-
1
-
-
4544368193
-
Stroke: Incidence, mortality, morbidity and risk
-
Ingall T. Stroke: incidence, mortality, morbidity and risk. J Insur Med 2004;36(2):143-152
-
(2004)
J Insur Med
, vol.36
, Issue.2
, pp. 143-152
-
-
Ingall, T.1
-
2
-
-
60449094498
-
Heart disease and stroke statistics: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009;119(3):480-486
-
(2009)
Circulation
, vol.119
, Issue.3
, pp. 480-486
-
-
Lloyd-Jones, D.1
Adams, R.2
Carnethon, M.3
-
3
-
-
77953641365
-
-
The Internet Stroke Center: stroke statistics. Available from: [Last accessed 17 May 2010]
-
The Internet Stroke Center: stroke statistics. Available from: http://www.strokecenter.org/patients/stats.htm. [Last accessed 17 May 2010]
-
-
-
-
4
-
-
0034057452
-
Ischemic stroke subtypes: A population-based study of functional outcome, survival, and recurrence
-
Petty GW, Brown RD Jr, Whisnant JP, et al. Ischemic stroke subtypes: a population-based study of functional outcome, survival, and recurrence. Stroke 2000;31(5):1062-1068
-
(2000)
Stroke
, vol.31
, Issue.5
, pp. 1062-1068
-
-
Petty, G.W.1
Brown Jr., R.D.2
Whisnant, J.P.3
-
5
-
-
0032735072
-
Ischemic stroke subtypes: A population-based study of incidence and risk factors
-
Petty GW, Brown RD Jr, Whisnant JP, et al. Ischemic stroke subtypes: a population-based study of incidence and risk factors. Stroke 1999;30(12):2513-2516
-
(1999)
Stroke
, vol.30
, Issue.12
, pp. 2513-2516
-
-
Petty, G.W.1
Brown Jr., R.D.2
Whisnant, J.P.3
-
6
-
-
0036850280
-
Development of thrombolytic therapy for stroke: A perspective
-
Lapchak PA. Development of thrombolytic therapy for stroke: a perspective. Expert Opin Investig Drugs 2002;11(11):1623-1632
-
(2002)
Expert Opin Investig Drugs
, vol.11
, Issue.11
, pp. 1623-1632
-
-
Lapchak, P.A.1
-
7
-
-
0034840614
-
Thrombolytic therapy for ischemic stroke: Review Part II: Tra- arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imaging
-
Schellinger PD, Fiebach JB, Mohr A, et al. Thrombolytic therapy for ischemic stroke: review. Part II: tra- arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imaging. Crit Care Med 2001;29(9):1819-1825
-
(2001)
Crit Care Med
, vol.29
, Issue.9
, pp. 1819-1825
-
-
Schellinger, P.D.1
Fiebach, J.B.2
Mohr, A.3
-
8
-
-
0034855790
-
Thrombolytic therapy for ischemic stroke: A review Part I: Intravenous thrombolysis
-
Schellinger PD, Fiebach JB, Mohr A, et al. Thrombolytic therapy for ischemic stroke: a review. Part I: Intravenous thrombolysis. Crit Care Med 2001;29(9):1812-1818
-
(2001)
Crit Care Med
, vol.29
, Issue.9
, pp. 1812-1818
-
-
Schellinger, P.D.1
Fiebach, J.B.2
Mohr, A.3
-
9
-
-
0032881338
-
Newer thrombolytic agents
-
Verstraete M. Newer thrombolytic agents. Ann Acad Med Singapore 1999;28(3):424-433
-
(1999)
Ann Acad Med Singapore
, vol.28
, Issue.3
, pp. 424-433
-
-
Verstraete, M.1
-
10
-
-
52649165720
-
Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
-
Extremely important study showing that alteplase could be used within 4.5 h of a stroke
-
Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359(13):1317-1329 .. Extremely important study showing that alteplase could be used within 4.5 h of a stroke.
