., Pestell R.G., Lisanti M.P. Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. American Journal of Pathology 2009, 174:746-761.
146. Tojo T., Ushio-Fukai M., Yamaoka-Tojo M., Ikeda S., Patrushev N., Alexander R.W. Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Circulation 2005, 111:2347-2355.
147. Tomiyama A., Serizawa S., Tachibana K., Sakurada K., Samejima H., Kuchino Y., Kitanaka C. Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressors Bax and Bak. Journal of the National Cancer Institute 2006, 98:1462-1473.
148. Toullec A., Gerald D., Despouy G., Bourachot B., Cardon M., Lefort S., Richardson M., Rigaill G., Parrini M.C., Lucchesi C., Bellanger D., Stern M.H., Dubois T., Sastre-Garau X., Delattre O., Vincent-Salomon A., Mechta-Grigoriou F. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Molecular Medicine 2010, 2:211-230.
149. Tsuyada A., Chow A., Wu J., Somlo G., Chu P., Loera S., Luu T., Li X., Wu X., Ye W., Chen S., Zhou W., Yu Y., Wang Y.Z., Ren X., Li H., Scherle P., Kuroki Y., Wang S.E. CCL2 mediates crosstalk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Research 2012, 72:2768-2779.
150. Ushio-Fukai M., Nakamura Y. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Letters 2008, 266:37-52.
151. Vaughn A.E., Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nature Cell Biology 2008, 10:1477-1483.
152. Venkataraman S., Alimova I., Fan R., Harris P., Foreman N., Vibhakar R. MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS One 2010, 5:e10748.
153. Veskoukis A.S., Tsatsakis A.M., Kouretas D. Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration. Cell Stress and Chaperones 2012, 17:11-21.
154. Vizan P., Alcarraz-Vizan G., Diaz-Moralli S., Solovjeva O.N., Frederiks W.M., Cascante M. Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. International Journal of Cancer 2009, 124:2789-2796.
155. Wang X.Q., Li H., Van P.V., Winn R.A., Heasley L.E., Nemenoff R.A. Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Molecular Biology of the Cell 2009, 20:791-800.
156. Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
157. Weinberg F., Chandel N.S. Mitochondrial metabolism and cancer. Annals of the New York Academy of Sciences 2009, 1177:66-73.
158. Weyemi U., Lagente-Chevallier O., Boufraqech M., Prenois F., Courtin F., Caillou B., Talbot M., Dardalhon M., Al G.A., Bidart J.M., Schlumberger M., Dupuy C. ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Oncogene 2012, 31:1117-1129.
159. Wiemer E.A. Stressed tumor cell, chemosensitized cancer. Nature Medicine 2011, 17:1552-1554.
160. Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.Y., Pfeiffer H.K., Nissim I., Daikhin E., Yudkoff M., McMahon S.B., Thompson C.B. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:18782-18787.
161. Won K.Y., Lim S.J., Kim G.Y., Kim Y.W., Han S.A., Song J.Y., Lee D.K. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. Human Pathology 2012, 43:221-228.
162. Wulf G.G., Wang R.Y., Kuehnle I., Weidner D., Marini F., Brenner M.K., Andreeff M., Goodell M.A. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood 2001, 98:1166-1173.
163. Yacoub A., Mitchell C., Hong Y., Gopalkrishnan R.V., Su Z.Z., Gupta P., Sauane M., Lebedeva I.V., Curiel D.T., Mahasreshti P.J., Rosenfeld M.R., Broaddus W.C., James C.D., Grant S., Fisher P.B., Dent P. MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells. Cancer Biology and Therapy 2004, 3:739-751.
164. Yagoda N., von R.M., Zaganjor E., Bauer A.J., Yang W.S., Fridman D.J., Wolpaw A.J., Smukste I., Peltier J.M., Boniface J.J., Smith R., Lessnick S.L., Sahasrabudhe S., Stockwell B.R. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007, 447:864-868.
165. Yalcin S., Marinkovic D., Mungamuri S.K., Zhang X., Tong W., Sellers R., Ghaffari S. ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO Journal 2010, 29:4118-4131.
166. Yau C., Benz C.C. Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers. Breast Cancer Research 2008, 10:R61.
167. Yin X., Zhou J., Jie C., Xing D., Zhang Y. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sciences 2004, 75:2233-2244.
168. Ying Q., Liang L., Guo W., Zha R., Tian Q., Huang S., Yao J., Ding J., Bao M., Ge C., Yao M., Li J., He X. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology 2011, 54:2064-2075.
169. Yoshida T., Oka S., Masutani H., Nakamura H., Yodoi J. The role of thioredoxin in the aging process: involvement of oxidative stress. Antioxidants & Redox Signaling 2003, 5:563-570.
170. Yu R., Lei W., Mandlekar S., Weber M.J., Der C.J., Wu J., Kong A.N. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. Journal of Biological Chemistry 1999, 274:27545-27552.
171. Zhang Z., Teruya K., Eto H., Shirahata S. Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways. PLoS One 2011, 6:e27441.
172. Zhao R., Xiang N., Domann F.E., Zhong W. Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Cancer Research 2006, 66:2296-2304.
173. Zong W.X., Ditsworth D., Bauer D.E., Wang Z.Q., Thompson C.B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes & Development 2004, 18:1272-1282.