-
(2008)
N Engl J Med
, vol.359
, Issue.13
, pp. 1317-1329
-
-
Hacke, W.1
Kaste, M.2
Bluhmki, E.3
-
11
-
-
71849095831
-
Stroke treatment with alteplase given 3.0-4.5 h after onset of acute ischaemic stroke (ECASS III): Additional outcomes and subgroup analysis of a randomised controlled trial
-
Bluhmki E, Chamorro A, Davalos A, et al. Stroke treatment with alteplase given 3.0-4.5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol 2009;8(12):1095-1102
-
(2009)
Lancet Neurol
, vol.8
, Issue.12
, pp. 1095-1102
-
-
Bluhmki, E.1
Chamorro, A.2
Davalos, A.3
-
12
-
-
0028783948
-
Tissue plasminogen activator for acute ischemic stroke
-
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
-
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333(24):1581-1587
-
(1995)
N Engl J Med
, vol.333
, Issue.24
, pp. 1581-1587
-
-
-
13
-
-
77953639695
-
Translational stroke research using a rabbit embolic stroke model: A correlative analysis hypothesis for novel therapy development
-
Lapchak PA. Translational stroke research using a rabbit embolic stroke model: a correlative analysis hypothesis for novel therapy development. Transl Stroke Res 2010;1(2):96-107
-
(2010)
Transl Stroke Res
, vol.1
, Issue.2
, pp. 96-107
-
-
Lapchak, P.A.1
-
14
-
-
0033199996
-
Pathobiology of ischaemic stroke: An integrated view
-
Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999;22(9):391-397
-
(1999)
Trends Neurosci
, vol.22
, Issue.9
, pp. 391-397
-
-
Dirnagl, U.1
Iadecola, C.2
Ma, M.3
-
15
-
-
33947652677
-
Advances in ischemic stroke treatment: Neuroprotective and combination therapies
-
Lapchak PA, Araujo DM. Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs 2007;12(1):97-112
-
(2007)
Expert Opin Emerg Drugs
, vol.12
, Issue.1
, pp. 97-112
-
-
Lapchak, P.A.1
Araujo, D.M.2
-
17
-
-
0032924640
-
Oxidative stress in brain ischemia
-
Love S. Oxidative stress in brain ischemia. Brain Pathol 1999;9(1):119-131
-
(1999)
Brain Pathol
, vol.9
, Issue.1
, pp. 119-131
-
-
Love, S.1
-
18
-
-
46849106962
-
The novel antioxidant edaravone: From bench to bedside
-
Watanabe T, Tahara M, Todo S. The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther 2008;26(2):101-114
-
(2008)
Cardiovasc Ther
, vol.26
, Issue.2
, pp. 101-114
-
-
Watanabe, T.1
Tahara, M.2
Todo, S.3
-
19
-
-
33746549327
-
Neuroprotective effects of edaravone: A novel free radical scavenger in cerebrovascular injury
-
Yoshida H, Yanai H, Namiki Y, et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev 2006;12(1):9-20
-
(2006)
CNS Drug Rev
, vol.12
, Issue.1
, pp. 9-20
-
-
Yoshida, H.1
Yanai, H.2
Namiki, Y.3
-
20
-
-
0032704101
-
Antioxidants, oxidative stress, and degenerative neurological disorders
-
Floyd RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999;222(3):236-245
-
(1999)
Proc Soc Exp Biol Med
, vol.222
, Issue.3
, pp. 236-245
-
-
Floyd, R.A.1
-
21
-
-
0032972451
-
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat
-
Nakashima M, Niwa M, Iwai T, Uematsu T. Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. Free Radic Biol Med 1999;26(5-6):722-729
-
(1999)
Free Radic Biol Med
, vol.26
, Issue.5-6
, pp. 722-729
-
-
Nakashima, M.1
Niwa, M.2
Iwai, T.3
Uematsu, T.4
-
22
-
-
29144435788
-
Potential markers of oxidative stress in stroke
-
Cherubini A, Ruggiero C, Polidori MC, Mecocci P. Potential markers of oxidative stress in stroke. Free Radic Biol Med 2005;39(7):841-852
-
(2005)
Free Radic Biol Med
, vol.39
, Issue.7
, pp. 841-852
-
-
Cherubini, A.1
Ruggiero, C.2
Polidori, M.C.3
Mecocci, P.4
-
23
-
-
0141954290
-
Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke
-
Lapchak PA, Araujo DM. Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke. CNS Drug Rev 2003;9(3):253-262
-
(2003)
CNS Drug Rev
, vol.9
, Issue.3
, pp. 253-262
-
-
Lapchak, P.A.1
Araujo, D.M.2
-
24
-
-
0028885588
-
Mechanisms of secondary brain damage in global and focal ischemia: A speculative synthesis
-
Siesjo BK, Katsura K, Zhao Q, et al. Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma 1995;12(5):943-956
-
(1995)
J Neurotrauma
, vol.12
, Issue.5
, pp. 943-956
-
-
Siesjo, B.K.1
Katsura, K.2
Zhao, Q.3
-
25
-
-
0029952158
-
Mechanisms of secondary brain injury
-
Siesjo BK, Siesjo P. Mechanisms of secondary brain injury. Eur J Anaesthesiol 1996;13(3):247-268
-
(1996)
Eur J Anaesthesiol
, vol.13
, Issue.3
, pp. 247-268
-
-
Siesjo, B.K.1
Siesjo, P.2
-
26
-
-
70749150769
-
Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
-
Lee BJ, Egi Y, van Leyen K, et al. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res 2010;1307:22-27
-
(2010)
Brain Res
, vol.1307
, pp. 22-27
-
-
Lee, B.J.1
Egi, Y.2
Van Leyen, K.3
-
27
-
-
65649115845
-
Edaravone for the treatment of acute cerebral infarction: Role of endothelium-derived nitric oxide and oxidative stress
-
Higashi Y. Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress. Expert Opin Pharmacother 2009;10(2):323-331
-
(2009)
Expert Opin Pharmacother
, vol.10
, Issue.2
, pp. 323-331
-
-
Higashi, Y.1
-
28
-
-
33744788665
-
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage
-
Kono H, Woods CG, Maki A, et al. Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Radic Res 2006;40(6):579-588
-
(2006)
Free Radic Res
, vol.40
, Issue.6
, pp. 579-588
-
-
Kono, H.1
Woods, C.G.2
Maki, A.3
-
29
-
-
13444292146
-
The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia
-
Banno M, Mizuno T, Kato H, et al. The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia. Neuropharmacology 2005;48(2):283-290
-
(2005)
Neuropharmacology
, vol.48
, Issue.2
, pp. 283-290
-
-
Banno, M.1
Mizuno, T.2
Kato, H.3
-
30
-
-
7944234144
-
Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
-
Shichinohe H, Kuroda S, Yasuda H, et al. Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res 2004;1029(2):200-206
-
(2004)
Brain Res
, vol.1029
, Issue.2
, pp. 200-206
-
-
Shichinohe, H.1
Kuroda, S.2
Yasuda, H.3
-
31
-
-
34250760916
-
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases
-
Higashi Y, Jitsuiki D, Chayama K, Yoshizumi M. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Patents Cardiovasc Drug Discov 2006;1(1):85-93
-
(2006)
Recent Patents Cardiovasc Drug Discov
, vol.1
, Issue.1
, pp. 85-93
-
-
Higashi, Y.1
Jitsuiki, D.2
Chayama, K.3
Yoshizumi, M.4
-
32
-
-
13844275484
-
Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase
-
Yoshida H, Sasaki K, Namiki Y, et al. Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase. Atherosclerosis 2005;179(1):97-102
-
(2005)
Atherosclerosis
, vol.179
, Issue.1
, pp. 97-102
-
-
Yoshida, H.1
Sasaki, K.2
Namiki, Y.3
-
33
-
-
20444417507
-
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats
-
Amemiya S, Kamiya T, Nito C, et al. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol 2005;516(2):125-130
-
(2005)
Eur J Pharmacol
, vol.516
, Issue.2
, pp. 125-130
-
-
Amemiya, S.1
Kamiya, T.2
Nito, C.3
-
34
-
-
39749173050
-
Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats
-
Xiao B, Bi FF, Hu YQ, et al. Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats. Neurotox Res 2007;12(3):155-162
-
(2007)
Neurotox Res
, vol.12
, Issue.3
, pp. 155-162
-
-
Xiao, B.1
Bi, F.F.2
Hu, Y.Q.3
-
35
-
-
66749132080
-
The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells
-
Kikuchi K, Kawahara K, Tancharoen S, et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. J Pharmacol Exp Ther 2009;329(3):865-874
-
(2009)
J Pharmacol Exp Ther
, vol.329
, Issue.3
, pp. 865-874
-
-
Kikuchi, K.1
Kawahara, K.2
Tancharoen, S.3
-
36
-
-
26444613280
-
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
-
Zhang N, Komine-Kobayashi M, Tanaka R, et al. Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 2005;36(10):2220-2225
-
(2005)
Stroke
, vol.36
, Issue.10
, pp. 2220-2225
-
-
Zhang, N.1
Komine-Kobayashi, M.2
Tanaka, R.3
-
37
-
-
35549012820
-
Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia
-
DOI 10.1016/j.neures.2007.08.008, PII S0168010207017452
-
Ishikawa A, Yoshida H, Metoki N, et al. Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. Neurosci Res 2007;59(4):406-412 (Pubitemid 350011198)
-
(2007)
Neuroscience Research
, vol.59
, Issue.4
, pp. 406-412
-
-
Ishikawa, A.1
Yoshida, H.2
Metoki, N.3
Toki, T.4
Imaizumi, T.5
Matsumiya, T.6
Yamashita, K.7
Taima, K.8
Satoh, K.9
-
38
-
-
70549090013
-
Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4
-
Kikuchi K, Tancharoen S, Matsuda F, et al. Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4. Biochem Biophys Res Commun 2009;390(4):1121-1125
-
(2009)
Biochem Biophys Res Commun
, vol.390
, Issue.4
, pp. 1121-1125
-
-
Kikuchi, K.1
Tancharoen, S.2
Matsuda, F.3
-
39
-
-
39349091206
-
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage
-
Nakamura T, Kuroda Y, Yamashita S, et al. Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. Stroke 2008;39(2):463-469
-
(2008)
Stroke
, vol.39
, Issue.2
, pp. 463-469
-
-
Nakamura, T.1
Kuroda, Y.2
Yamashita, S.3
-
40
-
-
60549111009
-
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator
-
Yagi K, Kitazato KT, Uno M, et al. Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Stroke 2009;40(2):626-631
-
(2009)
Stroke
, vol.40
, Issue.2
, pp. 626-631
-
-
Yagi, K.1
Kitazato, K.T.2
Uno, M.3
-
41
-
-
22844448204
-
Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: Evaluation in a rat thromboembolic stroke model
-
DOI 10.1179/016164105X17387
-
Kano T, Harada T, Katayama Y. Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model. Neurol Res 2005;27(5):499-502 (Pubitemid 41040836)
-
(2005)
Neurological Research
, vol.27
, Issue.5
, pp. 499-502
-
-
Kano, T.1
Harada, T.2
Katayama, Y.3
-
42
-
-
0024462418
-
Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain
-
Oishi R, Itoh Y, Nishibori M, et al. Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain. Stroke 1989;20(11):1557-1564
-
(1989)
Stroke
, vol.20
, Issue.11
, pp. 1557-1564
-
-
Oishi, R.1
Itoh, Y.2
Nishibori, M.3
-
43
-
-
0024414674
-
Effect of MCI-186 on brain edema in rats
-
Nishi H, Watanabe T, Sakurai H, et al. Effect of MCI-186 on brain edema in rats. Stroke 1989;20(9):1236-1240
-
(1989)
Stroke
, vol.20
, Issue.9
, pp. 1236-1240
-
-
Nishi, H.1
Watanabe, T.2
Sakurai, H.3
-
44
-
-
0036281518
-
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils
-
Jin YJ, Mima T, Raicu V, et al. Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. Neurosci Res 2002;43(1):75-79
-
(2002)
Neurosci Res
, vol.43
, Issue.1
, pp. 75-79
-
-
Jin, Y.J.1
Mima, T.2
Raicu, V.3
-
45
-
-
1442352732
-
The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats
-
Nito C, Kamiya T, Amemiya S, et al. The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats. Acta Neurochir Suppl 2003;86:199-203
-
(2003)
Acta Neurochir Suppl
, vol.86
, pp. 199-203
-
-
Nito, C.1
Kamiya, T.2
Amemiya, S.3
-
46
-
-
0028292964
-
Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions
-
Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994;268(3):1597-1604
-
(1994)
J Pharmacol Exp Ther
, vol.268
, Issue.3
, pp. 1597-1604
-
-
Watanabe, T.1
Yuki, S.2
Egawa, M.3
Nishi, H.4
-
47
-
-
0034730419
-
MCI-186: Further histochemical and biochemical evidence of neuroprotection
-
Wu TW, Zeng LH, Wu J, Fung KP. MCI-186: further histochemical and biochemical evidence of neuroprotection. Life Sci 2000;67(19):2387-2392
-
(2000)
Life Sci
, vol.67
, Issue.19
, pp. 2387-2392
-
-
Wu, T.W.1
Zeng, L.H.2
Wu, J.3
Kp, F.4
-
48
-
-
0036019074
-
Treatment of acute ischemic stroke: Recent progress
-
Tanahashi N, Fukuuchi Y. Treatment of acute ischemic stroke: recent progress. Intern Med 2002;41(5):337-344
-
(2002)
Intern Med
, vol.41
, Issue.5
, pp. 337-344
-
-
Tanahashi, N.1
Fukuuchi, Y.2
-
49
-
-
34547574317
-
Neuroprotective effects of free radical scavengers in stroke
-
Wang CX, Shuaib A. Neuroprotective effects of free radical scavengers in stroke. Drugs Aging 2007;24(7):537-546
-
(2007)
Drugs Aging
, vol.24
, Issue.7
, pp. 537-546
-
-
Wang, C.X.1
Shuaib, A.2
-
50
-
-
33645684629
-
Edaravone in acute ischemic stroke
-
Kitagawa Y. Edaravone in acute ischemic stroke. Intern Med 2006;45(5):225-226
-
(2006)
Intern Med
, vol.45
, Issue.5
, pp. 225-226
-
-
Kitagawa, Y.1
-
51
-
-
34249726192
-
Edaravone
-
Abe K. Edaravone. Nippon Rinsho 2006;64(Suppl 7):548-553
-
(2006)
Nippon Rinsho
, vol.64
, Issue.SUPPL. 7
, pp. 548-553
-
-
Abe, K.1
-
52
-
-
0344065373
-
Recommendations for standards regarding preclinical neuroprotective and restorative drug development
-
STAIR
-
STAIR. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999;30(12):2752-2758
-
(1999)
Stroke
, vol.30
, Issue.12
, pp. 2752-2758
-
-
-
53
-
-
0024519703
-
Evaluation of recombinant tissue plasminogen activator in embolic stroke
-
Chehrazi BB, Seibert JA, Kissel P, et al. Evaluation of recombinant tissue plasminogen activator in embolic stroke. Neurosurgery 1989;24(3):355-360
-
(1989)
Neurosurgery
, vol.24
, Issue.3
, pp. 355-360
-
-
Chehrazi, B.B.1
Seibert, J.A.2
Kissel, P.3
-
54
-
-
0029018613
-
Delayed tissue-plasminogen activator therapy in a rabbit model of thromboembolic stroke
-
Gross CE, Raymond SJ, Howard DB, Bednar MM. Delayed tissue-plasminogen activator therapy in a rabbit model of thromboembolic stroke. Neurosurgery 1995;36(6):1172-1177
-
(1995)
Neurosurgery
, vol.36
, Issue.6
, pp. 1172-1177
-
-
Gross, C.E.1
Raymond, S.J.2
Howard, D.B.3
Bednar, M.M.4
-
55
-
-
0023761117
-
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit
-
Phillips DA, Davis MA, Fisher M. Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit. AJNR Am J Neuroradiol 1988;9(5):899-902
-
(1988)
AJNR Am J Neuroradiol
, vol.9
, Issue.5
, pp. 899-902
-
-
Phillips, D.A.1
Ma, D.2
Fisher, M.3
-
56
-
-
0023949290
-
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model
-
Phillips DA, Fisher M, Smith TW, Davis MA. The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model. Ann Neurol 1988;23(4):391-394
-
(1988)
Ann Neurol
, vol.23
, Issue.4
, pp. 391-394
-
-
Phillips, D.A.1
Fisher, M.2
Smith, T.W.3
Ma, D.4
-
57
-
-
0022405261
-
Tissue plasminogen activator reduces neurological damage after cerebral embolism
-
Zivin JA, Fisher M, DeGirolami U, et al. Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science 1985;230(4731):1289-1292
-
(1985)
Science
, vol.230
, Issue.4731
, pp. 1289-1292
-
-
Zivin, J.A.1
Fisher, M.2
Degirolami, U.3
-
58
-
-
0347624526
-
Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits
-
Lapchak PA, Araujo DM, Zivin JA. Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits. Exp Neurol 2004;185(1):154-159
-
(2004)
Exp Neurol
, vol.185
, Issue.1
, pp. 154-159
-
-
Lapchak, P.A.1
Araujo, D.M.2
Zivin, J.A.3
-
59
-
-
57449103131
-
The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: A combination therapy study with tissue plasminogen activator
-
Lapchak PA, Zivin JA. The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator. Exp Neurol 2009;215(1):95-100
-
(2009)
Exp Neurol
, vol.215
, Issue.1
, pp. 95-100
-
-
Lapchak, P.A.1
Zivin, J.A.2
-
60
-
-
36749068009
-
Baicalein, an antioxidant 12/15 lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes
-
Lapchak PD, Maher P, Schubert D, Zivin JA. Baicalein, an antioxidant 12/15 lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. Neuroscience 2007;150(3):585-591
-
(2007)
Neuroscience
, vol.150
, Issue.3
, pp. 585-591
-
-
Lapchak, P.D.1
Maher, P.2
Schubert, D.3
Zivin, J.A.4
-
61
-
-
0033800679
-
Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial
-
Broderick JP, Lu M, Kothari R, et al. Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial. Stroke 2000;31(10):2335-2341
-
(2000)
Stroke
, vol.31
, Issue.10
, pp. 2335-2341
-
-
Broderick, J.P.1
Lu, M.2
Kothari, R.3
-
62
-
-
0034120507
-
The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): Results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators
-
Clark WM, Albers GW, Madden KP, Hamilton S. The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators. Stroke 2000;31(4):811-816
-
(2000)
Stroke
, vol.31
, Issue.4
, pp. 811-816
-
-
Clark, W.M.1
Albers, G.W.2
Kp, M.3
Hamilton, S.4
-
63
-
-
0027943114
-
Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group, the first study to validate a stroke scale in patients treated with tPA
-
Lyden P, Brott T, Tilley B, et al. Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. Stroke 1994;25(11):2220-2226. The first study to validate a stroke scale in patients treated with tPA.
-
(1994)
Stroke
, vol.25
, Issue.11
, pp. 2220-2226
-
-
Lyden, P.1
Brott, T.2
Tilley, B.3
-
64
-
-
0032700790
-
Underlying structure of the National Institutes of Health Stroke Scale: Results of a factor analysis. NINDS tPA Stroke Trial Investigators
-
Lyden P, Lu M, Jackson C, et al. Underlying structure of the National Institutes of Health Stroke Scale: results of a factor analysis. NINDS tPA Stroke Trial Investigators. Stroke 1999;30(11):2347-2354
-
(1999)
Stroke
, vol.30
, Issue.11
, pp. 2347-2354
-
-
Lyden, P.1
Lu, M.2
Jackson, C.3
-
65
-
-
0037229213
-
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters
-
Otomo E. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003;15(3):222-229
-
(2003)
Cerebrovasc Dis
, vol.15
, Issue.3
, pp. 222-229
-
-
Otomo, E.1
-
66
-
-
0345383004
-
Late phase 2 clinical trial of MCI-186 on acute cerebral infarction: A dose-finding double-blind study
-
Otomo E. Late phase 2 clinical trial of MCI-186 on acute cerebral infarction: a dose-finding double-blind study. J Clin Exp Med 1998;185:841-863
-
(1998)
J Clin Exp Med
, vol.185
, pp. 841-863
-
-
Otomo, E.1
-
67
-
-
0031665161
-
Clinical efficacy of a free radical scavenger, MCI-186, on acute cerebral infarction: Early phase II clinical trial
-
Otomo E, Tohgi H, Kogure K, et al. Clinical efficacy of a free radical scavenger, MCI-186, on acute cerebral infarction: Early phase II clinical trial. Ther Res 1998;19:1311-1332
-
(1998)
Ther Res
, vol.19
, pp. 1311-1332
-
-
Otomo, E.1
Tohgi, H.2
Kogure, K.3
-
68
-
-
33645681104
-
Efficacy of edaravone in cardioembolic stroke
-
Inatomi Y, Takita T, Yonehara T, et al. Efficacy of edaravone in cardioembolic stroke. Intern Med 2006;45(5):253-257
-
(2006)
Intern Med
, vol.45
, Issue.5
, pp. 253-257
-
-
Inatomi, Y.1
Takita, T.2
Yonehara, T.3
-
69
-
-
23844517474
-
Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction
-
discussion 8
-
Mishina M, Komaba Y, Kobayashi S, et al. Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction. Neurol Med Chir (Tokyo) 2005;45(7):344-8; discussion 8
-
(2005)
Neurol Med Chir (Tokyo)
, vol.45
, Issue.7
, pp. 344-348
-
-
Mishina, M.1
Komaba, Y.2
Kobayashi, S.3
-
70
-
-
0027514354
-
Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial (TOAST) Trial of Org 10172 in Acute Stroke Treatment
-
Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial (TOAST) Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24(1):35-41
-
(1993)
Stroke
, vol.24
, Issue.1
, pp. 35-41
-
-
Adams Jr., H.P.1
Bendixen, B.H.2
Kappelle, L.J.3
-
71
-
-
67649736219
-
Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction
-
Ohta Y, Takamatsu K, Fukushima T, et al. Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction. Intern Med 2009;48(8):593-596
-
(2009)
Intern Med
, vol.48
, Issue.8
, pp. 593-596
-
-
Ohta, Y.1
Takamatsu, K.2
Fukushima, T.3
-
72
-
-
62849084592
-
Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial)
-
Shinohara Y, Saito I, Kobayashi S, Uchiyama S. Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial). Cerebrovasc Dis 2009;27(5):485-492
-
(2009)
Cerebrovasc Dis
, vol.27
, Issue.5
, pp. 485-492
-
-
Shinohara, Y.1
Saito, I.2
Kobayashi, S.3
Uchiyama, S.4
-
73
-
-
70349644672
-
Edaravone in acute ischemic stroke, an Indian experience
-
Sinha MK, Anuradha HK, Juyal R, et al. Edaravone in acute ischemic stroke, an Indian experience. Neurol Asia 2009;14:7-10
-
(2009)
Neurol Asia
, vol.14
, pp. 7-10
-
-
Sinha, M.K.1
Anuradha, H.K.2
Juyal, R.3
-
74
-
-
2642551352
-
Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion
-
Toyoda K, Fujii K, Kamouchi M, et al. Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci 2004;221(1-2):11-17
-
(2004)
J Neurol Sci
, vol.221
, Issue.1-2
, pp. 11-17
-
-
Toyoda, K.1
Fujii, K.2
Kamouchi, M.3
-
75
-
-
0029914446
-
'Malignant' middle cerebral artery territory infarction: Clinical course and prognostic signs
-
Hacke W, Schwab S, Horn M, et al. 'Malignant' middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol 1996;53(4):309-315
-
(1996)
Arch Neurol
, vol.53
, Issue.4
, pp. 309-315
-
-
Hacke, W.1
Schwab, S.2
Horn, M.3
-
76
-
-
77249125873
-
Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment?: A retrospective study of edaravone therapy
-
Unno Y, Katayama M, Shimizu H. Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment?: a retrospective study of edaravone therapy. Clin Drug Investig 2010;30(3):143-155
-
(2010)
Clin Drug Investig
, vol.30
, Issue.3
, pp. 143-155
-
-
Unno, Y.1
Katayama, M.2
Shimizu, H.3
-
77
-
-
0000746722
-
Phase i clinical study of MCI-186 (Edaravone, 3-methyl-1-phenyl-2- pyrazolin-5-one) in healthy volunteers: Safety and pharmacokinetics of single and multiple administrations
-
Shibata H, Shigenori A, Izawa M, et al. Phase I clinical study of MCI-186 (Edaravone, 3-methyl-1-phenyl-2-pyrazolin-5-one) in healthy volunteers: safety and pharmacokinetics of single and multiple administrations. Jpn J Clin Pharmacol Ther 1998;29(6):863-876
-
(1998)
Jpn J Clin Pharmacol Ther
, vol.29
, Issue.6
, pp. 863-876
-
-
Shibata, H.1
Shigenori, A.2
Izawa, M.3
-
78
-
-
79951557483
-
TManalysis of CNB-001 a novel curcumin-based neurotrophic\ neuroprotective lead compound to treat stroke: Comparison with NXY-059 and Radicut
-
In press
-
TManalysis of CNB-001 a novel curcumin-based neurotrophic\ neuroprotective lead compound to treat stroke: comparison with NXY-059 and Radicut. Transl Stroke Res 2010; In press
-
(2010)
Transl Stroke Res
-
-
Lapchak, P.A.1
Kckim, J.M.2
-
80
-
-
37249053501
-
Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance
-
Hishida A. Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance. Clin Exp Nephrol 2007;11(4):292-296
-
(2007)
Clin Exp Nephrol
, vol.11
, Issue.4
, pp. 292-296
-
-
Hishida, A.1
-
81
-
-
67349183368
-
Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone
-
Hishida A. Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone. Clin Exp Nephrol 2009;13(2):118-122
-
(2009)
Clin Exp Nephrol
, vol.13
, Issue.2
, pp. 118-122
-
-
Hishida, A.1
-
82
-
-
34248173436
-
A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient
-
Abe M, Kaizu K, Matsumoto K. A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient. Ther Apher Dial 2007;11(3):235-240
-
(2007)
Ther Apher Dial
, vol.11
, Issue.3
, pp. 235-240
-
-
Abe, M.1
Kaizu, K.2
Matsumoto, K.3
-
83
-
-
48249155338
-
Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism
-
Mishina M, Komaba Y, Kobayashi S, et al. Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism. Neurol Med Chir (Tokyo) 2008;48(7):292-297
-
(2008)
Neurol Med Chir (Tokyo)
, vol.48
, Issue.7
, pp. 292-297
-
-
Mishina, M.1
Komaba, Y.2
Kobayashi, S.3
-
84
-
-
77953647516
-
Benefits of Pre-treatment with edaravone in tPA intravenous therapy for acute cerebral infarction. XXIII International Symposium on Cerebral Blood Flow [abstract]
-
Yoshifumi T. Benefits of Pre-treatment with edaravone in tPA intravenous therapy for acute cerebral infarction. XXIII International Symposium on Cerebral Blood Flow [abstract]. J Cereb Blood Flow Metab 2007;(Suppl 1):BP34-06M
-
(2007)
J Cereb Blood Flow Metab
, Issue.SUPPL. 1
-
-
Yoshifumi, T.1
-
86
-
-
77249083606
-
A post-marketing drug use survey of a neuroprotective drug Radicut injection 30mg (nonproprietary name: Edaravone) for acute ischmic stroke
-
Kageyama M, Toriyama S, Tsuboshita A. A post-marketing drug use survey of a neuroprotective drug Radicut injection 30mg (nonproprietary name: edaravone) for acute ischmic stroke. J New Rem Clin 2009;58:1212-1226
-
(2009)
J New Rem Clin
, vol.58
, pp. 1212-1226
-
-
Kageyama, M.1
Toriyama, S.2
Tsuboshita, A.3
-
87
-
-
34547795720
-
NXY-059 for the treatment of acute ischemic stroke
-
Shuaib A, Lees KR, Lyden P, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 2007;357(6):562-571
-
(2007)
N Engl J Med
, vol.357
, Issue.6
, pp. 562-571
-
-
Shuaib, A.1
Lees, K.R.2
Lyden, P.3
-
88
-
-
70350303591
-
Effects of NXY-059 in experimental stroke: An individual animal meta-analysis
-
Bath PM, Gray LJ, Bath AJ, et al. Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol 2009;157(7):1157-1171
-
(2009)
Br J Pharmacol
, vol.157
, Issue.7
, pp. 1157-1171
-
-
Bath, P.M.1
Gray, L.J.2
Bath, A.J.3
|